John McCarron

2024

Signalling switches maintain intercellular communication in the vascular endothelium: endothelial Ca2+ waves driven by regenerative IP3-induced IP3 production

Buckley, C., Lee, M. D., Zhang, X., Wilson, C. & McCarron, J. G., 1 Aug 2024, In: British Journal of Pharmacology. 181, 16, p. 2810-2832 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

14 Downloads (Pure)

Endothelial Membrane Potential Changes are Required for Propagated Vasodilation

Woodsend, C., Buckley, C., Zhang, X., Wilson, C., Lee, M. & McCarron, J., 21 May 2024, In: Physiology. 39, S1, 1 p.

Research output: Contribution to journal › Conference abstract › peer-review

Open Access

Mitochondria control IP₃-evoked Ca²⁺ release triggered by voltage-dependent Ca²⁺ entry in intact resistance arteries

Zhang, X., Lee, M., Buckley, C., Wilson, C. & McCarron, J., 21 May 2024, In: Physiology. 39, S1, 1 p.

Research output: Contribution to journal › Conference abstract › peer-review

Open Access

Signaling switches maintain intercellular communication in the vascular endothelium

Buckley, C., Lee, M., Zhang, X., Wilson, C. & McCarron, J., 21 May 2024, In: Physiology. 39, S1, 1 p.

Research output: Contribution to journal › Conference abstract › peer-review

Open Access

Simultaneous arrival of multiple agonists: how the endothelium senses and responds

Lee, M., Wilson, C., Buckley, C., Zhang, X., Woodsend, C., Osborne, C. & McCarron, J., 21 May 2024, In: Physiology. 39, S1, 1 p.

Research output: Contribution to journal › Conference abstract › peer-review

Open Access

2023

Endothelial PAR2 activation evokes resistance artery relaxation: PAR2 regulation of resistance arteries

Zhang, X., Lee, M. D., Buckley, C., Hollenberg, M. D., Wilson, C. & McCarron, J. G., Apr 2023, In: Journal of Cellular Physiology. 238, 4, p. 776-789 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

38 Downloads (Pure)

Mitochondrial ATP production is required for endothelial cell control of vascular tone

Wilson, C., Lee, M. D., Buckley, C., Zhang, X. & McCarron, J. G., 9 Feb 2023, In: Function. 4, 2, 16 p., zqac063.

Research output: Contribution to journal › Article › peer-review

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13 Citations (Scopus)

44 Downloads (Pure)

2022

Endothelial signalling operates on a small-world, scale-free network

Lee, M. D., Buckley, C., Wilson, C., Zhang, X. & McCarron, J., 30 Sept 2022, In: Acta Physiologica. 236, Supp. 725, p. 550-551 2 p., A 07-28.

Research output: Contribution to journal › Conference abstract

William Bayliss and the enduring fascination of myogenic tone

Wilson, C., McCarron, J. G. & Lee, M. D., 15 Sept 2022, In: The Journal of Physiology. 600, 18, p. 4043-4044 2 p.

Research output: Contribution to journal › Editorial › peer-review

1 Citation (Scopus)

Endothelial signalling operates on a small‐world network to control vascular function

Lee, M. D., Buckley, C., Zhang, X., Wilson, C. & McCarron, J. G., 13 May 2022, (E-pub ahead of print) In: FASEB Journal. 36, S1, 1 p.

Research output: Contribution to journal › Conference abstract › peer-review

Intercellular Ca ²⁺ waves propagate by regenerative IP ₃ ‐induced IP ₃ release

Buckley, C., Zhang, X., Lee, M., Wilson, C. & McCarron, J. G., 13 May 2022, (E-pub ahead of print) In: FASEB Journal. 36, S1

Research output: Contribution to journal › Conference abstract › peer-review

Mitochondrial oxidative phosphorylation fuels endothelial control of blood vessel tone

Wilson, C., Lee, M. D., Buckley, C., Zhang, X. & McCarron, J. G., 13 May 2022, (E-pub ahead of print) In: FASEB Journal. 36, S1

Research output: Contribution to journal › Conference abstract › peer-review

PAR2, not PAR1, regulates endothelium‐dependent vascular tone in resistance arteries

Zhang, X., Lee, M. D., Buckley, C., Wilson, C., Hollenberg, M. & McCarron, J. G., 13 May 2022, (E-pub ahead of print) In: FASEB Journal. 36, S1

Research output: Contribution to journal › Conference abstract › peer-review

Small-world connectivity dictates collective endothelial cell signaling: scale-free signaling in the endothelial network

Lee, M. D., Buckley, C., Zhang, X., Wilson, C. & McCarron, J., 28 Apr 2022, In: Proceedings of the National Academy of Sciences . 119, 18, 12 p., e2118927119.

Research output: Contribution to journal › Article › peer-review

Open Access

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10 Citations (Scopus)

28 Downloads (Pure)

Mitochondria regulate TRPV4 mediated release of ATP

Zhang, X., Lee, M. D., Buckley, C., Wilson, C. & McCarron, J. G., 31 Mar 2022, In: British Journal of Pharmacology. 179, 5, p. 1017-1032 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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10 Citations (Scopus)

23 Downloads (Pure)

BS22 TRPV4 is a phospholipase C coupled receptor when mitochondria are depolarised in intact endothelial cells

Zhang, X., Wilson, C. & McCarron, J., 8 Jan 2022, In: Heart . 107, Suppl. 1, p. A168.2-A169 2 p.

Research output: Contribution to journal › Conference abstract › peer-review

2021

The selfish mitochondrion

McCarron, J. G. & Wilson, C., 31 Dec 2021, In: Cell Calcium. 100, 102498.

Research output: Contribution to journal › Article › peer-review

Open Access

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25 Downloads (Pure)

Photoactivated release of membrane impermeant sulfonates inside cells

Caldwell, S. T., O’Byrne, S. N., Wilson, C., Cvetko, F., Murphy, M. P., McCarron, J. G. & Hartley, R. C., 25 Apr 2021, In: Chemical Communications. 57, 32, p. 3917-3920 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

21 Downloads (Pure)

Carbenoxolone and 18β-glycyrrhetinic acid inhibit inositol 1,4,5-trisphosphate-mediated endothelial cell calcium signalling and depolarise mitochondria

Buckley, C., Zhang, X., Wilson, C. & McCarron, J. G., 28 Feb 2021, In: British Journal of Pharmacology. 178, 4, p. 896-912 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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18 Citations (Scopus)

59 Downloads (Pure)

2020

Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity

Wilson, C., Zhang, X., Lee, M. D., MacDonald, M., Heathcote, H. R., Alorfi, N. M. N., Buckley, C., Dolan, S. & McCarron, J. G., 1 Oct 2020, In: Metabolism. 111, 10 p., 154340.

Research output: Contribution to journal › Article › peer-review

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25 Citations (Scopus)

28 Downloads (Pure)

Correcting field aberrations in optical instrumentation for imaging inside tubular organs

Lawton, P. F., Girkin, J. M., Saunter, C. D., McCarron, J. G. & Wilson, C., 26 Jun 2020, Adaptive Optics: Analysis, Methods & Systems 2020. Washington, DC, (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

Casciano, J. C., Perry, C., Cohen-Nowak, A. J., Miller, K. D., Voorde, J. V., Zhang, Q., Chalmers, S., Sandison, M. E., Lui, Q., Hedley, A., McBryan, T., Tang, H-Y., Gorman, N., Beer, T., Speicher, D. W., Adams, P. D., Lui, X., Schlegel, R., McCarron, J. G., Wakelam, M. J. O., & 3 othersGottlieb, E., Kossenkov, A. V. & Schug, Z. T., 17 Mar 2020, In: British Journal of Cancer. 122, 6, p. 868-884 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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58 Citations (Scopus)

132 Downloads (Pure)

FK506 regulates IP3 evoked Ca2+ release independently of FKBP in endothelial cells

Buckley, C., Wilson, C. & McCarron, J. G., Mar 2020, In: British Journal of Pharmacology. 177, 5, p. 1131-1149 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Citations (Scopus)

68 Downloads (Pure)

2019

Hydrogen peroxide depolarizes mitochondria and inhibits IP₃-evoked Ca²⁺ release in the endothelium of intact arteries

Zhang, X., Lee, M. D., Wilson, C. & McCarron, J. G., 31 Dec 2019, In: Cell Calcium. 84, 12 p., 102108.

Research output: Contribution to journal › Article › peer-review

Open Access

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22 Citations (Scopus)

33 Downloads (Pure)

Increased vascular contractility in hypertension results from impaired endothelial calcium signaling

Wilson, C., Zhang, X., Buckley, C., Heathcote, H. R., Lee, M. D. & McCarron, J. G., 1 Nov 2019, In: Hypertension. 74, 5, p. 1200-1214 15 p.

Research output: Contribution to journal › Article › peer-review

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55 Citations (Scopus)

51 Downloads (Pure)

Multi-plane remote refocussing epifluorescence microscopy to image dynamic Ca2+ events

Lawton, P. F., Buckley, C., Saunter, C. D., Wilson, C., Corbett, A. D., Slater, P. S., McCarron, J. G. & Girkin, J. M., 1 Nov 2019, In: Biomedical Optics Express. 10, 11, p. 5611-5624 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

21 Downloads (Pure)

Endothelial TRPV4 channels modulate vascular tone by Ca ²⁺-induced Ca ²⁺ release at inositol 1,4,5-trisphosphate receptors

Heathcote, H. R., Lee, M. D., Zhang, X., Saunter, C. D., Wilson, C. & McCarron, J. G., 30 Sept 2019, In: British Journal of Pharmacology. 176, 17, p. 3297-3317 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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46 Citations (Scopus)

94 Downloads (Pure)

Heterogeneity and emergent behaviour in the vascular endothelium

McCarron, J. G., Wilson, C., Heathcote, H. R., Zhang, X., Buckley, C. & Lee, M. D., 30 Apr 2019, In: Current Opinion in Pharmacology. 45, p. 23-32 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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41 Citations (Scopus)

48 Downloads (Pure)

IP 3 ‐evoked Ca 2+ release in endothelial cells is modulated by the immunosuppressant FK506‐binding protein (FKBP12)

Buckley, C., Wilson, C. & McCarron, J., 30 Apr 2019, In: FASEB Journal. 33, S1, p. 719.11-719.11 1 p.

Research output: Contribution to journal › Conference abstract › peer-review

Open Access

VasoTracker, a low-cost and open source pressure myograph system for vascular physiology

Lawton, P. F., Lee, M. D., Saunter, C. D., Girkin, J. M., McCarron, J. G. & Wilson, C., 21 Feb 2019, In: Frontiers in Physiology. 10, FEB, 17 p., 99.

Research output: Contribution to journal › Article › peer-review

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26 Citations (Scopus)

94 Downloads (Pure)

Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate–evoked calcium signaling: mitochondrial control of endothelial Ca2+ signaling

Wilson, C., Lee, M. D., Heathcote, H. R., Zhang, X., Buckley, C., Girkin, J. M., Saunter, C. D. & McCarron, J. G., 18 Jan 2019, In: Journal of Biological Chemistry. 294, 3, p. 737-758 22 p.

Research output: Contribution to journal › Article › peer-review

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32 Citations (Scopus)

48 Downloads (Pure)

2018

Spatially-structured cell populations process multiple sensory signals in parallel in intact vascular endothelium: stimulus-specific sensory cells in the intact vascular endothelium

Lee, M. D., Wilson, C., Saunter, C. D., Kennedy, C., Girkin, J. M. & McCarron, J. G., 18 Dec 2018, In: Science Signaling. 11, 561, 20 p., eaar4411.

Research output: Contribution to journal › Article › peer-review

Open Access

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33 Citations (Scopus)

33 Downloads (Pure)

Mitochondria structure and position in the local control of calcium signals in smooth muscle cells

McCarron, J. G., Saunter, C., Wilson, C., Girkin, J. M. & Chalmers, S., 6 Aug 2018, Signal Transduction and Smooth Muscle. Trebak, M. & Earley, S. (eds.). Boca Raton, Florida, p. 173-190 18 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access

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7 Citations (Scopus)

45 Downloads (Pure)

Abstract 1441: MYC expression promotes lipid metabolism and metabolic plasticity in human mammary epithelial cell

Casciano, J. C., Cohen-Nowak, A., Vande Voorde, J., Zhang, Q., Chalmers, S., Sandison, M., Hedley, A., McBryan, T., Beer, T., Tang, H-Y., Speicher, D. W., Adams, P., Liu, X., Schlegel, R., McCarron, J., Wakelam, M. J., Gottlieb, E. & Schug, Z. T., 31 Jul 2018, In: Cancer Research. 78, 13 Suppl, 1 p.

Research output: Contribution to journal › Conference Contribution › peer-review

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RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry

Patnaik, S. R., Zhang, X., Biswas, L., Akhtar, S., Zhou, X., Kusuluri, D. K., Reilly, J., May-Simera, H., Chalmers, S., McCarron, J. G. & Shu, X., 1 May 2018, In: Oncotarget. 9, 33, p. 23183-23197 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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14 Citations (Scopus)

94 Downloads (Pure)

Complex Interactions of excitatory and inhibitory stimuli in the vascular endothelium

Ratnayake, M., Wilson, C., Lee, M. D., Girkin, J. M., Saunter, C. M. & McCarron, J., 20 Apr 2018, In: FASEB Journal. 32, 1 Suppl., 1 p., 843.5.

Research output: Contribution to journal › Conference abstract › peer-review

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46 Downloads (Pure)

2017

Open Access

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67 Citations (Scopus)

177 Downloads (Pure)

Advancing age decreases pressure-sensitive modulation of calcium signaling in the endothelium of intact and pressurized arteries

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 30 Jan 2017, In: Journal of Vascular Research. 53, 5-6, p. 358–369 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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14 Citations (Scopus)

98 Downloads (Pure)

2016

Acetylcholine released by endothelial cells facilitates flow-mediated dilatation

Wilson, C., Lee, M. D. & McCarron, J. G., 15 Dec 2016, In: Journal of Physiology. 594, 24, p. 7267-7307 41 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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91 Citations (Scopus)

225 Downloads (Pure)

The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation

Sandison, M. E., Dempster, J. & McCarron, J. G., 1 Nov 2016, In: Journal of Physiology. 594, 21, p. 6189-6209 39 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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27 Citations (Scopus)

126 Downloads (Pure)

Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle: Smooth muscle mitochondrial shape and motility changes with age

Chalmers, S., Saunter, C., Girkin, J. M. & McCarron, J. G., 1 Aug 2016, In: Journal of Physiology. 594, 15, p. 4283–4295 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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30 Citations (Scopus)

74 Downloads (Pure)

Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle

McCarron, J. G., Chalmers, S., Wilson, C. & Sandison, M. E., 7 Jul 2016, Vascular Ion Channels in Physiology and Disease. Berlin: Springer, p. 233-254 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access

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38 Downloads (Pure)

Clusters of specialized detector cells provide sensitive and high fidelity receptor signaling in intact endothelium

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 31 May 2016, In: FASEB Journal. 30, 5, p. 2000-2013 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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36 Citations (Scopus)

81 Downloads (Pure)

Inhibition of mitochondrial fission as a potential therapeutic target for vascular disease?

Kaloya, S., McCarron, J., Chalmers, S. & McCormick, C., 2016, (Unpublished).

Research output: Contribution to conference › Poster

2015

Synthesis of an azido-tagged low affinity ratiometric calcium sensor

Caldwell, S. T., Cairns, A. G., Olson, M., Chalmers, S., Sandison, M., Mullen, W., McCarron, J. G. & Hartley, R. C., 23 Dec 2015, In: Tetrahedron. 71, 51, p. 9571–9578 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

117 Downloads (Pure)

Pressure-dependent regulation of Ca2+ signaling in the vascular endothelium

Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 15 Dec 2015, In: Journal of Physiology. 593, 24, p. 5231-5253 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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33 Citations (Scopus)

109 Downloads (Pure)

Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension

Chalmers, S., Saunter, C. D., Girkin, J. M. & McCarron, J. G., 23 Nov 2015, In: Scientific Reports. 5, 15 p., 16875.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Citations (Scopus)

140 Downloads (Pure)

Heterogeneity in the proliferative capacity of smooth muscle cells (SMCs)

Sandison, M. & McCarron, J., Apr 2015, In: FASEB Journal. 29, Suppl. 1, p. 418.8 1 p.

Research output: Contribution to journal › Conference Contribution › peer-review

Open Access

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John McCarron

Research output

Search results