Photo of Gwyn Gould
  • United Kingdom

Accepting PhD Students

20052019
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Research Output 2005 2019

2019

CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis

Camus, S. M., Camus, M. D., Figueras-Novoa, C., Boncompain, G., Sadacca, L. A., Esk, C., Bigot, A., Gould, G. W., Kioumourtzoglou, D., Perez, F., Bryant, N. J., Mukherjee, S. & Brodsky, F. M., 9 Oct 2019, (Accepted/In press) In : Journal of Cell Biology. 52 p.

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Facilitative Glucose Transport Proteins
Endoplasmic Reticulum
Secretory Pathway
Legionella pneumophila

Genetic and cytological methods to study ESCRT cell cycle function in fission yeast

Rezig, I. M., Bremner, S. K., Bhutta, M. S., Salt, I. P., Gould, G. W. & McInerny, C. J., 28 Jun 2019, Methods in Molecular Biology. New York, NY., p. 239-250 12 p. (Methods in Molecular Biology; vol. 1998).

Research output: Chapter in Book/Report/Conference proceedingChapter

Endosomal Sorting Complexes Required for Transport
Schizosaccharomyces
Cell Cycle
Ascomycota
Fungi

GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes

Bowman, P. R. T., Smith, G. L. & Gould, G. W., 25 Jul 2019, In : PLoS One. 14, 7, 16 p., e0217885.

Research output: Contribution to journalArticle

Open Access
File
Induced Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Insulin
Glucose

The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes

Sadler, J. B. A., Lamb, C. A., Welburn, C. R., Adamson, I. S., Kioumourtzoglou, D., Chi, N-W., Gould, G. W. & Bryant, N. J., 18 Mar 2019, In : Scientific Reports. 9, 7 p., 4710.

Research output: Contribution to journalArticle

Open Access
File
Tankyrases
Facilitative Glucose Transport Proteins
Adipocytes
Insulin
Ubiquitination
3 Downloads (Pure)

The human-specific and smooth muscle cell-enriched LncRNA SMILR promotes proliferation by regulating mitotic CENPF mRNA and drives cell-cycle progression which can be targeted to limit vascular remodeling

Mahmoud, A. D., Ballantyne, M. D., Miscianinov, V., Pinel, K., Hung, J., Scanlon, J. P., Iyinikkel, J., Kaczynski, J., Tavares, A. S., Bradshaw, A. C., Mills, N. L., Newby, D. E., Caporali, A., Gould, G. W., George, S. J., Ulitsky, I., Sluimer, J. C., Rodor, J. & Baker, A. H., 16 Aug 2019, In : Circulation Research. 125, 5, p. 535-551 17 p.

Research output: Contribution to journalArticle

Open Access
File
Smooth Muscle Myocytes
Cell Cycle
Messenger RNA
Vascular Smooth Muscle
Small Interfering RNA
2018

Proximity ligation assay to study the GLUT4 membrane trafficking machinery

Kioumourtzoglou, D., Gould, G. W. & Bryant, N. J., 1 Jan 2018, Methods in Molecular Biology. p. 217-227 11 p. (Methods in Molecular Biology; vol. 1713).

Research output: Chapter in Book/Report/Conference proceedingChapter

SNARE Proteins
Ligation
Membranes
Insulin
Munc18 Proteins
2017
2 Citations (Scopus)
1 Downloads (Pure)

SNARE phosphorylation: a control mechanism for insulin-stimulated glucose transport and other regulated exocytic events

Laidlaw, K. M. E., Livingstone, R., Al-Tobi, M., Bryant, N. J. & Gould, G. W., 15 Dec 2017, In : Biochemical Society Transactions. 45, 6, p. 1271-1277 7 p.

Research output: Contribution to journalReview article

Open Access
File
SNARE Proteins
Phosphorylation
Insulin
Glucose
Membrane Fusion
9 Citations (Scopus)

The trypanosome exocyst: a conserved structure revealing a new role in endocytosis

Boehm, C. M., Obado, S., Gadelha, C., Kaupisch, A., Manna, P. T., Gould, G. W., Munson, M., Chait, B. T., Rout, M. P. & Field, M. C., 23 Jan 2017, In : PLOS Pathogens. 13, 1, 25 p., e1006063.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
Endocytosis
Immune Evasion
Antigenic Variation
Trypanosoma brucei brucei
2016
13 Citations (Scopus)
Open Access
File
Cytokinesis
Proteome
Cell Membrane
Spindle Poles
Actomyosin
14 Citations (Scopus)
1 Downloads (Pure)

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487

Heathcote, H. R., Mancini, S. J., Strembitska, A., Jamal, K., Reihill, J. A., Palmer, T. M., Gould, G. W. & Salt, I. P., 9 Dec 2016, In : Biochemical journal. 473, 24, p. 4681-4697 17 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Phosphorylation
Protein Kinase C
Vascular Endothelial Growth Factor A
Endothelial cells
2015
6 Citations (Scopus)

Alternative routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4

Kioumourtzoglou, D., Pryor, P. R., Gould, G. W. & Bryant, N. J., 15 Jul 2015, In : Journal of Cell Science. 128, 14, p. 2423-2429 7 p.

Research output: Contribution to journalArticle

Open Access
File
Synaptogyrins
Insulin
Membranes
Adipocytes
Facilitative Glucose Transport Proteins
11 Citations (Scopus)

Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking

Sadler, J. B. A., Bryant, N. J. & Gould, G. W., 1 Feb 2015, In : Molecular Biology of the Cell. 26, 3, p. 530-536 7 p.

Research output: Contribution to journalArticle

Open Access
File
Adipocytes
Protein Isoforms
Vesicle-Associated Membrane Protein 2
Proteins
Vesicle-Associated Membrane Protein 3
1 Citation (Scopus)

mVps45 knockdown selectively modulates VAMP expression in 3T3-L1 adipocytes

Sadler, J. B. A., Roccisana, J., Virolainen, M., Bryant, N. J. & Gould, G. W., 24 Jun 2015, In : Communicative and Integrative Biology. 8, 3

Research output: Contribution to journalArticle

Open Access
File
Syntaxin 16
Vesicle-Associated Membrane Protein 2
glucose transporters
Facilitative Glucose Transport Proteins
adipocytes
2014
21 Citations (Scopus)

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism

Kioumourtzoglou, D., Gould, G. W. & Bryant, N. J., 30 Apr 2014, In : Molecular and Cellular Biology. 34, 7, p. 1271-1279 9 p.

Research output: Contribution to journalArticle

SNARE Proteins
Insulin
Cell Membrane
Adipocytes
Munc18 Proteins
5 Citations (Scopus)

Studies of the regulated assembly of SNARE complexes in adipocytes

Kioumourtzoglou, D., Sadler, J. B. A., Black, H. L., Berends, R., Wellburn, C., Bryant, N. J. & Gould, G. W., 31 Oct 2014, In : Biochemical Society Transactions. 42, 5, p. 1396-1400 5 p.

Research output: Contribution to journalReview article

SNARE Proteins
Adipocytes
Machinery
Glucose Transporter Type 4
Hormones
2013
10 Citations (Scopus)

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation

Sadler, J. B. A., Bryant, N. J., Gould, G. W. & Welburn, C. R., 10 May 2013, In : International Journal of Molecular Sciences. 14, 5, p. 9963-9978 16 p.

Research output: Contribution to journalReview article

Open Access
File
Glucose Transporter Type 4
transporter
Post Translational Protein Processing
glucose
Glucose
10 Citations (Scopus)

Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45

Roccisana, J., Sadler, J. B. A., Bryant, N. J. & Gould, G. W., 1 Aug 2013, In : Molecular Biology of the Cell. 24, 15, p. 2389-2397 9 p.

Research output: Contribution to journalArticle

Munc18 Proteins
Facilitative Glucose Transport Proteins
Protein Isoforms
Insulin
Adipocytes
22 Citations (Scopus)

Syntaxin 16 is a master recruitment factor for cytokinesis

Neto, H., Kaupisch, A., Collins, L. L. & Gould, G. W., 1 Dec 2013, In : Molecular Biology of the Cell. 24, 23, p. 3663-3674 12 p.

Research output: Contribution to journalArticle

Open Access
File
Syntaxin 16
Cytokinesis
Endosomal Sorting Complexes Required for Transport
SNARE Proteins
Endosomes
2012
26 Citations (Scopus)
339 Downloads (Pure)

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4)

Cunningham, M. R., McIntosh, K. A., Pediani, J. D., Robben, J., Cooke, A. E., Nilsson, M., Gould, G. W., Mundell, S., Milligan, G. & Plevin, R., 11 May 2012, In : Journal of Biological Chemistry. 287, 20, p. 16656-16669 14 p.

Research output: Contribution to journalArticle

Open Access
File
Proteinase-Activated Receptors
PAR-2 Receptor
Membranes
Cell membranes
Chemical activation
2011
5 Citations (Scopus)

IKKε: a kinase at the intersection of signaling and membrane traffic

Gould, G. W., 14 Jun 2011, In : Science Signaling. 4, 177, pe30.

Research output: Contribution to journalReview article

Phosphorylation
Phosphotransferases
Cytokinesis
Membranes
Cell signaling
35 Citations (Scopus)

SNARE Proteins Underpin Insulin-Regulated GLUT4 Traffic

Bryant, N. J. & Gould, G. W., 30 Jun 2011, In : Traffic. 12, 6, p. 657-664 8 p.

Research output: Contribution to journalReview article

Glucose Transporter Type 4
SNARE Proteins
Insulin
Membranes
Medical problems
31 Citations (Scopus)

The regulation of abscission by multi-protein complexes

Neto, H. & Gould, G. W., 1 Oct 2011, In : Journal of Cell Science. 124, 19, p. 3199-3207 9 p.

Research output: Contribution to journalComment/debate

Cytokinesis
Cell Division
Endosomal Sorting Complexes Required for Transport
Membranes
Microtubules
18 Citations (Scopus)

Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4

Aran, V., Bryant, N. J. & Gould, G. W., 6 May 2011, In : BMC Biochemistry. 12, 7 p., 19.

Research output: Contribution to journalArticle

Open Access
File
Qa-SNARE Proteins
Phosphorylation
Tyrosine
SNARE Proteins
Insulin
63 Citations (Scopus)

Vesicle trafficking and membrane remodelling in cytokinesis

Neto, H., Collins, L. L. & Gould, G. W., 31 Jul 2011, In : Biochemical journal. 437, 1, p. 13-24 12 p.

Research output: Contribution to journalReview article

Cytokinesis
Cell membranes
Membranes
Machinery
Actins
2009
145 Citations (Scopus)

New roles for endosomes: from vesicular carriers to multi-purpose platforms

Gould, G. W. & Lippincott-Schwartz, J., 11 Mar 2009, In : Nature Reviews Molecular Cell Biology. 10, 4, p. 287-292 6 p.

Research output: Contribution to journalReview article

Endosomes
Intracellular Membranes
Cytokinesis
Eukaryotic Cells
Endocytosis
2008
67 Citations (Scopus)

Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis

Simon, G. C., Schonteich, E., Wu, C. C., Piekny, A., Ekiert, D., Yu, X., Gould, G. W., Glotzer, M. & Prekeris, R., 9 Jul 2008, In : EMBO Journal. 27, 13, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

Telophase
Cytokinesis
pioglitazone
Endosomes
Recycling
2007
53 Citations (Scopus)

Role of endosomal Fab GTPases in cytokinesis

Yu, X., Prekeris, R. & Gould, G. W., 17 Jan 2007, In : European Journal of Cell Biology . 86, 1, p. 25-35 11 p.

Research output: Contribution to journalArticle

Cytokinesis
GTP Phosphohydrolases
Membranes
Telophase
RNA Interference
2006
66 Citations (Scopus)

Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surface

Choudhury, A., Marks, D. L., Proctor, K. M., Gould, G. W. & Pagano, R. E., 30 Apr 2006, In : Nature Cell Biology. 8, 4, p. 317-328 12 p.

Research output: Contribution to journalArticle

Qa-SNARE Proteins
Cellular Structures
Endocytosis
Caveolae
Membranes
2005
215 Citations (Scopus)

Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis

Fielding, A. B., Schonteich, E., Matheson, J., Wilson, G., Yu, X., Hickson, G. RX., Srivastava, S., Baldwin, S. A., Prekeris, R. & Gould, G. W., 5 Oct 2005, In : EMBO Journal. 24, 19, p. 3389-3399 11 p.

Research output: Contribution to journalArticle

Cytokinesis
Recycling
Endosomes
Membranes
Guanosine Triphosphate