• United Kingdom

Accepting PhD Students

1988 …2019
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Research Output 1988 2019

2019

IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4R alpha signalling via T cells

McFarlane, E., Mokgethi, T., Kaye, P. M., Hurdayal, R., Brombacher, F., Alexander, J. & Carter, K. C., 16 Aug 2019, In : Frontiers in Immunology. 10, 13 p., 1957.

Research output: Contribution to journalArticle

Open Access
File
Visceral Leishmaniasis
Leishmania donovani
Interleukin-4
Interleukin-13
T-Lymphocytes
2017
4 Citations (Scopus)

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., Khalaf, A., Carter, K., Scott, F., Suckling, C. & Guler, R., 1 Dec 2017, In : Journal of Antimicrobial Chemotherapy. 72, 12, p. 3334–3341 8 p.

Research output: Contribution to journalArticle

Open Access
File
Nonionic surfactants
Mycobacterium tuberculosis
Surface-Active Agents
Binders
Anti-Bacterial Agents
2016
5 Citations (Scopus)

An evaluation of minor groove binders as anti-lung cancer therapeutics

Scott, F., Khalaf, A., Suckling, C., Carter, K., Grant, M., Henderson, C., Westrop, G. & Watson, D., 15 Jun 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 11 p.

Research output: Contribution to journalArticle

Open Access
File
gemcitabine
Binders
Lung Neoplasms
Biological Products
Early Detection of Cancer
14 Citations (Scopus)

Chemical and antimicrobial profiling of propolis from different regions within Libya

Siheri, W., Zhang, T., Ebiloma, G. U., Biddau, M., Woods, N., Hussain, M. Y., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., Müller, S., Carter, K. C., Ferro, V. A., De Koning, H. P. & Watson, D. G., 19 May 2016, In : PLOS One. 11, 5, 16 p., e0155355.

Research output: Contribution to journalArticle

Open Access
File
Crithidia fasciculata
Mycobacterium marinum
Libya
Propolis
Leishmania donovani
24 Citations (Scopus)

In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization

Shaw, C. D., Lonchamp, J., Downing, T., Imamura, H., Freeman, T. M., Cotton, J. A., Sanders, M., Blackburn, G., Dujardin, J. C., Rijal, S., Khanal, B., Illingworth, C. J. R., Coombs, G. H. & Carter, K. C., 1 Mar 2016, In : Molecular Microbiology. 99, 6, p. 1134-1148 15 p.

Research output: Contribution to journalArticle

Open Access
File
miltefosine
Leishmania donovani
Nepal
Metabolomics
Parasites

New avenues for drug delivery in Leishmania: using treatment of visceral leishmaniasis with amphotericin B as an exemplar.

Carter, K. & Mullen, A., 20 Dec 2016, (Accepted/In press) Drug Discovery in Leishmaniasis. 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Visceral Leishmaniasis
Leishmania
Amphotericin B
Drug Delivery Systems
Pharmaceutical Preparations
2015

Nanocarriers made from non-ionic surfactants or natural polymers for pulmonary drug delivery.

Carter, K. & Puig, M., 6 Dec 2015, (Accepted/In press) In : Current Pharmaceutical Design. 28 p.

Research output: Contribution to journalArticle

Open Access
File
Surface-Active Agents
Polymers
Lung
Pharmaceutical Preparations
Drug Delivery Systems
2014
5 Citations (Scopus)

Lessons to be learnt from Leishmania studies

Shaw, CD. & Carter, KC., 1 Jul 2014, In : Nanomedicine. 9, 10, p. 1531-1544 14 p.

Research output: Contribution to journalArticle

Open Access
File
leishmaniasis
Leishmania
drug
Parasites
Mucocutaneous Leishmaniasis
10 Citations (Scopus)

The isolation of antiprotozoal compounds from Libyan propolis

Siheri, W., Igoli, J. O., Gray, A. I., Nasciemento, T. G., Zhang, T., Fearnley, J., Clements, C. J., Carter, K. C., Carruthers, J., Edrada-Ebel, R. & Watson, D. G., Dec 2014, In : Phytotherapy Research. 28, 12, p. 1756–1760 5 p.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trypanosoma brucei brucei
Libya
Leishmania donovani
Microbial Sensitivity Tests
2013
6 Citations (Scopus)
Nonionic surfactants
High performance liquid chromatography
Humidity
System stability
Surface-Active Agents
2012
9 Citations (Scopus)

Comparative assessment of a DNA and protein Leishmania donovani gamma glutamyl cysteine synthetase vaccine to cross-protect against murine cutaneous leishmaniasis caused by L. major or L. mexicana infection

Carter, K., Roberts, C., Doro, B. M., Alsaadi, M., Mullen, A., Campbell, S., Alawa, J., Alawa, C. & Nok, A., 2012, In : Vaccine. 30, 7, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Glutamate-Cysteine Ligase
Leishmania major
cutaneous leishmaniasis
Leishmania donovani
25 Citations (Scopus)

Evaluating the potential of polyester nanoparticles for per oral delivery of amphotericin B in treating visceral leishmaniasis

Italia, J. L., Kumar, M. N. V. R. & Carter, K., Aug 2012, In : Journal of Biomedical Nanotechnology. 8, 4, p. 695-702 8 p.

Research output: Contribution to journalArticle

Polyesters
Visceral Leishmaniasis
Amphotericin B
Nanoparticles
Macrophages
28 Citations (Scopus)

Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol

Hendrickx, S., Inocêncio da Luz, R. A., Bhandari, V., Kuypers, K., Shaw, C., Lonchamp, J., Salotra, P., Carter, K., Carter, K., Sundar, S., Rijal, S., Dujardin, J-C., Cos, P. & Maes, L., 29 May 2012, In : PLOS Neglected Tropical Diseases. 6, 5, 7 p., e1664.

Research output: Contribution to journalArticle

Open Access
File
Paromomycin
Antimony
Inhibitory Concentration 50
Phenotype
India
23 Citations (Scopus)

The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection

Alsaadi, M., Italia, J. L., Mullen, A., Kumar, M. N. V. R., Candlish, A. A., Williams, R., Shaw, C. D., Al-Gawhari, F., Coombs, G., Wiese, M., Thomson, A., Puig-Sellart, M., Wallace, J., Sharp, A., Wheeler, L., Warn, P. & Carter, K., 28 Jun 2012, In : Journal of Controlled Release. 160, 3, p. 685-691 7 p.

Research output: Contribution to journalArticle

Pulmonary Aspergillosis
Leishmaniasis
Amphotericin B
Aerosols
Surface-Active Agents

The role of mast cells in protection against Leishmania donovani infection

Carter, K., Ross, K., Tacchini-Cottier, F. & Lawrence, C., Sep 2012, In : Immunology. 137, 1 special issue, p. 562-563 2 p.

Research output: Contribution to journalMeeting abstract

Leishmania donovani
Posters
Cytoprotection
Myeloid Cells
Allergy and Immunology
2011
23 Citations (Scopus)
Interleukin-4 Receptor alpha Subunit
Leishmania donovani
Interleukin-13
Granuloma
Neutrophils
34 Citations (Scopus)

Peroral amphotericin B polymer nanoparticles lead to comparable or superior in vivo antifungal activity to that of intravenous Ambisome® or Fungizone™

Italia, J. L., Sharp, A., Carter, K. C., Warn, P. & Kumar, M. N. V. R., 6 Oct 2011, In : PLoS One. 6, 10, 8 p., e25744.

Research output: Contribution to journalArticle

Open Access
File
amphotericin B
Amphotericin B
nanoparticles
Nanoparticles
polymers
2010
9 Citations (Scopus)
glutamate-cysteine ligase
Glutamate-Cysteine Ligase
Leishmania donovani
vaccination
Ligases
2009
90 Citations (Scopus)
Influenza Vaccines
influenza
mouth
immune response
vaccines

Pulmonary drug delivery with vesicles comprising non-ionic surfactants

Carter, K., Mullen, A. & Ferro, V., 30 Dec 2009, IPC No. PCT/GB2009/000539, Patent No. WO/2009/156706

Research output: Patent

Drug Compounding
Platinum
Surface-Active Agents
Respiratory System
Lung Diseases
2008
88 Citations (Scopus)

Neutrophils contribute to development of a protective immune response during onset of infection with Leishmania donovani

McFarlane, E., Perez, C., Charmoy, M., Allenbach, C., Carter, K. C., Alexander, J. & Tacchini-Cottier, F., Feb 2008, In : Infection and Immunity. 76, 2, p. 532-541 10 p.

Research output: Contribution to journalArticle

Leishmania donovani
Neutrophils
Infection
Granuloma
Interleukin-4
68 Citations (Scopus)

Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors

Jones, L. A., Anthony, J., Henriquez, F. L., Lyons, R., Nickdel, M. B., Carter, K. C., Alexander, J. & Roberts, C. W., Jan 2008, In : Immunology. 125, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Macrophage Activation
Glucocorticoid Receptors
Progesterone Receptors
Progesterone
2007
20 Citations (Scopus)
Acanthamoeba
Inhibitory Concentration 50
Phospholipids
Acanthamoeba castellanii
Epithelial Cells
20 Citations (Scopus)

DNA vaccination against the parasite enzyme gamma-glutamylcysteine synthetase confers protection against Leishmania donovani infection

Carter, K. C., Henriquez, F. L., Campbell, S. A., Roberts, C. W., Nok, A., Mullen, A. B. & McFarlane, E., 30 May 2007, In : Vaccine. 25, 22, p. 4502-4509 8 p.

Research output: Contribution to journalArticle

glutamate-cysteine ligase
Glutamate-Cysteine Ligase
Leishmania donovani
plasmids
Parasites
48 Citations (Scopus)

Identification of the benzodiazepines as a new class of antileishmanial agent

Clark, R. L., Carter, K. C., Mullen, A. B., Coxon, G. D., Owusu-Dapaah, G., McFarlane, E., Dao Duong Thi, M., Grant, M. H., Tettey, J. N. A. & Mackay, S. P., Feb 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 3, p. 624-627 3 p.

Research output: Contribution to journalArticle

Sodium Compounds
Antimony Sodium Gluconate
Poisons
Benzodiazepines
Coinfection
2006
79 Citations (Scopus)

Carbohydrate-based micelle clusters which enhance hydrophobic drug bioavailability by up to 1 order of magnitude

Qu, X., Khutoryanskiy, V. V., Stewart, A., Rahman, S., Papahadjopoulos-Sternberg, B., Dufès, C., McCarthy, D., Wilson, C. G., Lyons, R., Carter, K. C., Schätzlein, A. & Uchegbu, I. F., 2006, In : Biomacromolecules. 7, 12, p. 3452-3459 7 p.

Research output: Contribution to journalArticle

Micelles
Carbohydrates
Prednisolone
Pharmacodynamics
Pharmaceutical Preparations
9 Citations (Scopus)
Antimony Sodium Gluconate
Leishmania donovani
Interleukin-18
Interferon-gamma
Immunity
5 Citations (Scopus)

Mucosal immunisation: successful approaches to targeting different tissues

Ferro, V. A. & Carter, K. C., 2006, In : Methods. 38, 2, p. 61-64 4 p.

Research output: Contribution to journalArticle

Immunization
Tissue
Antigens
Vaccination
Vaccines
54 Citations (Scopus)

Oral delivery of tetanus toxoid using vesicles containing bile salts (bilosomes) induces significant systemic and mucosal immunity

Alexander, J., Mann, J. F. S., Scales, H. E., Shakir, E., Carter, K. C., Mullen, A. & Ferro, V. A., Feb 2006, In : Methods. 38, 2, p. 90-95 5 p.

Research output: Contribution to journalArticle

Mucosal Immunity
Tetanus Toxoid
Bile Acids and Salts
Small Intestine
Antigens
40 Citations (Scopus)

Resistance of leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase

Carter, K. C., Hutchison, S., Henriquez, F. L., Legare, M., Ouellette, M., Roberts, C. W. & Mullen, A., Jan 2006, In : Antimicrobial Agents and Chemotherapy. 50, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

Antimony Sodium Gluconate
Glutamate-Cysteine Ligase
Leishmania donovani
Parasites
gamma-glutamylcysteine
1 Citation (Scopus)

Translation of an experimental oral vaccine formulation into a commercial product

Carter, K. C., Ferro, V. A., Alexander, J. & Mullen, A., 2006, In : Methods. 38, 2, p. 65-68 4 p.

Research output: Contribution to journalArticle

Vaccines
Research Personnel
Intellectual Property
Influenza Vaccines
Intellectual property

Translation of an experimental oral vaccine formulation into a commercial product.

Carter, K., Ferro, V., Alexander, J. & Mullen, A., 2006, Methods.. Vol. 38. p. 65-68 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vaccines
Research Personnel
Intellectual Property
Influenza Vaccines
Contracts
2005
20 Citations (Scopus)

Sodium stibogluconate resistance in leishmania donovani correlates with greater tolerance to macrophage antileishmanial responses and trivalent antimony therapy

Carter, K. C., Hutchison, S., Boitelle, A., Murray, H. W., Sundar, S. & Mullen, A., 2005, In : Parasitology. 131, 6, p. 747-757 10 p.

Research output: Contribution to journalArticle

Antimony Sodium Gluconate
antimony
Leishmania donovani
Antimony
macrophages
2004
23 Citations (Scopus)

Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy

Ferro, V. A., Costa, R., Carter, K. C., Harvey, M. J., Waterston, M. M., Mullen, A., Matschke, C., Mann, J. F. S., Colston, A. & Stimson, W. H., 25 Feb 2004, In : Vaccine. 22, 8, p. 1024-31 8 p.

Research output: Contribution to journalArticle

Gonadotropin-Releasing Hormone
adjuvants
Fertility
Vaccines
triacetin
45 Citations (Scopus)

Optimisation of a lipid based oral delivery system containing A/Panama influenza haemagglutinin

Mann, J. F. S., Ferro, V. A., Mullen, A., Tetley, L., Mullen, M., Carter, K. C., Alexander, J. & Stimson, W. H., 2004, In : Vaccine. 22, 19, p. 2425-2429 4 p.

Research output: Contribution to journalArticle

Panama
Hemagglutinins
hemagglutinins
influenza
Human Influenza
2003
37 Citations (Scopus)

Pharmacokinetics, toxicities, and efficacies of sodium stibogluconate formulations after intravenous administration in animals

Nieto, J., Alvar, J., Mullen, A., Carter, K. C., Rodriguez, C., San Andres, M. I., San Andres, M. D. & Baillie, A. J., Sep 2003, In : Antimicrobial Agents and Chemotherapy . 47, 9, p. 2781-2787 6 p.

Research output: Contribution to journalArticle

Antimony Sodium Gluconate
Intravenous Administration
Pharmacokinetics
Dextrans
Dogs
43 Citations (Scopus)

The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis

Carter, K. C., Sundar, S., Spickett, C. M., Pereira, O. C. & Mullen, A., May 2003, In : Antimicrobial Agents and Chemotherapy. 47, 5, p. 1529-1535 7 p.

Research output: Contribution to journalArticle

Antimony Sodium Gluconate
Leishmania donovani
Glutathione
Pharmaceutical Preparations
Buthionine Sulfoximine
2002
43 Citations (Scopus)

An essential role for IL-13 in maintaining a non-healing response following leishmania mexicana infection

Alexander, J., Brombacher, F., McGachy, H. A., McKenzie, A. N. J., Walker, W. & Carter, K. C., 2002, In : European Journal of Immunology. 32, 10, p. 2923-2933 11 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Interleukin-13
Interleukin-4
Infection
Growth
26 Citations (Scopus)

The effect of nitrostyrene on cell proliferation and macrophage immune responses

Nic Daeid, N., Carter, K. C., Finnon, Y. S., Waddell, R. J. H. & Robson, D. C., 2002, In : Immunopharmacology and Immunotoxicology. 24, 2, p. 187-197 11 p.

Research output: Contribution to journalArticle

Macrophages
Cell proliferation
Cell Proliferation
Amphetamine
Nitrites
2001
30 Citations (Scopus)

Efficacies of vesicular and free sodium stibogluconate formulations against clinical isolates of leishmania donovani

Carter, K. C., Mullen, A., Sundar, S. & Kenney, R. T., Dec 2001, In : Antimicrobial Agents and Chemotherapy. 45, 12, p. 355-359 5 p.

Research output: Contribution to journalArticle

Antimony Sodium Gluconate
Leishmania donovani
Parasites
Liver
2000
82 Citations (Scopus)

Endogenous IL-4 is necessary for effective treatment against visceral leishmaniasis.

Alexander, J., Carter, K. C., Al-Fasi, N., Satoskar, A. & Brombacher, F., 29 Nov 2000, In : European Journal of Immunology. 30, 10, p. 2935-2943 8 p.

Research output: Contribution to journalArticle

Open Access
Visceral Leishmaniasis
Interleukin-4
Antimony Sodium Gluconate
Leishmania donovani
Parasites

Non-ionic surfactant vesicles for the treatment of visceral leishmaniasis

Mullen, A. & Carter, K., 23 Feb 2000, Synthetic surfactant vesicles: niosomes and other non-phospholipid vesicular systems. Uchegbu, L. F. (ed.).

Research output: Chapter in Book/Report/Conference proceedingChapter

Surfactant

Non-Ionic Surfactant Vesicles for the Treatment of Visceral Leishmaniasis.

Mullen, A., Carter, K. & Baillie, A., 23 Feb 2000, Synthetic Surfactant Vesicles: Niosomes and Other Non-Phospholipid Vesicular Systems. Uchegbu, I. F. (ed.). Amsterdam , 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1999
Open Access
Antimony Sodium Gluconate
Visceral Leishmaniasis
Surface-Active Agents
Phenotype
Infection
1998
20 Citations (Scopus)
Open Access
Paromomycin
Visceral Leishmaniasis
Surface-Active Agents
Parasites
Leishmania donovani
43 Citations (Scopus)
Open Access
Antimony Sodium Gluconate
Drug Compounding
Visceral Leishmaniasis
Amphotericin B
Surface-Active Agents
1997
80 Citations (Scopus)

A comparison of the efficacy of various formulations of amphotericin B against murine visceral leishmaniasis.

Mullen, A. B., Carter, K. C. & Baillie, A. J., 1 Oct 1997, In : Antimicrobial Agents and Chemotherapy . 41, 10, p. 2089-2092 4 p.

Research output: Contribution to journalArticle

Open Access
Visceral Leishmaniasis
Amphotericin B
Surface-Active Agents
Parasites
Antiparasitic Agents

Immune responses of Leishmania donovani infected BALB/c mice following treatment with free and vesicular sodium stibogluconate.

Banduwardene, R., Mullen, A. B. & Carter, K. C., 1 Apr 1997, 19, 4, p. 195-203 8 p.

Research output: Contribution to journalArticle

Antimony Sodium Gluconate
Leishmania donovani
Surface-Active Agents
Parasites
Spleen
1995
17 Citations (Scopus)
Antimony Sodium Gluconate
Visceral Leishmaniasis
Surface-Active Agents
Suspensions
Parasites
1993
3 Citations (Scopus)

Genetic control of drug induced recovery from murine visceral leishmaniasis.

Carter, K. C., Baillie, A. J. & Alexander, J., 1 Sep 1993, In : Journal of Pharmacy and Pharmacology. 45, 9, p. 795-798 4 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Drug and Narcotic Control
Haplotypes
Parasites
Antimony Sodium Gluconate