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Personal profile

Research Interests

research interests have centred on the pivotal role that monocytes play in coordinating immune responses by releasing cytokines, prostaglandins and fatty acids. The cytokines released from monocytes, particularly interleukin-1 and tumour necrosis factor-alpha, can also amplify the antigen-induced activation of T-cells whereas prostaglandins such as PGE2 and fatty acids are potent inhibitors of activation. Recent data indicates that IL-1-stimulated fatty acid release can result in the biosynthesis of fatty acid ethanolamides including arachidonyl ethanolamide (anandamide) in addition to eicosanoids. Arachidonyl ethanolamide, regarded as an endogenous ligand for cannabinoid receptors, has been shown in our studies to modulate the activity of many monocyte and lymphocyte functions. Several major areas are being studied, including modulation of human monocyte and T-lymphocyte activities by PGE2, fatty acids and fatty acid ethanolamides.  Current work has been directed toward an attempt to understand the mechanisms by which PGE2 and fatty acids regulate: cytokine production, phagocytosis of E. coli O157 in human monocytes and the downregulation of human CD4+ lymphocyte function, especially  via the generation of intracellular cyclic AMP and cyclic GMP. The role of novel steroids, acting via PGs, on the modulation of immune cell activities is also being investigated as these provide another important potential therapeutic target

 

Negative feedback reguation of Immune responses by PGE2

Education/Academic qualification

Doctor of Philosophy, University of Glasgow

Bachelor of Science, University of Glasgow

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Projects 2011 2016

BBSRC Doctoral Training Grant (DTG) | Lumb, Felicity Elspeth

Harnett, W., Rotondo, D. & Lumb, F. E.

BBSRC (Biotech & Biological Sciences Research Council)

1/10/1123/02/16

Project: Research Studentship - Internally AllocatedResearch Studentship (Internally Allocated)

Research Output 2001 2019

Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

Brown, I., Lee, J., Sneddon, A. A., Cascio, M. G., Pertwee, R. G., Wahle, K. W. J., Rotondo, D. & Heys, S. D., 16 Oct 2019, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. p. 1-10 10 p., 102024 .

Research output: Contribution to journalArticle

Endocannabinoids
Ethanolamine
Cell growth
Breast Neoplasms
Derivatives

Predictive binding affinity of plant-derived natural products towards the protein kinase G enzyme of Mycobacterium tuberculosis (MtPknG)

M. Qasaymeh, R., Rotondo, D., Oosthuizen, C. B., Lall, N. & Seidel, V., 6 Nov 2019, 8, 11, 14 p., 477.

Research output: Contribution to journalArticle

Open Access
File
Biological Products
Pelargonium
Mycobacterium tuberculosis
Ligands
Tuberculosis

Thesis

Regulation of prostaglandin receptor expression in human monocytic cells following inflammatory activation

Author: Kashmiry, A. A. A., 1 Feb 2015

Supervisor: Rotondo, D. (Supervisor) & (Supervisor)

Student thesis: Doctoral Thesis

Activities 2008 2008

  • 1 Editorial board member

Member of the Editorial Commentary Team- \Current Opinion in Lipidology\""

D Rotondo (Editorial board member)
Jan 2008Dec 2015

Activity: Publication peer-review and editorial work typesEditorial board member