• 2066 Citations
1997 …2023
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Personal profile

Research Interests

Our research deals with materials and processes at colloidal (nanometer to micrometer) length scales. The focus is on synthesis and processing of particulate, colloidal and biomolecular systems.

Particle formation processes/pharmaceutical engineering

Numerous pharmaceutical particulates are formed through antisolvent driven processes, where two solutions are mixed in order to create a thermodynamic driving force for particle formation due to a limited solubility of one or more solutes in the resulting solvent mixture. Such processes are often mixing controlled and can lead to a wide range of intermediate and/or metastable liquid or solid phases. We study kinetics and mechanisms of these processes in order to design and novel continuous processes for manufacturing of nanostructured particles for various pharmaceutical applications. We also study subsequent downstream processes and their effects on resulting particulate products.

Protein Aggregation

Understanding, controlling and utilizing colloidal interactions of proteins is crucial for their downstream processing, including purification, sterilization and storage. Protein interactions with each other determine whether they stay stable in solution or whether they aggregate. Understanding and tuning of protein interactions is thus necessary for improvement of the lifetime stability of therapeutic proteins as well as for rational development of novel separation and sensing procedures for bioprocessing. In fact, there are numerous issues in biotechnology and biomedical engineering, where protein aggregation phenomena have been identified as key factors controlling our success in producing, sensing, handling, and applying biomaterials and therapeutics as desired. We study protein aggregation in solutions under non-equilibrium conditions. The proteins of interest include enzymes and therapeutic proteins in applications such as heat treatment or bioseparations. The modelling work is focused in detailed scattering and spectroscopic characterisation of aggregating protein systems as well as on development and validation of population balance models describing how the mass distribution, structure and activity of protein aggregates evolve in time.

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  • 3 Similar Profiles
Agglomeration Chemical Compounds
Crystallization Chemical Compounds
Kinetics Chemical Compounds
Gels Engineering & Materials Science
Dispersions Chemical Compounds
Particle size analysis Chemical Compounds
Crystals Chemical Compounds
Nucleation Chemical Compounds

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Projects 2004 2023

GSK PhD studentship top up

Sefcik, J.

Glaxo Smithkline (UK)

1/10/1830/09/22

Project: Research - StudentshipResearch Studentship

Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | McKechnie, David

Sefcik, J., Johnston, K. & McKechnie, D.

EPSRC (Engineering and Physical Sciences Research Council)

1/06/171/12/20

Project: Research Studentship - Internally AllocatedResearch Studentship (Internally Allocated)

Research Output 1997 2018

Crystal shape modification via cycles of growth and dissolution in a tubular crystallizer

Neugebauer, P., Cardona, J., Besenhard, M. O., Peter, A., Gruber-Woelfler, H., Tachtatzis, C., Cleary, A., Andonovic, I., Sefcik, J. & Khinast, J. G. 15 Jun 2018 In : Crystal Growth and Design.

Research output: Contribution to journalArticle

Crystallizers
dissolving
Dissolution
Crystals
cycles

Effect of particle size distribution on spatially and angularly resolved diffuse reflectance measurement

Chen, Y-C., Tiernan-Vandermotten, S., Lue, L., Ferreira, C. S., Sefcik, J. & Thennadil, S. 28 Feb 2018 In : European Pharmaceutical Review. 23, 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Compounding
Near infrared spectroscopy
Near-Infrared Spectroscopy
Reflectometers
Particle Size

Thesis

Batch to continuous organic salt crystallisation : model based design

Author: McGinty, J., 1 Jul 2017

Supervisor: Sefcik, J. (Supervisor) & Florence, A. (Supervisor)

Student thesis: Doctoral Thesis

Computational modelling and design of bioinspired silica materials

Author: Centi, A., 1 Oct 2016

Supervisor: Jorge, M. (Supervisor) & Sefcik, J. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2005 2018

Modelling of particle size and shape distribution in pharmaceutical suspensions and the effects on UV-vis-NIR

Stoliarskaia, D. (Speaker), Ferreira, C. S. (Contributor), Thomson, K. (Contributor), Lue, L. (Contributor), Sefcik, J. (Contributor), Chen, Y. (Contributor)
10 May 2017

Activity: Oral presentation