Projects per year
Personal profile
Personal Statement
Gwyn did his undergraduate Biochemistry degree at the University of Southampton. He followed this with a PhD at the same institution with Professor Tony Lee on the biophysics of membrane protein/lipid interactions, graduating in 1986. He then moved to Dartmouth Medical School in New Hampshire, working with Professor Gustav E. Lienhard, where he began his interest in glucose transport. He moved to the University of Glasgow in 1989 developing his interest in the structure and function of glucose transporters and the cell biology of membrane trafficking. He and his laboratory moved to SIPBS in October 2019.
Studies in Gwyn’s group seek to understand the cellular and molecular mechanisms which regulate glucose transport in adipocytes, cardiomyocytes and skeletal muscle. Studies focus upon identifying the molecular machinery that control GLUT4 function, defining how this machinery interacts with the insulin signalling system, and defining how these processes are impaired in disease.
In particular we are interested in using cutting edge imaging approaches to study the behaviour of gluocse transporters in health and disease.
Lab web site: https://gwyngould.wixsite.com/strathclydelab
Research Interests
A major consequence of insulin action is a dramatic increase in the rate of glucose transport into fat and muscle. This is achieved by the delivery of the facilitative glucose transporter GLUT4 from insulin-sensitive intracellular stores to the cell surface. Insulin-stimulated glucose transport is impaired in Type-2 diabetes; this is underpinned by reduced delivery of GLUT4 to the cell surface. Metabolic disorders such as Type-2 diabetes are linked to the development of cardiovascular disease. Our lab uses cellular, genetic and systems biology approaches to understand insulin regulated GLUT4 trafficking in different cells.
Studies in our group use a range of experimental systems and approaches. These include genome editing of cultured adipocytes to probe the regulatory pathways controlling GLUT4 trafficking and activity, cutting-edge imaging techniques including STED-FCS and dSTORM, analysis of signalling and trafficking in subcellular fractions and analysis of transport kinetics in intact cells. We also employ Saccharomyces cerevisiae as a tool to study membrane trafficking.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Calcium fluxes in the sarcoplasmic reticulum, University of Southampton
1 Oct 1983 → 31 Oct 1986
Award Date: 31 Oct 1986
Bachelor of Science, University of Southampton
1 Oct 1980 → 1 Jun 1983
Award Date: 1 Jun 1983
Doctor of Philosophy, Calcium fluxes in the sarcoplasmic retirculum
Keywords
- Insulin
- Glucose Transport
- Membrane Trafficking
- Diabetes
- super-resolution imaging
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis
Camus, S. M., Camus, M. D., Figueras-Novoa, C., Boncompain, G., Sadacca, L. A., Esk, C., Bigot, A., Gould, G. W., Kioumourtzoglou, D., Perez, F., Bryant, N. J., Mukherjee, S. & Brodsky, F. M., 19 Dec 2019, In: Journal of Cell Biology. 219, 1, 21 p., e201812135.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)68 Downloads (Pure) -
GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes
Bowman, P. R. T., Smith, G. L. & Gould, G. W., 25 Jul 2019, In: PLoS One. 14, 7, 16 p., e0217885.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)52 Downloads (Pure)
Datasets
-
Data for: "A Novel 3D Imaging Approach for Quantification of GLUT4 Levels across the Intact Myocardium"
Geiser, A. (Creator), Gould, G. (Supervisor) & McConnell, G. (Supervisor), University of Strathclyde, 26 Mar 2024
DOI: 10.15129/04700d85-f2b2-40f7-a3a2-58261aabf572
Dataset
-
Data for "Obtaining super-resolved images at the mesoscale through Super-Resolution Radial Fluctuations"
Brown, M. (Creator), Foylan, S. (Creator), Rooney, L. (Creator), Gould, G. (Creator) & McConnell, G. (Creator), University of Strathclyde, 30 Oct 2024
DOI: 10.15129/1897cdca-4dae-4ab4-8a21-aec16c8820d5
Dataset
Prizes
-
Wellcome Trust Research Leave Award
Gould, G. (Recipient), 2004
Prize: Fellowship awarded competitively
-
Lister Institute of Preventive Medicine Research Fellowship
Gould, G. (Recipient), 1 Jun 1992
Prize: Fellowship awarded competitively
-
Cells (Journal)
Gould, G. (Editorial board member)
2019 → 28 Feb 2021Activity: Publication peer-review and editorial work types › Editorial board member
-
PeerJ (Journal)
Gould, G. (Editorial board member)
2017 → 2022Activity: Publication peer-review and editorial work types › Editorial board member
Equipment
-
-
DIGITAL ROTATOR
Strathclyde Institute Of Pharmacy And Biomedical SciencesFacility/equipment: Equipment