Research output per year
Research output per year
Search results
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2025
Monitoring radical intermediates in photoactivated palladium-catalysed coupling of aryl halides to arenes by an aryl radical assay
Tyerman, S., MacKay, D. G., Clark, K. F., Kennedy, A. R., Robertson, C. M., Evans, L., Edkins, R. M. & Murphy, J. A., 17 Jan 2025, In: ACS Catalysis. 15, 2, p. 917-927 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2024
Reductive activation of arenes by potassium metal with potassium salts
Nocera, G., Robb, I., Clark, K. F., McGuire, T. M., Evans, L., Chiba, S. & Murphy, J. A., Sept 2024, In: Organic Chemistry Frontiers. 11, 18, p. 5099-5106 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Development of a horizontal dynamically mixed flow reactor for laboratory scale-up of photochemical Wohl–Ziegler bromination
Pratley, C., Shaalan, Y., Boulton, L., Jamieson, C., Murphy, J. A. & Edwards, L. J., 17 May 2024, In: Organic Process Research and Development. 28, 5, p. 1725-1733 9 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Direct, selective α-aryloxyalkyl radical cyanation and allylation of aryl alkyl ethers
Robb, I. & Murphy, J. A., 22 Mar 2024, In: Organic Letters. 26, 11, p. 2218-2222 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)20 Downloads (Pure) -
Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes
Anderson, J. M., Poole, D. L., Cook, G. C., Murphy, J. A. & Measom, N. D., 26 Feb 2024, In: Chemistry - A European Journal. 30, 12, e202304070.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Ground state generation and cyclization of aminium radicals in the formation of tetrahydroquinolines
Pratley, C., Fenner, S. & Murphy, J. A., 16 Feb 2024, In: Organic Letters. 26, 6, p. 1287-1292 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)20 Downloads (Pure) -
An assay for aryl radicals using BHAS coupling
Clark, K. F., Tyerman, S., Evans, L., Robertson, C. M. & Murphy, J. A., 7 Feb 2024, In: Organic and Biomolecular Chemistry. 22, 5, p. 1018-1022 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)14 Downloads (Pure) -
Radical coupling of aryl halides to arenes facilitated by Ni(COD)(DQ) and other nickel sources
Tyerman, S., Robertson, C. M. & Murphy, J. A., 7 Feb 2024, In: Organic and Biomolecular Chemistry. 22, 5, p. 1023-1026 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)21 Downloads (Pure) -
2023
A hierarchy of ligands controls formation and reaction of aryl radicals in Pd-catalyzed ground state base-promoted coupling reactions
Clark, K. F., Tyerman, S., Evans, L., Robertson, C. M., Nelson, D. J., Kennedy, A. R. & Murphy, J. A., 27 Sept 2023, In: Journal of the American Chemical Society. 145, 38, p. 20849-20858 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)34 Downloads (Pure) -
Recent advances in C–H functionalisation through indirect hydrogen atom transfer
Meger, F. S. & Murphy, J. A., 18 Aug 2023, In: Molecules. 28, 16, 83 p., 6127.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)33 Downloads (Pure) -
Bridge heteroarylation of bicyclo[1.1.1]pentane derivatives
Anderson, J. M., Measom, N. D., Murphy, J. A. & Poole, D. L., 31 Mar 2023, In: Organic Letters. 25, 12, p. 2053–2057 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)13 Downloads (Pure) -
2022
A study of the reactivity of cyclic aminomethylammonium mannich salts
Dimitrova, D., McMahon, C., Kennedy, A. R., Parkinson, J. A., Leach, S. G., Boulton, L. T., Pascoe, D. D. & Murphy, J. A., 3 Dec 2022, In: Tetrahedron. 128, 17 p., 133120.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)423 Downloads (Pure) -
Highly selective α-aryloxyalkyl C–H functionalisation of aryl alkyl ethers
Bell, J. D., Robb, I. & Murphy, J. A., 20 Oct 2022, In: Chemical Science. 13, 43, p. 12921-12926 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)38 Downloads (Pure) -
Nitrogen-centered radicals in functionalization of sp2 systems: generation, reactivity, and applications in synthesis
Pratley, C., Fenner, S. & Murphy, J. A., 11 May 2022, In: Chemical Reviews. 122, 9, p. 8181-8260 80 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile225 Citations (Scopus)351 Downloads (Pure) -
2021
Bridge functionalisation of bicyclo[1.1.1]pentane derivatives
Anderson, J. M., Measom, N. D., Murphy, J. A. & Poole, D. L., 15 Nov 2021, In: Angewandte Chemie International Edition. 60, 47, p. 24754-24769 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile73 Citations (Scopus)126 Downloads (Pure) -
Radical and ionic mechanisms in rearrangements of o-tolyl aryl ethers and amines initiated by the Grubbs-Stoltz reagent, Et3SiH/KOtBu
Kolodziejczak, K., Stewart, A. J., Tuttle, T. & Murphy, J. A., 15 Nov 2021, In: Molecules. 26, 22, 18 p., 6879.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)59 Downloads (Pure) -
Recent advances in visible light-activated radical coupling reactions triggered by (i) ruthenium, (ii) iridium and (iii) organic photoredox agents
Bell, J. D. & Murphy, J. A., 7 Sept 2021, In: Chemical Society Reviews . 50, 17, p. 9540-9685 146 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile302 Citations (Scopus)18 Downloads (Pure) -
Synthesis of arylethylamines via C(sp3)–C(sp3) palladium-catalyzed cross-coupling
Lippa, R. A., Battersby, D. J., Murphy, J. A. & Barrett, T. N., 19 Feb 2021, In: Journal of Organic Chemistry. 86, 4, p. 3583–3604 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)34 Downloads (Pure) -
2020
Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core
Lippa, R. A., Barrett, J., Pal, S., Rowedder, J. E., Murphy, J. A. & Barrett, T. N., 15 Dec 2020, In: European Journal of Medicinal Chemistry. 208, 76 p., 112719.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)38 Downloads (Pure) -
Et3SiH + KOtBu provide multiple reactive intermediates that compete in the reactions and rearrangements of benzylnitriles and indolenines
Smith, A. J., Dimitrova, D., Arokianathar, J. N., Clark, K. F., Poole, D. L., Leach, S. G. & Murphy, J. A., 7 Dec 2020, In: Chemical Science. 11, 45, p. 12364-12370 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)28 Downloads (Pure) -
Visible light-mediated smiles rearrangements and annulations of non-activated aromatics
Lawson, C. A., Dominey, A. P., Williams, G. D. & Murphy, J. A., 4 Oct 2020, In: Chemical Communications. 56, 77, p. 11445-11448 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)78 Downloads (Pure) -
Computational study on the boundary between the concerted and stepwise mechanism of bimolecular SNAr reactions
Rohrbach, S., Murphy, J. A. & Tuttle, T., 2 Sept 2020, In: Journal of the American Chemical Society. 142, 35, p. 14871-14876 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)43 Downloads (Pure) -
Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner-Wadsworth-Emmons-based approach
Lippa, R. A., Murphy, J. A. & Barrett, T. N., 8 Jul 2020, In: Beilstein Journal of Organic Chemistry. 16, p. 1617-1626 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)24 Downloads (Pure) -
Benzylic C-H functionalisation by [Et3SiH + KOtBu] leads to radical rearrangements in o-tolylaryl ethers, amines
Arokianathar, J. N., Kolodziejczak, K., Bugden, F. E., Clark, K. F., Tuttle, T. & Murphy, J. A., 26 May 2020, In: Advanced Synthesis and Catalysis. 362, 11, p. 2260-2267 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)24 Downloads (Pure) -
New reductive rearrangement of N-Arylindoles triggered by the Grubbs-Stoltz reagent Et3SiH/KOtBu
Smith, A. J., Dimitrova, D., Arokianathar, J. N., Kolodziejczak, K., Young, A., Allison, M., Poole, D. L., Leach, S. G., Parkinson, J. A., Tuttle, T. & Murphy, J. A., 14 Apr 2020, In: Chemical Science. 11, 14, p. 3719-3726 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)52 Downloads (Pure) -
Hi-JAK-ing the ubiquitin system: the design and physicochemical optimisation of JAK PROTACs
Shah, R. R., Redmond, J. M., Mihut, A., Menon, M., Evans, J. P., Murphy, J. A., Bartholomew, M. A. & Coe, D. M., 1 Mar 2020, In: Bioorganic and Medicinal Chemistry. 28, 5, 115326.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)179 Downloads (Pure) -
The right light: de novo design of a robust modular photochemical reactor for optimum batch and flow chemistry
Bonfield, H. E., Mercer, K., Diaz-Rodriguez, A., Cook, G. C., McKay, B. S. J., Slade, P., Taylor, G. M., Ooi, W. X., Williams, J. D., Roberts, J. P. M., Murphy, J. A., Schmermund, L., Kroutil, W., Mielke, T., Cartwright, J., Grogan, G. & Edwards, L. J., 31 Jan 2020, In: ChemPhotoChem. 4, 1, p. 45-51 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
N-Silylation of amines mediated by Et3SiH/KOtBu
Palumbo, F., Rohrbach, S., Tuttle, T. & Murphy, J. A., 1 Dec 2019, In: Helvetica Chimica Acta. 102, 12, p. 1-8 8 p., e1900235.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)43 Downloads (Pure) -
The role of organic electron donors in the initiation of BHAS base-induced coupling reactions between haloarenes and arenes
Smith, A. J., Poole, D. L. & Murphy, J. A., 30 Nov 2019, In: Science China Chemistry. 62, 11, p. 1425-1438 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)30 Downloads (Pure) -
Concerted nucleophilic aromatic substitution reactions
Rohrbach, S., Smith, A. J., Pang, J. H., Poole, D. L., Tuttle, T., Chiba, S. & Murphy, J. A., 11 Nov 2019, In: Angewandte Chemie International Edition. 58, 46, p. 16368-16388 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile192 Citations (Scopus)2031 Downloads (Pure) -
Konzertierte nukleophile aromatische Substitutionen
Rohrbach, S., Smith, A. J., Pang, J. H., Poole, D. L., Tuttle, T., Chiba, S. & Murphy, J. A., 11 Nov 2019, In: Angewandte Chemie. 131, 46, p. 16518-16540 23 p.Research output: Contribution to journal › Article › peer-review
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Ground state cross-coupling of haloarenes with arenes initiated by organic electron donors, formed in situ: an overview
Nocera, G. & Murphy, J. A., 13 Sept 2019, (E-pub ahead of print) In: Synthesis. 51, 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)44 Downloads (Pure) -
Neutral organic super electron donors made catalytic
Rohrbach, S., Shah, R. S., Tuttle, T. & Murphy, J. A., 12 Aug 2019, In: Angewandte Chemie International Edition. 58, 33, p. 11454-11458 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)14 Downloads (Pure) -
2018
Hydrogen atom transfer‐mediated cyclisations of nitriles
Turner, O. J., Murphy, J. A., Hirst, D. J. & Talbot, E. P. A., 12 Dec 2018, In: Chemistry - A European Journal. 24, 70, p. 18658–18662 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)55 Downloads (Pure) -
Reduction of nitroarenes, azoarenes and hydrazine derivatives by an organic electron donor
Cumine, F., Palumbo, F. & Murphy, J. A., 20 Sept 2018, In: Tetrahedron. 74, 38, p. 5539-5545 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)43 Downloads (Pure) -
Dual roles for potassium hydride in haloarene reduction: CSNAr and SET reduction via organic electron donors formed in benzene
Barham, J. P., Dalton, S. E., Allison, M., Nocera, G., Young, A., John, M. P., McGuire, T., Campos, S., Tuttle, T. & Murphy, J. A., 17 Aug 2018, (E-pub ahead of print) In: Journal of the American Chemical Society. 140, 36, p. 11510-11518 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)80 Downloads (Pure) -
Applications of organocatalysed visible-light redox reactions for medicinal chemistry
Bogdos, M. K., Pinard, E. & Murphy, J. A., 3 Aug 2018, In: Beilstein Journal of Organic Chemistry . 2018, 14, p. 2035-2064 30 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile114 Citations (Scopus)18 Downloads (Pure) -
Electron transfer reactions: KOtBu (but not NaOtBu) photoreduces benzophenone under activation by visible light
Nocera, G., Young, A., Palumbo, F., Emery, K. J., Coulthard, G., McGuire, T., Tuttle, T. & Murphy, J. A., 1 Aug 2018, In: Journal of the American Chemical Society. 140, 30, p. 9751–9757 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Citations (Scopus)49 Downloads (Pure) -
KOtBu as a single electron donor? Revisiting the halogenation of alkanes with CBr4 and CCl4
Emery, K. J., Young, A., Arokianathar, J. N., Tuttle, T. & Murphy, J. A., 1 May 2018, In: Molecules. 23, 5, 16 p., 1055.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)41 Downloads (Pure) -
Selectively targeting the kinome-conserved lysine of PI3K (delta) as a general approach to covalent kinase inhibition
Dalton, S. E., Dittus, L., Thomas, D. A., Convery, M. A., Nunes, J., Bush, J. T., Evans, J. P., Werner, T., Bantscheff, M., Murphy, J. A. & Campos, S., 24 Jan 2018, In: Journal of the American Chemical Society. 140, 3, p. 932-939 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Citations (Scopus)126 Downloads (Pure) -
2017
A computational study of anionic alkoxide–allene and amide–allene cyclizations
Cumine, F., Young, A., Reissig, H.-U., Tuttle, T. & Murphy, J. A., 15 Dec 2017, In: European Journal of Organic Chemistry. 2017, 46, p. 6867-6871 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)74 Downloads (Pure) -
Evidence of single electron transfer from the enolate anion of an N,N'-dialkyldiketopiperazine additive in BHAS coupling reactions
Emery, K. J., Tuttle, T. & Murphy, J. A., 25 Oct 2017, In: Organic and Biomolecular Chemistry. 15, 41, p. 8810-8819 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)75 Downloads (Pure) -
Electron transfer and hydride transfer pathways in the Stoltz-Grubbs reducing system (KOtBu-Et3SiH)
Smith, A. J., Young, A., Rohrbach, S., O'Connor, E. F., Allison, M., Wang, H.-S., Poole, D. L., Tuttle, T. & Murphy, J. A., 23 Oct 2017, In: Angewandte Chemie International Edition. 56, 44, p. 13747–13751 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus)67 Downloads (Pure) -
A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling
Cumine, F., Zhou, S., Tuttle, T. & Murphy, J. A., 19 Apr 2017, In: Organic and Biomolecular Chemistry. 15, p. 3324 - 3336 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)28 Downloads (Pure) -
Effect of solvent on radical cyclisation pathways: SRN1 vs. aryl-aryl bond forming mechanisms
Emery, K. J., Murphy, J. A. & Tuttle, T., 28 Jan 2017, In: Organic and Biomolecular Chemistry. 15, 4, p. 920-927 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)63 Downloads (Pure) -
2016
C-C bond-forming reactions of ground-state aryl halides under reductive activation
Emery, K. J., Tuttle, T., Kennedy, A. R. & Murphy, J. A., 1 Dec 2016, In: Tetrahedron. 72, 48, p. 7875-7887 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)68 Downloads (Pure) -
Contra-thermodynamic hydrogen atom abstraction in the selective C−H functionalization of trialkylamine N‑CH3 groups
Barham, J. P., John, M. P. & Murphy, J. A., 30 Nov 2016, In: Journal of the American Chemical Society. 138, 47, p. 15482-87 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile91 Citations (Scopus)92 Downloads (Pure) -
KOtBu: a privileged reagent for electron transfer reactions?
Barham, J. P., Coulthard, G., Emery, K. J., Doni, E., Cumine, F., Nocera, G., John, M. P., Berlouis, L. E. A., McGuire, T., Tuttle, T. & Murphy, J. A., 15 Jun 2016, In: Journal of the American Chemical Society. 138, 23, p. 7402-7410 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile271 Citations (Scopus)173 Downloads (Pure) -
Proton transfer reactions of a bridged bis-propyl bis-imidazolium salt
Massey, R. S., Quinn, P., Zhou, S., Murphy, J. A. & O'Donoghue, A. C., 5 May 2016, (E-pub ahead of print) In: Journal of Physical Organic Chemistry. 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)109 Downloads (Pure) -
Double deprotonation of pyridinols generates potent organic electron donor initiators for haloarene-arene coupling
Barham, J. P., Coulthard, G., Kane, R. G., Delgado, N., John, M. P. & Murphy, J. A., 24 Mar 2016, In: Agewandte Chemie-International Edition. 55, 14, p. 4492-4496 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Citations (Scopus)121 Downloads (Pure)