Projects per year
Personal profile
Research Interests
research interests have centred on the pivotal role that monocytes play in coordinating immune responses by releasing cytokines, prostaglandins and fatty acids. The cytokines released from monocytes, particularly interleukin-1 and tumour necrosis factor-alpha, can also amplify the antigen-induced activation of T-cells whereas prostaglandins such as PGE2 and fatty acids are potent inhibitors of activation. Recent data indicates that IL-1-stimulated fatty acid release can result in the biosynthesis of fatty acid ethanolamides including arachidonyl ethanolamide (anandamide) in addition to eicosanoids. Arachidonyl ethanolamide, regarded as an endogenous ligand for cannabinoid receptors, has been shown in our studies to modulate the activity of many monocyte and lymphocyte functions. Several major areas are being studied, including modulation of human monocyte and T-lymphocyte activities by PGE2, fatty acids and fatty acid ethanolamides. Current work has been directed toward an attempt to understand the mechanisms by which PGE2 and fatty acids regulate: cytokine production, phagocytosis of E. coli O157 in human monocytes and the downregulation of human CD4+ lymphocyte function, especially via the generation of intracellular cyclic AMP and cyclic GMP. The role of novel steroids, acting via PGs, on the modulation of immune cell activities is also being investigated as these provide another important potential therapeutic target
Negative feedback reguation of Immune responses by PGE2
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University of Glasgow
Award Date: 1 Jan 1984
Bachelor of Science, University of Glasgow
Award Date: 1 Jan 1980
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Network
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Industrial PhD studentship with ILC LTD- Doctorate@work. The Development of Treatment for Atopic Dermatitis Through the use of Interferons
Mullen, A., Rotondo, D. & Mullen, A.
1/02/21 → 31/01/24
Project: Research - Studentship
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Phytochemical study and immunomodulatory activity of Fraxinus excelsior L.
Qasaymeh, R. M., Rotondo, D. & Seidel, V., 4 Nov 2022, (E-pub ahead of print) In: Journal of Pharmacy and Pharmacology. 12 p., rgac076.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Garcinia mangostana, anti-acne and anti-inflammatory potential: an in silico study
Blicharska, N., Rotondo, D., Jackson, S. & Seidel, V., 31 Aug 2022.Research output: Contribution to conference › Poster › peer-review
Activities
- 1 Editorial board member
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Member of the Editorial Commentary Team- \Current Opinion in Lipidology\""
D Rotondo (Editorial board member)
Jan 2008 → Dec 2015Activity: Publication peer-review and editorial work types › Editorial board member