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Research Output 2011 2019

2019

Cyrene is a green alternative to DMSO as a solvent for antibacterial drug discovery against ESKAPE pathogens

Camp, J. E., Nyamini, S. B. & Scott, F. J., 24 Aug 2019, (Accepted/In press) 9 p.

Research output: Contribution to journalArticle

Pathogens
Dimethyl Sulfoxide
Toxicity
Solvation
Pharmaceutical Preparations

Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model

Giordani, F., Khalaf, A. I., Gillingwater, K., Munday, J. C., De Koning, H. P., Suckling, C. J., Barrett, M. P. & Scott, F. J., 28 Mar 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 3021-3035 15 p.

Research output: Contribution to journalArticle

African Trypanosomiasis
Pentamidine
Trypanosoma congolense
Trypanosoma vivax
Africa South of the Sahara

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Nichol, R., Khalaf, A., Sooda, K., Hussain, O., Griffiths, H., Phillips, R., Javid, F., Suckling, C. J., Allison, S. & Scott, F., 1 Sep 2019, 10, 9, p. 1620-1634 15 p.

Research output: Contribution to journalArticle

Binders
Cell Line
Ovarian Neoplasms
Cisplatin
Carboplatin

What do our school reports really say?

Turner, K. L., Scott, F. & Jackson, A., 17 May 2019, In : Impact: Journal of the Chartered College of Teaching. 6, 4 p.

Research output: Contribution to journalArticle

Open Access
File
school
parents
school education
education
secondary school
2018
Open Access
File
Polycondensation
Foams
Polymers
secondary school teacher
chemistry
1 Citation (Scopus)

Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis

Suckling, C. J., Mukherjee, S., Khalaf, A. I., Narayan, A., Scott, F. J., Khare, S., Dhakshinamoorthy, S., Harnett, M. M. & Harnett, W., 30 Sep 2018, In : Acta Tropica. 185, p. 212-218 7 p.

Research output: Contribution to journalArticle

Open Access
File
Helminths
fibrosis
helminths
Fibrosis
lungs
2017
6 Citations (Scopus)

An evaluation of minor groove binders as anti-fungal and anti-mycobacterial therapeutics

Scott, F., Nichol, R. J. O., Khalaf, A. I., Giordani, F., Gillingwater, K., Ramu, S., Elliott, A., Zuegg, J., Duffy, P., Rosslee, M-J., Hlaka, L., Kumar, S., Ozturk, M., Brombacher, F., Barrett, M., Guler, R. & Suckling, C. J., 18 Aug 2017, In : European Journal of Medicinal Chemistry. 136, p. 561-572 12 p.

Research output: Contribution to journalArticle

Open Access
File
Biological Products
Mycobacterium tuberculosis
Cell Wall
Binders
Fungi
2 Citations (Scopus)

Empowering students by enhancing their employability skills

Scott, F. J., Connell, P., Thomson, L. A. & Willison, D., 22 Nov 2017, In : Journal of Further and Higher Education. 16 p.

Research output: Contribution to journalArticle

Open Access
File
employability
student
honor
confidence
graduate
5 Citations (Scopus)

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., Khalaf, A., Carter, K., Scott, F., Suckling, C. & Guler, R., 1 Dec 2017, In : Journal of Antimicrobial Chemotherapy. 72, 12, p. 3334–3341 8 p.

Research output: Contribution to journalArticle

Open Access
File
Nonionic surfactants
Mycobacterium tuberculosis
Surface-Active Agents
Binders
Anti-Bacterial Agents
1 Citation (Scopus)
Open Access
File
Pyrroles
pyrroles
grooves
Binders
Hydrogen bonds

Minor groove binders for DNA as antitypanosomal agents: the veterinary context

Suckling, C. J., Scott, F., Khalaf, A., Gillingwater, K., Morrison, L., de Koning, H., Barrett, M. & Giordani, F., 1 Nov 2017. 19 p.

Research output: Contribution to conferencePaper

Open Access
File
isometamidium
African Trypanosomiasis
Binders
Parasites
parasites

Selectivity in anti-infective minor groove binders

Suckling, C. J. & Scott, F. J., 1 Nov 2017. 18 p.

Research output: Contribution to conferencePaper

Open Access
File
Binders
Cells
Cell membranes
Fungi
Esters

Why antibacterial minor groove binders are a good thing

Suckling, C. J., Khalaf, A., Scott, F. J., Tucker, N., Niemenen, L., Lemonidis, K. & Hunter, I. S., 1 Nov 2017. 21 p.

Research output: Contribution to conferencePaper

Open Access
File
Binders
Bacteria
Clostridium Infections
Biological Phenomena
Clostridium
2016
7 Citations (Scopus)

An evaluation of minor groove binders as anti-lung cancer therapeutics

Scott, F., Khalaf, A., Suckling, C., Carter, K., Grant, M., Henderson, C., Westrop, G. & Watson, D., 15 Jun 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 11 p.

Research output: Contribution to journalArticle

Open Access
File
gemcitabine
Binders
Lung Neoplasms
Biological Products
Early Detection of Cancer
12 Citations (Scopus)

An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics

Scott, F. J., Khalaf, A. I., Giordani, F., Wong, P. E., Duffy, S., Barrett, M., Avery, V. M. & Suckling, C. J., 30 Jun 2016, In : European Journal of Medicinal Chemistry. 116, p. 116-125 10 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Bioactivity
Biological Products
Modulators
Open Access
File
Biology
biology
mathematics
Science Education
school
Open Access
File
high schools
peers
biology
students
Students
5 Citations (Scopus)

Selective anti-malarial minor groove binders

Scott, F. J., Khalaf, A. I., Duffy, S., Avery, V. M. & Suckling, C. J., 15 Jul 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, p. 3326-3329 4 p.

Research output: Contribution to journalArticle

Open Access
File
Chloroquine
Antimalarials
Binders
Plasmodium
Alkenes
2015

Crystal structure of N,N-dimethyl-2-[(4-methylbenzyl) sulfonyl]ethanamine

Kennedy, A. R., Khalaf, A. I., Scott, F. J. & Suckling, C. J., Jul 2015, In : Acta Crystallographica Section E: Structure Reports. 71, 7, p. 757-759 3 p.

Research output: Contribution to journalArticle

Open Access
File
Amines
Conformations
amines
Crystal structure
fragments
2014
2 Citations (Scopus)
Students
performance
student
classroom
9 Citations (Scopus)

Novel TPP-riboswitch activators bypass metabolic enzyme dependency

Mayer, G., Lünse, C., Suckling, C. & Scott, F., 1 Jul 2014, (Accepted/In press) In : Frontiers in Chemistry. 2, 53.

Research output: Contribution to journalArticle

Open Access
File
Riboswitch
Thiamine Pyrophosphate
Enzymes
Thiamine
Pyrithiamine
2013
51 Citations (Scopus)
Acanthocheilonema
Experimental Arthritis
Helminths
Anti-Inflammatory Agents
Collagen
7 Citations (Scopus)
Open Access
File
Binders
DNA
Oligomers
Temperature
Therapeutics
2012
12 Citations (Scopus)

Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups

Khalaf, A., Bourdin, C., Breen, D., Donoghue, G., Scott, F., Suckling, C., MacMillan, D., Clements, C., Fox, K. & Sekibo, D., 2012, In : European Journal of Medicinal Chemistry. 56, p. 39-47 9 p.

Research output: Contribution to journalArticle

Open Access
File
Ion Channels
Binders
DNA Footprinting
Nucleic Acid Denaturation
DNA
21 Citations (Scopus)
chemistry
mathematics
Students
school
student
2011
19 Citations (Scopus)

Amide isosteres in structure-activity studies of antibacterial minor groove binders

Khalaf, A. I., Anthony, N., Breen, D., Donoghue, G., Mackay, S. P., Scott, F. J. & Suckling, C. J., Nov 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5343-5355 13 p.

Research output: Contribution to journalArticle

Amides
Binders
Alkenes
DNA
Pyrroles