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Personal profile

Personal Statement

Research Professor (2013-), Professor of Systems Neuroscience (2003), PhD (Institute of Psychiatry 1982).  Co-Director of Psychiatric Research Institute of Neuroscience in Glasgow (PsyRING; psyring.co.uk) a collaboration between the Universities of Strathclyde and Glasgow and NHS Greater Glasgow & Clyde.  Since 1997, PsyRING has engaged in major collaborations with Pharmaceutical companies to provide translational solutions for drug discovery and development in Psychiatric disease. 

Research Interests are focussed on understanding the molecular and neural systems that underpin behaviour in mental health and disease. We are a multidisciplinary, friendly team with expertise spanning genetics, molecular biology, brain imaging and behaviour.

Schizophrenia: PsyRING has provided new insight into the glutamate hypothesis of schizophrenia.  We have demonstrated that PCP produces schizophrenia-like changes in brain imaging, GABAergic interneurone markers and cognition. Novel therapeutic targets have been identified (e.g. serominic) and validated.   We have determined the functional brain networks subserving PCP-induced disruption of cognition and their restoration by the pro-cognitive drug modafinil.  Current work is focussed on understanding the neurobiological mechanisms of genetic risk factors for schizophrenia. We have identified a novel risk gene for schizophrenia MAP2K7 and shown that it produces schizophrenia-like working memory deficits. In a recent multicentre translational medicine grant with Pfizer we have identified key neural substrates underpinning behavioural deficits in DISC1 mouse models and demonstrated that the thalamic reticular nucleus is a key region affected in the models.

Cannabinoids: We are investigating the mechanisms of interaction between the constituents of cannabis (e.g. THC and cannabidiol) and with THC and other psychoactive drugs.  Recent work is focussed on environment-environment interactions determining the impact of prenatal infection and adolescence THC exposure on brain systems and behaviour in adulthood.

CeNsUS (Centre for Neuroscience at the University of Strathclyde): Through multidisciplinary collaborations within CeNsUS we are 1) applying novel algorithms from network science to understanding brain systems underpinning drug actions in disease and  2) developing medical devices for deep brain stimulation 3) Investigating the role of the reticular thalamic nucleus in the corticothalamic system using optogenetics

Public engagement.  Engaged in activities at the Glasgow Science Festival, Glasgow Science Centre, Schools, Restaurants, British Association for the Advancement of Science 

Education/Academic qualification

Doctor of Philosophy, University of London

Fingerprint Dive into the research topics where Judith Pratt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2006 2019

Research Output 2001 2019

JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk

Openshaw, R. L., Kwon, J., McColl, A., Penninger, J. M., Cavanagh, J., Pratt, J. A. & Morris, B. J., 28 Jan 2019, In : Journal of Neuroinflammation. 16, 1, 11 p., 18.

Research output: Contribution to journalArticle

Open Access
File
Schizophrenia
Genotype
Mothers
Chemokines
Cytokines
6 Citations (Scopus)

Biomarkers in neuropsychiatry: a prospect for the twenty-first century?

Pratt, J. & Hall, J., 3 Jul 2018, Current Topics in Behavioral Neurosciences. Berlin: Springer, 8 p. (Current Topics in Behavioral Neurosciences).

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuropsychiatry
Biomarkers
Mental Disorders
Psychiatry
Mental Health

Thesis

Characterising mismatch negativity biomarker signatures in preclinical models relevant to schizophrenia

Author: O'Reilly, J., 1 Oct 2015

Supervisor: Conway, B. (Supervisor) & Pratt, J. (Supervisor)

Student thesis: Doctoral Thesis

Exploring the links between the ZDHHC9 gene and intellectual disability

Author: Kouskou, M., 1 Dec 2017

Supervisor: Chamberlain, L. (Supervisor) & Pratt, J. (Supervisor)

Student thesis: Doctoral Thesis

Prizes

BAP Public Communication Prize

Judith Pratt (Recipient), 24 Jul 2018

Prize: Prize (including medals and awards)

Psychopharmacology
Reward
Communication

Activities 2002 2018

  • 4 Participation in conference
  • 3 Key-note speaker and plenary lectures at conferences
  • 3 Invited talk
  • 2 Editorial board member

Translational rodent models of social behaviours and social cognition: challenges, insights and prospects for new treatments

Judith Pratt (Speaker)
22 Jul 201825 Jul 2018

Activity: Talk or presentation typesInvited talk