John McCarron

Search results

• 2014

  Direct visualisation of smooth muscle cell phenotypic plasticity and migration by long-term imaging

  Sandison, M., Chalmers, S., Dempster, J. & McCarron, J., 30 Apr 2014, In: FASEB Journal. 28, Suppl 1, 1 p., 867.12.

  Research output: Contribution to journal › Conference Contribution › peer-review

  • Smooth Muscle Cell 100%
  • Phenotypic Plasticity 100%
  • Time 28%
  • Modulation 28%
  • Vascular Remodeling 14%
• 2013

  From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle

  McCarron, J. G., Wilson, C., Sandison, M. E., Olson, M. L., Girkin, J. M., Saunter, C. & Chalmers, S., Oct 2013, In: Journal of Vascular Research. 50, 5, p. 357-371 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Morphology 100%
  • Vascular Smooth Muscle 100%
  • Mitochondrial Function 100%
  • Cell Function 50%
  • Cell Culture 50%
  97 Citations (Scopus)

• Examining the role of mitochondria in Ca²⁺ Signaling in native vascular smooth muscle

  Mccarron, J. G., Olson, M. L., Wilson, C., Sandison, M. E. & Chalmers, S., May 2013, In: Microcirculation. 20, 4, p. 317-329 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondria 100%
  • Gradients 100%
  • Vascular Smooth Muscle 100%
  • Mitochondrion 100%
  • Protons 83%
  15 Citations (Scopus)

• Single cell and subcellular measurements of intracellular Ca²⁺ concentration

  McCarron, J. G., Olson, M. L., Chalmers, S. & Girkin, J. M., 2013, Calcium Signaling Protocols. Lambert, D. G. & Rainbow, R. D. (eds.). Vol. 937. p. 239-251 13 p. (Methods in Molecular Biology; vol. 937).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Volume 100%
  • Fluorescence Microscopy 66%
  • Ion Channel 33%
  • Steady State 33%
  • Cell Membrane 33%
  1 Citation (Scopus)
• 2012

  Mitochondrial motility and vascular smooth muscle proliferation

  Chalmers, S., Saunter, C., Wilson, C., Coats, P., Girkin, J. M. & McCarron, J. G., Dec 2012, In: Arteriosclerosis Thrombosis, and Vascular Biology. 32, 12, p. 3000-3011 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Smooth Muscle 100%
  • Locomotion 100%
  • Mitochondria 100%
  • Mitochondrion 100%
  • Artery Resistance 30%
  55 Citations (Scopus)

• Mitochondrial motility and vascular smooth muscle proliferation

  Chalmers, S., Saunter, C., Wilson, C., Coats, P., Girkin, J. & McCarron, J., Dec 2012, In: Arteriosclerosis Thrombosis, and Vascular Biology. 32, 12, p. 3000-3011 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Organ Culture 100%
  • Muscle Mitochondrion 100%
  • Mitochondrial Dynamics 100%
  • Fission 100%
  55 Citations (Scopus)

• Microdomains of muscarinic acetylcholine and InsP3 receptors create InsP3 junctions and sites of Ca2+ wave initiation in smooth muscle

  Olson, M. L., Sandison, M. E., Chalmers, S. & McCarron, J. G., 15 Nov 2012, In: Journal of Cell Science. 125, p. 5315-5328 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptors 100%
  • Smooth Muscle 100%
  • Cells 40%
  • Inositol 20%
  • Couplings 20%
  14 Citations (Scopus)

• ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors

  MacMillan, D., Kennedy, C. & McCarron, J., 1 Nov 2012, In: Journal of Cell Science. 125, 21, p. 5151-5158 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenosine Triphosphate 100%
  • Calcium Ion 100%
  • Purinergic P2Y1 Receptor 100%
  • Guanine Nucleotide Binding Protein 20%
  • Adenosine 20%
  11 Citations (Scopus)

• Subplasma membrane Ca2+ signals

  McCarron, J., Chalmers, S., Olson, M. & Girkin, J., Jul 2012, In: IUBMB Life. 64, 7, p. 573-585 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Ion 100%
  • Membrane 100%
  • Indicator 63%
  • Cells 27%
  • Cell Membrane 18%
  9 Citations (Scopus)

• Mitochondrial organization and Ca2+ uptake

  Olson, M. L., Chalmers, S. & McCarron, J. G., 2012, In: Biochemical Society Transactions. 40, 1, p. 158-167 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Organelle 100%
  • Organizations 100%
  • Mitochondrion 66%
  • Mitochondria 66%
  • Cells 33%
  36 Citations (Scopus)

• Mitochondrial regulation of cytosolic Ca2+ signals in smooth muscle

  McCarron, J., Olson, M. & Chalmers, S., 2012, In: Pflügers Archiv European Journal of Physiology . 464, special issue, p. 51-62 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrion 100%
  • Regulatory Mechanism 100%
  • Dynamics 28%
  • Eicosanoid Receptor 28%
  • Ion Channel 14%
  23 Citations (Scopus)

• Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore

  Chalmers, S., Caldwell, S. T., Quin, C., Prime, T. A., James, A. M., Cairns, A., Murphy, M. P., McCarron, J. & Hartley, R. C., 2012, In: Journal of the American Chemical Society . 134, 2, p. 758-761 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondria 100%
  • Probe 85%
  • Molecular Cluster 28%
  • Photolysis 14%
  • Molecules 14%
  104 Citations (Scopus)
• 2011

  Mitochondrial motility and vascular smooth muscle proliferation

  Chalmers, S., Coats, P. & McCarron, J. G., Dec 2011, In: Heart. 97, 24

  Research output: Contribution to journal › Conference abstract › peer-review

  • Vascular Smooth Muscle 100%
  • Locomotion 100%

• Modulation of calcium signalling pathways

  McCarron, J., Chalmers, S. & Olson, M., Sept 2011, In: Journal of Vascular Research. 48, Suppl.1, p. 42-42 1 p., IS24.

  Research output: Contribution to journal › Conference Contribution › peer-review

  • Calcium Signaling 100%
  • Calcium Signaling Pathway 100%
  • Calcineurin 5%
  • Mammalian Target of Rapamycin 5%
  • Fk 506 Binding Protein 5%
• 2010

  Agonist-evoked Ca2+ wave progression requires Ca2+ and IP3

  McCarron, J. G., Chalmers, S., MacMillan, D. & Olson, M. L., Aug 2010, In: Journal of Cellular Physiology. 224, 2, p. 334-344 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Agonist 100%
  • Cells 100%
  • Wave Fronts 80%
  • Amplitudes 60%
  • Length 60%
  31 Citations (Scopus)

• The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle

  MacMillan, D. & McCarron, J. G., Jul 2010, In: British Journal of Pharmacology. 160, 6, p. 1295–1301 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Ion 100%
  • Adenosine Triphosphatase (Calcium) 100%
  • Phospholipase C Inhibitor 100%
  • Phospholipase C 100%
  • Carbachol 15%
  69 Citations (Scopus)

• Mitochondrial Ca2+ uptake increases Ca2+ release from Inositol 1,4,5-trisphosphate receptor clusters in smooth muscle cells

  Olson, M., Chalmers, S. & McCarron, J. G., 15 Jan 2010, In: Journal of Biological Chemistry. 285, 3, p. 2040-2050 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Protonophore 100%
  • Rotenone 100%
  47 Citations (Scopus)
• 2009

  The sarcoplasmic reticulum Ca2+ store arrangement in vascular smooth muscle

  Rainbow, R., MacMillan, D. & McCarron, J. G., Dec 2009, In: Cell Calcium. 45, 5-6, p. 313-322 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscle Development 100%
  • Portal Vein 100%
  24 Citations (Scopus)

• Regulation by FK506 and rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR

  MacMillan, D. & McCarron, J. G., Oct 2009, In: British Journal of Pharmacology. 158, 4, p. 1112-1120 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Fluo 3 100%
  33 Citations (Scopus)

• Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle

  McCarron, J. G., Olson, M., Currie, S., Wright, A., Anderson, K. I. & Girkin, J. M., Mar 2009, In: Journal of General Physiology. 133, 4, p. 439-457 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Voltage-Dependent Calcium Channel 100%
  • Calcium Cell Level 100%
  • Calcium Channel 100%
  • Vascular Smooth Muscle 100%
  • Dihydropyridine 38%
  17 Citations (Scopus)

• Caged AG10: new tools for spatially predefined mitochondrial uncoupling

  Avionitis, N., Chalmers, S., McDougall, C., Stanton-Humphreys, M. N., Brown, C. T. A., McCarron, J. G. & Conway, S. J., 2009, In: Molecular BioSystems. 5, p. 450-457 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative Phosphorylation Uncoupling 100%
  • Photolysis 50%
  • Mitochondrial Membrane Potential 12%
  • Mitochondrion 12%
  • Calcium Signaling 12%
  9 Citations (Scopus)

• Inhibition of mitochondrial calcium uptake rather than efflux impedes calcium release by inositol-1,4,5-trisphosphate-sensitive receptors

  Chalmers, S. & McCarron, J. G., 2009, In: Cell Calcium. 46, 2, p. 107-113 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Uniporter 100%
  20 Citations (Scopus)
• 2008

  IP3R-mediated Ca2+ release is modulated by anandamide in isolated cardiac nuclei

  Currie, S., Rainbow, R., Ewart, M-A., Kitson, S., Pliego, E. H., Kane, K. A. & McCarron, J. G., 22 Jul 2008, In: Journal of Molecular and Cellular Cardiology. 45, 6, p. 804-811 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Anandamide 100%
  • Cannabinoid Receptor 50%
  • Nuclear Pore 33%
  • Cannabinoid 33%
  • Reperfusion Injury 16%
  20 Citations (Scopus)

• A single luminally continuous sarcoplasmic reticulum with apparently separate Ca2+ stores in smooth muscle

  McCarron, J. G. & Olson, M., 14 Mar 2008, In: Journal of Biological Chemistry. 283, 11, p. 7206-7218 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Sarcoplasmic reticulum 100%
  • Smooth Muscle 100%
  • Ryanodine Receptor 44%
  • Receptors 33%
  • Inositol 11%
  39 Citations (Scopus)

• The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle

  Chalmers, S. & McCarron, J. G., 1 Jan 2008, In: Journal of Cell Science. 121, 1, p. 75-85 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ciclosporin 100%
  • Antioxidant 100%
  92 Citations (Scopus)

• FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle

  MacMillan, D., Currie, S. & McCarron, J. G., 2008, In: Cell Calcium. 43, 6, p. 539-549 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Fk 506 Binding Protein 100%
  • Mammalian Target of Rapamycin 46%
  • Calcineurin 35%
  • Rapamycin 14%
  • Okadaic Acid 7%
  15 Citations (Scopus)

• "Quantal" Ca2+ release at the cytoplasmic aspect of the Ins(1,4,5)P3R channel in smooth muscle

  McCarron, J. G., Chalmers, S. & Muir, T. C., 2008, In: Journal of Cell Science. 121, 1, p. 86-98 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Sarcoplasmic reticulum 100%
  • Smooth Muscle 100%
  • Inositol 22%
  • Receptors 22%
  • Organizations 11%
  13 Citations (Scopus)
• 2007

  Ion channels in smooth muscle: regulation by the sarcoplasmic reticulum and mitochondria

  Chalmers, S., Olson, M., MacMillan, D., Rainbow, R. & McCarron, J. G., 13 Jul 2007, In: Cell Calcium. 42, 4-5, p. 447-466 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Ion Channels 100%
  • Organelle 33%
  • Cell Division 16%
  • Cell Excitability 16%
  • Excitability 16%
  48 Citations (Scopus)

• Ins(1,4,5)P3 receptor regulation during ‘quantal’ Ca2+ release in smooth muscle

  McCarron, J. G., Olson, M., Rainbow, R., MacMillan, D. & Chalmers, S., 2007, In: Trends in Pharmacological Sciences. 28, 6, p. 271-279 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Inositol 100%
  8 Citations (Scopus)
• 2006

  Ca2+ microdomains in smooth muscle

  McCarron, J. G., Chalmers, S., Bradley, K. N., MacMillan, D. & Muir, T. C., 2006, In: Cell Calcium. 40, 5-6, p. 461-493 32 p.

  Research output: Contribution to journal › Article › peer-review

  • Ion Channel 100%
  • Sarcoplasmic Reticulum 50%
  • Cell Membrane 50%
  • Sarcoplasmic reticulum 50%
  • Plasma Membrane 50%
  81 Citations (Scopus)
• 2005

  In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin

  MacMillan, D., Currie, S., Bradley, K. N., Muir, T. C. & McCarron, J. G., Aug 2005, In: Journal of Cell Science. 118, 23, p. 5443-5451 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Fk 506 Binding Protein 100%
  • Calcineurin 100%
  • Mammalian Target of Rapamycin 100%
  • Receptors 100%
  • Binding Protein 100%
  54 Citations (Scopus)

• IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells

  MacMillan, D., Chalmers, S., Muir, T. C. & McCarron, J. G., 2005, In: Journal of Physiology. 569, 2, p. 533-544 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ryanodine Receptor 100%
  • Cells 100%
  • Smooth Muscle 100%
  • Ryanodine 60%
  • Sarcolemma 26%
  64 Citations (Scopus)
• 2004

  The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle

  Mccarron, J., Bradley, K., Macmillan, D., Chalmers, S. & Muir, T. C., Jun 2004, In: News in Physiological Sciences. 19, p. 138-147 10 p., 15143210.

  Research output: Contribution to journal › Article › peer-review

  • Sarcoplasmic reticulum 100%
  • Trapping 100%
  • Smooth Muscle 100%
  • Inositol 20%
  • Sarcolemma 20%
  16 Citations (Scopus)

• Origin and mechanisms of Ca2+ waves in smooth muscle as revealed by localized photolysis of caged inositol 1,4,5-trisphosphate

  McCarron, J. G., MacMillan, D., Bradley, K. N., Chalmers, S. & Muir, T. C., 2004, In: Journal of Biological Chemistry. 279, p. 8417-8427 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Inositol 100%
  • Receptors 100%
  • Smooth Muscle 100%
  • Cells 66%
  • Sarcolemma 33%
  54 Citations (Scopus)
• 2003

  Sarcolemma agonist-induced interactions between InsP3 and ryanodine receptors in Ca2+ oscillations and waves in smooth muscle

  Mccarron, J., Bradley, K., MacMillan, D. & Muir, T. C., Oct 2003, In: Biochemical Society Transactions. 31, 5, p. 920-924 5 p., 14505449.

  Research output: Contribution to journal › Literature review › peer-review

  • Sarcolemma 100%
  • Agonist 100%
  • Ryanodine Receptor 100%
  • Smooth Muscle 100%
  • Calcium Ion 100%
  31 Citations (Scopus)

• Cyclic ADP-ribose increases Ca2+ removal in smooth muscle

  Bradley, K. N., Currie, S., MacMillan, D., Muir, T. C. & McCarron, J. G., 9 Sept 2003, In: Journal of Cell Science. 116, p. 4291-306 3985 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribose 100%
  • Protocerebrum 9%
  • Western Blot 9%
  • Gene Expression 9%
  • Cytoplasm 9%
  29 Citations (Scopus)
• 2002

  Agonist-induced phasic and tonic responses in smooth muscle are mediated by InsP3

  McCarron, J. G., Craig, J. W., Bradley, K. N. & Muir, T. C., 2002, In: Journal of Cell Science. 115, p. 2207-2218 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Agonist 100%
  • Smooth Muscle 100%
  • Receptors 30%
  • Ryanodine Receptor 30%
  • Channel Blocker 30%
  61 Citations (Scopus)

• Ca2+ regulation in guinea pig colonic smooth muscle: the role of the na+-Ca2+ exchanger and the sarcoplasmic reticulum

  Bradley, K. N., Flynn, E. R. M., Muir, T. C. & McCarron, J. G., 2002, In: Journal of Physiology. 538, p. 465-482 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Vitamin C 100%
  • Choline 100%
  • Lithium 100%
  • Adenosine Triphosphatase (Calcium) 100%
  • Cytosol 100%
  30 Citations (Scopus)
• 2001

  Functionally-separate intracellular ca2+ stores in smooth muscle

  Flynn, E. R. M., Bradley, K. N., Muir, T. C. & McCarron, J. G., 28 Sept 2001, In: Journal of Biological Chemistry. 276, p. 36411-18 36393 p.

  Research output: Contribution to journal › Article › peer-review

  • Thapsigargin 100%
  • Inositol 1,4,5 Trisphosphate 100%
  • Sarcoplasmic Reticulum Calcium Transporting Adenosine Triphosphatase 100%
  • Cyclopiazonic Acid 100%
  • Inositol 100%
  93 Citations (Scopus)