• United Kingdom

Accepting PhD Students

19982021
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Research Output 1998 2019

2019

Developing a method to determine the flux of material arriving and leaving a crystal at equilibrium

Nguyen, T. T. H., Vesga, J., Parkinson, J. & Price, C. J., 9 Jul 2019, p. 74. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
crystals
surface layers

Investigation of molecular and mesoscale clusters in undersaturated glycine aqueous solutions

Zimbitas, G., Jawor-Baczynska, A., Vesga, M. J., Javid, N., Moore, B. D., Parkinson, J. & Sefcik, J., 20 Oct 2019, In : Colloids and Surfaces A: Physicochemical and Engineering Aspects. 579, 8 p., 123633.

Research output: Contribution to journalArticle

Open Access
File
molecular clusters
glycine
Glycine
Amino acids
aqueous solutions
Open Access
File
Bee Venoms
Metabolomics
Immune System
Macrophages
Interleukin-1beta

Sequence-selective minor groove recognition of a DNA duplex containing synthetic genetic components

Padroni, G., Withers, J. M., Taladriz Sender, A., Reichenbach, L. F., Parkinson, J. A. & Burley, G. A., 19 Jun 2019, In : Journal of the American Chemical Society. 141, 24, p. 9555-9563 9 p.

Research output: Contribution to journalArticle

Open Access
File
Nylons
Polyamides
DNA
Base Pairing
Pyrroles

Structural and kinetic profiling of allosteric modulation of duplex DNA induced by DNA-binding polyamide analogues

Aman, K., Padroni, G., Parkinson, J. A., Welte, T. & Burley, G. A., 21 Feb 2019, In : Chemistry - A European Journal. 25, 11, p. 2757-2763 7 p.

Research output: Contribution to journalArticle

Open Access
File
Nylons
Polyamides
DNA
Modulation
Kinetics
2018
4 Citations (Scopus)
Open Access
File
Melitten
Metabolomics
Cytokines
Lipopolysaccharides
Macrophages

NMR spectroscopy methods in metabolic phenotyping

Parkinson, J. A., 5 Oct 2018, The Handbook of Metabolic Phenotyping. Lindon, J., Nicholson, J. & Holmes, E. (eds.). Cambridge, MA, p. 53-96 44 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nuclear magnetic resonance spectroscopy
Protons
Magnetic Resonance Spectroscopy
Metabolomics
Nuclear magnetic resonance
7 Citations (Scopus)

Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL and interleukin-12

Altwaijry, N., Somani, S., Parkinson, J. A., Tate, R. J., Keating, P., Warzecha, M., MacKenzie, G. R., Leung, H. Y. & Dufès, C., 1 Mar 2018, In : Drug Delivery. 25, 1, p. 679-689 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lactoferrin
Interleukin-12
Intravenous Administration
Prostate
Tumor Necrosis Factor-alpha
9 Citations (Scopus)

Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides

Padroni, G., Parkinson, J. A., Fox, K. R. & Burley, G. A., 9 Jan 2018, In : Nucleic Acids Research. 46, 1, p. 42-53 12 p.

Research output: Contribution to journalArticle

Open Access
File
Thiazoles
Nylons
DNA sequences
DNA
Freezing
2017
4 Citations (Scopus)

Determination of equilibrium constant of C60 fullerene binding with drug molecules

Mosunov, A. A., Pashkova, I., Sidorova, M., Pronozin, A., Lantushenko, A., Prylutskyy, Y. I., Parkinson, J. A. & Evstigneev, M. P., 1 Mar 2017, In : Physical Chemistry Chemical Physics. 19, 9, p. 6777-6784 8 p.

Research output: Contribution to journalArticle

Open Access
File
Equilibrium constants
fullerenes
drugs
Molecules
Ligands
6 Citations (Scopus)
Open Access
File
Formaldehyde
Nuclear magnetic resonance spectroscopy
Polymerization
Kinetics
Gels
9 Citations (Scopus)

Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells

Alonezi, S., Tusiimire, J., Wallace, J., Dufton, M. J., Parkinson, J. A., Young, L. C., Clements, C. J., Park, J-K., Jeon, J-W., Ferro, V. A. & Watson, D. G., 14 Apr 2017, In : Metabolites. 7, 14, p. 1-18 18 p.

Research output: Contribution to journalArticle

Open Access
File
Melitten
Metabolomics
Ovarian Neoplasms
Cisplatin
Cells
2016
5 Citations (Scopus)

Effect of bee venom and its fractions on the release of pro-inflammatory cytokines in PMA-differentiated U937 cells co-stimulated with LPS

Tusiimire, J., Wallace, J., Woods, N., Dufton, M. J., Parkinson, J. A., Abbott, G., Clements, C. J., Young, L., Park, J. K., Jeon, J. W., Ferro, V. A. & Watson, D. G., 19 Apr 2016, In : Vaccines. 4, 2, 15 p., 11.

Research output: Contribution to journalArticle

Open Access
File
Bee Venoms
U937 Cells
Acetates
Cytokines
Interleukin-6
3 Citations (Scopus)

Metabolomic profiling of the effects of melittin on cisplatin resistant and cisplatin sensitive ovarian cancer cells using mass spectrometry and biolog microarray technology

Alonezi, S., Tusiimire, J., Wallace, J., Dufton, M. J., Parkinson, J. A., Young, L. C., Clements, C. J., Park, J. K., Jeon, J. W., Ferro, V. A. & Watson, D. G., 13 Oct 2016, In : Metabolites. 6, 4, 18 p.

Research output: Contribution to journalArticle

Open Access
File
Melitten
Metabolomics
Microarrays
Ovarian Neoplasms
Cisplatin
1 Citation (Scopus)

Standardless, automated determination of Chlorine-35 by 35Cl nuclear magnetic resonance

Watson, S. A., Edwards, A. J. & Parkinson, J. A., 24 May 2016, In : Analytical Letters. 50, 1, p. 161-172 12 p.

Research output: Contribution to journalArticle

Open Access
File
Chlorine
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Chlorides
Limit of Detection
2015
5 Citations (Scopus)

1H nuclear magnetic resonance spectroscopy-based metabonomic study in patients with cirrhosis and hepatic encephalopathy

Dabos, K. J., Parkinson, J. A., Sadler, I. H., Plevris, J. N. & Hayes, P. C., 28 Jun 2015, In : World Journal of Hepatology. 7, 12, p. 1701-1707 7 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Hepatic Encephalopathy
Fibrosis
Magnetic Resonance Spectroscopy
Discriminant Analysis
17 Citations (Scopus)

Adding a structural context to the deprotometalation and trans-metal trapping chemistry of phenyl-substituted benzotriazole

Fuentes, M. Á., Kennedy, A. R., Mulvey, R. E., Parkinson, J. A., Rantanen, T., Robertson, S. D. & Snieckus, V., 12 Oct 2015, In : Chemistry - A European Journal . 21, 42, p. 14812-14822 11 p.

Research output: Contribution to journalArticle

Open Access
File
Organometallics
Isomers
Nuclear magnetic resonance spectroscopy
Extrusion
Quenching
4 Citations (Scopus)

Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition

Rubinson, M. A., Parkinson, J. A. & Evstigneev, M. P., 16 Mar 2015, In : Chemical Physics Letters. 624, p. 12-14 3 p.

Research output: Contribution to journalArticle

Open Access
File
drugs
deoxyribonucleic acid
Binders
grooves
DNA
9 Citations (Scopus)

HOBS methods for enhancing resolution and sensitivity in small DNA oligonucleotide NMR studies

McKenna, J. M. & Parkinson, J. A., Apr 2015, In : Magnetic Resonance in Chemistry . 53, 4, p. 249-255 7 p.

Research output: Contribution to journalArticle

Open Access
File
Oligonucleotides
DNA
Nuclear magnetic resonance
Protons
Biopolymers
1 Citation (Scopus)

Modern NMR Pulse Sequences in Pharmaceutical R & D

Parkinson, J., 16 Mar 2015, eMagRes. Harris, R., Everett, J., Wilson, I. & Lindon, J. (eds.). Chichester, UK, Vol. 4. p. 69-82 14 p.

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

File
Nuclear magnetic resonance
Pharmaceutical Preparations
Calibration
7 Citations (Scopus)

Shape-independent model (SHIM) approach for studying aggregation by NMR diffusometry

Santiago, A. A. H., Buchelnikov, A. S., Rubinson, M. A., Yesylevskyy, S. O., Parkinson, J. A. & Evstigneev, M. P., 2015, In : Journal of Chemical Physics. 142, 10, 12 p., 104202.

Research output: Contribution to journalArticle

Open Access
File
Agglomeration
Nuclear magnetic resonance
nuclear magnetic resonance
assembly
Complexation
2014
13 Citations (Scopus)
Formaldehyde
Nuclear magnetic resonance spectroscopy
Methanol
Water
Glycols

Inside cover: The synthesis of highly active iridium(I) complexes and their application in catalytic hydrogen isotope exchange (Adv. Synth. Catal. 17/2014)

Brown, J. A., Cochrane, A. R., Irvine, S., Kerr, W. J., Mondal, B., Parkinson, J. A., Paterson, L. C., Reid, M., Tuttle, T., Andersson, S. & Nilsson, G. N., 24 Nov 2014, In : Advanced Synthesis and Catalysis. 356, 17, p. 3474 1 p.

Research output: Contribution to journalArticle

Open Access
File
Iridium
Isotopes
Hydrogen
phosphine
Catalysts
17 Citations (Scopus)

Mechanistic insights into the malonoyl peroxide syn-dihydroxylation of alkenes

Rawling, M., Rowley, J., Campbell, M., Kennedy, A., Parkinson, J. & Tomkinson, N., 2014, In : Chemical Science. 2014, 5, p. 1777-1785 9 p.

Research output: Contribution to journalArticle

Peroxides
Alkenes
Reaction intermediates
Discrete Fourier transforms
Labeling
12 Citations (Scopus)

Recognition of the DNA minor groove by thiazotropsin analogues

Alniss, H. Y., Salvia, M. V., Sadikov, M., Golovchenko, I., Anthony, N. G., Khalaf, A. I., MacKay, S. P., Suckling, C. J. & Parkinson, J. A., 5 Sep 2014, In : Chembiochem. 15, 13, p. 1978–1990 13 p.

Research output: Contribution to journalArticle

DNA
Self assembly
Association reactions
Ligands
Thiazoles

Selected Applications of NMR Spectroscopy

Parkinson, J. A., Brkljaca, R., Urban, S., Hollingsworth, K. & Turnbull, B., 13 Oct 2014, Modern NMR Techniques for Synthetic Chemistry. Fisher, J. (ed.). Florida , USA, p. 263-328 66 p. (New Directions in Organic & Biological Chemistry).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nuclear magnetic resonance spectroscopy
39 Citations (Scopus)

The synthesis of highly active iridium(I) complexes and their application in catalytic hydrogen isotope exchange

Brown, J. A., Cochrane, A. R., Irvine, S., Kerr, W. J., Mondal, B., Parkinson, J. A., Paterson, L., Reid, M., Tuttle, T., Andersson, S. & Nilsson, G. N., Nov 2014, In : Advanced Synthesis and Catalysis. 356, 17, p. 3551-3562 12 p.

Research output: Contribution to journalArticle

Open Access
File
Iridium
Isotopes
Hydrogen
phosphine
Celecoxib
2013
52 Citations (Scopus)

C60 fullerene aggregation in aqueous solution

Prylutskyy, Y. I., Buchelnikov, A. S., Voronin, D. P., Kostjukov, V. V., Ritter, U., Parkinson, J. A. & Evstigneev, M. P., 2013, In : Physical Chemistry Chemical Physics. 15, 23, p. 9351-9360 10 p.

Research output: Contribution to journalArticle

fullerenes
light scattering
Dynamic light scattering
Agglomeration
aqueous solutions
7 Citations (Scopus)
Open Access
File
Binders
DNA
Oligomers
Temperature
Therapeutics
7 Citations (Scopus)

Flexible access to conformationally-locked bicyclic morpholines

Bogacki, R., Gill, D. M., Kerr, W. J., Lamont, S., Parkinson, J. A. & Paterson, L. C., 10 Sep 2013, In : Journal of the Chemical Society, Chemical Communications. 49, 79, p. 8931-8933 3 p.

Research output: Contribution to journalArticle

Open Access
File
Morpholines
Scaffolds
Lead
3 Citations (Scopus)

Metabonomics as a clinical tool of analysis: LC-MS approaches

Alzweiri, M., Watson, D. G. & Parkinson, J. A., 2013, In : Journal of Liquid Chromatography and Related Technologies. 36, 1, p. 94-115 22 p.

Research output: Contribution to journalArticle

Metabolomics
Multivariate Analysis
Passive Cutaneous Anaphylaxis
Metabolites
Principal Component Analysis
2 Citations (Scopus)
sodium carbonates
formaldehyde
Formaldehyde
Methanol
Carbonates
1 Citation (Scopus)

Multigramme synthesis and asymmetric dihydroxylation of a 4-fluorobut-2E-enoate

Laurenson, J. A. B., Parkinson, J. A., Percy, J. M., Rinaudo, G. & Roig, R., 26 Nov 2013, In : Beilstein Journal of Organic Chemistry . 9, p. 2660–2668 9 p.

Research output: Contribution to journalArticle

Open Access
File
Fluorination
Enantiomers
Chloroform
Free Radicals
Esters
4 Citations (Scopus)

Taming the shrew: [TMEDALi-Zn(C2H4)(2)L] as a model compound for anionic ethene polymerisation

Sassmannshausen, J., Klett, J., Kennedy, A. R., Parkinson, J. A. & Armstrong, D., 2013, In : New Journal of Chemistry. 37, 2, p. 494-501 8 p.

Research output: Contribution to journalArticle

Thymidine Monophosphate
Anionic polymerization
Density functional theory
Lithium
Ligands
8 Citations (Scopus)

Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove

Salvia, M-V., Addison, F., Alniss, H. Y. H., Buurma, N. J., Khalaf, A., MacKay, S., Anthony, N. G., Suckling, C., Evstigneev, M. P., Santiago, A. H., Waigh, R. & Parkinson, J., Sep 2013, In : Biophysical Chemistry. 179, p. 1-11 11 p.

Research output: Contribution to journalArticle

File
Molecular recognition
Agglomeration
DNA
Molecules
Binders
2012
19 Citations (Scopus)

Imidazole-derived carbenes and their elusive tetraazafulvalene dimers

Jolly, P. I., Zhou, S., Thomson, D. W., Garnier, J., Parkinson, J. A., Tuttle, T. & Murphy, J. A., 14 Feb 2012, In : Chemical Science. 3, 5, p. 1675-1679 5 p.

Research output: Contribution to journalArticle

Dimers
Deprotonation
Salts
Electrons
carbene
1 Citation (Scopus)
Lewis Acids
Polydimethylsiloxane
Reaction kinetics
Nuclear magnetic resonance spectroscopy
Cyclic voltammetry
27 Citations (Scopus)
Open Access
File
Cadmium
Lithium
Metals
Nuclear magnetic resonance
Substrates
17 Citations (Scopus)

Rationalising sequence selection by ligand assemblies in the DNA minor groove: the case for thiazotropsin A

Alniss, H. Y., Anthony, N. G. H., Khalaf, A., Mackay, S., Suckling, C., Waigh, R., Wheate, N. & Parkinson, J., 2012, In : Chemical Science. 3, 3, p. 711-722 12 p.

Research output: Contribution to journalArticle

Open Access
File
Ligands
DNA
Calorimetry
Titration
Binding Sites
24 Citations (Scopus)
Street Drugs
Salts
Derivatives
Chemical analysis
mephedrone
2011
6 Citations (Scopus)

Impaired Gluconeogenesis in a porcine model of paracetamol induced acute liver failure

Dabos, K., Whalen, H., Newsome, P., Parkinson, J., Henderson, N., Sadler, I., Hayes, P. & Plevris, J., 21 Mar 2011, In : World Journal of Gastroenterology. 17, 11, p. 1457-1461 5 p.

Research output: Contribution to journalArticle

Gluconeogenesis
Acute Liver Failure
Acetaminophen
Swine
Pyruvic Acid

Insights into DNA platination within unusual structural settings

Harvie, S., Wilson, O. & Parkinson, J. A., 2011, In : International Journal of Inorganic Chemistry. 2011, 17 p., 319757.

Research output: Contribution to journalArticle

Open Access
File
Sulfur
Nucleic Acids
Platinum
Dimers
DNA
1 Citation (Scopus)

Microscopic trends in methanol/water and acetonitrile/water systems

Alzweiri, M., Parkinson, J., Watson, D. & Steer, S., 2011, In : Jordan Journal of Pharmaceutical Sciences. 4, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

Methanol
Water
Acids
acetonitrile
11 Citations (Scopus)

NMR analysis of Nile Blue (C. I. Basic Blue 12) and Thionine (C. I. 52000) in solution

Hazafy, D., Salvia, M-V., Mills, A., Hutchings, M. G., Evstigneev, M. P. & Parkinson, J. A., Mar 2011, In : Dyes and Pigments. 88, 3, p. 315-325 11 p.

Research output: Contribution to journalArticle

Coloring Agents
Dyes
Nuclear magnetic resonance
Self assembly
Molecules
24 Citations (Scopus)

Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations

Nelson, D., Ashworth, I. W., Hillier, I. H., Kyne, S. H., Pandian, S., Parkinson, J. A., Percy, J. M., Rinaudo, G. & Vincent, M. A., 11 Nov 2011, In : Chemistry - A European Journal. 17, 46, p. 13087-13094 8 p.

Research output: Contribution to journalArticle

Dimerization
Electronic structure
Cycloparaffins
Thermodynamics
Solvation
58 Citations (Scopus)

“LiZn(TMP)3”, a zincate or a turbo-lithium amide reagent? DOSY NMR spectroscopic evidence

Garcia-Alvarez, P., Mulvey, R. & Parkinson, J., 4 Oct 2011, In : Angewandte Chemie. 50, 41, p. 9668-9671 4 p.

Research output: Contribution to journalArticle

Thymidine Monophosphate
Lithium
Amides
Nuclear magnetic resonance
Salts
2010
25 Citations (Scopus)

Cross-linked polymers based on 2,3,5,6-tetra-substituted pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione (DPP): synthesis, optical and electronic properties

Zhang, K., Tieke, B., Forgie, J. C., Vilela, F., Parkinson, J. A. & Skabara, P. J., 10 Dec 2010, In : Polymer. 51, 26, p. 6107-6114 8 p.

Research output: Contribution to journalArticle

Thiophenes
Pyrroles
Thiophene
Electronic properties
Polymers
63 Citations (Scopus)

Diisopropylamide and TMP turbo-grignard reagents: a structural rationale for their contrasting reactivities

Armstrong, D. R., Garcia-Álvarez, P., Kennedy, A. R., Mulvey, R. E. & Parkinson, J. A., 19 Apr 2010, In : Angewandte Chemie International Edition . 49, 18, p. 3185–3188 4 p.

Research output: Contribution to journalArticle

Open Access
File
Thymidine Monophosphate
Ion exchange
Nuclear magnetic resonance
Crystals
Molecules
62 Citations (Scopus)

Effect of alkali on methylene blue (C.I. basic blue 9) and other thiazine dyes

Mills, A., Hazafy, D., Parkinson, J., Tuttle, T. & Hutchings, M. G., Feb 2010, In : Dyes and Pigments. 88, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

Thiazines
Methylene Blue
Alkalies
Coloring Agents
Dyes
3 Citations (Scopus)

Hexamer oligonucleotide topology and assembly under solution phase NMR and theoretical modeling scrutiny

Evstigneev, M. P., Parkinson, J. A., Lantushenko, A. O., Kostjukov, V. V. & Pahomov, V. I., Dec 2010, In : Biopolymers. 93, 12, p. 1023-1038 16 p.

Research output: Contribution to journalArticle

File
Oligonucleotides
Molecular modeling
Nuclear magnetic resonance
Topology
Thermodynamics