Projects per year
Personal profile
Research Interests
Our research group is focused on elucidating bacterial adaptations for commensalism and immune evasion. Her work delves into the intricate interactions between bacteria and hosts, aiming to understand the evolution of virulence and commensal traits. With a particular interest in immune evasion strategies employed by bacteria, our research spans across diverse model systems, including Gram-negative gut and Gram-positive respiratory infection models. By studying pathogens like Salmonella enterica serovar Uganda and Streptococcus species, we investigate how these bacteria modulate the immune system and establish symbiotic relationships with hosts. This research not only sheds light on fundamental biological mechanisms but also holds promise for informing strategies to combat infections, especially in the context of global challenges such as antimicrobial resistance and the aftermath of the COVID-19 pandemic.
Current University of Strathclyde collaborators:
- Professor Paul Hoskisson
- Dr Ralf Bauer
- Dr Melanie Jimenez
External collaborators include:
- Professor Séamus Fanning (University College Dublin)
- Professor Mogens Kilian (Aarhus University)
- Professor Jeremy Brown (University College London)
- Professor Laurent Bozec (University of Toronto)
- Professor Ian Henderson (University of Queensland, Australia)
- Dr CJ Anderson (University of Edinburgh)
- Professor Hervé Tettelin (University of Maryland)
- Dr Jason Rosch (St Jude's Children's Hospital, Memphis)
- Centers for Disease Control, USA
- Health Protection Agency, UK
- Professor Jay Hinton (University of Liverpool)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University College London
Award Date: 17 Apr 2017
External positions
Elected member of the Young Academy of Scotland, Royal Society of Edinburgh
2024 → …
Adjunct Assistant Professor, University College Dublin, Dublin
2023 → …
Founding Editor and Editor-in-Chief for Access Microbiology, Microbiology Society
2018 → …
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Collaborations and top research areas from the last five years
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Decoding the pathogenic role of the capsule in Streptococcus mitis vs. Streptococcus pneumoniae
Marshall, H. (Principal Investigator)
1/10/25 → …
Project: Internally funded project
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Beyond Commensalism: Investigating the mechanisms for increased virulence potential in clinically isolated Streptococcus mitis.
Marshall, H. (Principal Investigator)
1/10/25 → 31/03/27
Project: Research
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Clinical isolates of antimicrobial resistant Enterobacter species can persist in human macrophages without replication and overt cellular cytotoxicity
Parau, G., Parks, H. J., Anderson, A. J. G., Bisaro, F., García-Romero, I., Gilmore, M. C., Korankye, S. O., Marshall, H. & Valvano, M. A., 15 Jul 2025, In: Journal of Infectious Diseases. 232, 1, p. e3-e16 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
Sá-Pessoa, J., López-Montesino, S., Przybyszewska, K., Rodríguez-Escudero, I., Marshall, H., Ova, A., Schroeder, G. N., Barabas, P., Molina, M., Curtis, T., Cid, V. J. & Bengoechea, J. A., 16 Feb 2023, In: Nature Communications. 14, 20 p., 871.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)29 Downloads (Pure)
Prizes
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30 under 30 Outstanding Young Scientists Worldwide
Marshall, H. (Recipient), 2020
Prize: National/international honour
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Activities
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Sir William Dunn School of Pathology, University of Oxford, United Kingdom (M.M.L.).
Marshall, H. (Visiting researcher)
Feb 2025Activity: Visiting an External Institution › Visiting an external academic institution
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17th European Meeting on the Molecular Biology of the Pneumococcus
Marshall, H. (Organiser)
2025Activity: Presenting or Organising an Event › Participation in conference