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Accepting PhD Students

1987 …2023
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Research Output 1987 2019

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Article
2019
1 Citation (Scopus)

Characterisation and optimisation of diclofenac sodium orodispersible thin film formulation

Khadra, I., Obeid, M. A., Dunn, C., Watts, S., Halbert, G., Ford, S. & Mullen, A., 20 Apr 2019, In : International Journal of Pharmaceutics. 561, p. 43-46 4 p.

Research output: Contribution to journalArticle

Diclofenac
Water
Drug Delivery Systems
Pharmaceutical Preparations
Tooth
2 Citations (Scopus)
Extrusion
Printing
Fabrication
Chemical analysis
Pharmaceutical Preparations
1 Citation (Scopus)
Saccharin
Indomethacin
Dimers
Compaction
dimers

The topography of simulated intestinal equilibrium solubility

Dunn, C., Perrier, J., Khadra, I., Wilson, C. G. & Halbert, G. W., 6 May 2019, In : Molecular Pharmaceutics. 16, 5, p. 1890-1905 16 p.

Research output: Contribution to journalArticle

Open Access
File
Solubility
Bile Acids and Salts
Phospholipids
Pharmaceutical Preparations
Monoglycerides
Open Access
File
Terahertz Spectroscopy
Raman Spectrum Analysis
Solubility
Pharmaceutical Preparations
Polymers
Open Access
File
Terahertz Spectroscopy
Raman Spectrum Analysis
Solubility
Pharmaceutical Preparations
Polymers
2018
13 Citations (Scopus)

Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations

Brown, C. J., McGlone, T., Yerdelen, S., Srirambhatla, V., Mabbott, F., Gurung, R., Briuglia, M. L., Ahmed, B., Polyzois, H., McGinty, J., Perciballi, F., Fysikopoulos, D., Macfhionnghaile, P., Siddique, H., Raval, V., Harrington, T. S., Vassileiou, A., Robertson, M., Prasad, E., Johnston, A. & 9 othersJohnston, B., Nordon, A., Srai, J., Halbert, G., Ter Horst, J. H., Price, C. J., Rielly, C. D., Sefcik, J. & Florence, A. J., 1 Jun 2018, In : Molecular Systems Design & Engineering. 2018, 3, p. 518-549 32 p.

Research output: Contribution to journalArticle

Open Access
File
Workflow
Crystallization
Drug products
Cooling
Pharmaceutical Preparations
7 Citations (Scopus)
Open Access
File
Solubility
Pharmaceutical Preparations
aprepitant
Probucol
Felodipine

The impact of channel fill level on internal forces during continuous twin screw wet granulation

Torrecillas, C. M., Gorringe, L. J., Rajoub, N., Robertson, J., Elkes, R. G., Lamprou, D. A. & Halbert, G. W., 28 Dec 2018, In : International Journal of Pharmaceutics. p. 1-43 43 p.

Research output: Contribution to journalArticle

Torque
Particle Size
Powders
Rupture
Coloring Agents
2017
4 Citations (Scopus)
Open Access
File
Particle Size
Excipients
Torque
Lactose
Powders
3 Citations (Scopus)
Open Access
File
Solubility
Pharmaceutical Preparations
Bile Acids and Salts
Monoglycerides
Intestinal Absorption
3 Citations (Scopus)
Open Access
File
Surface-Active Agents
Solubility
Pharmaceutical Preparations
Lecithins
aprepitant
17 Citations (Scopus)
Open Access
File
Solubility
Oleic Acid
Pharmaceutical Preparations
Bile Acids and Salts
Lecithins
2016
27 Citations (Scopus)

A novel hot-melt extrusion formulation of albendazole for increasing dissolution properties

Martinez Marcos, L., Lamprou, D., McBurney, R. & Halbert, G., 29 Feb 2016, In : International Journal of Pharmaceutics. 499, 1-2, p. 175-185 11 p.

Research output: Contribution to journalArticle

Open Access
File
Albendazole
Powder Diffraction
Differential Scanning Calorimetry
X-Ray Diffraction
Electron Scanning Microscopy
4 Citations (Scopus)

Evaluation of the impact of excipients and an albendazole salt on albendazole concentrations in upper small intestine using an in vitro biorelevant gastrointestinal transfer (BioGIT) system

Kourentas, A., Vertzoni, M., Khadra, I., Symillides, M., Clark, H., Halbert, G., Butler, J. & Reppas, C., 30 Sep 2016, In : Journal of Pharmaceutical Sciences. 105, 9, p. 2896-2903 8 p.

Research output: Contribution to journalArticle

Open Access
File
Albendazole
Excipients
Small Intestine
Salts
Solubility
5 Citations (Scopus)

Scaling of continuous twin screw wet granulation

Osorio, J. G., Sayin, R., Kalbag, A. V., Litster, J. D., Martinez-Marcos, L., Lamprou, D. A. & Halbert, G. W., 19 Aug 2016, In : AIChE Journal. 12 p.

Research output: Contribution to journalArticle

Open Access
File
Granulation
Porosity
Powders
Granulators
Liquids

The influence of non-ionisable excipients on precipitation parameters measured using the CheqSol method

Etherson, K., Halbert, G. & Elliott, M., 30 Sep 2016, In : Journal of Pharmacy and Pharmacology. 68, 9, p. 1131-1142 12 p.

Research output: Contribution to journalArticle

Open Access
File
Excipients
Solubility
Poloxamer
Gliclazide
Atenolol
2015
12 Citations (Scopus)

Investigation of an 11mm diameter twin screw granulator: screw element performance and in-line monitoring via image analysis

Sayin, R., Martinez Marcos, L., Osorio, J. G., Cruise, P., Jones, I., Halbert, G. W., Lamprou, D. A. & Litster, J. D., 2015, In : International Journal of Pharmaceutics. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Particle Size
Drug Industry
2014
4 Citations (Scopus)

Determination of excipient based solubility increases using the CheqSol method

Etherson, K., Halbert, G. & Elliott, M., 25 Apr 2014, In : International Journal of Pharmaceutics. 465, 1-2, p. 202-209 8 p.

Research output: Contribution to journalArticle

Excipients
Solubility
Pharmaceutical Preparations
Poloxamer
Gliclazide
138 Citations (Scopus)

Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs

Bergström, C. A. S., Holm, R., Jørgensen, S. A., Andersson, S. B. E., Artursson, P., Beato, S., Borde, A., Box, K., Brewster, M., Dressman, J., Feng, K-I., Halbert, G., Kostewicz, E., McAllister, M., Muenster, U., Thinnes, J., Taylor, R. & Mullertz, A., 16 Jun 2014, In : European Journal of Pharmaceutical Sciences. 57, p. 173-199 27 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Pharmaceutical Chemistry
Excipients
Computer Simulation
Oral Administration
28 Citations (Scopus)

GRP receptor imaging of prostate cancer using [(99m)Tc]Demobesin 4: a first-in-man study

Mather, S. J., Nock, B. A., Maina, T., Gibson, V., Ellison, D., Murray, I., Sobnack, R., Colebrook, S., Wan, S., Halbert, G., Szysko, T., Powles, T. & Avril, N., Dec 2014, In : Molecular Imaging and Biology. 16, 6, p. 888-895 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Bombesin Receptors
Radiopharmaceuticals
Single-Photon Emission-Computed Tomography
Pancreas

The acute physiological effects of the vaso-active drug, L-NNA, a nitric oxide synthase inhibitor, on renal and tumour perfusion in human subjects

Yip, K., Goh, V., Gregory, J., Simcock, I., Stirling, J. J., Taylor, N. J., Kozarski, R., Mitchell, A., Bosopem, S., Halbert, G., Alonzi, R., Miles, D. & Hoskin, P., 8 Jan 2014, In : Journal of Cancer Therapy. 5, 1, p. 44-52 9 p., 05.

Research output: Contribution to journalArticle

Open Access
File
Nitric Oxide Synthase
Perfusion
Kidney
Pharmaceutical Preparations
Renal Circulation
2013
18 Citations (Scopus)

A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

Horsley, L., Cummings, J., Middleton, M., Ward, T., Backen, A., Clamp, A., Dawson, M., Farmer, H., Fisher, N., Halbert, G., Halford, S., Harris, A., Hasan, J., Hogg, P., Kumaran, G., Little, R., Parker, G. J. M., Potter, P., Saunders, M., Roberts, C. & 9 othersShaw, D., Smith, N., Smythe, J., Taylor, A., Turner, H., Watson, Y., Dive, C., Jayson, G. C. & Cancer Research UK Drug Development Office Phase I clinical trial, 1 Dec 2013, In : Cancer Chemotherapy and Pharmacology. 72, 6, p. 1343-1352 10 p.

Research output: Contribution to journalArticle

Toxicity
Tumors
Maximum Tolerated Dose
Nucleotide Transport Proteins
Magnetic resonance
Arsenicals
Infertility
Amino Acids
Neoplasms
Poisons
Boron Neutron Capture Therapy
Mannitol
Pharmaceutical Preparations
Fructose
Temperature
2012
1 Citation (Scopus)
File
Organic carbon
Carbon
Water
Pharmaceutical Preparations
Equipment Design
8 Citations (Scopus)
File
Boron Neutron Capture Therapy
Excipients
Fructose
Mannitol
Solubility
2011
3 Citations (Scopus)
Boron Neutron Capture Therapy
Boron
Phenylalanine
High Pressure Liquid Chromatography
Impurities
23 Citations (Scopus)

Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1

Danson, S. J., Johnson, P., Ward, T. H., Dawson, M., Denneny, O., Dickinson, G., Aarons, L., Watson, A., Jowle, D., Cummings, J., Robson, L., Halbert, G., Dive, C. & Ranson, M., Jul 2011, In : Annals of Oncology. 22, 7, p. 1653-1660 8 p.

Research output: Contribution to journalArticle

NAD(P)H Dehydrogenase (Quinone)
Pharmacokinetics
Maximum Tolerated Dose
Pharmaceutical Preparations
DNA
2010

Experimental scrutiny and project timelines: an example

Dooley, N., Ford, S. J., Prasad, E., Elliott, M. & Halbert, G., Oct 2010, In : Journal of Pharmacy and Pharmacology. 62, 10, p. 1208-1209 2 p.

Research output: Contribution to journalArticle

Open Access
File
src-Family Kinases
Research
Neoplasms
Clinical Trials
Pharmaceutical Preparations
19 Citations (Scopus)

Uptake of synthetic low density Lipoprotein by leukemic stem cells--a potential stem cell targeted drug delivery strategy

Zhou, P., Hatziieremia, S., Elliott, M. A., Scobie, L., Crossan, C., Michie, A. M., Holyoake, T. L., Halbert, G. W. & Jørgensen, H. G., 20 Dec 2010, In : Journal of Controlled Release. 148, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
LDL Lipoproteins
Stem Cells
Pharmaceutical Preparations
Myeloid Cells
2009
13 Citations (Scopus)

A Cancer Research UK pharmacokinetic study of bpa-mannitol in patients with high grade glioma to optimise uptake parameters for clinical trials of BNCT

Cruickshank, G. S., Ngoga, D., Detta, A., Green, S., James, N. D., Wojnecki, C., Doran, J. & Halbert, G. W., Jul 2009, In : Applied Radiation and Isotopes. 67, 7-8, p. S31-S33

Research output: Contribution to journalArticle

mannitol
grade
cancer
brain
tumors
29 Citations (Scopus)

A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy

Lee, C. P., Payne, G. S., Oregioni, A., Ruddle, R., Tan, S., Raynaud, F. I., Eaton, D., Campbell, M. J., Cross, K., Halbert, G. W., Tracy, M., McNamara, J., Seddon, B., Leach, M. O., Workman, P. & Judson, I., 2009, In : British Journal of Cancer. 101, p. 1860-1868 9 p.

Research output: Contribution to journalArticle

Nitroimidazoles
Magnetic Resonance Spectroscopy
Neoplasms
Hypoxia
Half-Life

The weakest link is getting stronger

Halbert, G. W., 2009, In : European Pharmaceutical Review. 14, 6, p. 68-72 4 p.

Research output: Contribution to journalArticle

Controlled Environment
Clean rooms
Technology
2008
1 Citation (Scopus)
Open Access
File
Hospital Distribution Systems
Clinical Trials, Phase I
Temperature
Dry Ice
Appointments and Schedules
2007
23 Citations (Scopus)

The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study

Steward, W. P., Middleton, M., Benghiat, A., Loadman, P. M., Hayward, C., Waller, S., Ford, S., Halbert, G., Patterson, L. H. & Talbot, D., Jun 2007, In : Annals of Oncology. 18, 6, p. 1098-1103 6 p.

Research output: Contribution to journalArticle

Cytotoxins
Radiotherapy
Pharmacokinetics
Area Under Curve
Neoplasms
2006
99 Citations (Scopus)

Lomeguatrib, a potent inhibitor of o-6-alkylguanine-DNA-alkyltrasnferase: phase i safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumours

Ranson, M., Middleton, M. R., Bridgewater, J., Lee, S. M., Dawson, M., Jowle, D., Halbert, G. W., Waller, S., McGrath, H., Gumbrell, L., McElhinney, R. S., Donnelly, D., McMurry, T. B. H. & Margison, G. P., 2006, In : Clinical Cancer Research. 12, 5, p. 1577-1584 8 p.

Research output: Contribution to journalArticle

temozolomide
Pharmacokinetics
Safety
DNA
Alkyl and Aryl Transferases
2005
14 Citations (Scopus)
Hospital Distribution Systems
Refrigeration
Clinical Trials, Phase I
Gels
Costs and Cost Analysis
22 Citations (Scopus)

Synthetic low density lipoprotein, a novel biomimetic LiPID supplement for serum free tissue culture

Hayavi, S. & Halbert, G. W., 2005, In : Biotechnology Progress. 21, 4, p. 1262-1268 7 p.

Research output: Contribution to journalArticle

Biomimetics
LDL Lipoproteins
Lipids
Serum
Cholesterol
2004
299 Citations (Scopus)

Hormonal impact of the 17 alpha-hydroxylase/C-17,C-20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer

O'Donnell, A., Judson, I., Dowsett, M., Raynaud, F., Dearnaley, D., Mason, M., Harland, S., Robbins, A., Halbert, G. W., Nutley, B. & Jarman, M., 2004, In : British Journal of Cancer. 90, 12, p. 2317-2325 9 p.

Research output: Contribution to journalArticle

Steroid 17-alpha-Hydroxylase
Prostatic Neoplasms
Testosterone
Luteinizing Hormone
Mixed Function Oxygenases
2003
43 Citations (Scopus)

A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy

Seddon, B. M., Payne, G. S., Simmons, L., Ruddle, R., Grimshaw, R., Tan, S., Turner, A., Raynaud, F., Halbert, G. W., Leach, M. O., Judson, I. & Workman, P., 2003, In : Clinical Cancer Research. 9, 14, p. 5101-12 5089 p.

Research output: Contribution to journalArticle

Intravenous Administration
Magnetic Resonance Spectroscopy
Neoplasms
Maximum Tolerated Dose
Nausea
4 Citations (Scopus)
File
Prodrugs
Linear Models
High Pressure Liquid Chromatography
Impurities
Derivatives
2002
29 Citations (Scopus)

A synthetic low density lipoprotein particle capable of supporting U937 proliferation in vitro

Baillie, G., Owens, M. & Halbert, G. W., Jan 2002, In : Journal of Lipid Research. 43, p. 69-73 4 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
LDL Receptors
Peptides
oxidized low density lipoprotein
In Vitro Techniques
8 Citations (Scopus)

Development of a lyophilised RH1 formulation: a novel DT diaphorase activated alkylating agent

Elliott, M. A., Ford, S. J., Walker, A. A., Hargreaves, R. H. J. & Halbert, G. W., Apr 2002, In : Journal of Pharmacy and Pharmacology. 54, 4, p. 487-492 6 p.

Research output: Contribution to journalArticle

NAD(P)H Dehydrogenase (Quinone)
Povidone
Alkylating Agents
Freeze Drying
Solubility
1996
1 Citation (Scopus)

Pre-clinical development of the anti-tumour agent CB 7646, bis N-(hydroxymethyl) trimethylmelamine, a stable analogue of trimelamol

Coley, H. M., Jarman, M., Brooks, N., Kubota, T., Goddard, P. M., Jones, M., Lee, N., Owens, M. D., Halbert, G. W. & Judson, I. R., 4 Nov 1996, In : International Journal of Cancer. 68, 3, p. 356-363 8 p.

Research output: Contribution to journalArticle

Neoplasms
Heterografts
Platinum
Ovarian Neoplasms
Clinical Trials, Phase I
1987
14 Citations (Scopus)

The effect of the non-ionic surfactant brij 30 on the cytotoxicity of adriamycin in monolayer, spheroid and clonogenic culture systems

Kerr, D. J., Wheldon, T. E., Russell, J. G., Maurer, H. R., Florence, A. T., Halbert, G. W., Freshney, R. I. & Kaye, S. B., 30 Sep 1987, 23, 9, 7 p.

Research output: Contribution to journalArticle

Surface-Active Agents
Doxorubicin
Granulocytes
Brij 30
Ether