Research output per year
Research output per year
- 1 - 50 out of 68 results
Search results
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2023
Computer vision as a new paradigm for monitoring of solution and solid phase peptide synthesis
Yan, C., Fyfe, C., Minty, L., Barrington, H., Jamieson, C. & Reid, M., 21 Nov 2023, In: Chemical Science. 14, 42, p. 11872-11880 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
Synthesis and evaluation of small molecule inhibitors of the androgen receptor N-terminal domain
Henry, M. C., Riley, C. M., Hunter, I., Elwood, J. M. L., Lopez-Fernandez, J. D., Minty, L., Coe, D. M., McEwan, I. J. & Jamieson, C., 17 Nov 2023, (E-pub ahead of print) In: ACS Medicinal Chemistry Letters . 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Current and emerging approaches to noncompetitive AR inhibition
Riley, C. M., Elwood, J. M. L., Henry, M. C., Hunter, I., Lopez-Fernandez, J. D., McEwan, I. J. & Jamieson, C., 30 Sept 2023, In: Medicinal Research Reviews . 43, 5, p. 1701-1747 47 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
Multigram-scale synthesis of a gem-difluoro-substituted 4,5,6,7-tetrahydrobenzo[c]thiophen-4-one heterocycle via oxidative chlorination and radical Smiles rearrangement
Henry, M. C., Anderson, J. Q. & Jamieson, C., 27 Sept 2023, (E-pub ahead of print) In: Synlett. 34, 6 p.Research output: Contribution to journal › Article › peer-review
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2022
Functionalized tetrazoles as latent active esters in the synthesis of amide bonds
Elwood, J. M. L., Henry, M. C., Lopez-Fernandez, J. D., Mowat, J. M., Boyle, M., Buist, B., Livingstone, K. & Jamieson, C., 16 Dec 2022, (E-pub ahead of print) In: Organic Letters. 24, 51, p. 9491-9496 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)14 Downloads (Pure) -
Identification and optimization of a ligand-efficient benzoazepinone bromodomain and extra terminal (BET) family acetyl-lysine mimetic into the oral candidate quality molecule I-BET432
Humphreys, P. G., Anderson, N. A., Bamborough, P., Baxter, A., Chung, C., Cookson, R., Craggs, P. D., Dalton, T., Fournier, J. C. L., Gordon, L. J., Gray, H. F., Gray, M. W., Gregory, R., Hirst, D. J., Jamieson, C., Jones, K. L., Kessedjian, H., Lugo, D., McGonagle, G., Patel, V. K., & 15 others, 24 Nov 2022, In: Journal of Medicinal Chemistry. 65, 22, p. 15174-15207 34 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)1 Downloads (Pure) -
Author correction: Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
Kay, E. J., Paterson, K., Riera-Domingo, C., Sumpton, D., Däbritz, J. H. M., Tardito, S., Boldrini, C., Hernandez-Fernaud, J. R., Athineos, D., Dhayade, S., Stepanova, E., Gjerga, E., Neilson, L. J., Lilla, S., Hedley, A., Koulouras, G., McGregor, G., Jamieson, C., Johnson, R. M., Park, M., & 9 others, 4 Aug 2022, In: Nature metabolism. 4, 8, p. 1084-1084 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
A type IV Autotaxin inhibitor ameliorates acuteliver injury and nonalcoholic steatohepatitis
Booijink, R., Salgado-Polo, F., Jamieson, C., Perrakis, A. & Bansal, R., 14 Jul 2022, In: EMBO Molecular Medicine. 14, 9, 18 p., e16333.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)9 Downloads (Pure) -
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
Kay, E. J., Paterson, K., Riero-Domingo, C., Sumpton, D., Däbritz, J. H. M., Tardito, S., Boldrini, C., Hernandez-Fernaud, J. R., Athineos, D., Dhayade, S., Stepanova, E., Gjerga, E., Neilson, L. J., Lilla, S., Hedley, A., Koulouras, G., McGregor, G., Jamieson, C., Johnson, R. M., Park, M., & 9 others, 27 Jun 2022, In: Nature metabolism. 4, 6, p. 693-710 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)13 Downloads (Pure) -
Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators
Clark, J. M., Salgado-Polo, F., Macdonald, S. J. F., Barrett, T. N., Perrakis, A. & Jamieson, C., 28 Apr 2022, In: Journal of Medicinal Chemistry. 65, 8, p. 6338–6351 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)6 Downloads (Pure) -
Amide bond formation via the rearrangement of nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides
Boyle, M., Livingstone, K., Henry, M. C., Elwood, J. M. L., Lopez Fernandez, J. D. & Jamieson, C., 14 Jan 2022, In: Organic Letters. 24, 1, p. 334-338 5 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile6 Citations (Scopus)28 Downloads (Pure) -
2021
Synthesis of an allylic gem-difluoromethylene building block via radical-mediated difluorocyclopropane ring opening
Milne, K., Henry, M. C. & Jamieson, C., 28 Sept 2021, In: Tetrahedron Letters. 81, 4 p., 153344.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)14 Downloads (Pure) -
Recent advances in the generation of nitrilium betaine 1,3-dipoles
Livingstone, K., Little, G. & Jamieson, C., 20 Jul 2021, In: Synthesis. 53, 14, p. 2399-2407 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)7 Downloads (Pure) -
2020
Ruthenium-catalyzed ester reductions applied to pharmaceutical intermediates
Shaalan, Y., Boulton, L. & Jamieson, C., 20 Nov 2020, In: Organic Process Research and Development. 24, 11, p. 2745-2751 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)21 Downloads (Pure) -
UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow
Green, L., Livingstone, K., Bertrand, S., Peace, S. & Jamieson, C., 20 Nov 2020, In: Chemistry - A European Journal. 26, 65, p. 14866-14870 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)41 Downloads (Pure) -
Transition metal-free coupling of 1,3-dipoles and boronic acids as a sustainable approach to C-C bond formation
Livingstone, K., Bertrand, S., Kennedy, A. R. & Jamieson, C., 17 Aug 2020, In: Chemistry - A European Journal. 26, 46, p. 10591-10597 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)43 Downloads (Pure) -
Design and development of a macrocyclic series targeting phosphoinositide 3-kinase δ
Spencer, J. A., Baldwin, I. R., Barton, N., Chung, C-W., Convery, M. A., Edwards, C. D., Jamieson, C., Mallett, D. N., Rowedder, J. E., Rowland, P., Thomas, D. A. & Hardy, C. J., 9 Jul 2020, In: ACS Medicinal Chemistry Letters . 11, 7, p. 1386-1391 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)6 Downloads (Pure) -
A one-pot Suzuki-hydrogenolysis protocol for the modular synthesis of 2,5-diaryltetrazoles
Livingstone, K., Bertrand, S. & Jamieson, C., 5 Jun 2020, In: Journal of Organic Chemistry. 85, 11, p. 7413-7423 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)18 Downloads (Pure) -
The Nitrile Imine 1,3-Dipole: Properties, Reactivity and Applications
Jamieson, C. & Livingstone, K., 26 Mar 2020, Cham, Switzerland: Springer Nature. 166 p.Research output: Book/Report › Book
25 Citations (Scopus) -
Design, synthesis and evaluation of E2-25K derived stapled peptides
Watson, M. E., Scott, D., Jamieson, C., Layfield, R. & Mason, A. M., 24 Mar 2020, (E-pub ahead of print) In: Peptide Science. 10 p., e24158.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)8 Downloads (Pure) -
2019
Photocatalytic E→Z Isomerization of β-Ionyl Derivatives
Livingstone, K., Tenberge, M., Pape, F., Daniliuc, C. G., Jamieson, C. & Gilmour, R., 6 Dec 2019, In: Organic Letters. 21, 23, p. 9677-9680 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)63 Downloads (Pure) -
Metal free C-C bond formation via coupling of nitrile imines and boronic acids
Livingstone, K., Betrand, S., Mowat, J. & Jamieson, C., 28 Nov 2019, In: Chemical Science. 10, 44, p. 10412-10416 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)103 Downloads (Pure) -
A fragment-like approach to PYCR1 inhibition
Milne, K., Sun, J., Zaal, E. A., Mowat, J., Celie, P. H. N., Fish, A., Berkers, C. R., Forlani, G., Loayza-Puch, F., Jamieson, C. & Agami, R., 15 Sept 2019, In: Bioorganic and Medicinal Chemistry Letters . 29, 18, p. 2626-2631 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)32 Downloads (Pure) -
A reappraisal of the Ni-[(Benzylprolyl)amino]benzophenone complex in the synthesis of α,α-disubstituted amino acid derivatives
Watson, M. E., Jamieson, C., Kennedy, A. R. & Mason, A. M., 6 Sept 2019, In: Tetrahedron. 75, 36, 130485.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)16 Downloads (Pure) -
2018
Atom efficient synthesis of selectively difluorinated carbocycles through a gold(I) catalyzed cyclization
McCarter, A. W., Sommer, M., Percy, J. M., Jamieson, C., Kennedy, A. R. & Hirst, D. J., 6 Jul 2018, (E-pub ahead of print) In: Journal of Organic Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)8 Downloads (Pure) -
Cyrene as a bio-based solvent for HATU mediated amide coupling
Wilson, K. L., Murray, J., Jamieson, C. & Watson, A. J. B., 28 Apr 2018, In: Organic and Biomolecular Chemistry. 16, p. 2851-2854 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)25 Downloads (Pure) -
Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine
Littleson, M. M., Baker, C. M., Dalencon, A. J., Frye, E. C., Jamieson, C., Kennedy, A. R., Ling, K. B., McLachlan, M. M., Montgomery, M. G., Russell, C. J. & Watson, A. J. B., 13 Feb 2018, (Accepted/In press) In: Nature Communications. 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Downloads (Pure) -
Surface functionalization with carboxylic acids by photochemical microcontact printing and tetrazole chemistry
Buten, C., Lamping, S., Korsgen, M., Arlinghaus, H. F., Jamieson, C. & Ravoo, B. J., 16 Jan 2018, (E-pub ahead of print) In: Langmuir. 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)290 Downloads (Pure) -
2017
A multicomponent route to functionalized amides and oxazolidinones
McPherson, C. G., Cooper, A. K., Bubliauskas, A., Mulrainey, P., Jamieson, C. & Watson, A. J. B., 1 Dec 2017, In: Organic Letters. 4 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile8 Citations (Scopus)20 Downloads (Pure) -
Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character
Campbell, P. S., Jamieson, C., Simpson, I. & Watson, A. J. B., 27 Nov 2017, (E-pub ahead of print) In: Chemical Communications (London). 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)20 Downloads (Pure) -
One-pot, three-step synthesis of cyclopropylboronic acid pinacol esters from synthetically tractable propargylic silyl ethers
Spencer, J. A., Jamieson, C. & Talbot, E. P. A., 6 Jul 2017, (E-pub ahead of print) In: Organic Letters. 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)276 Downloads (Pure) -
Amidation of unactivated ester derivatives mediated by trifluoroethanol
McPherson, C. G., Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 4 Apr 2017, In: Organic and Biomolecular Chemistry. 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)23 Downloads (Pure) -
Rational design of autotaxin inhibitors by structural evolution of endogenous modulators
Keune, W-J., Potjewyd, F., Heidebrecht, T., Salgado-Polo, F., Macdonald, S. J. F., Chelvarajan, L., Abdel Latif, A., Soman, S., Morris, A. J., Watson, A. J. B., Jamieson, C. & Perrakis, A., 9 Mar 2017, In: Journal of Medicinal Chemistry. 60, 5, p. 2006-2017 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)39 Downloads (Pure) -
Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrins
Miller, L. M., Pritchard, J. M., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 30 Jan 2017, In: Journal of Medicinal Chemistry. 60, 8, 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)190 Downloads (Pure) -
Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding mode
Miller, L. M., Keune, W-J., Castagna, D., Young, L. C., Duffy, E. L., Potjewyd, F., Salgado-Polo, F., Garcia, P. E., Semaan, D., Pritchard, J. M., Perrakis, A., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 26 Jan 2017, In: Journal of Medicinal Chemistry. 60, 2, p. 722-748 27 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)67 Downloads (Pure) -
2016
Investigation of a bicyclo[1.1.1]pentane as a phenyl replacement within an LpPLA2 inhibitor
Measom, N., Down, K. D., Hirst, D. J., Jamieson, C., Manas, E. S., Patel, V. K. & Somers, D. O., 15 Nov 2016, In: ACS Medicinal Chemistry Letters . 7, 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile125 Citations (Scopus)84 Downloads (Pure) -
Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
Wilson, K., Kennedy, A., Murray, J., Greatex, B., Jamieson, C. & Watson, A., 8 Sept 2016, In: Beilstein Journal of Organic Chemistry . 12, p. 2005-2011 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Citations (Scopus)395 Downloads (Pure) -
Synthetic approaches to coronafacic acid, coronamic acid, and coronatine
Littleson, M. M., Russell, C. J., Frye, E. C., Ling, K. B., Jamieson, C. & Watson, A. J. B., 15 Aug 2016, (E-pub ahead of print) In: Synthesis. 48, 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)154 Downloads (Pure) -
Evolution of a novel orally bioavailable series of PI3Kδ inhibitors from an inhaled lead for the treatment of respiratory disease.
Amour, A., Barton, N., Cooper, A. W. J., Inglis, G., Jamieson, C., Luscombe, C. N., Perez, D., Peace, S., Rowland, P., Tame, C., Uddin, S., Vitulli, G. & Wellaway, N., 18 Jul 2016, (E-pub ahead of print) In: Journal of Medicinal Chemistry. 34 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)95 Downloads (Pure) -
Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening
Borthwick, J. A., Ancellin, N., Bertrand, S. M., Bingham, R. P., Carter, P. S., Chung, C., Churcher, I., Dodic, N., Fournier, C., Francis, P. L., Hobbs, A., Jamieson, C., Pickett, S. D., Smith, S. E., Somers, D. ON., Spitzfaden, C., Suckling, C. J. & Young, R. J., 24 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2452-2467 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)71 Downloads (Pure) -
Palladium-catalyzed synthesis of aryl amides through silanoate-mediated hydrolysis of nitriles
McPherson, C. G., Livingstone, K., Jamieson, C. & Simpson, I., 4 Jan 2016, In: Synlett. 27, 1, p. 88-92 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)50 Downloads (Pure) -
2015
The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits
Bertrand, S. M., Ancellin, N., Beaufils, B., Bingham, R. P., Borthwick, J. A., Boullay, A. B., Boursier, E., Carter, P. S., Chung, C. W., Churcher, I., Dodic, N., Fouchet, M. H., Fournier, C., Francis, P. L., Gummer, L. A., Herry, K., Hobbs, A., Hobbs, C. I., Homes, P., Jamieson, C., & 12 others, 24 Sept 2015, In: Journal of Medicinal Chemistry. 58, 18, p. 7140-7163 24 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol
Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 11 Jun 2015, In: Chemical Communications. 51, 46, p. 9495-9498 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)49 Downloads (Pure) -
Identification of a novel class of autotaxin inhibitors through cross-screening
Castagna, D., Duffy, E. L., Semaan, D., Young, L. C., Pritchard, J. M., Macdonald, S. J. F., Budd, D. C., Jamieson, C. & Watson, A. J. B., 1 Jun 2015, In: MedChemComm. 2015, 6, p. 1149-1155 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)84 Downloads (Pure) -
Rational design of a novel AMPA receptor modulator through a hybridization approach
Caldwell, N., Harms, J. E., Partin, K. M. & Jamieson, C., 2015, In: ACS Medicinal Chemistry Letters .Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)100 Downloads (Pure) -
2014
Amidation of esters with amino alcohols using organobase catalysis
Caldwell, N., Campbell, P. S., Jamieson, C., Potjewyd, F., Simpson, I. & Watson, A. J. B., 3 Oct 2014, In: Journal of Organic Chemistry. 79, 19, p. 9347-9354 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)145 Downloads (Pure) -
Molar efficiency: a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry
McGonagle, F. I., Sneddon, H. F., Jamieson, C. & Watson, A., 3 Mar 2014, In: ACS Sustainable Chemistry and Engineering. 2, 3, p. 523-532 10 p.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
Regiospecific synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles via photochemically generated nitrile imine intermediates
Stewart, S., Harris, R. & Jamieson, C., 2014, In: Synlett. 25, 17, p. 2480-2484 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)183 Downloads (Pure) -
2013
Development of a sustainable catalytic ester amidation process
Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 7 Oct 2013, In: ACS Sustainable Chemistry and Engineering. 1, 10, p. 1339-1344 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)81 Downloads (Pure) -
Organobase-catalyzed amidation of esters with amino alcohols
Caldwell, N., Jamieson, C., Simpson, I. & Tuttle, T., 17 May 2013, In: Organic Letters. 15, 10, p. 2506-2509 4 p.Research output: Contribution to journal › Article › peer-review
47 Citations (Scopus)