• United Kingdom

Accepting PhD Students

PhD projects

Design and Development of Anti-Infective Drugs

20112022

Research output per year

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Research Output

2019

Cyrene is a green alternative to DMSO as a solvent for antibacterial drug discovery against ESKAPE pathogens

Camp, J. E., Nyamini, S. B. & Scott, F. J., 17 Dec 2019, In : RSC Medicinal Chemistry. 9 p.

Research output: Contribution to journalArticle

Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model

Giordani, F., Khalaf, A. I., Gillingwater, K., Munday, J. C., De Koning, H. P., Suckling, C. J., Barrett, M. P. & Scott, F. J., 28 Mar 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 3021-3035 15 p.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Nichol, R., Khalaf, A., Sooda, K., Hussain, O., Griffiths, H., Phillips, R., Javid, F., Suckling, C. J., Allison, S. & Scott, F., 1 Sep 2019, In : Medicinal Chemistry Communications. 10, 9, p. 1620-1634 15 p.

Research output: Contribution to journalArticle

What do our school reports really say?

Turner, K. L., Scott, F. & Jackson, A., 17 May 2019, In : Impact: Journal of the Chartered College of Teaching. 6, 4 p.

Research output: Contribution to journalArticle

Open Access
File
3 Downloads (Pure)
2018
Open Access
File

Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis

Suckling, C. J., Mukherjee, S., Khalaf, A. I., Narayan, A., Scott, F. J., Khare, S., Dhakshinamoorthy, S., Harnett, M. M. & Harnett, W., 30 Sep 2018, In : Acta Tropica. 185, p. 212-218 7 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
4 Downloads (Pure)
2017

An evaluation of minor groove binders as anti-fungal and anti-mycobacterial therapeutics

Scott, F., Nichol, R. J. O., Khalaf, A. I., Giordani, F., Gillingwater, K., Ramu, S., Elliott, A., Zuegg, J., Duffy, P., Rosslee, M-J., Hlaka, L., Kumar, S., Ozturk, M., Brombacher, F., Barrett, M., Guler, R. & Suckling, C. J., 18 Aug 2017, In : European Journal of Medicinal Chemistry. 136, p. 561-572 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
19 Downloads (Pure)

Empowering students by enhancing their employability skills

Scott, F. J., Connell, P., Thomson, L. A. & Willison, D., 22 Nov 2017, In : Journal of Further and Higher Education. 16 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
10 Downloads (Pure)

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., Khalaf, A., Carter, K., Scott, F., Suckling, C. & Guler, R., 1 Dec 2017, In : Journal of Antimicrobial Chemotherapy. 72, 12, p. 3334–3341 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
13 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
50 Downloads (Pure)

Minor groove binders for DNA as antitypanosomal agents: the veterinary context

Suckling, C. J., Scott, F., Khalaf, A., Gillingwater, K., Morrison, L., de Koning, H., Barrett, M. & Giordani, F., 1 Nov 2017. 19 p.

Research output: Contribution to conferencePaper

Open Access
File

Selectivity in anti-infective minor groove binders

Suckling, C. J. & Scott, F. J., 1 Nov 2017. 18 p.

Research output: Contribution to conferencePaper

Open Access
File
1 Downloads (Pure)

Why antibacterial minor groove binders are a good thing

Suckling, C. J., Khalaf, A., Scott, F. J., Tucker, N., Niemenen, L., Lemonidis, K. & Hunter, I. S., 1 Nov 2017. 21 p.

Research output: Contribution to conferencePaper

Open Access
File
2 Downloads (Pure)
2016

An evaluation of minor groove binders as anti-lung cancer therapeutics

Scott, F., Khalaf, A., Suckling, C., Carter, K., Grant, M., Henderson, C., Westrop, G. & Watson, D., 15 Jun 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 11 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
33 Downloads (Pure)

An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics

Scott, F. J., Khalaf, A. I., Giordani, F., Wong, P. E., Duffy, S., Barrett, M., Avery, V. M. & Suckling, C. J., 30 Jun 2016, In : European Journal of Medicinal Chemistry. 116, p. 116-125 10 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
114 Downloads (Pure)

An investigation into students' difficulties in numerical problem solving questions in high school biology using a numeracy framework

Scott, F. J., 1 Apr 2016, In : European Journal of Science and Mathematics Education. 4, 2, p. 115-128 14 p.

Research output: Contribution to journalArticle

Open Access
File
3 Downloads (Pure)
Open Access
File
44 Downloads (Pure)

Selective anti-malarial minor groove binders

Scott, F. J., Khalaf, A. I., Duffy, S., Avery, V. M. & Suckling, C. J., 15 Jul 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, p. 3326-3329 4 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
24 Downloads (Pure)
2015

Crystal structure of N,N-dimethyl-2-[(4-methylbenzyl) sulfonyl]ethanamine

Kennedy, A. R., Khalaf, A. I., Scott, F. J. & Suckling, C. J., Jul 2015, In : Acta Crystallographica Section E: Structure Reports. 71, 7, p. 757-759 3 p.

Research output: Contribution to journalArticle

Open Access
File
61 Downloads (Pure)
2014
2 Citations (Scopus)

Novel TPP-riboswitch activators bypass metabolic enzyme dependency

Mayer, G., Lünse, C., Suckling, C. & Scott, F., 1 Jul 2014, (Accepted/In press) In : Frontiers in Chemistry. 2, 53.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
81 Downloads (Pure)
2013
52 Citations (Scopus)
Open Access
File
7 Citations (Scopus)
91 Downloads (Pure)
2012

Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups

Khalaf, A., Bourdin, C., Breen, D., Donoghue, G., Scott, F., Suckling, C., MacMillan, D., Clements, C., Fox, K. & Sekibo, D., 2012, In : European Journal of Medicinal Chemistry. 56, p. 39-47 9 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
86 Downloads (Pure)
24 Citations (Scopus)
2011

Amide isosteres in structure-activity studies of antibacterial minor groove binders

Khalaf, A. I., Anthony, N., Breen, D., Donoghue, G., Mackay, S. P., Scott, F. J. & Suckling, C. J., Nov 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5343-5355 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)