Gail McConnell

Prof

Professor, Physics
Measurement Science and Enabling Technologies
Health and Wellbeing

https://orcid.org/0000-0002-7213-0686

Phone01415483059
Emailg.mcconnell@strath.ac.uk

United Kingdom

Accepting PhD Students

Research output per year

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Personal profile

Research Interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

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Projects

3 Not started
8 Active
27 Finished

Doctoral Training Partnership 2018-19 University of Strathclyde | Bottura, Beatrice

McConnell, G., Hoskisson, P. & Bottura, B.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/19 → 1/04/23

Project: Research Studentship - Internally Allocated

EPSRC iCASE NPL S Foylan: Quantitative optical mesoscopy for screening of novel antimicrobial compounds

McConnell, G.

National Physical Laboratory NPL

1/10/18 → 30/09/22

Project: Research - Studentship Case

Research Output

Characterisation of a deep-ultraviolet light-emitting diode emission pattern via fluorescence

McFarlane, M. & McConnell, G., 9 Apr 2020, In : Measurement Science and Technology . 31, 7, 5 p., 077001.

Research output: Contribution to journal › Article

Open Access

File

1 Downloads (Pure)

Intra-colony channels in E. coli function as a nutrient uptake system

Rooney, L. M., Amos, W. B., Hoskisson, P. A. & McConnell, G., 17 Jun 2020, In : ISME Journal. 13 p.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

Datasets

Data for: "Application of the Mesolens for sub-cellular resolution imaging of intact larval and whole adult Drosophila"

McConnell, G. (Creator), University of Strathclyde, 9 Mar 2018

DOI: 10.15129/0ddee1e3-513b-4fa0-847a-5a4bba92875e

Dataset

Two-color, two-photon imaging at long excitation wavelengths using a diamond Raman laser

Trägårdh, J. (Creator), Robb, G. (Creator), Murtagh, M. (Creator), Parsons, M. (Creator), McConnell, G. (Creator), University of Strathclyde, 21 Jul 2016

DOI: 10.15129/42dd4b11-e327-47da-bc01-3ab2a7029f2d

Dataset