Research Output per year
Research Output 2008 2019
2019
A fragment-like approach to PYCR1 inhibition
Milne, K., Sun, J., Zaal, E. A., Mowat, J., Celie, P. H. N., Fish, A., Berkers, C. R., Forlani, G., Loayza-Puch, F., Jamieson, C. & Agami, R., 25 Jul 2019, In : Bioorganic and Medicinal Chemistry Letters .Research output: Contribution to journal › Article
Pyrroline Carboxylate Reductases
Oxidoreductases
Proline
Pargyline
Neoplasms
A reappraisal of the Ni-[(Benzylprolyl)amino]benzophenone complex in the synthesis of α,α-disubstituted amino acid derivatives
Watson, M. E., Jamieson, C., Kennedy, A. R. & Mason, A. M., 27 Jul 2019, In : Tetrahedron.Research output: Contribution to journal › Article
Proline
Derivatives
Amino Acids
Peptides
Erosion
2018
Atom efficient synthesis of selectively difluorinated carbocycles through a gold(I) catalyzed cyclization
McCarter, A. W., Sommer, M., Percy, J. M., Jamieson, C., Kennedy, A. R. & Hirst, D. J., 6 Jul 2018, In : Journal of Organic Chemistry.Research output: Contribution to journal › Article
Open Access
File
Acetals
Cyclization
Gold
Bearings (structural)
Trifluoroethanol
Cyrene as a bio-based solvent for HATU mediated amide coupling
Wilson, K. L., Murray, J., Jamieson, C. & Watson, A. J. B., 28 Apr 2018, In : Organic and Biomolecular Chemistry. 16, p. 2851-2854 4 p.Research output: Contribution to journal › Article
Open Access
File
Amides
amides
Dipeptides
Drug Discovery
synthesis
Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine
Littleson, M. M., Baker, C. M., Dalencon, A. J., Frye, E. C., Jamieson, C., Kennedy, A. R., Ling, K. B., McLachlan, M. M., Montgomery, M. G., Russell, C. J. & Watson, A. J. B., 13 Feb 2018, (Accepted/In press) In : Nature Communications. 14 p.Research output: Contribution to journal › Article
Open Access
File
Agrochemicals
Structure-Activity Relationship
synthesis
Biological Products
Libraries
Surface functionalization with carboxylic acids by photochemical microcontact printing and tetrazole chemistry
Buten, C., Lamping, S., Korsgen, M., Arlinghaus, H. F., Jamieson, C. & Ravoo, B. J., 16 Jan 2018, In : Langmuir. 17 p.Research output: Contribution to journal › Article
Open Access
File
tetrazoles
Carboxylic Acids
Carboxylic acids
carboxylic acids
printing
2017
Amidation of unactivated ester derivatives mediated by trifluoroethanol
McPherson, C. G., Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 4 Apr 2017, In : Organic and Biomolecular Chemistry. 12 p.Research output: Contribution to journal › Article
Open Access
File
Trifluoroethanol
Amines
esters
amines
Esters
A multicomponent route to functionalized amides and oxazolidinones
McPherson, C. G., Cooper, A. K., Bubliauskas, A., Mulrainey, P., Jamieson, C. & Watson, A. J. B., 1 Dec 2017, In : Organic Letters. 4 p.Research output: Contribution to journal › Letter
Open Access
File
Oxazolidinones
epoxy compounds
Epoxy Compounds
Amides
amides
Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrins
Miller, L. M., Pritchard, J. M., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 30 Jan 2017, In : Journal of Medicinal Chemistry. 60, 8, 11 p.Research output: Contribution to journal › Article
Open Access
File
Integrins
Pharmacology
Molecules
Aspartic Acid
Thrombosis
One-pot, three-step synthesis of cyclopropylboronic acid pinacol esters from synthetically tractable propargylic silyl ethers
Spencer, J. A., Jamieson, C. & Talbot, E. P. A., 6 Jul 2017, In : Organic Letters. 4 p.Research output: Contribution to journal › Article
Open Access
File
Ethers
esters
ethers
Esters
Lewis Acids
Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character
Campbell, P. S., Jamieson, C., Simpson, I. & Watson, A. J. B., 27 Nov 2017, In : Chemical Communications (London). 4 p.Research output: Contribution to journal › Article
Open Access
File
Hydrogenation
Drug Discovery
Molecules
Bioactivity
Lead
Rational design of autotaxin inhibitors by structural evolution of endogenous modulators
Keune, W-J., Potjewyd, F., Heidebrecht, T., Salgado-Polo, F., Macdonald, S. J. F., Chelvarajan, L., Abdel Latif, A., Soman, S., Morris, A. J., Watson, A. J. B., Jamieson, C. & Perrakis, A., 9 Mar 2017, In : Journal of Medicinal Chemistry. 60, 5, p. 2006-2017 12 p.Research output: Contribution to journal › Article
Open Access
File
Drug Discovery
Biological Products
Bile Acids and Salts
Catalytic Domain
Pathology
Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding mode
Miller, L. M., Keune, W-J., Castagna, D., Young, L. C., Duffy, E. L., Potjewyd, F., Salgado-Polo, F., Garcia, P. E., Semaan, D., Pritchard, J. M., Perrakis, A., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 722-748 27 p.Research output: Contribution to journal › Article
Open Access
File
Structure-Activity Relationship
Lysophosphatidylcholines
Enzymes
Choline
Cell Movement
2016
Evolution of a novel orally bioavailable series of PI3Kδ inhibitors from an inhaled lead for the treatment of respiratory disease.
Amour, A., Barton, N., Cooper, A. W. J., Inglis, G., Jamieson, C., Luscombe, C. N., Perez, D., Peace, S., Rowland, P., Tame, C., Uddin, S., Vitulli, G. & Wellaway, N., 18 Jul 2016, In : Journal of Medicinal Chemistry. 34 p.Research output: Contribution to journal › Article
Open Access
File
Phosphatidylinositol 3-Kinases
Growth
Lead
Investigation of a bicyclo[1.1.1]pentane as a phenyl replacement within an LpPLA2 inhibitor
Measom, N., Down, K. D., Hirst, D. J., Jamieson, C., Manas, E. S., Patel, V. K. & Somers, D. O., 15 Nov 2016, In : ACS Medicinal Chemistry Letters . 7, 6 p.Research output: Contribution to journal › Article
Open Access
File
X-Rays
X rays
dichlorocarbene
butane
pentane
Palladium-catalyzed synthesis of aryl amides through silanoate-mediated hydrolysis of nitriles
McPherson, C. G., Livingstone, K., Jamieson, C. & Simpson, I., 4 Jan 2016, In : Synlett. 27, 1, p. 88-92 5 p.Research output: Contribution to journal › Article
Open Access
File
Imidoesters
Nitriles
Palladium
Bromides
Amides
Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
Wilson, K., Kennedy, A., Murray, J., Greatex, B., Jamieson, C. & Watson, A., 8 Sep 2016, In : Beilstein Journal of Organic Chemistry . 12, p. 2005-2011 7 p.Research output: Contribution to journal › Article
Open Access
File
Agrochemicals
Pharmaceutical Preparations
Industry
Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening
Borthwick, J. A., Ancellin, N., Bertrand, S. M., Bingham, R. P., Carter, P. S., Chung, C., Churcher, I., Dodic, N., Fournier, C., Francis, P. L., Hobbs, A., Jamieson, C., Pickett, S. D., Smith, S. E., Somers, D. ON., Spitzfaden, C., Suckling, C. J. & Young, R. J., 24 Mar 2016, In : Journal of Medicinal Chemistry. 59, 6, p. 2452-2467 16 p.Research output: Contribution to journal › Article
Open Access
File
X Ray Crystallography
Sexually Transmitted Diseases
Solubility
Screening
Hot Temperature
Synthetic approaches to coronafacic acid, coronamic acid, and coronatine
Littleson, M. M., Russell, C. J., Frye, E. C., Ling, K. B., Jamieson, C. & Watson, A. J. B., 15 Aug 2016, In : Synthesis. 48, 20 p.Research output: Contribution to journal › Article
Open Access
File
Acids
Agrochemicals
Plant Growth Regulators
Isoleucine
Bioactivity
2015
Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol
Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 11 Jun 2015, In : Chemical Communications. 51, 46, p. 9495-9498 4 p.Research output: Contribution to journal › Article
Open Access
File
Trifluoroethanol
Esters
Derivatives
Amides
Amines
Identification of a novel class of autotaxin inhibitors through cross-screening
Castagna, D., Duffy, E. L., Semaan, D., Young, L. C., Pritchard, J. M., Macdonald, S. J. F., Budd, D. C., Jamieson, C. & Watson, A. J. B., 1 Jun 2015, In : MedChemComm. 2015, 6, p. 1149-1155 6 p.Research output: Contribution to journal › Article
Open Access
File
Lysophosphatidic Acid Receptors
Lead compounds
Screening
Blood
Solubility
Rational design of a novel AMPA receptor modulator through a hybridization approach
Caldwell, N., Harms, J. E., Partin, K. M. & Jamieson, C., 2015, In : ACS Medicinal Chemistry Letters .Research output: Contribution to journal › Article
Open Access
File
AMPA Receptors
Modulators
Ligands
Ion Channels
Synaptic Transmission
The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits
Bertrand, S. M., Ancellin, N., Beaufils, B., Bingham, R. P., Borthwick, J. A., Boullay, A. B., Boursier, E., Carter, P. S., Chung, C. W., Churcher, I., Dodic, N., Fouchet, M. H., Fournier, C., Francis, P. L., Gummer, L. A., Herry, K., Hobbs, A., Hobbs, C. I., Homes, P., Jamieson, C. & 12 others, 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7140-7163 24 p.Research output: Contribution to journal › Article
Pyrimidinones
Branched Chain Amino Acids
Pharmacokinetics
Isoleucine
Valine
2014
Amidation of esters with amino alcohols using organobase catalysis
Caldwell, N., Campbell, P. S., Jamieson, C., Potjewyd, F., Simpson, I. & Watson, A. J. B., 3 Oct 2014, In : Journal of Organic Chemistry. 79, 19, p. 9347-9354 8 p.Research output: Contribution to journal › Article
Open Access
File
Amino Alcohols
Oxazolidinones
Transesterification
Catalysis
Esters
Molar efficiency: a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry
McGonagle, F. I., Sneddon, H. F., Jamieson, C. & Watson, A., 3 Mar 2014, In : ACS Sustainable Chemistry and Engineering. 2, 3, p. 523-532 10 p.Research output: Contribution to journal › Article
Gages
gauge
Pharmaceutical Chemistry
calculation
comparison
Regiospecific synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles via photochemically generated nitrile imine intermediates
Stewart, S., Harris, R. & Jamieson, C., 2014, In : Synlett. 25, 17, p. 2480-2484 5 p.Research output: Contribution to journal › Article
Open Access
File
Tetrazoles
Nitriles
Triazoles
Imines
Derivatives
2013
Development of a solvent selection guide for aldehyde-based direct reductive amination processes
McGonagle, F. I., MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A. J. B., 1 May 2013, In : Green Chemistry. 15, 5, p. 1159-1165 7 p.Research output: Contribution to journal › Article
Amination
aldehyde
Aldehydes
Boranes
Reducing Agents
Development of a sustainable catalytic ester amidation process
Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 7 Oct 2013, In : ACS Sustainable Chemistry and Engineering. 1, 10, p. 1339-1344 6 p.Research output: Contribution to journal › Article
Open Access
File
ester
alcohol
Esters
Amino alcohols
Amino Alcohols
Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide
MacMillan, D., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A., 2013, In : Green Chemistry. 15, 3, p. 596-600 5 p.Research output: Contribution to journal › Article
Open Access
File
Dimethylformamide
Methylene Chloride
Dichloromethane
Amides
replacement
Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy
Harms, J. E., Benveniste, M., Maclean, J. K. F., Partin, K. M. & Jamieson, C., Jan 2013, In : Neuropharmacology. 64, p. 45-52 8 p.Research output: Contribution to journal › Article
AMPA Receptors
Drug Design
Benzamides
Nootropic Agents
Isoxazoles
Organobase-catalyzed amidation of esters with amino alcohols
Caldwell, N., Jamieson, C., Simpson, I. & Tuttle, T., 17 May 2013, In : Organic Letters. 15, 10, p. 2506-2509 4 p.Research output: Contribution to journal › Article
Amino Alcohols
esters
Esters
alcohols
optimization
2012
AMPA receptor positive modulators
Jamieson, C., Morrow, J. & Maclean, J., Jul 2012, Targets and Emerging Therapies for Schizophrenia. Albert, J. & Wood, M. (eds.). 1 ed. Hoboken, NJ, p. 187-231 44 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents
MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A., 2012, In : Green Chemistry. 14, 11, p. 3016-3019 4 p.Research output: Contribution to journal › Article
Open Access
File
Methylene Chloride
Dichloromethane
Purification
purification
replacement
2011
Amino-heteroaryl derivatives as HCN blockers
Grove, S. J. A., Morrison, A. J., Jamieson, C., Palin, R. & Maclean, J. K. F., 30 Jun 2011, IPC No. PCT/EP2010/070213, Patent No. WO2011076723A1Research output: Patent
Salts
Pain
Guanidine
Neuralgia
Amines
Structure based evolution of a novel series of positive modulators of the AMPA receptor
Jamieson, C., Maclean, J. K. F., Brown, C. I., Campbell, R. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., LAMONT, YVONNE., Lyons, A. J., Moir, E. M., Morrow, J. A., Pantling, J., Rankovic, Z. & Smith, L., 15 Jan 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 2, p. 805-811 7 p.Research output: Contribution to journal › Article
Open Access
File
AMPA Receptors
Modulators
2010
A novel series of positive modulators of the AMPA receptor: structure-based lead optimization
Jamieson, C., Campbell, R. A., Cumming, I. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A. J., Maclean, J. K. F., Martin, F., Moir, E. M., Morrow, J. A., Pantling, J., Rankovic, Z. & Smith, L., 15 Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6072-6075 4 p.Research output: Contribution to journal › Article
Open Access
File
AMPA Receptors
Modulators
Biological Availability
Lead compounds
X-Rays
A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies
Jamieson, C., Basten, S., Campbell, R. A., Cumming, I. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A. J., Maclean, J. K. F., Moir, E. M., Morrow, J. A., Papakosta, M., Rankovic, Z. & Smith, L., 1 Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 19, p. 5753-5756 4 p.Research output: Contribution to journal › Article
Open Access
File
AMPA Receptors
Drug Design
Glutamate Receptors
Modulators
Demonstrations
Dioxo-triazines as a novel series of cathepsin K inhibitors
Rankovic, Z., Cai, J., Fradera, X., Dempster, M., Mistry, A., Long, C., Hamilton, E., King, A., Boucharens, S., Jamieson, C., Gillespie, J., Cumming, I., Uitdehaag, J. & van Zeeland, M., 1 Mar 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1488-1490 3 p.Research output: Contribution to journal › Article
Cathepsin K
Triazines
Inhibitory Concentration 50
Assays
Cats
6
Citations
(Scopus)
High throughput screening approach to lead discovery
Rankovic, Z., Jamieson, C. & Morphy, R., 2010, Lead Generation Approaches in Drug Discovery. Hoboken, NJ, p. 21-71 51 p.Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution
High-Throughput Screening Assays
Equipment and Supplies
Lead
Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor
Grove, S. J. A., Jamieson, C., Maclean, J. K. F., Morrow, J. A. & Rankovic, Z., 2010, In : Journal of Medicinal Chemistry. 53, 20, p. 7271-7279 8 p.Research output: Contribution to journal › Article
Open Access
File
AMPA Receptors
Glutamic Acid
Acids
Ligand-Gated Ion Channels
Ionotropic Glutamate Receptors
Preparation of indane derivatives for treating and preventing psychiatric diseases.
Gillen, K. J., Gillespie, J., Jamieson, C., MacLean, J. K. F., Moir, E. M. & Rankovic, Z., 14 Oct 2010, Patent No. WO2010115952A1Research output: Patent
AMPA Receptors
Psychiatry
Schizophrenia
Alzheimer Disease
Salts
2009
Heterocyclic derivatives.
Gallagher, M. G., Jamieson, C. C., Lyons, A. J., MacLean, J. K. F. & Moir, E. M., 21 May 2009, Patent No. US20090131455A1Research output: Patent
AMPA Receptors
Learning Disorders
Memory Disorders
Psychiatry
Schizophrenia
Preparation of indane derivatives as AMPA receptor modulators.
Gillespie, J., Jamieson, C., Maclean, J. K. F., Moir, E. M. & Rankovic, Z., 10 Dec 2009, Patent No. WO2009147167A1Research output: Patent
AMPA Receptors
Bromine
Carbon Monoxide
Psychiatry
Schizophrenia
Synthesis of the originally proposed structures of elatenyne and an enyne from Laurencia majuscula
Sheldrake, H. M., Jamieson, C., Pascu, S. I. & Burton, J. W., 2009, In : Organic and Biomolecular Chemistry. 7, 2, p. 238-252 15 p.Research output: Contribution to journal › Article
Open Access
File
Laurencia
Chemical shift
Biological Products
chemical equilibrium
Nuclear magnetic resonance
2008
Preparation of pyrazolealkanamide substituted thiophenes as AMPA potentiators.
Gillen, K. J., Jamieson, C., Maclean, J. K. F., Moir, E. M. & Rankovic, Z., 10 Jan 2008, Patent No. WO2008003452A1Research output: Patent
Thiophenes
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Salts
Modulation
Psychiatry
Strategy and tactics for hERG optimizations
Jamieson, C., Moir, E. M., Rankovic, Z. & Wishart, G., Jan 2008, Antitargets: Prediction and Prevention of Drug Side Effects. Vaz, R. J. & Klabunde, T. (eds.). Weinheim, Germany, Vol. 38. p. 423-455 33 p. (Methods and Principles in Medicinal Chemistry).Research output: Chapter in Book/Report/Conference proceeding › Chapter
ethers
genes