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Research Output 2001 2019

2019
Open Access
File
Inositol 1,4,5-Trisphosphate Receptors
Blood Vessels
Endothelium
Ion Channels
Cations
Open Access
Tacrolimus
Carrier Proteins
Endothelial Cells
Sirolimus
Calcineurin
2 Citations (Scopus)
Open Access
File
Vascular Endothelium
Endothelium
Blood Vessels
Endothelial Cells
Pericytes
Open Access
File
Hydrogen Peroxide
Acetylcholine
Endothelium
Mitochondria
Arteries
Open Access
File
Calcium Signaling
Blood Vessels
Hypertension
Phenylephrine
Endothelial Cells
3 Citations (Scopus)
Open Access
File
Mitochondria
Calcium Signaling
Inositol
Adenosine Triphosphate
Calcium

Multi-plane remote refocussing epifluorescence microscopy to image dynamic Ca2+ events

Lawton, P. F., Buckley, C., Saunter, C. D., Wilson, C., Corbett, A. D., Slater, P. S., McCarron, J. G. & Girkin, J. M., 12 Sep 2019, (Accepted/In press) In : Biomedical Optics Express.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Microscopy
smooth muscle
Endothelial Cells
microscopy
2 Citations (Scopus)

VasoTracker, a low-cost and open source pressure myograph system for vascular physiology

Lawton, P. F., Lee, M. D., Saunter, C. D., Girkin, J. M., McCarron, J. G. & Wilson, C., 21 Feb 2019, In : Frontiers in Physiology. 10, FEB, 17 p., 99.

Research output: Contribution to journalArticle

Open Access
File
Blood Vessels
Pressure
Costs and Cost Analysis
Myography
Systems Analysis
2018

Abstract 1441: MYC expression promotes lipid metabolism and metabolic plasticity in human mammary epithelial cell

Casciano, J. C., Cohen-Nowak, A., Vande Voorde, J., Zhang, Q., Chalmers, S., Sandison, M., Hedley, A., McBryan, T., Beer, T., Tang, H-Y., Speicher, D. W., Adams, P., Liu, X., Schlegel, R., McCarron, J., Wakelam, M. J., Gottlieb, E. & Schug, Z. T., 31 Jul 2018, In : Cancer Research. 78, 13 Suppl, 1 p.

Research output: Contribution to journalConference Contribution

Open Access
File
Lipid Metabolism
Breast
Epithelial Cells
Triple Negative Breast Neoplasms
Breast Neoplasms

Complex Interactions of excitatory and inhibitory stimuli in the vascular endothelium

Ratnayake, M., Wilson, C., Lee, M. D., Girkin, J. M., Saunter, C. M. & McCarron, J., 20 Apr 2018, In : FASEB Journal. 32, 1 Suppl., 1 p., 843.5.

Research output: Contribution to journalMeeting abstract

Open Access
File
Vascular Endothelium
Phenylephrine
Acetylcholine
Endothelium
Angiotensins

Mitochondria structure and position in the local control of calcium signals in smooth muscle cells

McCarron, J. G., Saunter, C., Wilson, C., Girkin, J. M. & Chalmers, S., 6 Aug 2018, Signal Transduction and Smooth Muscle. Trebak, M. & Earley, S. (eds.). Boca Raton, Florida, p. 173-190 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
File
Mitochondria
Organelles
Smooth Muscle Myocytes
Muscle
Cells
4 Citations (Scopus)

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry

Patnaik, S. R., Zhang, X., Biswas, L., Akhtar, S., Zhou, X., Kusuluri, D. K., Reilly, J., May-Simera, H., Chalmers, S., McCarron, J. G. & Shu, X., 1 May 2018, In : Oncotarget. 9, 33, p. 23183-23197 15 p.

Research output: Contribution to journalArticle

Open Access
File
Proteasome Endopeptidase Complex
Calcium
Cell Polarity
Actin Cytoskeleton
Proteins
6 Citations (Scopus)
Open Access
File
Vascular Endothelium
Endothelium
Cells
Population
Blood
2017
5 Citations (Scopus)

Advancing age decreases pressure-sensitive modulation of calcium signaling in the endothelium of intact and pressurized arteries

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 30 Jan 2017, In : Journal of Vascular Research. 53, 5-6, p. 358–369 12 p.

Research output: Contribution to journalArticle

Open Access
File
Calcium Signaling
Endothelium
Arteries
Calcium
Pressure
Mitochondrial Dynamics
Mitochondria
Endothelial cells
Modulation
Endothelial Cells
18 Citations (Scopus)

The endothelium solves problems that endothelial cells do not know exist

McCarron, J. G., Lee, M. D. & Wilson, C., 16 Feb 2017, In : Trends in Pharmacological Sciences. 38, 4, p. 322-338 17 p.

Research output: Contribution to journalArticle

Open Access
File
Endothelial cells
Endothelium
Blood
Endothelial Cells
Cardiovascular system
2016
25 Citations (Scopus)

Acetylcholine released by endothelial cells facilitates flow-mediated dilatation

Wilson, C., Lee, M. D. & McCarron, J. G., 14 Dec 2016, In : Journal of Physiology. 594, 24, p. 7267-7307 41 p.

Research output: Contribution to journalArticle

Open Access
File
Acetylcholine
Dilatation
Endothelial Cells
Endothelium
Blood Vessels
13 Citations (Scopus)
Open Access
File
Mitochondrial Size
Vascular Smooth Muscle
Smooth Muscle
Mitochondria
Muscle Cells

Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle

McCarron, J. G., Chalmers, S., Wilson, C. & Sandison, M. E., 7 Jul 2016, Vascular Ion Channels in Physiology and Disease. Berlin: Springer, p. 233-254 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
File
Ryanodine Receptor Calcium Release Channel
Mitochondria
Ion Channels
Smooth Muscle
Muscle
15 Citations (Scopus)

Clusters of specialized detector cells provide sensitive and high fidelity receptor signaling in intact endothelium

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 12 Feb 2016, In : FASEB Journal. 30, 5, p. 2000-2013 14 p.

Research output: Contribution to journalArticle

Open Access
File
Acetylcholine
Endothelium
Detectors
Noise
Endothelial cells
Mitochondrial Dynamics
Vascular Diseases
Stents
Endothelial Cells
Cell Proliferation
10 Citations (Scopus)
Open Access
File
Smooth Muscle Myocytes
Phenotype
Macrophages
Atherosclerotic Plaques
Myeloid Cells
2015
7 Citations (Scopus)

Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension

Chalmers, S., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 23 Nov 2015, In : Scientific Reports. 5, 15 p., 16875.

Research output: Contribution to journalArticle

Open Access
File
Microscopy
Mitochondria
Hypertension
Mitochondrial Size
Mitochondrial Membrane Potential

Heterogeneity in the proliferative capacity of smooth muscle cells (SMCs)

Sandison, M. & McCarron, J., Apr 2015, In : FASEB Journal. 29, Suppl. 1, p. 418.8 1 p.

Research output: Contribution to journalConference Contribution

Open Access
File
Smooth Muscle Myocytes
Muscle
Cells
Smooth Muscle
Portal Vein
13 Citations (Scopus)

Pressure-dependent regulation of Ca2+ signaling in the vascular endothelium

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 15 Dec 2015, In : Journal of Physiology. 593, 24, p. 5231-5253 23 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Endothelium
Endothelial cells
Pressure
Endothelial Cells
Arteries
3 Citations (Scopus)

Synthesis of an azido-tagged low affinity ratiometric calcium sensor

Caldwell, S. T., Cairns, A. G., Olson, M., Chalmers, S., Sandison, M., Mullen, W., McCarron, J. G. & Hartley, R. C., 23 Dec 2015, In : Tetrahedron. 71, 51, p. 9571–9578 8 p.

Research output: Contribution to journalArticle

Open Access
File
Thiohydantoins
Calcium ion sensors
Allylation
Ions
Cell signaling
2014

Direct visualisation of smooth muscle cell phenotypic plasticity and migration by long-term imaging

Sandison, M., Chalmers, S., Dempster, J. & McCarron, J., 30 Apr 2014, In : FASEB Journal. 28, Suppl 1, 1 p., 867.12.

Research output: Contribution to journalConference Contribution

Smooth Muscle Myocytes
Cell Movement
Plasticity
Muscle
Visualization
2013
9 Citations (Scopus)

Examining the role of mitochondria in Ca2+ Signaling in native vascular smooth muscle

Mccarron, J. G., Olson, M. L., Wilson, C., Sandison, M. E. & Chalmers, S., May 2013, In : Microcirculation. 20, 4, p. 317-329 13 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Protons
Mitochondria
Membrane Potentials
Smooth Muscle
26 Citations (Scopus)

From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle

McCarron, J. G., Wilson, C., Sandison, M. E., Olson, M. L., Girkin, J. M., Saunter, C. & Chalmers, S., Oct 2013, In : Journal of Vascular Research. 50, 5, p. 357-371 15 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Cultured Cells
Organelles
Anatomy
Mitochondria
1 Citation (Scopus)

Single cell and subcellular measurements of intracellular Ca2+ concentration

McCarron, J. G., Olson, M. L., Chalmers, S. & Girkin, J. M., 2013, Calcium Signaling Protocols. Lambert, D. G. & Rainbow, R. D. (eds.). Vol. 937. p. 239-251 13 p. (Methods in Molecular Biology; vol. 937).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescence Microscopy
Electrophysiology
Ion Channels
Mouth
Cytoplasm
2012
9 Citations (Scopus)

ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors

MacMillan, D., Kennedy, C. & McCarron, J., 1 Nov 2012, In : Journal of Cell Science. 125, 21, p. 5151-5158 8 p.

Research output: Contribution to journalArticle

Purinergic P2Y1 Receptors
Smooth Muscle
Adenosine Triphosphate
Type C Phospholipases
GTP-Binding Proteins
12 Citations (Scopus)
Inositol 1,4,5-Trisphosphate
Muscarinic Receptors
Smooth Muscle Myocytes
Smooth Muscle
Cluster Analysis
29 Citations (Scopus)

Mitochondrial motility and vascular smooth muscle proliferation

Chalmers, S., Saunter, C., Wilson, C., Coats, P., Girkin, J. & McCarron, J., Dec 2012, In : Arteriosclerosis Thrombosis, and Vascular Biology. 32, 12, p. 3000-3011 12 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Mitochondria
Smooth Muscle
Arteries
Organelles
35 Citations (Scopus)

Mitochondrial motility and vascular smooth muscle proliferation

Chalmers, S., Saunter, C., Wilson, C., Coats, P., Girkin, J. M. & McCarron, J. G., Dec 2012, In : Arteriosclerosis Thrombosis, and Vascular Biology. 32, 12, p. 3000-3011 12 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Mitochondria
Mitochondrial Dynamics
Smooth Muscle
Arteries
23 Citations (Scopus)

Mitochondrial organization and Ca2+ uptake

Olson, M. L., Chalmers, S. & McCarron, J. G., 2012, In : Biochemical Society Transactions. 40, 1, p. 158-167 10 p.

Research output: Contribution to journalArticle

Mitochondria
Organelles
Cell membranes
Cell Membrane
Modulation
15 Citations (Scopus)

Mitochondrial regulation of cytosolic Ca2+ signals in smooth muscle

McCarron, J., Olson, M. & Chalmers, S., 2012, In : Pflügers Archiv European Journal of Physiology . 464, special issue, p. 51-62 11 p.

Research output: Contribution to journalArticle

Mitochondria
Muscle Mitochondrion
Smooth Muscle
Muscle
Organelles
68 Citations (Scopus)

Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore

Chalmers, S., Caldwell, S. T., Quin, C., Prime, T. A., James, A. M., Cairns, A., Murphy, M. P., McCarron, J. & Hartley, R. C., 2012, In : Journal of the American Chemical Society . 134, 2, p. 758-761 4 p.

Research output: Contribution to journalArticle

Mitochondria
2,4-Dinitrophenol
Photolysis
Depolarization
Ultraviolet Rays
4 Citations (Scopus)

Subplasma membrane Ca2+ signals

McCarron, J., Chalmers, S., Olson, M. & Girkin, J., Jul 2012, In : IUBMB Life. 64, 7, p. 573-585 12 p.

Research output: Contribution to journalArticle

Membranes
Cell membranes
Cell Membrane
Imaging techniques
Calibration
2011

Mitochondrial motility and vascular smooth muscle proliferation

Chalmers, S., Coats, P. & McCarron, J. G., Dec 2011, In : Heart. 97, 24

Research output: Contribution to journalMeeting abstract

Vascular Smooth Muscle

Modulation of calcium signalling pathways

McCarron, J., Chalmers, S. & Olson, M., Sep 2011, In : Journal of Vascular Research. 48, Suppl.1, p. 42-42 1 p., IS24.

Research output: Contribution to journalConference Contribution

Calcium Signaling
Cytoplasm
Tacrolimus Binding Protein 1A
Tacrolimus Binding Proteins
Sarcolemma
2010
21 Citations (Scopus)

Agonist-evoked Ca2+ wave progression requires Ca2+ and IP3

McCarron, J. G., Chalmers, S., MacMillan, D. & Olson, M. L., Aug 2010, In : Journal of Cellular Physiology. 224, 2, p. 334-344 11 p.

Research output: Contribution to journalArticle

Carbachol
Buffers
Photolysis
Smooth Muscle Myocytes
Smooth Muscle
37 Citations (Scopus)
Inositol 1,4,5-Trisphosphate Receptors
Mitochondria
Smooth Muscle Myocytes
Muscle
Cells
41 Citations (Scopus)
Sarcoplasmic Reticulum
Type C Phospholipases
Smooth Muscle
Phosphoinositide Phospholipase C
Carbachol
2009
7 Citations (Scopus)

Caged AG10: new tools for spatially predefined mitochondrial uncoupling

Avionitis, N., Chalmers, S., McDougall, C., Stanton-Humphreys, M. N., Brown, C. T. A., McCarron, J. G. & Conway, S. J., 2009, In : Molecular BioSystems. 5, p. 450-457 7 p.

Research output: Contribution to journalArticle

Photolysis
Tyrphostins
Mitochondrial Membrane Potential
Smooth Muscle Myocytes
Mitochondria
13 Citations (Scopus)
Calcium Channels
Vascular Smooth Muscle
Calcium
Membranes
Cytoplasm
16 Citations (Scopus)
Inositol 1,4,5-Trisphosphate Receptors
Mitochondria
Calcium
Sarcoplasmic Reticulum
Ions
22 Citations (Scopus)
Tacrolimus Binding Proteins
Sarcoplasmic Reticulum
Tacrolimus
Sirolimus
Vascular Smooth Muscle
17 Citations (Scopus)

The sarcoplasmic reticulum Ca2+ store arrangement in vascular smooth muscle

Rainbow, R., MacMillan, D. & McCarron, J. G., Dec 2009, In : Cell Calcium. 45, 5-6, p. 313-322 10 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Vascular Smooth Muscle
Inositol 1,4,5-Trisphosphate Receptors
Ryanodine Receptor Calcium Release Channel
Muscle Cells
2008
33 Citations (Scopus)

A single luminally continuous sarcoplasmic reticulum with apparently separate Ca2+ stores in smooth muscle

McCarron, J. G. & Olson, M., 14 Mar 2008, In : Journal of Biological Chemistry. 283, 11, p. 7206-7218 13 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
Smooth Muscle
Muscle
Inositol 1,4,5-Trisphosphate Receptors