1991 …2019
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Research Output 1991 2019

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Article
2019

Deletion of TSPO resulted in change of metabolomic profile in retinal pigment epithelial cells

Alamri, A., Biswas, L., Watson, D. G. & Shu, X., 19 Mar 2019, In : International Journal of Molecular Sciences. 20, 6, 17 p., 1387.

Research output: Contribution to journalArticle

Open Access
File
deletion
Retinal Pigments
Metabolomics
pigments
Pigments
Open Access
File
Soccer
Dehydroepiandrosterone
Tandem Mass Spectrometry
Saliva
Testosterone
4 Citations (Scopus)

Discovery of sustainable drugs for neglected tropical diseases: Cashew Nut Shell Liquid (CNSL)-based hybrids target mitochondrial function and ATP production in Trypanosoma brucei

Cerone, M., Uliassi, E., Prati, F., Ebiloma, G. U., Lemgruber, L., Bergamini, C., Watson, D. G., de A. M. Ferreira, T., Roth Cardoso, G. S. H., Soares Romeiro, L. A., de Koning, H. P. & Bolognesi, M. L., 22 Mar 2019, In : ChemMedChem. 14, 6, p. 621-635 15 p.

Research output: Contribution to journalArticle

Open Access
File
Anacardium
Neglected Diseases
Trypanosoma brucei brucei
Nuts
Drug Discovery

European propolis is highly active against trypanosomatids including Crithidia fasciculata

Alotaibi, A., Ebiloma, G. U., Williams, R., Alenezi, S., Donachie, A-M., Guillaume, S., Igoli, J. O., Fearnley, J., de Koning, H. P. & Watson, D. G., 6 Aug 2019, In : Scientific Reports. 9, 1, 10 p., 11364.

Research output: Contribution to journalArticle

Open Access
File
Crithidia fasciculata
Leishmania mexicana
Propolis
Crithidia
Trypanosoma congolense
Open Access
File
Metabolomics
Scaling
Principal Component Analysis
Chemical Analysis
Pareto Set

Isolation of a novel flavanonol and an alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolis

Siheri, W., Ebiloma, G. U., Igoli, J. O., Gray, A. I., Biddau, M., Akrachalanont, P., Samya Sh M D Alenezi, S., Alwashih, M. A., Edrada Ebel, R., Müller, S., Lawrence, C. E., Fearnley, J., Watson, D. G. & De Koning, H. P., 15 Mar 2019, In : Molecules. 24, 6, 12 p., 1041.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trichinella spiralis
Caenorhabditis elegans
Plasmodium falciparum
isolation
Open Access
File
Bee Venoms
Metabolomics
Immune System
Macrophages
Interleukin-1beta

Plasma free fatty acids metabolic profile with LC-MS and appetite-related hormones in South Asian and white European men in relation to adiposity, physical activity and cardiorespiratory fitness: a cross-sectional study

Benedetti, S., Al-Tannak, N. F., Alzharani, M., Moir, H. J., Stensel, D. J., Thackray, A. E., Naughton, D. P., Dorak, M. T., Spendif, O., Hill, N., Watson, D. & Allgrove, J., 13 Apr 2019, In : Metabolites. 9, 4, 20 p., 71.

Research output: Contribution to journalArticle

Open Access
File
Physical Fitness
Metabolome
Adiposity
Appetite
Nonesterified Fatty Acids

Plasma metabolomics identifies lipid and amino acid markers of weight loss in patients with upper gastrointestinal cancer

Miller, J., Alshehri, A., Ramage, M. I., Stevens, N. A., Mullen, A. B., Boyd, M., Ross, J. A., Wigmore, S. J., Watson, D. G. & Skipworth, R. J. E., 19 Oct 2019, 11, 10, 11 p., 1594.

Research output: Contribution to journalArticle

Open Access
File
Cachexia
Gastrointestinal Neoplasms
Metabolomics
Weight Loss
Lipids

Preliminary studies: the potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization

Iqbal, M., Fan, T., Watson, D., Alenezi, S., Saleh, K. & Sahlan, M., 31 Jul 2019, In : Heliyon. 5, 7, 12 p., e01978.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Indonesia
Islands
Blood Vessels
Pericytes
2 Citations (Scopus)

Propolis exerts an anti-inflammatory effect on PMA-differentiated THP-1 cells via inhibition of purine nucleoside phosphorylase

Alqarni, A. M., Niwasabutra, K., Sahlan, M., Fearnley, H., Fearnley, J., Ferro, V. A. & Watson, D. G., 16 Apr 2019, In : Metabolites. 9, 4, 21 p., 75.

Research output: Contribution to journalArticle

Open Access
File
Purine-Nucleoside Phosphorylase
Propolis
Lipopolysaccharides
Anti-Inflammatory Agents
Macrophages
2018
4 Citations (Scopus)
Open Access
File
Melitten
Metabolomics
Cytokines
Lipopolysaccharides
Macrophages
15 Citations (Scopus)

Treatment of active Crohn's disease with an ordinary food-based diet that replicates exclusive enteral nutrition

Svolos, V., Hansen, R., Nichols, B., Quince, C., Ijaz, U. Z., Papadopoulou, R. T., Edwards, C. A., Watson, D., Alghamdi, A., Brejnrod, A., Ansalone, C., Duncan, H., Gervais, L., Tayler, R., Salmond, J., Bolognini, D., Klopfleisch, R., Gaya, D. R., Milling, S., Russell, R. K. & 1 othersGerasimidis, K., 11 Dec 2018, In : Gastroenterology.

Research output: Contribution to journalArticle

Open Access
File
Enteral Nutrition
Crohn Disease
Diet
Food
Microbiota
Open Access
File
Vitamin E
Vitamin D
Pulmonary Artery
Smooth Muscle Myocytes
Muscle
Open Access
File
Pediatrics
Metabolomics
Enteral Nutrition
Nutrition
Crohn Disease
8 Citations (Scopus)

Untargeted metabolomics profiling of an 80.5 km simulated treadmill ultramarathon

Howe, C. C. F., Alshehri, A., Muggeridge, D., Mullen, A. B., Boyd, M., Spendiff, O., Moir, H. J. & Watson, D. G., 13 Feb 2018, In : Metabolites. 8, 1, 17 p., 14.

Research output: Contribution to journalArticle

Open Access
File
Exercise equipment
Metabolomics
Fatty Acids
Peroxisomes
Carnitine
2017
1 Citation (Scopus)

Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans

Alwashih, M. A., Stimson, R. H., Andrew, R., Walker, B. R. & Watson, D. G., 13 Sep 2017, In : Scientific Reports. 7, 1, 10 p., 11488.

Research output: Contribution to journalArticle

Open Access
File
Metabolome
Hydrocortisone
Insulin
Branched Chain Amino Acids
Glucocorticoids
6 Citations (Scopus)
Open Access
File
Amination
Biological systems
Chromatography
Hydrophobic and Hydrophilic Interactions
Sugars
2 Citations (Scopus)
Open Access
File
Tritrichomonas foetus
Cystathionine
Trichomonas vaginalis
cystathionine
Isotope Labeling
8 Citations (Scopus)

Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells

Alonezi, S., Tusiimire, J., Wallace, J., Dufton, M. J., Parkinson, J. A., Young, L. C., Clements, C. J., Park, J-K., Jeon, J-W., Ferro, V. A. & Watson, D. G., 14 Apr 2017, In : Metabolites. 7, 14, p. 1-18 18 p.

Research output: Contribution to journalArticle

Open Access
File
Melitten
Metabolomics
Ovarian Neoplasms
Cisplatin
Cells
2 Citations (Scopus)

Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia

Alwashih, M. A., Watson, D. G., Andrew, R., Stimson, R. H., Alossaimi, M., Blackburn, G. & Walker, B. R., 6 Dec 2017, In : Scientific Reports. 7, 1, 7 p., 17092.

Research output: Contribution to journalArticle

Open Access
File
Congenital Adrenal Hyperplasia
Metabolomics
Glucocorticoids
Therapeutics
Prednisolone

Rapid changes in Atlantic grey seal milk from birth to weaning - immune factors and indicators of metabolic strain

Lowe, A. D., Bawazeer, S., Watson, D. G., McGill, S., Burchmore, R. J. S., Pomeroy, P. P. P. & Kennedy, M. W., 23 Nov 2017, In : Scientific Reports. 7, p. 1-11 11 p., 16093.

Research output: Contribution to journalArticle

Open Access
File
Earless Seals
Immunologic Factors
Weaning
Lactation
Milk
1 Citation (Scopus)

Specialised information processing deficits and distinct metabolomic profiles following TM-domain disruption of Nrg1

O'Tuathaigh, C. M. P., Mathur, N., O'Callaghan, M. J., MacIntyre, L., Harvey, R., Lai, D., Waddington, J. L., Pickard, B. S., Watson, D. G. & Moran, P. M., 30 Sep 2017, In : Schizophrenia Bulletin. 43, 5, p. 1100–1113 14 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Automatic Data Processing
Neuregulin-1
Schizophrenia
Neuregulins
6 Citations (Scopus)

The chemical characterization of Nigerian propolis samples and their activity against Trypanosoma brucei

Omar, R., Igoli, J. O., Zhang, T., Gray, A. I., Ebiloma, G. U., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., de Koning, H. P. & Watson, D. G., 19 Apr 2017, In : Scientific Reports. 7, 1, 10 p., 01038.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trypanosoma brucei brucei
Liquid Chromatography
Mass Spectrometry
Nigeria
2016
6 Citations (Scopus)

An evaluation of minor groove binders as anti-lung cancer therapeutics

Scott, F., Khalaf, A., Suckling, C., Carter, K., Grant, M., Henderson, C., Westrop, G. & Watson, D., 15 Jun 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 11 p.

Research output: Contribution to journalArticle

Open Access
File
gemcitabine
Binders
Lung Neoplasms
Biological Products
Early Detection of Cancer
2 Citations (Scopus)

Changeover from signalling to energy-provisioning lipids during transition from colostrum to mature milk in the giant panda (Ailuropoda melanoleuca)

Zhang, T., Watson, D. G., Zhang, R., Hou, R., Loeffler, I. K. & Kennedy, M. W., 3 Nov 2016, In : Scientific Reports. 6, p. 1-10 10 p., 36141.

Research output: Contribution to journalArticle

Open Access
File
Ailuropoda melanoleuca
colostrum
milk
energy
lipids
15 Citations (Scopus)

Chemical and antimicrobial profiling of propolis from different regions within Libya

Siheri, W., Zhang, T., Ebiloma, G. U., Biddau, M., Woods, N., Hussain, M. Y., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., Müller, S., Carter, K. C., Ferro, V. A., De Koning, H. P. & Watson, D. G., 19 May 2016, In : PLOS One. 11, 5, 16 p., e0155355.

Research output: Contribution to journalArticle

Open Access
File
Crithidia fasciculata
Mycobacterium marinum
Libya
Propolis
Leishmania donovani
26 Citations (Scopus)

Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei

Omar, R. M. K., Igoli, J., Gray, A. I., Ebiloma, G. U., Clements, C., Fearnley, J., Edrada Ebel, R. A., Zhang, T., De Koning, H. P. & Watson, D. G., 31 Mar 2016, In : Phytochemical Analysis. 27, 2, p. 107–115 9 p.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trypanosoma brucei
Trypanosoma brucei brucei
propolis
Bioactivity
5 Citations (Scopus)

Effect of bee venom and its fractions on the release of pro-inflammatory cytokines in PMA-differentiated U937 cells co-stimulated with LPS

Tusiimire, J., Wallace, J., Woods, N., Dufton, M. J., Parkinson, J. A., Abbott, G., Clements, C. J., Young, L., Park, J. K., Jeon, J. W., Ferro, V. A. & Watson, D. G., 19 Apr 2016, In : Vaccines. 4, 2, 15 p., 11.

Research output: Contribution to journalArticle

Open Access
File
Bee Venoms
U937 Cells
Acetates
Cytokines
Interleukin-6
9 Citations (Scopus)

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. & Pyne, N., 1 Aug 2016, In : Cellular Signalling. 28, 8, p. 946-955 11 p.

Research output: Contribution to journalArticle

Open Access
File
Pulmonary Hypertension
Right Ventricular Hypertrophy
Cardiac Myocytes
Lung
Oxidants

Identification of novel metabolic pathways of sitagliptin (STG) by LC/MS and LC/MS2 after incubations with rat hepatcoytes

Khreit, O. IG., Grant, H. M., Henderson, C., Watson, D. G. & Sutcliffe, O. B., 30 Dec 2016, In : Drug Metabolism and Disposition. 7, 4, 7 p., 1000220.

Research output: Contribution to journalArticle

Open Access
File
Metabolic Networks and Pathways
Glucuronides
Sulfates
Ions
Hydroxylation
10 Citations (Scopus)
Open Access
File
Metabolomics
Metabolites
Bipolar Disorder
Metabolism
Glucose
10 Citations (Scopus)

Metabolomic profiling of submaximal exercise at a standardised relative intensity in healthy adults

Ali, A. M., Burleigh, M., Daskalaki, E., Zhang, T., Easton, C. & Watson, D. G., 26 Feb 2016, In : Metabolites.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Metabolites
Passive Cutaneous Anaphylaxis
Exercise
Exercise Test
3 Citations (Scopus)

Metabolomic profiling of the effects of melittin on cisplatin resistant and cisplatin sensitive ovarian cancer cells using mass spectrometry and biolog microarray technology

Alonezi, S., Tusiimire, J., Wallace, J., Dufton, M. J., Parkinson, J. A., Young, L. C., Clements, C. J., Park, J. K., Jeon, J. W., Ferro, V. A. & Watson, D. G., 13 Oct 2016, In : Metabolites. 6, 4, 18 p.

Research output: Contribution to journalArticle

Open Access
File
Melitten
Metabolomics
Microarrays
Ovarian Neoplasms
Cisplatin
5 Citations (Scopus)

Polymeric nanoparticles of Brazilian red propolis extract: preparation, characterization, antioxidant and leishmanicidal activity

do Nascimento, T. G., da Silva, P. F., Azevedo, L. F., da Rocha, L. G., de Moraes Porto, I. C. C., Lima e Moura, T. F. A., Basílio-Júnior, I. D., Grillo, L. A. M., Dornelas, C. B., Fonseca, E. J. D. S., de Jesus Oliveira, E., Zhang, A. T. & Watson, D. G., 17 Jun 2016, In : Nanoscale Research Letters. 11, 16 p., 301.

Research output: Contribution to journalArticle

Open Access
File
Propolis
antioxidants
Antioxidants
Nanoparticles
nanoparticles
2015
26 Citations (Scopus)

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output

Daskalaki, E., Blackburn, G., Kalna, G., Zhang, T., Anthony, N. & Watson, D. G., 27 Feb 2015, In : Metabolites. 5, 1, p. 119-139 21 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolome
Metabolites
Metabolism
Urine
Exercise
3 Citations (Scopus)

Changes in the milk metabolome of the giant panda (ailuropoda melanoleuca) with time after birth - three phases in early lactation and progressive individual differences

Zhang, T., Zhang, R., Zhang, L., Zhang, Z., Hou, R., Wang, H., Loeffler, I. K., Watson, D. G. & Kennedy, M. W., 2 Dec 2015, In : PLOS One. 10, 12, 18 p., e0143417.

Research output: Contribution to journalArticle

Open Access
File
Ursidae
Ailuropoda melanoleuca
metabolome
Metabolome
early lactation
16 Citations (Scopus)

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

Mcilroy, G. D., Tammireddy, S. R., Maskrey, B. H., Grant, L., Doherty, M. K., Watson, D. G., Delibegović, M., Whitfield, P. D. & Mody, N., 22 Nov 2015, In : Biochemical Pharmacology. 12 p.

Research output: Contribution to journalArticle

Open Access
File
Fenretinide
Adipogenesis
Retinoic Acid Receptors
Ceramides
Biosynthesis
1 Citation (Scopus)

Improving arteriovenous fistula patency: transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation

MacAskill, M. G., Watson, D. G., Ewart, M-A., Wadsworth, R., Jackson, A., Aitken, E., MacKenzie, G., Kingsmore, D., Currie, S. & Coats, P., 1 Aug 2015, In : Vascular pharmacology. 71, p. 108-115 8 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Diclofenac
Arteriovenous Fistula
Catheterization
Hyperplasia
1 Citation (Scopus)

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method

Zaid, A. N., Abualhasan, M. N., Watson, D. G., Mousa, A., Ghazal, N. & Bustami, R., 23 Sep 2015, In : Drug Design, Development and Therapy. 9, p. 5315-5321 7 p.

Research output: Contribution to journalArticle

Open Access
File
montelukast
Therapeutic Equivalency
Tablets
Oral Administration
Pediatrics
25 Citations (Scopus)

LC-MS metabolomics of psoriasis patients reveals disease severity-dependent increases in circulating amino acids that are ameliorated by anti-TNFα treatment

Kamleh, M. A., Snowden, S. G., Grapov, D., Blackburn, G. J., Watson, D. G., Xu, N., Ståhle, M. & Wheelock, C. E., 2 Jan 2015, In : Journal of Proteome Research. 14, 1, p. 557-566 10 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Psoriasis
Metabolites
Amino Acids
Skin
19 Citations (Scopus)

Metabolomic analyses of Leishmania reveal multiple species differences and large differences in amino acid metabolism

Westrop, G. D., Williams, R. A. M., Wang, L., Zhang, T., Watson, D. G., Silva, A. M. & Coombs, G. H., 14 Sep 2015, In : PLOS One. 10, 9, 29 p., e0136891.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Leishmania
amino acid metabolism
metabolomics
Metabolites
56 Citations (Scopus)

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

Creek, D. J., Mazet, M., Achcar, F., Anderson, J., Kim, D. H., Kamour, R., Morand, P., Millerioux, Y., Biran, M., Kerkhoven, E. J., Chokkathukalam, A., Weidt, S. K., Burgess, K. E. V., Breitling, R., Watson, D. G., Bringaud, F. & Barrett, M. P., 16 Mar 2015, In : PLOS Pathogens. 11, 3, 25 p., e1004689.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma brucei brucei
Metabolomics
Metabolic Networks and Pathways
Isotopes
Glucose
5 Citations (Scopus)

Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca

Griffiths, K., Hou, R., Wang, H., Zhang, Z., Zhang, L., Zhang, T., Watson, D. G., Burchmore, R. J. S., Loeffler, I. K. & Kennedy, M. W., 21 Oct 2015, In : Royal Society Open Science. 2, 10, p. 150395 14 p.

Research output: Contribution to journalArticle

Open Access
File
Ursidae
Colostrum
Milk
Lactation
Postpartum Period
22 Citations (Scopus)

Ropivacaine plasma levels following high-dose local infiltration analgesia for total knee arthroplasty

Gill, A. M., Scott, N. B., Abbas, M., Watson, D. G., Place, K. & McDonald, D., 1 Jul 2015, In : Anaesthesia. 70, 7, p. 784-790 7 p.

Research output: Contribution to journalArticle

Open Access
File
Knee Replacement Arthroplasties
Analgesia
Poisons
Catheters
Tourniquets
2014
11 Citations (Scopus)

Characterisation of triterpenes and new phenolic lipids in Cameroonian propolis

Kardar, M. N., Zhang, T., Coxon, G. D., Watson, D. G., Fearnley, J. & Seidel, V., 1 Oct 2014, In : Phytochemistry. 106, p. 156-163 8 p.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Triterpenes
propolis
triterpenoids
Lipids
32 Citations (Scopus)

Chromatographic analysis with different detectors in the chemical characterisation and dereplication of African propolis

Zhang, T., Omar, R., Siheri, W., Al Mutairi, S., Clements, C., Fearnley, J., Edrada-Ebel, R. & Watson, D., 1 Mar 2014, In : Talanta. 120, p. 181-190 10 p.

Research output: Contribution to journalArticle

Chromatographic analysis
Propolis
Chromatography
Detectors
Liquid chromatography
46 Citations (Scopus)
Open Access
File
Leishmania
Liquid chromatography
Metabolites
Hydrophobic and Hydrophilic Interactions
Liquid Chromatography
24 Citations (Scopus)

Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism

Storm, J., Sethia, S., Blackburn, G., Chokkathukalam, A., Watson, D., Breitling, R., Coombs, G. & Muller, S., 16 Jan 2014, In : PLOS Pathogens. 10, 1, p. 1-14 14 p., e1003876.

Research output: Contribution to journalArticle

Open Access
File
Phosphoenolpyruvate Carboxylase
Plasmodium falciparum
Fumarates
Parasites
Carbon
ferulic acid
Metabolites
Glutathione
Rats
Hepatocytes