1991 …2018
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Research Output 1991 2018

2018
Open Access
File
Melitten
Metabolomics
Cytokines
Lipopolysaccharides
Macrophages

Treatment of active Crohn's disease with an ordinary food-based diet that replicates exclusive enteral nutrition

Svolos, V., Hansen, R., Nichols, B., Quince, C., Ijaz, U. Z., Papadopoulou, R. T., Edwards, C. A., Watson, D., Alghamdi, A., Brejnrod, A., Ansalone, C., Duncan, H., Gervais, L., Tayler, R., Salmond, J., Bolognini, D., Klopfleisch, R., Gaya, D. R., Milling, S., Russell, R. K. & 1 othersGerasimidis, K., 11 Dec 2018, In : Gastroenterology.

Research output: Contribution to journalArticle

Open Access
File
Enteral Nutrition
Crohn Disease
Diet
Food
Microbiota
Open Access
File
Vitamin E
Vitamin D
Pulmonary Artery
Smooth Muscle Myocytes
Muscle
Open Access
File
Pediatrics
Metabolomics
Enteral Nutrition
Nutrition
Crohn Disease
3 Citations

Untargeted metabolomics profiling of an 80.5 km simulated treadmill ultramarathon

Howe, C. C. F., Alshehri, A., Muggeridge, D., Mullen, A. B., Boyd, M., Spendiff, O., Moir, H. J. & Watson, D. G., 13 Feb 2018, In : Metabolites. 8, 1, 17 p., 14.

Research output: Contribution to journalArticle

Open Access
File
Exercise equipment
Metabolomics
Fatty Acids
Peroxisomes
Carnitine
2017
1 Citations

Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans

Alwashih, M. A., Stimson, R. H., Andrew, R., Walker, B. R. & Watson, D. G., 13 Sep 2017, In : Scientific Reports. 7, 1, 10 p., 11488.

Research output: Contribution to journalArticle

Open Access
File
Metabolome
Hydrocortisone
Insulin
Branched Chain Amino Acids
Glucocorticoids
5 Citations
Open Access
File
Amination
Biological systems
Chromatography
Hydrophobic and Hydrophilic Interactions
Sugars
1 Citations
Open Access
File
Tritrichomonas foetus
Cystathionine
Trichomonas vaginalis
cystathionine
Isotope Labeling
4 Citations

Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells

Alonezi, S., Tusiimire, J., Wallace, J., Dufton, M. J., Parkinson, J. A., Young, L. C., Clements, C. J., Park, J-K., Jeon, J-W., Ferro, V. A. & Watson, D. G., 14 Apr 2017, In : Metabolites. 7, 14, p. 1-18 18 p.

Research output: Contribution to journalArticle

Open Access
File
Melitten
Metabolomics
Ovarian Neoplasms
Cisplatin
Cells
2 Citations

Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia

Alwashih, M. A., Watson, D. G., Andrew, R., Stimson, R. H., Alossaimi, M., Blackburn, G. & Walker, B. R., 6 Dec 2017, In : Scientific Reports. 7, 1, 7 p., 17092.

Research output: Contribution to journalArticle

Open Access
File
Congenital Adrenal Hyperplasia
Metabolomics
Glucocorticoids
Therapeutics
Prednisolone

Rapid changes in Atlantic grey seal milk from birth to weaning - immune factors and indicators of metabolic strain

Lowe, A. D., Bawazeer, S., Watson, D. G., McGill, S., Burchmore, R. J. S., Pomeroy, P. P. P. & Kennedy, M. W., 23 Nov 2017, In : Scientific Reports. 7, p. 1-11 11 p., 16093.

Research output: Contribution to journalArticle

Open Access
File
Earless Seals
Immunologic Factors
Weaning
Lactation
Milk
1 Citations

Specialised information processing deficits and distinct metabolomic profiles following TM-domain disruption of Nrg1

O'Tuathaigh, C. M. P., Mathur, N., O'Callaghan, M. J., MacIntyre, L., Harvey, R., Lai, D., Waddington, J. L., Pickard, B. S., Watson, D. G. & Moran, P. M., 30 Sep 2017, In : Schizophrenia Bulletin. 43, 5, p. 1100–1113 14 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Automatic Data Processing
Neuregulin-1
Schizophrenia
Neuregulins

The chemical and biological properties of propolis

Siheri, W., Alenezi, S., Tusiimire, J. & Watson, D. G., 5 Sep 2017, Bee Products - Chemical and Biological Properties. Alvarez-Suarez, J. M. (ed.). Cham, p. 137-178 42 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Propolis
Bees
Bacteria
Gram-Negative Bacteria
Viruses
4 Citations

The chemical characterization of Nigerian propolis samples and their activity against Trypanosoma brucei

Omar, R., Igoli, J. O., Zhang, T., Gray, A. I., Ebiloma, G. U., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., de Koning, H. P. & Watson, D. G., 19 Apr 2017, In : Scientific Reports. 7, 1, 10 p., 01038.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trypanosoma brucei brucei
Liquid Chromatography
Mass Spectrometry
Nigeria
2016
5 Citations

An evaluation of minor groove binders as anti-lung cancer therapeutics

Scott, F., Khalaf, A., Suckling, C., Carter, K., Grant, M., Henderson, C., Westrop, G. & Watson, D., 15 Jun 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 11 p.

Research output: Contribution to journalArticle

Open Access
File
gemcitabine
Binders
Lung Neoplasms
Biological Products
Early Detection of Cancer
1 Citations

Changeover from signalling to energy-provisioning lipids during transition from colostrum to mature milk in the giant panda (Ailuropoda melanoleuca)

Zhang, T., Watson, D. G., Zhang, R., Hou, R., Loeffler, I. K. & Kennedy, M. W., 3 Nov 2016, In : Scientific Reports. 6, p. 1-10 10 p., 36141.

Research output: Contribution to journalArticle

Open Access
File
Ailuropoda melanoleuca
colostrum
milk
energy
lipids
11 Citations

Chemical and antimicrobial profiling of propolis from different regions within Libya

Siheri, W., Zhang, T., Ebiloma, G. U., Biddau, M., Woods, N., Hussain, M. Y., Clements, C. J., Fearnley, J., Edrada Ebel, R., Paget, T., Müller, S., Carter, K. C., Ferro, V. A., De Koning, H. P. & Watson, D. G., 19 May 2016, In : PLOS One. 11, 5, 16 p., e0155355.

Research output: Contribution to journalArticle

Open Access
File
Crithidia fasciculata
Mycobacterium marinum
Libya
Propolis
Leishmania donovani
17 Citations

Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei

Omar, R. M. K., Igoli, J., Gray, A. I., Ebiloma, G. U., Clements, C., Fearnley, J., Edrada Ebel, R. A., Zhang, T., De Koning, H. P. & Watson, D. G., 31 Mar 2016, In : Phytochemical Analysis. 27, 2, p. 107–115 9 p.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trypanosoma brucei
Trypanosoma brucei brucei
propolis
Bioactivity
Open Access
Metabolites
Metabolism
Rats
Hepatocytes
Mass spectrometers
2 Citations

Effect of bee venom and its fractions on the release of pro-inflammatory cytokines in PMA-differentiated U937 cells co-stimulated with LPS

Tusiimire, J., Wallace, J., Woods, N., Dufton, M. J., Parkinson, J. A., Abbott, G., Clements, C. J., Young, L., Park, J. K., Jeon, J. W., Ferro, V. A. & Watson, D. G., 19 Apr 2016, In : Vaccines. 4, 2, 15 p., 11.

Research output: Contribution to journalArticle

Open Access
File
Bee Venoms
U937 Cells
Acetates
Cytokines
Interleukin-6
7 Citations

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. & Pyne, N., 1 Aug 2016, In : Cellular Signalling. 28, 8, p. 946-955 11 p.

Research output: Contribution to journalArticle

Open Access
File
Pulmonary Hypertension
Right Ventricular Hypertrophy
Cardiac Myocytes
Lung
Oxidants

Identification of novel metabolic pathways of sitagliptin (STG) by LC/MS and LC/MS2 after incubations with rat hepatcoytes

Khreit, O. IG., Grant, H. M., Henderson, C., Watson, D. G. & Sutcliffe, O. B., 30 Dec 2016, In : Drug Metabolism and Disposition. 7, 4, 7 p., 1000220.

Research output: Contribution to journalArticle

Open Access
File
Metabolic Networks and Pathways
Glucuronides
Sulfates
Ions
Hydroxylation
6 Citations
Open Access
File
Metabolomics
Metabolites
Bipolar Disorder
Metabolism
Glucose
7 Citations

Metabolomic profiling of submaximal exercise at a standardised relative intensity in healthy adults

Ali, A. M., Burleigh, M., Daskalaki, E., Zhang, T., Easton, C. & Watson, D. G., 26 Feb 2016, In : Metabolites.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Metabolites
Passive Cutaneous Anaphylaxis
Exercise
Exercise Test
3 Citations

Metabolomic profiling of the effects of melittin on cisplatin resistant and cisplatin sensitive ovarian cancer cells using mass spectrometry and biolog microarray technology

Alonezi, S., Tusiimire, J., Wallace, J., Dufton, M. J., Parkinson, J. A., Young, L. C., Clements, C. J., Park, J. K., Jeon, J. W., Ferro, V. A. & Watson, D. G., 13 Oct 2016, In : Metabolites. 6, 4, 18 p.

Research output: Contribution to journalArticle

Open Access
File
Melitten
Metabolomics
Microarrays
Ovarian Neoplasms
Cisplatin
3 Citations

Natural vaccine adjuvants and immunopotentiators derived from plants, fungi, marine organisms, and insects

Woods, N., Niwasabutra, K., Acevedo, R., Igoli, J., Altwaijry, N. A., Tusiimire, J., Gray, A. I., Watson, D. G. & Ferro, V. A., 10 Nov 2016, Immunopotentiators in Modern Vaccines. Schijns, V. E. J. C. & O'Hagan, D. T. (eds.). 2nd ed. London, p. 211-230 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunologic Adjuvants
Aquatic Organisms
Insects
Fungi
Vaccines
5 Citations

Polymeric nanoparticles of Brazilian red propolis extract: preparation, characterization, antioxidant and leishmanicidal activity

do Nascimento, T. G., da Silva, P. F., Azevedo, L. F., da Rocha, L. G., de Moraes Porto, I. C. C., Lima e Moura, T. F. A., Basílio-Júnior, I. D., Grillo, L. A. M., Dornelas, C. B., Fonseca, E. J. D. S., de Jesus Oliveira, E., Zhang, A. T. & Watson, D. G., 17 Jun 2016, In : Nanoscale Research Letters. 11, 16 p., 301.

Research output: Contribution to journalArticle

Open Access
File
Propolis
antioxidants
Antioxidants
Nanoparticles
nanoparticles

Time of flight secondary ion mass spectrometry (ToF-SIMS) in pharmaceutical sciences

Paladino, E., Watson, D. G., Passarelli, M. K. & Lamprou, D. A., Apr 2016, (Unpublished). 1 p.

Research output: Contribution to conferencePoster

Secondary Ion Mass Spectrometry
Secondary ion mass spectrometry
Complex Mixtures
Drug products
Pharmaceutical Preparations
2015
25 Citations

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output

Daskalaki, E., Blackburn, G., Kalna, G., Zhang, T., Anthony, N. & Watson, D. G., 27 Feb 2015, In : Metabolites. 5, 1, p. 119-139 21 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolome
Metabolites
Metabolism
Urine
Exercise
3 Citations

Changes in the milk metabolome of the giant panda (ailuropoda melanoleuca) with time after birth - three phases in early lactation and progressive individual differences

Zhang, T., Zhang, R., Zhang, L., Zhang, Z., Hou, R., Wang, H., Loeffler, I. K., Watson, D. G. & Kennedy, M. W., 2 Dec 2015, In : PLOS One. 10, 12, 18 p., e0143417.

Research output: Contribution to journalArticle

Open Access
File
Ursidae
Ailuropoda melanoleuca
metabolome
Metabolome
early lactation
14 Citations

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

Mcilroy, G. D., Tammireddy, S. R., Maskrey, B. H., Grant, L., Doherty, M. K., Watson, D. G., Delibegović, M., Whitfield, P. D. & Mody, N., 22 Nov 2015, In : Biochemical Pharmacology. 12 p.

Research output: Contribution to journalArticle

Open Access
File
Fenretinide
Adipogenesis
Retinoic Acid Receptors
Ceramides
Biosynthesis
1 Citations

Improving arteriovenous fistula patency: transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation

MacAskill, M. G., Watson, D. G., Ewart, M-A., Wadsworth, R., Jackson, A., Aitken, E., MacKenzie, G., Kingsmore, D., Currie, S. & Coats, P., 1 Aug 2015, In : Vascular pharmacology. 71, p. 108-115 8 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Diclofenac
Arteriovenous Fistula
Catheterization
Hyperplasia
1 Citations

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method

Zaid, A. N., Abualhasan, M. N., Watson, D. G., Mousa, A., Ghazal, N. & Bustami, R., 23 Sep 2015, In : Drug Design, Development and Therapy. 9, p. 5315-5321 7 p.

Research output: Contribution to journalArticle

Open Access
File
montelukast
Therapeutic Equivalency
Tablets
Oral Administration
Pediatrics
22 Citations

LC-MS metabolomics of psoriasis patients reveals disease severity-dependent increases in circulating amino acids that are ameliorated by anti-TNFα treatment

Kamleh, M. A., Snowden, S. G., Grapov, D., Blackburn, G. J., Watson, D. G., Xu, N., Ståhle, M. & Wheelock, C. E., 2 Jan 2015, In : Journal of Proteome Research. 14, 1, p. 557-566 10 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Psoriasis
Metabolites
Amino Acids
Skin
16 Citations

Metabolomic analyses of Leishmania reveal multiple species differences and large differences in amino acid metabolism

Westrop, G. D., Williams, R. A. M., Wang, L., Zhang, T., Watson, D. G., Silva, A. M. & Coombs, G. H., 14 Sep 2015, In : PLOS One. 10, 9, 29 p., e0136891.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Leishmania
amino acid metabolism
metabolomics
Metabolites
Metabolomics
Medicinal Plants
Phenylalanine
Software
Mycobacterium marinum

Metabolomics as a tool to investigate mephadrone as a drug of abuse in rat hepatocytes.

Alwashih, M., Watson, D., Grant, M. & Henderson, C., 25 Jun 2015, p. 93-94. 2 p.

Research output: Contribution to conferenceAbstract

52 Citations

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

Creek, D. J., Mazet, M., Achcar, F., Anderson, J., Kim, D. H., Kamour, R., Morand, P., Millerioux, Y., Biran, M., Kerkhoven, E. J., Chokkathukalam, A., Weidt, S. K., Burgess, K. E. V., Breitling, R., Watson, D. G., Bringaud, F. & Barrett, M. P., 16 Mar 2015, In : PLOS Pathogens. 11, 3, 25 p., e1004689.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma brucei brucei
Metabolomics
Metabolic Networks and Pathways
Isotopes
Glucose
4 Citations

Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca

Griffiths, K., Hou, R., Wang, H., Zhang, Z., Zhang, L., Zhang, T., Watson, D. G., Burchmore, R. J. S., Loeffler, I. K. & Kennedy, M. W., 21 Oct 2015, In : Royal Society Open Science. 2, 10, p. 150395 14 p.

Research output: Contribution to journalArticle

Open Access
File
Ursidae
Colostrum
Milk
Lactation
Postpartum Period
18 Citations

Ropivacaine plasma levels following high-dose local infiltration analgesia for total knee arthroplasty

Gill, A. M., Scott, N. B., Abbas, M., Watson, D. G., Place, K. & McDonald, D. A., 1 Jul 2015, In : Anaesthesia. 70, 7, p. 784-790 7 p.

Research output: Contribution to journalArticle

Open Access
File
Knee Replacement Arthroplasties
Analgesia
Poisons
Catheters
Tourniquets
2014
11 Citations

Characterisation of triterpenes and new phenolic lipids in Cameroonian propolis

Kardar, M. N., Zhang, T., Coxon, G. D., Watson, D. G., Fearnley, J. & Seidel, V., 1 Oct 2014, In : Phytochemistry. 106, p. 156-163 8 p.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Triterpenes
propolis
triterpenoids
Lipids
29 Citations

Chromatographic analysis with different detectors in the chemical characterisation and dereplication of African propolis

Zhang, T., Omar, R., Siheri, W., Al Mutairi, S., Clements, C., Fearnley, J., Edrada-Ebel, R. & Watson, D., 1 Mar 2014, In : Talanta. 120, p. 181-190 10 p.

Research output: Contribution to journalArticle

Chromatographic analysis
Propolis
Chromatography
Detectors
Liquid chromatography
39 Citations
Open Access
File
Leishmania
Liquid chromatography
Metabolites
Hydrophobic and Hydrophilic Interactions
Liquid Chromatography
22 Citations

Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism

Storm, J., Sethia, S., Blackburn, G., Chokkathukalam, A., Watson, D., Breitling, R., Coombs, G. & Muller, S., 16 Jan 2014, In : PLOS Pathogens. 10, 1, p. 1-14 14 p., e1003876.

Research output: Contribution to journalArticle

Open Access
File
Phosphoenolpyruvate Carboxylase
Plasmodium falciparum
Fumarates
Parasites
Carbon
ferulic acid
Metabolites
Glutathione
Rats
Hepatocytes

The application of metabolomic profiling to the effects of physical activity

Daskalaki, E., Easton, C. & Watson, D. G., 2014, In : Current Metabolomics. 2, 4, p. 233-263 31 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Exercise
Fatty Acids
Pantothenic Acid
Citric Acid Cycle
3 Citations

The complex degradation and metabolism of quercetin in rat hepatocyte incubations

Omar, K., Grant, M. H., Henderson, C. & Watson, D. G., 1 Dec 2014, In : Xenobiotica. 44, 12, p. 1074-1082 9 p.

Research output: Contribution to journalArticle

Open Access
File
Quercetin
Metabolism
Rats
Hepatocytes
Metabolites
10 Citations

The isolation of antiprotozoal compounds from Libyan propolis

Siheri, W., Igoli, J. O., Gray, A. I., Nasciemento, T. G., Zhang, T., Fearnley, J., Clements, C. J., Carter, K. C., Carruthers, J., Edrada-Ebel, R. & Watson, D. G., Dec 2014, In : Phytotherapy Research. 28, 12, p. 1756–1760 5 p.

Research output: Contribution to journalArticle

Open Access
File
Propolis
Trypanosoma brucei brucei
Libya
Leishmania donovani
Microbial Sensitivity Tests
2013
33 Citations

Application of holistic liquid chromatography-high resolution mass spectrometry based urinary metabolomics for prostate cancer detection and biomarker discovery

Zhang, T., Watson, D. G., Wang, L., Abbas, M., Murdoch, L., Bashford, L., Ahmad, I., Lam, N-Y., Ng, A. C. F. & Leung, H. Y., 18 Jun 2013, In : PLoS ONE. 8, 6, p. e65880

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Liquid chromatography
metabolomics
prostatic neoplasms
Tumor Biomarkers