Projects per year
Our laboratory specialises in studying the interaction of the immune system with intracellular protozoan parasites, particularly Leishmania and Toxoplasma gondii. The use of cytokine, cytokine receptor, costimulatory molecule, and signaling molecule gene deficient mice is currently providing a very powerful tool in the analysis of immunoregulatory control of parasitic disease. We have recently further expanded our studies to utilize 2nd generation gene reporter as well as cytokine receptor tissue/cell specific knockouts. Of particular interest to our group is is the development of vaccines against these parasites using recombinant antigen preparations and gene deficient mutants. The development and characterisation of novel adjuvants for use with modern technology vaccines is a particular area of expertise within the group. The development of vaccine delivery formulations, which function as well as orally as they do parenterally is an area of top priority.
We have pioneered studies on the immunopathology of Toxoplasma gondii particularly in the central nervous system and characterised a laboratory model of congenital toxoplasmosis suitable for testing vaccines and chemotherapeutic agents. How these immune responses to parasite infection are influenced by gender and sex hormones is an area of particular interest.
Ongoing collaborations with the Universities of Glasgow, York, Birmingham, Cape Town, Lusanne and Chicago complement these studies.
Millington, O., Alexander, J. & Crowe, J.
1/10/11 → 21/10/15
Project: Research Studentship - Internally Allocated
1/04/10 → 31/03/11
IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Rα signaling via T cellsMcFarlane, E., Mokgethi, T., Kaye, P. M., Hurdayal, R., Brombacher, F., Alexander, J. & Carter, K. C., 16 Aug 2019, In: Frontiers in Immunology. 10, 13 p., 1957.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile7 Citations (Scopus)8 Downloads (Pure)
Ross, K., McIntosh, K., Jabbar, S. K. J., Woods, S., Crowe, J., Patterson-Kane, J. C., Alexander, J., Lawrence, C. & Plevin, R., 11 Jan 2019, In: RMD Open. 5, 1, p. e000711 9 p., e000711.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)19 Downloads (Pure)
James Alexander (Keynote/plenary speaker)Jan 2008
Activity: Participating in or organising an event types › Key-note speaker and plenary lectures at conferences
Economic benefit and competitive advantage from commercial adoption of an innovative non-invasive delivery method for drugs and vaccines
Impact: Impact - for External Portal › Economic and commerce, Health and welfare - new products, guidelines and servicesFile