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Research Output 2008 2019

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A fragment-like approach to PYCR1 inhibition

Milne, K., Sun, J., Zaal, E. A., Mowat, J., Celie, P. H. N., Fish, A., Berkers, C. R., Forlani, G., Loayza-Puch, F., Jamieson, C. & Agami, R., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters . 29, 18, p. 2626-2631 6 p.

Research output: Contribution to journalArticle

Pyrroline Carboxylate Reductases
Oxidoreductases
Proline
Pargyline
Neoplasms
23 Citations (Scopus)
120 Downloads (Pure)

Amidation of esters with amino alcohols using organobase catalysis

Caldwell, N., Campbell, P. S., Jamieson, C., Potjewyd, F., Simpson, I. & Watson, A. J. B., 3 Oct 2014, In : Journal of Organic Chemistry. 79, 19, p. 9347-9354 8 p.

Research output: Contribution to journalArticle

Open Access
File
Amino Alcohols
Oxazolidinones
Transesterification
Catalysis
Esters
11 Citations (Scopus)
15 Downloads (Pure)

Amidation of unactivated ester derivatives mediated by trifluoroethanol

McPherson, C. G., Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 4 Apr 2017, In : Organic and Biomolecular Chemistry. 12 p.

Research output: Contribution to journalArticle

Open Access
File
Trifluoroethanol
Amines
esters
amines
Esters
23 Citations (Scopus)
270 Downloads (Pure)

A novel series of positive modulators of the AMPA receptor: structure-based lead optimization

Jamieson, C., Campbell, R. A., Cumming, I. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A. J., Maclean, J. K. F., Martin, F., Moir, E. M., Morrow, J. A., Pantling, J., Rankovic, Z. & Smith, L., 15 Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6072-6075 4 p.

Research output: Contribution to journalArticle

Open Access
File
AMPA Receptors
Modulators
Biological Availability
Lead compounds
X-Rays
30 Citations (Scopus)
76 Downloads (Pure)

A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies

Jamieson, C., Basten, S., Campbell, R. A., Cumming, I. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A. J., Maclean, J. K. F., Moir, E. M., Morrow, J. A., Papakosta, M., Rankovic, Z. & Smith, L., 1 Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 19, p. 5753-5756 4 p.

Research output: Contribution to journalArticle

Open Access
File
AMPA Receptors
Drug Design
Glutamate Receptors
Modulators
Demonstrations
1 Citation (Scopus)

A reappraisal of the Ni-[(Benzylprolyl)amino]benzophenone complex in the synthesis of α,α-disubstituted amino acid derivatives

Watson, M. E., Jamieson, C., Kennedy, A. R. & Mason, A. M., 6 Sep 2019, In : Tetrahedron. 75, 36, 130485.

Research output: Contribution to journalArticle

Proline
Derivatives
Amino Acids
Peptides
Erosion
1 Citation (Scopus)
2 Downloads (Pure)

Atom efficient synthesis of selectively difluorinated carbocycles through a gold(I) catalyzed cyclization

McCarter, A. W., Sommer, M., Percy, J. M., Jamieson, C., Kennedy, A. R. & Hirst, D. J., 6 Jul 2018, In : Journal of Organic Chemistry.

Research output: Contribution to journalArticle

Open Access
File
Acetals
Cyclization
Gold
Bearings (structural)
Trifluoroethanol
31 Citations (Scopus)
36 Downloads (Pure)

Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 11 Jun 2015, In : Chemical Communications. 51, 46, p. 9495-9498 4 p.

Research output: Contribution to journalArticle

Open Access
File
Trifluoroethanol
Esters
Derivatives
Amides
Amines
13 Citations (Scopus)
13 Downloads (Pure)

Cyrene as a bio-based solvent for HATU mediated amide coupling

Wilson, K. L., Murray, J., Jamieson, C. & Watson, A. J. B., 28 Apr 2018, In : Organic and Biomolecular Chemistry. 16, p. 2851-2854 4 p.

Research output: Contribution to journalArticle

Open Access
File
Amides
amides
Dipeptides
Drug Discovery
synthesis
38 Citations (Scopus)

Development of a solvent selection guide for aldehyde-based direct reductive amination processes

McGonagle, F. I., MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A. J. B., 1 May 2013, In : Green Chemistry. 15, 5, p. 1159-1165 7 p.

Research output: Contribution to journalArticle

Amination
aldehyde
Aldehydes
Boranes
Reducing Agents
27 Citations (Scopus)
76 Downloads (Pure)

Development of a sustainable catalytic ester amidation process

Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 7 Oct 2013, In : ACS Sustainable Chemistry and Engineering. 1, 10, p. 1339-1344 6 p.

Research output: Contribution to journalArticle

Open Access
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ester
alcohol
Esters
Amino alcohols
Amino Alcohols
12 Citations (Scopus)

Dioxo-triazines as a novel series of cathepsin K inhibitors

Rankovic, Z., Cai, J., Fradera, X., Dempster, M., Mistry, A., Long, C., Hamilton, E., King, A., Boucharens, S., Jamieson, C., Gillespie, J., Cumming, I., Uitdehaag, J. & van Zeeland, M., 1 Mar 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1488-1490 3 p.

Research output: Contribution to journalArticle

Cathepsin K
Triazines
Inhibitory Concentration 50
Assays
Cats
20 Citations (Scopus)
70 Downloads (Pure)

Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrins

Miller, L. M., Pritchard, J. M., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 30 Jan 2017, In : Journal of Medicinal Chemistry. 60, 8, 11 p.

Research output: Contribution to journalArticle

Open Access
File
Integrins
Pharmacology
Molecules
Aspartic Acid
Thrombosis
77 Citations (Scopus)
227 Downloads (Pure)

Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide

MacMillan, D., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A., 2013, In : Green Chemistry. 15, 3, p. 596-600 5 p.

Research output: Contribution to journalArticle

Open Access
File
Dimethylformamide
Methylene Chloride
Dichloromethane
Amides
replacement
13 Citations (Scopus)
45 Downloads (Pure)

Evolution of a novel orally bioavailable series of PI3Kδ inhibitors from an inhaled lead for the treatment of respiratory disease.

Amour, A., Barton, N., Cooper, A. W. J., Inglis, G., Jamieson, C., Luscombe, C. N., Perez, D., Peace, S., Rowland, P., Tame, C., Uddin, S., Vitulli, G. & Wellaway, N., 18 Jul 2016, In : Journal of Medicinal Chemistry. 34 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphatidylinositol 3-Kinases
Growth
Lead
22 Citations (Scopus)

Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy

Harms, J. E., Benveniste, M., Maclean, J. K. F., Partin, K. M. & Jamieson, C., Jan 2013, In : Neuropharmacology. 64, p. 45-52 8 p.

Research output: Contribution to journalArticle

Isoxazoles
Drug Design
Benzamides
Nootropic Agents
Neuronal Plasticity
6 Citations (Scopus)
64 Downloads (Pure)

Identification of a novel class of autotaxin inhibitors through cross-screening

Castagna, D., Duffy, E. L., Semaan, D., Young, L. C., Pritchard, J. M., Macdonald, S. J. F., Budd, D. C., Jamieson, C. & Watson, A. J. B., 1 Jun 2015, In : MedChemComm. 2015, 6, p. 1149-1155 6 p.

Research output: Contribution to journalArticle

Open Access
File
Lysophosphatidic Acid Receptors
Lead compounds
Screening
Blood
Solubility
22 Citations (Scopus)
41 Downloads (Pure)

Investigation of a bicyclo[1.1.1]pentane as a phenyl replacement within an LpPLA2 inhibitor

Measom, N., Down, K. D., Hirst, D. J., Jamieson, C., Manas, E. S., Patel, V. K. & Somers, D. O., 15 Nov 2016, In : ACS Medicinal Chemistry Letters . 7, 6 p.

Research output: Contribution to journalArticle

Open Access
File
X-Rays
X rays
dichlorocarbene
butane
pentane
4 Downloads (Pure)

Metal free C-C bond formation via coupling of nitrile imines and boronic acids

Livingstone, K., Betrand, S., Mowat, J. & Jamieson, C., 28 Nov 2019, In : Chemical Science. 10, 44, p. 10412-10416 5 p.

Research output: Contribution to journalArticle

Open Access
File
Boronic Acids
Nitriles
Imines
Carbon
Metals
23 Citations (Scopus)

Molar efficiency: a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry

McGonagle, F. I., Sneddon, H. F., Jamieson, C. & Watson, A., 3 Mar 2014, In : ACS Sustainable Chemistry and Engineering. 2, 3, p. 523-532 10 p.

Research output: Contribution to journalArticle

Gages
gauge
Pharmaceutical Chemistry
calculation
comparison
11 Citations (Scopus)
36 Downloads (Pure)

One-pot, three-step synthesis of cyclopropylboronic acid pinacol esters from synthetically tractable propargylic silyl ethers

Spencer, J. A., Jamieson, C. & Talbot, E. P. A., 6 Jul 2017, In : Organic Letters. 4 p.

Research output: Contribution to journalArticle

Open Access
File
Ethers
esters
ethers
Esters
Lewis Acids
32 Citations (Scopus)

Organobase-catalyzed amidation of esters with amino alcohols

Caldwell, N., Jamieson, C., Simpson, I. & Tuttle, T., 17 May 2013, In : Organic Letters. 15, 10, p. 2506-2509 4 p.

Research output: Contribution to journalArticle

Amino Alcohols
esters
Esters
alcohols
optimization
6 Citations (Scopus)
38 Downloads (Pure)

Palladium-catalyzed synthesis of aryl amides through silanoate-mediated hydrolysis of nitriles

McPherson, C. G., Livingstone, K., Jamieson, C. & Simpson, I., 4 Jan 2016, In : Synlett. 27, 1, p. 88-92 5 p.

Research output: Contribution to journalArticle

Open Access
File
Imidoesters
Nitriles
Palladium
Bromides
Amides

Photocatalytic E→Z Isomerization of β-Ionyl Derivatives

Livingstone, K., Tenberge, M., Pape, F., Daniliuc, C. G., Jamieson, C. & Gilmour, R., 6 Dec 2019, In : Organic Letters. 21, 23, p. 9677-9680 4 p.

Research output: Contribution to journalArticle

Riboflavin
Isomerization
isomerization
Derivatives
riboflavin
28 Citations (Scopus)
210 Downloads (Pure)

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor

Grove, S. J. A., Jamieson, C., Maclean, J. K. F., Morrow, J. A. & Rankovic, Z., 2010, In : Journal of Medicinal Chemistry. 53, 20, p. 7271-7279 8 p.

Research output: Contribution to journalArticle

Open Access
File
AMPA Receptors
Glutamic Acid
Acids
Ligand-Gated Ion Channels
Ionotropic Glutamate Receptors
7 Citations (Scopus)
10 Downloads (Pure)

Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

Campbell, P. S., Jamieson, C., Simpson, I. & Watson, A. J. B., 27 Nov 2017, In : Chemical Communications (London). 4 p.

Research output: Contribution to journalArticle

Open Access
File
Hydrogenation
Drug Discovery
Molecules
Bioactivity
Lead
7 Citations (Scopus)
94 Downloads (Pure)

Rational design of a novel AMPA receptor modulator through a hybridization approach

Caldwell, N., Harms, J. E., Partin, K. M. & Jamieson, C., 2015, In : ACS Medicinal Chemistry Letters .

Research output: Contribution to journalArticle

Open Access
File
AMPA Receptors
Modulators
Ligands
Ion Channels
Synaptic Transmission
8 Citations (Scopus)
16 Downloads (Pure)

Rational design of autotaxin inhibitors by structural evolution of endogenous modulators

Keune, W-J., Potjewyd, F., Heidebrecht, T., Salgado-Polo, F., Macdonald, S. J. F., Chelvarajan, L., Abdel Latif, A., Soman, S., Morris, A. J., Watson, A. J. B., Jamieson, C. & Perrakis, A., 9 Mar 2017, In : Journal of Medicinal Chemistry. 60, 5, p. 2006-2017 12 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Discovery
Biological Products
Bile Acids and Salts
Catalytic Domain
Pathology
6 Citations (Scopus)
165 Downloads (Pure)

Regiospecific synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles via photochemically generated nitrile imine intermediates

Stewart, S., Harris, R. & Jamieson, C., 2014, In : Synlett. 25, 17, p. 2480-2484 5 p.

Research output: Contribution to journalArticle

Open Access
File
Tetrazoles
Nitriles
Triazoles
Imines
Derivatives
32 Citations (Scopus)
386 Downloads (Pure)

Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A., 2012, In : Green Chemistry. 14, 11, p. 3016-3019 4 p.

Research output: Contribution to journalArticle

Open Access
File
Methylene Chloride
Dichloromethane
Purification
purification
replacement
56 Downloads (Pure)

Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine

Littleson, M. M., Baker, C. M., Dalencon, A. J., Frye, E. C., Jamieson, C., Kennedy, A. R., Ling, K. B., McLachlan, M. M., Montgomery, M. G., Russell, C. J. & Watson, A. J. B., 13 Feb 2018, (Accepted/In press) In : Nature Communications. 14 p.

Research output: Contribution to journalArticle

Open Access
File
Agrochemicals
synthesis
Biological Products
Libraries
acids
29 Citations (Scopus)
349 Downloads (Pure)

Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

Wilson, K., Kennedy, A., Murray, J., Greatex, B., Jamieson, C. & Watson, A., 8 Sep 2016, In : Beilstein Journal of Organic Chemistry . 12, p. 2005-2011 7 p.

Research output: Contribution to journalArticle

Open Access
File
Agrochemicals
Pharmaceutical Preparations
Industry
9 Citations (Scopus)
46 Downloads (Pure)

Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening

Borthwick, J. A., Ancellin, N., Bertrand, S. M., Bingham, R. P., Carter, P. S., Chung, C., Churcher, I., Dodic, N., Fournier, C., Francis, P. L., Hobbs, A., Jamieson, C., Pickett, S. D., Smith, S. E., Somers, D. ON., Spitzfaden, C., Suckling, C. J. & Young, R. J., 24 Mar 2016, In : Journal of Medicinal Chemistry. 59, 6, p. 2452-2467 16 p.

Research output: Contribution to journalArticle

Open Access
File
X Ray Crystallography
Sexually Transmitted Diseases
Solubility
Screening
Hot Temperature
11 Citations (Scopus)
37 Downloads (Pure)

Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding mode

Miller, L. M., Keune, W-J., Castagna, D., Young, L. C., Duffy, E. L., Potjewyd, F., Salgado-Polo, F., Garcia, P. E., Semaan, D., Pritchard, J. M., Perrakis, A., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 722-748 27 p.

Research output: Contribution to journalArticle

Open Access
File
Structure-Activity Relationship
Lysophosphatidylcholines
Enzymes
Choline
Cell Movement
26 Citations (Scopus)
100 Downloads (Pure)

Structure based evolution of a novel series of positive modulators of the AMPA receptor

Jamieson, C., Maclean, J. K. F., Brown, C. I., Campbell, R. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., LAMONT, YVONNE., Lyons, A. J., Moir, E. M., Morrow, J. A., Pantling, J., Rankovic, Z. & Smith, L., 15 Jan 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 2, p. 805-811 7 p.

Research output: Contribution to journalArticle

Open Access
File
AMPA Receptors
Modulators
7 Citations (Scopus)
33 Downloads (Pure)

Surface functionalization with carboxylic acids by photochemical microcontact printing and tetrazole chemistry

Buten, C., Lamping, S., Korsgen, M., Arlinghaus, H. F., Jamieson, C. & Ravoo, B. J., 16 Jan 2018, In : Langmuir. 17 p.

Research output: Contribution to journalArticle

Open Access
File
tetrazoles
Carboxylic Acids
Carboxylic acids
carboxylic acids
printing
28 Citations (Scopus)
481 Downloads (Pure)

Synthesis of the originally proposed structures of elatenyne and an enyne from Laurencia majuscula

Sheldrake, H. M., Jamieson, C., Pascu, S. I. & Burton, J. W., 2009, In : Organic and Biomolecular Chemistry. 7, 2, p. 238-252 15 p.

Research output: Contribution to journalArticle

Open Access
File
Laurencia
Chemical shift
Biological Products
chemical equilibrium
Nuclear magnetic resonance
1 Citation (Scopus)
140 Downloads (Pure)

Synthetic approaches to coronafacic acid, coronamic acid, and coronatine

Littleson, M. M., Russell, C. J., Frye, E. C., Ling, K. B., Jamieson, C. & Watson, A. J. B., 15 Aug 2016, In : Synthesis. 48, 20 p.

Research output: Contribution to journalArticle

Open Access
File
Acids
Agrochemicals
Plant Growth Regulators
Isoleucine
Bioactivity
16 Citations (Scopus)

The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits

Bertrand, S. M., Ancellin, N., Beaufils, B., Bingham, R. P., Borthwick, J. A., Boullay, A. B., Boursier, E., Carter, P. S., Chung, C. W., Churcher, I., Dodic, N., Fouchet, M. H., Fournier, C., Francis, P. L., Gummer, L. A., Herry, K., Hobbs, A., Hobbs, C. I., Homes, P., Jamieson, C. & 12 others, Nicodeme, E., Pickett, S. D., Reid, I. H., Simpson, G. L., Sloan, L. A., Smith, S. E., Somers, D. O. N., Spitzfaden, C., Suckling, C. J., Valko, K., Washio, Y. & Young, R. J., 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7140-7163 24 p.

Research output: Contribution to journalArticle

Pyrimidinones
Branched Chain Amino Acids
Pharmacokinetics
Isoleucine
Valine