1989 …2019
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Personal profile

Personal Statement

Our laboratory specialises in studying the interaction of the immune system with intracellular protozoan parasites, particularly Leishmania and Toxoplasma gondii. The use of cytokine, cytokine receptor, costimulatory molecule, and signaling molecule gene deficient mice is currently providing a very powerful tool in the analysis of immunoregulatory control of parasitic disease. We have recently further expanded our studies to utilize 2nd generation gene reporter as well as cytokine receptor tissue/cell specific knockouts. Of particular interest to our group is is the development of vaccines against these parasites using recombinant antigen preparations and gene deficient mutants. The development and characterisation of novel adjuvants for use with modern technology vaccines is a particular area of expertise within the group. The development of vaccine delivery formulations, which function as well as orally as they do parenterally is an area of top priority.

We have pioneered studies on the immunopathology of Toxoplasma gondii particularly in the central nervous system and characterised a laboratory model of congenital toxoplasmosis suitable for testing vaccines and chemotherapeutic agents. How these immune responses to parasite infection are influenced by gender and sex hormones is an area of particular interest.

Ongoing collaborations with the Universities of Glasgow, York, Birmingham, Cape Town, Lusanne and Chicago complement these studies.

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Toxoplasma Medicine & Life Sciences
Parasites Medicine & Life Sciences
Toxoplasmosis Medicine & Life Sciences
Interleukin-4 Medicine & Life Sciences
Leishmania mexicana Medicine & Life Sciences
Infection Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Vaccines Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2004 2015

BBSRC Doctoral Training Grant (DTG) | Crowe, Jenny

Millington, O., Alexander, J. & Crowe, J.

BBSRC (Biotech & Biological Sciences Research Council)

1/10/1121/10/15

Project: Research Studentship - Internally AllocatedResearch Studentship (Internally Allocated)

Nanoparticles
Spectrum Analysis
Fluorescence
Aorta
Antibodies

Research Output 1989 2019

IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Rα signaling via T cells

McFarlane, E., Mokgethi, T., Kaye, P. M., Hurdayal, R., Brombacher, F., Alexander, J. & Carter, K. C., 16 Aug 2019, In : Frontiers in Immunology. 10, 13 p., 1957.

Research output: Contribution to journalArticle

Open Access
File
Visceral Leishmaniasis
Leishmania donovani
Interleukin-4
Interleukin-13
T-Lymphocytes

Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis

Schroeder, J., Ross, K., McIntosh, K., Jabbar, S. K. J., Woods, S., Crowe, J., Patterson-Kane, J. C., Alexander, J., Lawrence, C. & Plevin, R., 11 Jan 2019, 5, 1, p. e000711 9 p., e000711.

Research output: Contribution to journalArticle

Open Access
File
Mitogen-Activated Protein Kinase Phosphatases
Protein Phosphatase 2
Mitogen-Activated Protein Kinase 1
Phosphoric Monoester Hydrolases
Arthritis

Thesis

An investigation of how dendritic cell migration is modulated during Leishmania mexicana infection

Author: Crowe, J., 1 Apr 2015

Supervisor: Alexander, J. (Supervisor) & (Supervisor)

Student thesis: Doctoral Thesis

Characterization of Acanthamoeba macrophage activation

Author: Cano, A., 1 Oct 2014

Supervisor: Roberts, C. (Supervisor) & Alexander, J. (Supervisor)

Student thesis: Doctoral Thesis

Activities 1996 2008

International Congresses on Toxoplasmosis , USA

James Alexander (Chair)
Jan 2008

Activity: Participating in or organising an event typesParticipation in conference

Second Generation Vaccines for Leishmania, WHO, Mexico

James Alexander (Keynote/plenary speaker)
Jan 2008

Activity: Participating in or organising an event typesKey-note speaker and plenary lectures at conferences

Impacts

Economic benefit and competitive advantage from commercial adoption of an innovative non-invasive delivery method for drugs and vaccines

Katharine Carter (Participant), Valerie Ferro (Participant), Alexander Mullen (Participant), James Alexander (Participant)

Impact: Impact - for External PortalEconomic and commerce, Health and welfare - new products, guidelines and services

File