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Research Output 2001 2019

2001
86 Citations (Scopus)

Functionally-separate intracellular ca2+ stores in smooth muscle

Flynn, E. R. M., Bradley, K. N., Muir, T. C. & McCarron, J. G., 28 Sep 2001, In : Journal of Biological Chemistry. 276, p. 36411-18 36393 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Smooth Muscle
Muscle
Sarcoplasmic Reticulum
Caffeine
2002
56 Citations (Scopus)

Agonist-induced phasic and tonic responses in smooth muscle are mediated by InsP3

McCarron, J. G., Craig, J. W., Bradley, K. N. & Muir, T. C., 2002, In : Journal of Cell Science. 115, p. 2207-2218 11 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Smooth Muscle
Sarcolemma
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Muscle Contraction
28 Citations (Scopus)

Ca2+ regulation in guinea pig colonic smooth muscle: the role of the na+-Ca2+ exchanger and the sarcoplasmic reticulum

Bradley, K. N., Flynn, E. R. M., Muir, T. C. & McCarron, J. G., 2002, In : Journal of Physiology. 538, p. 465-482 18 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Smooth Muscle
Guinea Pigs
Caffeine
Ryanodine
2003
27 Citations (Scopus)

Cyclic ADP-ribose increases Ca2+ removal in smooth muscle

Bradley, K. N., Currie, S., MacMillan, D., Muir, T. C. & McCarron, J. G., 9 Sep 2003, In : Journal of Cell Science. 116, p. 4291-306 3985 p.

Research output: Contribution to journalArticle

Cyclic ADP-Ribose
Smooth Muscle
Sea Urchins
Caffeine
Muscle Cells
28 Citations (Scopus)

Sarcolemma agonist-induced interactions between InsP3 and ryanodine receptors in Ca2+ oscillations and waves in smooth muscle

Mccarron, J., Bradley, K., MacMillan, D. & Muir, T. C., Oct 2003, In : Biochemical Society Transactions. 31, 5, p. 920-924 5 p., 14505449.

Research output: Contribution to journalLiterature review

Sarcolemma
Ryanodine Receptor Calcium Release Channel
Smooth Muscle
Muscle
Ryanodine
2004
52 Citations (Scopus)

Origin and mechanisms of Ca2+ waves in smooth muscle as revealed by localized photolysis of caged inositol 1,4,5-trisphosphate

McCarron, J. G., MacMillan, D., Bradley, K. N., Chalmers, S. & Muir, T. C., 2004, In : Journal of Biological Chemistry. 279, p. 8417-8427 11 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Photolysis
Smooth Muscle
Muscle
Sarcolemma
15 Citations (Scopus)

The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle

Mccarron, J., Bradley, K., Macmillan, D., Chalmers, S. & Muir, T. C., Jun 2004, In : News in Physiological Sciences. 19, p. 138-147 10 p., 15143210.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Smooth Muscle
Inositol 1,4,5-Trisphosphate Receptors
Sarcolemma
Calcium Signaling
2005
47 Citations (Scopus)

In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin

MacMillan, D., Currie, S., Bradley, K. N., Muir, T. C. & McCarron, J. G., Aug 2005, In : Journal of Cell Science. 118, 23, p. 5443-5451 8 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Tacrolimus Binding Protein 1A
Inositol 1,4,5-Trisphosphate Receptors
Calcineurin
Sirolimus
52 Citations (Scopus)
Ryanodine Receptor Calcium Release Channel
Smooth Muscle Myocytes
Ryanodine
Guinea Pigs
Sarcolemma
2006
67 Citations (Scopus)

Ca2+ microdomains in smooth muscle

McCarron, J. G., Chalmers, S., Bradley, K. N., MacMillan, D. & Muir, T. C., 2006, In : Cell Calcium. 40, 5-6, p. 461-493 32 p.

Research output: Contribution to journalArticle

Smooth Muscle
Cell Membrane
Sarcoplasmic Reticulum
Ion Channels
Cyclic ADP-Ribose
2007
7 Citations (Scopus)

Ins(1,4,5)P3 receptor regulation during ‘quantal’ Ca2+ release in smooth muscle

McCarron, J. G., Olson, M., Rainbow, R., MacMillan, D. & Chalmers, S., 2007, In : Trends in Pharmacological Sciences. 28, 6, p. 271-279 8 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Smooth Muscle
Muscle
Inositol 1,4,5-Trisphosphate
Cell membranes
37 Citations (Scopus)

Ion channels in smooth muscle: regulation by the sarcoplasmic reticulum and mitochondria

Chalmers, S., Olson, M., MacMillan, D., Rainbow, R. & McCarron, J. G., 13 Jul 2007, In : Cell Calcium. 42, 4-5, p. 447-466 19 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Ion Channels
Smooth Muscle
Mitochondria
Cell Membrane
2008
33 Citations (Scopus)

A single luminally continuous sarcoplasmic reticulum with apparently separate Ca2+ stores in smooth muscle

McCarron, J. G. & Olson, M., 14 Mar 2008, In : Journal of Biological Chemistry. 283, 11, p. 7206-7218 13 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
Smooth Muscle
Muscle
Inositol 1,4,5-Trisphosphate Receptors
11 Citations (Scopus)

FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle

MacMillan, D., Currie, S. & McCarron, J. G., 2008, In : Cell Calcium. 43, 6, p. 539-549 10 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Protein 1A
Tacrolimus Binding Proteins
Ryanodine Receptor Calcium Release Channel
Smooth Muscle
Calcineurin
15 Citations (Scopus)

IP3R-mediated Ca2+ release is modulated by anandamide in isolated cardiac nuclei

Currie, S., Rainbow, R., Ewart, M-A., Kitson, S., Pliego, E. H., Kane, K. A. & McCarron, J. G., 22 Jul 2008, In : Journal of Molecular and Cellular Cardiology. 45, 6, p. 804-811 8 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Cannabinoids
Nuclear Envelope
Inositol 1,4,5-Trisphosphate Receptors
Cytoplasmic and Nuclear Receptors
13 Citations (Scopus)

"Quantal" Ca2+ release at the cytoplasmic aspect of the Ins(1,4,5)P3R channel in smooth muscle

McCarron, J. G., Chalmers, S. & Muir, T. C., 2008, In : Journal of Cell Science. 121, 1, p. 86-98 12 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Smooth Muscle
Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Cytoplasmic and Nuclear Receptors
73 Citations (Scopus)

The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle

Chalmers, S. & McCarron, J. G., 1 Jan 2008, In : Journal of Cell Science. 121, 1, p. 75-85 10 p.

Research output: Contribution to journalArticle

Mitochondrial Membrane Potential
Smooth Muscle
Mitochondria
Smooth Muscle Myocytes
Inositol 1,4,5-Trisphosphate
2009
7 Citations (Scopus)

Caged AG10: new tools for spatially predefined mitochondrial uncoupling

Avionitis, N., Chalmers, S., McDougall, C., Stanton-Humphreys, M. N., Brown, C. T. A., McCarron, J. G. & Conway, S. J., 2009, In : Molecular BioSystems. 5, p. 450-457 7 p.

Research output: Contribution to journalArticle

Photolysis
Tyrphostins
Mitochondrial Membrane Potential
Smooth Muscle Myocytes
Mitochondria
13 Citations (Scopus)
Calcium Channels
Vascular Smooth Muscle
Calcium
Membranes
Cytoplasm
17 Citations (Scopus)
Inositol 1,4,5-Trisphosphate Receptors
Mitochondria
Calcium
Sarcoplasmic Reticulum
Ions
24 Citations (Scopus)
Tacrolimus Binding Proteins
Sarcoplasmic Reticulum
Tacrolimus
Sirolimus
Vascular Smooth Muscle
17 Citations (Scopus)

The sarcoplasmic reticulum Ca2+ store arrangement in vascular smooth muscle

Rainbow, R., MacMillan, D. & McCarron, J. G., Dec 2009, In : Cell Calcium. 45, 5-6, p. 313-322 10 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Vascular Smooth Muscle
Inositol 1,4,5-Trisphosphate Receptors
Ryanodine Receptor Calcium Release Channel
Muscle Cells
2010
22 Citations (Scopus)

Agonist-evoked Ca2+ wave progression requires Ca2+ and IP3

McCarron, J. G., Chalmers, S., MacMillan, D. & Olson, M. L., Aug 2010, In : Journal of Cellular Physiology. 224, 2, p. 334-344 11 p.

Research output: Contribution to journalArticle

Carbachol
Buffers
Photolysis
Smooth Muscle Myocytes
Smooth Muscle
39 Citations (Scopus)
Inositol 1,4,5-Trisphosphate Receptors
Mitochondria
Smooth Muscle Myocytes
Muscle
Cells
41 Citations (Scopus)
Sarcoplasmic Reticulum
Type C Phospholipases
Smooth Muscle
Phosphoinositide Phospholipase C
Carbachol
2011

Mitochondrial motility and vascular smooth muscle proliferation

Chalmers, S., Coats, P. & McCarron, J. G., Dec 2011, In : Heart. 97, 24

Research output: Contribution to journalMeeting abstract

Vascular Smooth Muscle

Modulation of calcium signalling pathways

McCarron, J., Chalmers, S. & Olson, M., Sep 2011, In : Journal of Vascular Research. 48, Suppl.1, p. 42-42 1 p., IS24.

Research output: Contribution to journalConference Contribution

Calcium Signaling
Cytoplasm
Tacrolimus Binding Protein 1A
Tacrolimus Binding Proteins
Sarcolemma
2012
9 Citations (Scopus)

ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors

MacMillan, D., Kennedy, C. & McCarron, J., 1 Nov 2012, In : Journal of Cell Science. 125, 21, p. 5151-5158 8 p.

Research output: Contribution to journalArticle

Purinergic P2Y1 Receptors
Smooth Muscle
Adenosine Triphosphate
Type C Phospholipases
GTP-Binding Proteins
12 Citations (Scopus)
Inositol 1,4,5-Trisphosphate
Muscarinic Receptors
Smooth Muscle Myocytes
Smooth Muscle
Cluster Analysis
29 Citations (Scopus)

Mitochondrial motility and vascular smooth muscle proliferation

Chalmers, S., Saunter, C., Wilson, C., Coats, P., Girkin, J. & McCarron, J., Dec 2012, In : Arteriosclerosis Thrombosis, and Vascular Biology. 32, 12, p. 3000-3011 12 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Mitochondria
Smooth Muscle
Arteries
Organelles
35 Citations (Scopus)

Mitochondrial motility and vascular smooth muscle proliferation

Chalmers, S., Saunter, C., Wilson, C., Coats, P., Girkin, J. M. & McCarron, J. G., Dec 2012, In : Arteriosclerosis Thrombosis, and Vascular Biology. 32, 12, p. 3000-3011 12 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Mitochondria
Mitochondrial Dynamics
Smooth Muscle
Arteries
24 Citations (Scopus)

Mitochondrial organization and Ca2+ uptake

Olson, M. L., Chalmers, S. & McCarron, J. G., 2012, In : Biochemical Society Transactions. 40, 1, p. 158-167 10 p.

Research output: Contribution to journalArticle

Mitochondria
Organelles
Cell membranes
Cell Membrane
Modulation
16 Citations (Scopus)

Mitochondrial regulation of cytosolic Ca2+ signals in smooth muscle

McCarron, J., Olson, M. & Chalmers, S., 2012, In : Pflügers Archiv European Journal of Physiology . 464, special issue, p. 51-62 11 p.

Research output: Contribution to journalArticle

Mitochondria
Muscle Mitochondrion
Smooth Muscle
Muscle
Organelles
68 Citations (Scopus)

Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore

Chalmers, S., Caldwell, S. T., Quin, C., Prime, T. A., James, A. M., Cairns, A., Murphy, M. P., McCarron, J. & Hartley, R. C., 2012, In : Journal of the American Chemical Society . 134, 2, p. 758-761 4 p.

Research output: Contribution to journalArticle

Mitochondria
2,4-Dinitrophenol
Photolysis
Depolarization
Ultraviolet Rays
4 Citations (Scopus)

Subplasma membrane Ca2+ signals

McCarron, J., Chalmers, S., Olson, M. & Girkin, J., Jul 2012, In : IUBMB Life. 64, 7, p. 573-585 12 p.

Research output: Contribution to journalArticle

Membranes
Cell membranes
Cell Membrane
Imaging techniques
Calibration
2013
9 Citations (Scopus)

Examining the role of mitochondria in Ca2+ Signaling in native vascular smooth muscle

Mccarron, J. G., Olson, M. L., Wilson, C., Sandison, M. E. & Chalmers, S., May 2013, In : Microcirculation. 20, 4, p. 317-329 13 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Protons
Mitochondria
Membrane Potentials
Smooth Muscle
27 Citations (Scopus)

From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle

McCarron, J. G., Wilson, C., Sandison, M. E., Olson, M. L., Girkin, J. M., Saunter, C. & Chalmers, S., Oct 2013, In : Journal of Vascular Research. 50, 5, p. 357-371 15 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Cultured Cells
Organelles
Anatomy
Mitochondria
1 Citation (Scopus)

Single cell and subcellular measurements of intracellular Ca2+ concentration

McCarron, J. G., Olson, M. L., Chalmers, S. & Girkin, J. M., 2013, Calcium Signaling Protocols. Lambert, D. G. & Rainbow, R. D. (eds.). Vol. 937. p. 239-251 13 p. (Methods in Molecular Biology; vol. 937).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescence Microscopy
Electrophysiology
Ion Channels
Mouth
Cytoplasm
2014

Direct visualisation of smooth muscle cell phenotypic plasticity and migration by long-term imaging

Sandison, M., Chalmers, S., Dempster, J. & McCarron, J., 30 Apr 2014, In : FASEB Journal. 28, Suppl 1, 1 p., 867.12.

Research output: Contribution to journalConference Contribution

Smooth Muscle Myocytes
Cell Movement
Plasticity
Muscle
Visualization
2015
7 Citations (Scopus)

Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension

Chalmers, S., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 23 Nov 2015, In : Scientific Reports. 5, 15 p., 16875.

Research output: Contribution to journalArticle

Open Access
File
Microscopy
Mitochondria
Hypertension
Mitochondrial Size
Mitochondrial Membrane Potential

Heterogeneity in the proliferative capacity of smooth muscle cells (SMCs)

Sandison, M. & McCarron, J., Apr 2015, In : FASEB Journal. 29, Suppl. 1, p. 418.8 1 p.

Research output: Contribution to journalConference Contribution

Open Access
File
Smooth Muscle Myocytes
Muscle
Cells
Smooth Muscle
Portal Vein
14 Citations (Scopus)

Pressure-dependent regulation of Ca2+ signaling in the vascular endothelium

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 15 Dec 2015, In : Journal of Physiology. 593, 24, p. 5231-5253 23 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Endothelium
Endothelial cells
Pressure
Endothelial Cells
Arteries
3 Citations (Scopus)

Synthesis of an azido-tagged low affinity ratiometric calcium sensor

Caldwell, S. T., Cairns, A. G., Olson, M., Chalmers, S., Sandison, M., Mullen, W., McCarron, J. G. & Hartley, R. C., 23 Dec 2015, In : Tetrahedron. 71, 51, p. 9571–9578 8 p.

Research output: Contribution to journalArticle

Open Access
File
Thiohydantoins
Calcium ion sensors
Allylation
Ions
Cell signaling
2016
27 Citations (Scopus)

Acetylcholine released by endothelial cells facilitates flow-mediated dilatation

Wilson, C., Lee, M. D. & McCarron, J. G., 14 Dec 2016, In : Journal of Physiology. 594, 24, p. 7267-7307 41 p.

Research output: Contribution to journalArticle

Open Access
File
Acetylcholine
Dilatation
Endothelial Cells
Endothelium
Blood Vessels
15 Citations (Scopus)
Open Access
File
Mitochondrial Size
Vascular Smooth Muscle
Smooth Muscle
Mitochondria
Muscle Cells

Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle

McCarron, J. G., Chalmers, S., Wilson, C. & Sandison, M. E., 7 Jul 2016, Vascular Ion Channels in Physiology and Disease. Berlin: Springer, p. 233-254 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
File
Ryanodine Receptor Calcium Release Channel
Mitochondria
Ion Channels
Smooth Muscle
Muscle
16 Citations (Scopus)

Clusters of specialized detector cells provide sensitive and high fidelity receptor signaling in intact endothelium

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 12 Feb 2016, In : FASEB Journal. 30, 5, p. 2000-2013 14 p.

Research output: Contribution to journalArticle

Open Access
File
Acetylcholine
Endothelium
Detectors
Noise
Endothelial cells
Mitochondrial Dynamics
Vascular Diseases
Stents
Endothelial Cells
Cell Proliferation
11 Citations (Scopus)
Open Access
File
Smooth Muscle Myocytes
Phenotype
Macrophages
Atherosclerotic Plaques
Myeloid Cells
2017
5 Citations (Scopus)

Advancing age decreases pressure-sensitive modulation of calcium signaling in the endothelium of intact and pressurized arteries

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 30 Jan 2017, In : Journal of Vascular Research. 53, 5-6, p. 358–369 12 p.

Research output: Contribution to journalArticle

Open Access
File
Calcium Signaling
Endothelium
Arteries
Calcium
Pressure