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Research Output 2001 2019

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Article
2019

JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk

Openshaw, R. L., Kwon, J., McColl, A., Penninger, J. M., Cavanagh, J., Pratt, J. A. & Morris, B. J., 28 Jan 2019, In : Journal of Neuroinflammation. 16, 1, 11 p., 18.

Research output: Contribution to journalArticle

Open Access
File
Schizophrenia
Genotype
Mothers
Chemokines
Cytokines
2018
1 Citation (Scopus)

Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse

Kouskou, M., Thomson, D. M., Brett, R. R., Wheeler, L., Tate, R. J., Pratt, J. A. & Chamberlain, L. H., 31 Oct 2018, In : Experimental Neurology. 308, p. 35-46 12 p.

Research output: Contribution to journalArticle

Open Access
File
Intellectual Disability
Acylation
Corpus Callosum
Protein S
Genes
Open Access
File
Serum Albumin
Culture Media
Albumins
Proteins
Western Blotting
2017
5 Citations (Scopus)
Open Access
File
Minocycline
Schizophrenia
Neocortex
Mitogen-Activated Protein Kinase Kinases
Tetracycline
8 Citations (Scopus)

Thalamo-cortical communication, glutamatergic neurotransmission and neural oscillations: a unique window into the origins of ScZ?

Pratt, J., Dawson, N., Morris, B. J., Grent T'Jong, T., Roux, F. & Uhlhaas, P. J., Feb 2017, In : Schizophrenia Research. 180, p. 4-12 9 p.

Research output: Contribution to journalArticle

Open Access
File
Synaptic Transmission
Schizophrenia
Communication
N-Methylaspartate
Cognition
2015
20 Citations (Scopus)

Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

Dawson, N., Kurihara, M., Thomson, DM., Winchester, CL., McVie, A., Hedde, JR., Randall, AD., Shen, S., Seymour, PA., Hughes, ZA., Dunlop, J., Brown, JT., Brandon, NJ., Morris, BJ. & Pratt, JA., 19 May 2015, In : Translational Psychiatry. 5, 12 p., e569.

Research output: Contribution to journalArticle

Open Access
File
Transgenic Mice
Glutamic Acid
Brain
Schizophrenia
Prefrontal Cortex
14 Citations (Scopus)

Functional brain connectivity phenotypes for schizophrenia drug discovery

Dawson, N., Morris, B. J. & Pratt, J. A., 1 Feb 2015, In : Journal of Psychopharmacology. 29, 2, p. 169-177 9 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Discovery
Schizophrenia
Phenotype
Brain
Rodentia
8 Citations (Scopus)

Miniature wireless recording and stimulation system for rodent behavioural testing

Pinnell, R. C., Dempster, J. & Pratt, J., 19 Oct 2015, In : Journal of Neural Engineering. 12, 6, 15 p., 066015.

Research output: Contribution to journalArticle

Open Access
File
Deep Brain Stimulation
Rodentia
Brain Fornix
Short-Term Memory
Electroencephalography
29 Citations (Scopus)
Open Access
File
Thalamic Nuclei
Drug Discovery
Schizophrenia
Thalamus
Neuroanatomy
2014
20 Citations (Scopus)

Risk genes for schizophrenia: translational opportunities for drug discovery

Winchester, C. L., Pratt, J. A. & Morris, B. J., Jul 2014, In : Pharmacology and Therapeutics. 143, 1, p. 34-50 17 p.

Research output: Contribution to journalArticle

Drug Discovery
Schizophrenia
Genes
Glutamic Acid
Dopamine
22 Citations (Scopus)
Ketamine
Schizophrenia
Brain
N-Methylaspartate
Prefrontal Cortex
27 Citations (Scopus)

Sustained NMDA receptor hypofunction induces compromised neural systems integration and schizophrenia-like alterations in functional brain networks

Dawson, N., Xiao, X., McDonald, M. D., Higham, D., Morris, B. J. & Pratt, J., Feb 2014, In : Cerebral Cortex. 24, 2, p. 452-464 13 p.

Research output: Contribution to journalArticle

Systems Integration
N-Methylaspartate
Schizophrenia
Brain
Psychiatry
2013
32 Citations (Scopus)

Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice

Kirshenbaum, G. S., Dawson, N., Mullins, J. G. L., Johnston, T. H., Drinkhill, M. J., Edwards, I. J., Fox, S. H., Pratt, J. A., Brotchie, J. M., Roder, J. C. & Clapcote, S. J., 20 Mar 2013, In : PLOS One. 8, 3, 15 p., e60141.

Research output: Contribution to journalArticle

sodium-potassium-exchanging ATPase
childhood
Adenosine Triphosphatases
Phenotype
phenotype
9 Citations (Scopus)
Mediodorsal Thalamic Nucleus
Deep Brain Stimulation
Frontal Lobe
Immediate-Early Genes
Motor Cortex
43 Citations (Scopus)

Subanaesthetic ketamine treatment alters prefrontal cortex connectivity with thalamus and ascending subcortical systems

Dawson, N., Morris, B. J. & Pratt, J., 2 Mar 2013, In : Schizophrenia Bulletin. 39, 2, p. 366-377 12 p.

Research output: Contribution to journalArticle

Ketamine
Prefrontal Cortex
N-Methyl-D-Aspartate Receptors
Thalamus
Thalamic Nuclei
2012
5 Citations (Scopus)

Chronic phencyclidine (PCP)-induced modulation of muscarinic receptor mRNAs in rat brain: impact of antipsychotic drug treatment

Steward, L. J., Kennedy, M. D., Morris, B. J. & Pratt, J. A., Mar 2012, In : Neuropharmacology. 62, 3, p. 1554-1563 10 p.

Research output: Contribution to journalArticle

pamidronate
Phencyclidine
Muscarinic Receptors
Antipsychotic Agents
Clozapine
23 Citations (Scopus)

Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia

Winchester, C., Ohzeki, H., Vouyiouklis, D., Thompson, R., Yamagami, K., Norrie, J., Hunter, R., Pratt, J. & Morris, B. J., 15 Nov 2012, In : Human Molecular Genetics . 21, 22, p. 4910-4921 12 p.

Research output: Contribution to journalArticle

Schizophrenia
Genes
Prefrontal Cortex
JNK Mitogen-Activated Protein Kinases
Genetic Association Studies
31 Citations (Scopus)

Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity

Dawson, N., Thompson, R. J., McVie, A., Thomson, D. M., Morris, B. J. & Pratt, J., 3 May 2012, In : Schizophrenia Bulletin. 38, 3, p. 457-474 18 p.

Research output: Contribution to journalArticle

Phencyclidine
Brain
Least-Squares Analysis
Schizophrenia
Aptitude
2011
16 Citations (Scopus)

Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways

Ledgerwood, C., Greenwood, S. M., Brett, R. R., Pratt, J. A. & Bushell, T., Jan 2011, In : British Journal of Pharmacology. 162, 1, p. 286-294 9 p.

Research output: Contribution to journalArticle

Cannabidiol
Synaptic Transmission
Cannabinoid Receptor CB1
Receptor, Serotonin, 5-HT1A
Serotonin 5-HT1 Receptor Antagonists
21 Citations (Scopus)

Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

Thomson, D. M., McVie, A., Morris, B. J. & Pratt, J. A., 2011, In : Psychopharmacology. 213, 4, p. 681-95 15 p.

Research output: Contribution to journalArticle

Phencyclidine
Clozapine
Reaction Time
Schizophrenia
Nootropic Agents
13 Citations (Scopus)

Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the generalized singular value decomposition

Xiao, X., Dawson, N., MacIntyre, L., Morris, B. J., Pratt, J. A., Watson, D. G. & Higham, D. J., 16 May 2011, In : BMC Systems Biology. 5, 20 p., 72.

Research output: Contribution to journalArticle

Open Access
File
Generalized Singular Value Decomposition
Phencyclidine
Singular value decomposition
Metabolic Networks and Pathways
Pathway
35 Citations (Scopus)

Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of Δ9-tetrahydrocannabinol on spatial memory

Sousa, V. C., Assaife-Lopes, N., Ribeiro, J. A., Pratt, J. A., Brett, R. R. & Sebastião, A. M., 2011, In : Neuropsychopharmacology . 36, 2, p. 472-487 16 p.

Research output: Contribution to journalArticle

Adenosine A1 Receptors
Cannabinoid Receptor CB1
Dronabinol
Caffeine
gamma-Aminobutyric Acid

Viral-mediated knockdown of ERBB4 in the rodent prefrontal cortex enhances cognitive performance

Winchester, C. L., Paterson, C., Morris, B., Glover, C. P., Storey, J., Hussein, I. & Pratt, J. A., Aug 2011, In : Journal of Psychopharmacology. 25, 8 Supplement S, p. A68-A68 1 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Rodentia
2009
111 Citations (Scopus)

Neuropsychiatric disease and toxoplasma gondii infection

Henriquez, S. A., Brett, R., Alexander, J., Pratt, J. & Roberts, C. W., 2009, In : Neuroimmunomodulation. 16, 2, p. 122-133 12 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Toxoplasma
Schizophrenia
Depression
Aromatic Amino Acids
2008

Clozapine produces modest effects on pcp-induced performance deficits in the 5-choice serial reaction time task

Thomson, D. M., Mcvie, A., Morris, B. J. & Pratt, J. A., Sep 2008, In : Behavioural Pharmacology. 19, 5-6, p. 655-656 1 p.

Research output: Contribution to journalArticle

Clozapine
Ireland
Pharmacology
Education
114 Citations (Scopus)

Modelling prefrontal cortex deficits in schizophrenia: implications for treatment

Pratt, J. A., Winchester, C., Egerton, A., Cochran, S. M. & Morris, B. J., Mar 2008, In : British Journal of Pharmacology. 153, p. S465-S470

Research output: Contribution to journalArticle

Prefrontal Cortex
Schizophrenia
Parvalbumins
Executive Function
Interneurons
88 Citations (Scopus)

Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats

Egerton, A., Reid, L., McGregor, S., Cochran, S. M., Morris, B. J. & Pratt, J., Apr 2008, In : Psychopharmacology. 198, 1, p. 37-49 13 p.

Research output: Contribution to journalArticle

Schizophrenia
Aptitude
Amphetamine
Interpersonal Relations
N-Methyl-D-Aspartate Receptors
2007
17 Citations (Scopus)

M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds

Suckling, C. J., Murphy, J. A., Khalaf, A. I., Zhou, S., Lizos, D. E., Nguyen Van Nhien, A., Yasumatsu, H., McVie, A., Young, L. C., McCraw, C., Waterman, P. G., Morris, B. J., Pratt, J. A. & Harvey, A., 1 May 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 9, p. 2649-2655 7 p.

Research output: Contribution to journalArticle

Tetrahydroisoquinolines
Phencyclidine
Muscarinic Receptors
Drug Delivery Systems
Biological Products
2006
103 Citations (Scopus)

Cannabinoids and prefrontal cortical function: insights from preclinical studies

Egerton, A. D., Allison, C., Brett, R. R. & Pratt, J. A., 2006, In : Neuroscience and Biobehavioral Reviews. 30, 5, p. 680-695 16 p.

Research output: Contribution to journalArticle

Cannabinoids
Prefrontal Cortex
Cannabis
Cognition
Cognition Disorders
20 Citations (Scopus)

Differential effects of two chronic diazepam treatment regimes on withdrawal anxiety and aMPA receptor characteristics

Allison, C. & Pratt, J. A., Jun 2006, In : Neuropsychopharmacology. 31, p. 602-619 18 p.

Research output: Contribution to journalArticle

Diazepam
Anxiety
AMPA Receptors
Amygdala
Benzodiazepines
2005
37 Citations (Scopus)

Acute ∆9-tetrahydrocannabinol-induced deficits in reversal learning: neural correlates of affective inflexibility

Egerton, A. D., Brett, R. R. & Pratt, J. A., 6 Apr 2005, In : Neuropsychopharmacology. 30, p. 1895-1905 11 p.

Research output: Contribution to journalArticle

Reversal Learning
Dronabinol
Cannabis
Aptitude
Prefrontal Cortex
8 Citations (Scopus)

AMPA receptor autoradiography in mouse brain following single and repeated withdrawal from diazepam

Allison, C., Pratt, J. A., Ripley, T. & Stephens, D. N., 2005, In : European Journal of Neuroscience. 21, p. 1045-1056 11 p.

Research output: Contribution to journalArticle

Propionates
Diazepam
Autoradiography
Seizures
Anxiety
111 Citations (Scopus)

Impairment in perceptual attentional set shifting following PCP administration: a rodent model of set-shifting deficits in schizophrenia

Egerton, A. D., Reid, L., McKerchar, C., Morris, B. J. & Pratt, J. A., 2005, In : Psychopharmacology. 179, p. 77-84 8 p.

Research output: Contribution to journalArticle

Parvalbumins
Aptitude
Rodentia
Schizophrenia
Phencyclidine
2003
182 Citations (Scopus)

Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: differential modulation by antipsychotic drugs

Cochran, S. M., Steward, L., Kennedy, M. D., McKerchar, C., Pratt, J. A. & Morris, B. J., 2003, In : Neuropsychopharmacology. 28, p. 265-275 11 p.

Research output: Contribution to journalArticle

Phencyclidine
Prefrontal Cortex
Antipsychotic Agents
Parvalbumins
Schizophrenia
2001

[DELTA]9-tetrahydrocannabinol-induced alterations in limbic system glucose use in the rat

Brett, R., MacKenzie, F. & Pratt, J., 16 Nov 2001, In : NeuroReport. 12, 16, p. 3573-3577 4 p.

Research output: Contribution to journalArticle

Limbic System
Dronabinol
Glucose
Hippocampus
Deoxyglucose
2 Citations (Scopus)
Charybdotoxin
Glucose
Brain
Hippocampus
Deoxyglucose