20052019
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Personal profile

Personal Statement

Gwyn did his undergraduate Biochemistry degree at the University of Southampton. He followed this with a PhD at the same institution with Professor Tony Lee on the biophysics and membrane protein/lipid interactions, graduating in 1986. He then moved to Dartmouth Medical School in New Hampshire, working with Professor Gustav E. Lienhard, where he began his interest in glucose transport. He moved to the University of Glasgow in 1989 developing his interest in the structure and function of glucose transporters and the cell biology of membrane trafficking. He and his laboratory moved to SIPBS in October 2019.

Studies in Gwyn’s group seek to understand the cellular and molecular mechanisms which regulate glucose transport in adipocytes, cardiomyocytes and skeletal muscle. Studies focus upon identifying the molecular machinery that control GLUT4 function, defining how this machinery interacts with the insulin signalling system, and defining how these processes are impaired in disease.

Lab web site: https://gwyngould.wixsite.com/strathclydelab 

Research Interests

A major consequence of insulin action is a dramatic increase in the rate of glucose transport into fat and muscle. This is achieved by the delivery of the facilitative glucose transporter GLUT4 from insulin-sensitive intracellular stores to the cell surface. Insulin-stimulated glucose transport is impaired in Type-2 diabetes; this is underpinned by reduced delivery of GLUT4 to the cell surface. Metabolic disorders such as Type-2 diabetes are linked to the development of cardiovascular disease. Cardiovascular disease represents the single biggest cause of death in T2DM and is independent of concurrent vascular disease. Our lab uses cellular and systems biology approaches to understand insulin-regulated GLUT4 trafficking in different cells.

 

Our lab uses a range of experimental systems and approaches. These include studies of cultured adipocytes and genome-edited adipocytes, and iPSC-derived cardiomyocytes as our work-horse models, and employ approaches including imaging techniques such as confocal microscopy and dSTORM, analysis of signalling and trafficking in subcellular fractions and analysis of transport kinetics in intact cells. We also employ Saccharomyces cerevisiae as a tool to study membrane trafficking.

Education/Academic qualification

Doctor of Philosophy, University of Southampton

1 Oct 198331 Oct 1986

Bachelor of Science, University of Southampton

1 Oct 19801 Jun 1983

Doctor of Philosophy

Keywords

  • Insulin
  • Glucose Transport
  • Membrane Trafficking
  • Diabetes
  • Cardiovascular disease

Fingerprint Dive into the research topics where Gwyn Gould is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Cytokinesis Medicine & Life Sciences
Insulin Medicine & Life Sciences
SNARE Proteins Medicine & Life Sciences
Membranes Medicine & Life Sciences
Facilitative Glucose Transport Proteins Medicine & Life Sciences
Adipocytes Medicine & Life Sciences
Phosphorylation Chemical Compounds
Endosomes Medicine & Life Sciences

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Selected Research Output 2005 2019

CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis

Camus, S. M., Camus, M. D., Figueras-Novoa, C., Boncompain, G., Sadacca, L. A., Esk, C., Bigot, A., Gould, G. W., Kioumourtzoglou, D., Perez, F., Bryant, N. J., Mukherjee, S. & Brodsky, F. M., 9 Oct 2019, (Accepted/In press) In : Journal of Cell Biology. 52 p.

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Facilitative Glucose Transport Proteins
Endoplasmic Reticulum
Secretory Pathway
Legionella pneumophila

GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes

Bowman, P. R. T., Smith, G. L. & Gould, G. W., 25 Jul 2019, In : PLoS One. 14, 7, 16 p., e0217885.

Research output: Contribution to journalArticle

Open Access
File
Induced Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Insulin
Glucose

The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes

Sadler, J. B. A., Lamb, C. A., Welburn, C. R., Adamson, I. S., Kioumourtzoglou, D., Chi, N-W., Gould, G. W. & Bryant, N. J., 18 Mar 2019, In : Scientific Reports. 9, 7 p., 4710.

Research output: Contribution to journalArticle

Open Access
File
Tankyrases
Facilitative Glucose Transport Proteins
Adipocytes
Insulin
Ubiquitination
12 Citations (Scopus)
Open Access
File
Cytokinesis
Proteome
Cell Membrane
Spindle Poles
Actomyosin
10 Citations (Scopus)

Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking

Sadler, J. B. A., Bryant, N. J. & Gould, G. W., 1 Feb 2015, In : Molecular Biology of the Cell. 26, 3, p. 530-536 7 p.

Research output: Contribution to journalArticle

Open Access
File
Adipocytes
Protein Isoforms
Vesicle-Associated Membrane Protein 2
Proteins
Vesicle-Associated Membrane Protein 3
21 Citations (Scopus)

Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism

Kioumourtzoglou, D., Gould, G. W. & Bryant, N. J., 30 Apr 2014, In : Molecular and Cellular Biology. 34, 7, p. 1271-1279 9 p.

Research output: Contribution to journalArticle

SNARE Proteins
Insulin
Cell Membrane
Adipocytes
Munc18 Proteins

Prizes

Wellcome Trust Research Leave Award

Gwyn Gould (Recipient), 2004

Prize: Fellowship awarded competitively

Selected Activities 1991 2019

Cells (Journal)

Gwyn Gould (Editorial board member)
20192022

Activity: Publication peer-review and editorial work typesEditorial board member

PeerJ (Journal)

Gwyn Gould (Editorial board member)
20172021

Activity: Publication peer-review and editorial work typesEditorial board member

Scientific Reports (Journal)

Gwyn Gould (Editorial board member)
20172021

Activity: Publication peer-review and editorial work typesEditorial board member