Research Output per year
Research Output 2008 2019
A fragment-like approach to PYCR1 inhibition
Milne, K., Sun, J., Zaal, E. A., Mowat, J., Celie, P. H. N., Fish, A., Berkers, C. R., Forlani, G., Loayza-Puch, F., Jamieson, C. & Agami, R., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters . 29, 18, p. 2626-2631 6 p.Research output: Contribution to journal › Article
A reappraisal of the Ni-[(Benzylprolyl)amino]benzophenone complex in the synthesis of α,α-disubstituted amino acid derivatives
Watson, M. E., Jamieson, C., Kennedy, A. R. & Mason, A. M., 6 Sep 2019, In : Tetrahedron. 75, 36, 130485.Research output: Contribution to journal › Article
Metal free C-C bond formation via coupling of nitrile imines and boronic acids
Livingstone, K., Betrand, S., Mowat, J. & Jamieson, C., 28 Nov 2019, In : Chemical Science. 10, 44, p. 10412-10416 5 p.Research output: Contribution to journal › Article
Atom efficient synthesis of selectively difluorinated carbocycles through a gold(I) catalyzed cyclization
McCarter, A. W., Sommer, M., Percy, J. M., Jamieson, C., Kennedy, A. R. & Hirst, D. J., 6 Jul 2018, In : Journal of Organic Chemistry.Research output: Contribution to journal › Article
Cyrene as a bio-based solvent for HATU mediated amide coupling
Wilson, K. L., Murray, J., Jamieson, C. & Watson, A. J. B., 28 Apr 2018, In : Organic and Biomolecular Chemistry. 16, p. 2851-2854 4 p.Research output: Contribution to journal › Article
Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine
Littleson, M. M., Baker, C. M., Dalencon, A. J., Frye, E. C., Jamieson, C., Kennedy, A. R., Ling, K. B., McLachlan, M. M., Montgomery, M. G., Russell, C. J. & Watson, A. J. B., 13 Feb 2018, (Accepted/In press) In : Nature Communications. 14 p.Research output: Contribution to journal › Article
Surface functionalization with carboxylic acids by photochemical microcontact printing and tetrazole chemistry
Buten, C., Lamping, S., Korsgen, M., Arlinghaus, H. F., Jamieson, C. & Ravoo, B. J., 16 Jan 2018, In : Langmuir. 17 p.Research output: Contribution to journal › Article
Amidation of unactivated ester derivatives mediated by trifluoroethanol
McPherson, C. G., Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 4 Apr 2017, In : Organic and Biomolecular Chemistry. 12 p.Research output: Contribution to journal › Article
A multicomponent route to functionalized amides and oxazolidinones
McPherson, C. G., Cooper, A. K., Bubliauskas, A., Mulrainey, P., Jamieson, C. & Watson, A. J. B., 1 Dec 2017, In : Organic Letters. 4 p.Research output: Contribution to journal › Letter
Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrins
Miller, L. M., Pritchard, J. M., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 30 Jan 2017, In : Journal of Medicinal Chemistry. 60, 8, 11 p.Research output: Contribution to journal › Article
One-pot, three-step synthesis of cyclopropylboronic acid pinacol esters from synthetically tractable propargylic silyl ethers
Spencer, J. A., Jamieson, C. & Talbot, E. P. A., 6 Jul 2017, In : Organic Letters. 4 p.Research output: Contribution to journal › Article
Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character
Campbell, P. S., Jamieson, C., Simpson, I. & Watson, A. J. B., 27 Nov 2017, In : Chemical Communications (London). 4 p.Research output: Contribution to journal › Article
Rational design of autotaxin inhibitors by structural evolution of endogenous modulators
Keune, W-J., Potjewyd, F., Heidebrecht, T., Salgado-Polo, F., Macdonald, S. J. F., Chelvarajan, L., Abdel Latif, A., Soman, S., Morris, A. J., Watson, A. J. B., Jamieson, C. & Perrakis, A., 9 Mar 2017, In : Journal of Medicinal Chemistry. 60, 5, p. 2006-2017 12 p.Research output: Contribution to journal › Article
Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding mode
Miller, L. M., Keune, W-J., Castagna, D., Young, L. C., Duffy, E. L., Potjewyd, F., Salgado-Polo, F., Garcia, P. E., Semaan, D., Pritchard, J. M., Perrakis, A., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 722-748 27 p.Research output: Contribution to journal › Article
Evolution of a novel orally bioavailable series of PI3Kδ inhibitors from an inhaled lead for the treatment of respiratory disease.
Amour, A., Barton, N., Cooper, A. W. J., Inglis, G., Jamieson, C., Luscombe, C. N., Perez, D., Peace, S., Rowland, P., Tame, C., Uddin, S., Vitulli, G. & Wellaway, N., 18 Jul 2016, In : Journal of Medicinal Chemistry. 34 p.Research output: Contribution to journal › Article
Investigation of a bicyclo[1.1.1]pentane as a phenyl replacement within an LpPLA2 inhibitor
Measom, N., Down, K. D., Hirst, D. J., Jamieson, C., Manas, E. S., Patel, V. K. & Somers, D. O., 15 Nov 2016, In : ACS Medicinal Chemistry Letters . 7, 6 p.Research output: Contribution to journal › Article
Palladium-catalyzed synthesis of aryl amides through silanoate-mediated hydrolysis of nitriles
McPherson, C. G., Livingstone, K., Jamieson, C. & Simpson, I., 4 Jan 2016, In : Synlett. 27, 1, p. 88-92 5 p.Research output: Contribution to journal › Article
Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation
Wilson, K., Kennedy, A., Murray, J., Greatex, B., Jamieson, C. & Watson, A., 8 Sep 2016, In : Beilstein Journal of Organic Chemistry . 12, p. 2005-2011 7 p.Research output: Contribution to journal › Article
Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening
Borthwick, J. A., Ancellin, N., Bertrand, S. M., Bingham, R. P., Carter, P. S., Chung, C., Churcher, I., Dodic, N., Fournier, C., Francis, P. L., Hobbs, A., Jamieson, C., Pickett, S. D., Smith, S. E., Somers, D. ON., Spitzfaden, C., Suckling, C. J. & Young, R. J., 24 Mar 2016, In : Journal of Medicinal Chemistry. 59, 6, p. 2452-2467 16 p.Research output: Contribution to journal › Article
Synthetic approaches to coronafacic acid, coronamic acid, and coronatine
Littleson, M. M., Russell, C. J., Frye, E. C., Ling, K. B., Jamieson, C. & Watson, A. J. B., 15 Aug 2016, In : Synthesis. 48, 20 p.Research output: Contribution to journal › Article
Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol
Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 11 Jun 2015, In : Chemical Communications. 51, 46, p. 9495-9498 4 p.Research output: Contribution to journal › Article
Identification of a novel class of autotaxin inhibitors through cross-screening
Castagna, D., Duffy, E. L., Semaan, D., Young, L. C., Pritchard, J. M., Macdonald, S. J. F., Budd, D. C., Jamieson, C. & Watson, A. J. B., 1 Jun 2015, In : MedChemComm. 2015, 6, p. 1149-1155 6 p.Research output: Contribution to journal › Article
Rational design of a novel AMPA receptor modulator through a hybridization approach
Caldwell, N., Harms, J. E., Partin, K. M. & Jamieson, C., 2015, In : ACS Medicinal Chemistry Letters .Research output: Contribution to journal › Article
The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits
Bertrand, S. M., Ancellin, N., Beaufils, B., Bingham, R. P., Borthwick, J. A., Boullay, A. B., Boursier, E., Carter, P. S., Chung, C. W., Churcher, I., Dodic, N., Fouchet, M. H., Fournier, C., Francis, P. L., Gummer, L. A., Herry, K., Hobbs, A., Hobbs, C. I., Homes, P., Jamieson, C. & 12 others , 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7140-7163 24 p.Research output: Contribution to journal › Article
Amidation of esters with amino alcohols using organobase catalysis
Caldwell, N., Campbell, P. S., Jamieson, C., Potjewyd, F., Simpson, I. & Watson, A. J. B., 3 Oct 2014, In : Journal of Organic Chemistry. 79, 19, p. 9347-9354 8 p.Research output: Contribution to journal › Article
Molar efficiency: a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry
McGonagle, F. I., Sneddon, H. F., Jamieson, C. & Watson, A., 3 Mar 2014, In : ACS Sustainable Chemistry and Engineering. 2, 3, p. 523-532 10 p.Research output: Contribution to journal › Article
Regiospecific synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles via photochemically generated nitrile imine intermediates
Stewart, S., Harris, R. & Jamieson, C., 2014, In : Synlett. 25, 17, p. 2480-2484 5 p.Research output: Contribution to journal › Article
Development of a solvent selection guide for aldehyde-based direct reductive amination processes
McGonagle, F. I., MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A. J. B., 1 May 2013, In : Green Chemistry. 15, 5, p. 1159-1165 7 p.Research output: Contribution to journal › Article
Development of a sustainable catalytic ester amidation process
Caldwell, N., Jamieson, C., Simpson, I. & Watson, A. J. B., 7 Oct 2013, In : ACS Sustainable Chemistry and Engineering. 1, 10, p. 1339-1344 6 p.Research output: Contribution to journal › Article
Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide
MacMillan, D., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A., 2013, In : Green Chemistry. 15, 3, p. 596-600 5 p.Research output: Contribution to journal › Article
Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy
Harms, J. E., Benveniste, M., Maclean, J. K. F., Partin, K. M. & Jamieson, C., Jan 2013, In : Neuropharmacology. 64, p. 45-52 8 p.Research output: Contribution to journal › Article
Organobase-catalyzed amidation of esters with amino alcohols
Caldwell, N., Jamieson, C., Simpson, I. & Tuttle, T., 17 May 2013, In : Organic Letters. 15, 10, p. 2506-2509 4 p.Research output: Contribution to journal › Article
AMPA receptor positive modulators
Jamieson, C., Morrow, J. & Maclean, J., Jul 2012, Targets and Emerging Therapies for Schizophrenia. Albert, J. & Wood, M. (eds.). 1 ed. Hoboken, NJ, p. 187-231 44 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents
MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C. & Watson, A., 2012, In : Green Chemistry. 14, 11, p. 3016-3019 4 p.Research output: Contribution to journal › Article
Amino-heteroaryl derivatives as HCN blockers
Grove, S. J. A., Morrison, A. J., Jamieson, C., Palin, R. & Maclean, J. K. F., 30 Jun 2011, IPC No. PCT/EP2010/070213, Patent No. WO2011076723A1Research output: Patent
Structure based evolution of a novel series of positive modulators of the AMPA receptor
Jamieson, C., Maclean, J. K. F., Brown, C. I., Campbell, R. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., LAMONT, YVONNE., Lyons, A. J., Moir, E. M., Morrow, J. A., Pantling, J., Rankovic, Z. & Smith, L., 15 Jan 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 2, p. 805-811 7 p.Research output: Contribution to journal › Article
A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies
Jamieson, C., Basten, S., Campbell, R. A., Cumming, I. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A. J., Maclean, J. K. F., Moir, E. M., Morrow, J. A., Papakosta, M., Rankovic, Z. & Smith, L., 1 Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 19, p. 5753-5756 4 p.Research output: Contribution to journal › Article
A novel series of positive modulators of the AMPA receptor: structure-based lead optimization
Jamieson, C., Campbell, R. A., Cumming, I. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A. J., Maclean, J. K. F., Martin, F., Moir, E. M., Morrow, J. A., Pantling, J., Rankovic, Z. & Smith, L., 15 Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6072-6075 4 p.Research output: Contribution to journal › Article
Dioxo-triazines as a novel series of cathepsin K inhibitors
Rankovic, Z., Cai, J., Fradera, X., Dempster, M., Mistry, A., Long, C., Hamilton, E., King, A., Boucharens, S., Jamieson, C., Gillespie, J., Cumming, I., Uitdehaag, J. & van Zeeland, M., 1 Mar 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1488-1490 3 p.Research output: Contribution to journal › Article
High throughput screening approach to lead discovery
Rankovic, Z., Jamieson, C. & Morphy, R., 2010, Lead Generation Approaches in Drug Discovery. Hoboken, NJ, p. 21-71 51 p.Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution
Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor
Grove, S. J. A., Jamieson, C., Maclean, J. K. F., Morrow, J. A. & Rankovic, Z., 2010, In : Journal of Medicinal Chemistry. 53, 20, p. 7271-7279 8 p.Research output: Contribution to journal › Article
Preparation of indane derivatives for treating and preventing psychiatric diseases.
Gillen, K. J., Gillespie, J., Jamieson, C., MacLean, J. K. F., Moir, E. M. & Rankovic, Z., 14 Oct 2010, Patent No. WO2010115952A1Research output: Patent
Heterocyclic derivatives.
Gallagher, M. G., Jamieson, C. C., Lyons, A. J., MacLean, J. K. F. & Moir, E. M., 21 May 2009, Patent No. US20090131455A1Research output: Patent
Preparation of indane derivatives as AMPA receptor modulators.
Gillespie, J., Jamieson, C., Maclean, J. K. F., Moir, E. M. & Rankovic, Z., 10 Dec 2009, Patent No. WO2009147167A1Research output: Patent
Synthesis of the originally proposed structures of elatenyne and an enyne from Laurencia majuscula
Sheldrake, H. M., Jamieson, C., Pascu, S. I. & Burton, J. W., 2009, In : Organic and Biomolecular Chemistry. 7, 2, p. 238-252 15 p.Research output: Contribution to journal › Article
Preparation of pyrazolealkanamide substituted thiophenes as AMPA potentiators.
Gillen, K. J., Jamieson, C., Maclean, J. K. F., Moir, E. M. & Rankovic, Z., 10 Jan 2008, Patent No. WO2008003452A1Research output: Patent
Strategy and tactics for hERG optimizations
Jamieson, C., Moir, E. M., Rankovic, Z. & Wishart, G., Jan 2008, Antitargets: Prediction and Prevention of Drug Side Effects. Vaz, R. J. & Klabunde, T. (eds.). Weinheim, Germany, Vol. 38. p. 423-455 33 p. (Methods and Principles in Medicinal Chemistry).Research output: Chapter in Book/Report/Conference proceeding › Chapter