Colin Suckling, OBE BSc PhD DSc CChem FRSC FRCS(Glasg) Hon FRCS (Edin) FRSA FRSE

Prof

  • United Kingdom

1991 …2022

Research output per year

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Research Output

2011

Evaluating nitric oxide synthase as a potential therapeutic target in schizophrenia

Lee, G., Thomson, D. M., Suckling, C., Morris, B. J. & Pratt, J. A., Aug 2011, In : Journal of Psychopharmacology. 25, 8 Supplement S, p. A67-A67 1 p.

Research output: Contribution to journalMeeting abstract

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: concise synthesis of alangiobussinine

Baiget, J., Llona-Minguez, S., Lang, S., MacKay, S. P., Suckling, C. J. & Sutcliffe, O. B., 12 Oct 2011, In : Beilstein Journal of Organic Chemistry. 7, p. 1407-1411 5 p.

Research output: Contribution to journalLetter

9 Citations (Scopus)

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties

Kunuthur, S. P., Milliken, P. H., Gibson, C., Suckling, C. J. & Wadsworth, R. M., 10 Jan 2011, In : European Journal of Pharmacology. 650, 1, p. 371-377 7 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
119 Downloads (Pure)
2010

2,2,2-Trifluoro-N-(isoquinolin-5-ylmethyl)acetamide

Kennedy, A., Khalaf, A. I. & Suckling, C. J., 2010, In : Acta Crystallographica Section E: Structure Reports. 66, Pt 1, p. o135 11 p.

Research output: Contribution to journalArticle

Blocked dihydropteridines as nitric oxide synthase activators

McInnes, C. R., Suckling, C. J., Gibson, C. L., Morthala, R. R., Daff, S. & Gazur, B., 2010, In : Pteridines. 20, p. 27-35 8 p.

Research output: Contribution to journalArticle

File
2 Citations (Scopus)
813 Downloads (Pure)

Ranking ligand affinity for the DNA minor groove by experiment and simulation

Wittayanarakul, K., Anthony, N. G., Treesuwan, W., Hannongbua, S., Alniss, H., Khalaf, A. I., Suckling, C. J., Parkinson, J. A., Mackay, S. P., Royal Golden Jubilee Ph.D. Program (Funder), Thailand Research Fund (Funder), W.T. and EPSRC (Funder) & Scottish Funding Council (Funder), 30 Jul 2010, In : Medicinal Chemistry Letters. 1, 8, p. 376-680 5 p.

Research output: Contribution to journalArticle

File
6 Citations (Scopus)
115 Downloads (Pure)

Small molecule analogues of an immunomodulatory helminth product provide a novel approach to dissecting macrophage signal transduction pathways: Poster abstract

Al-Riyami, L., Rzepecka, J., Khalaf, A., Suckling, C., Harnett, M. & Harnett, W., Dec 2010, In : Immunology. 131, Supplement 1, p. 164-164 1 p.

Research output: Contribution to journalArticle

Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases

Tulloch, L. B., Martini, V. P., Iulek, J., Huggan, J., Lee, J. H., Gibson, C. L., Smith, T. K., Suckling, C. J. & Hunter, W. N., 2010, In : Journal of Medicinal Chemistry. 53, 1, p. 221-229 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2009

A detailed binding free energy study of 2 : 1 ligand–DNA complex formation by experiment and simulation

Treesuwan, W., Wittayanarakul, K., Anthony, N. G., Huchet, G., Alniss, H., Hannongbua, S., Khalaf, A. I., Suckling, C. J., Parkinson, J. A. & Mackay, S. P., Aug 2009, In : Physical Chemistry Chemical Physics. 11, 45, p. 10682-10693 12 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
220 Downloads (Pure)
6 Citations (Scopus)
18 Citations (Scopus)

Comparison of DNA complex formation behaviour for two closely related lexitropsin analogues

Parkinson, J. A., Khalaf, A. I., Anthony, N. G., Mackay, S. P., Suckling, C. J. & Waigh, R. D., 2009, In : Helvetica Chimica Acta. 92, 5, p. 795-822 27 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

Gibson, C. L., Huggan, J. K., Kennedy, A., Kiefer, L., Lee, J. H., Suckling, C. J., Clements, C. J., Harvey, A. L., Hunter, W. N. & Tulloch, L. B., 7 May 2009, In : Organic and Biomolecular Chemistry. 7, 9, p. 1829-1842 14 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
305 Downloads (Pure)

In situ detection of pterins by SERS

Stevenson, R., Stokes, R. J., MacMillan, D., Armstrong, D., Faulds, K., Wadsworth, R., Kununthur, S., Suckling, C. J. & Graham, D., Aug 2009, In : Analyst. 134, p. 1561-1564 3 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2008

6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases

Suckling, C. J., Gibson, C. L., Huggan, J. K., Morthala, R. R., Clarke, B., Kununthur, S., Wadsworth, R. M., Daff, S. & Papale, D., 1 Mar 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 5, p. 1563-1566 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
31 Citations (Scopus)

Novel hydrophobic minor groove binders

Waigh, R., Suckling, C. & Khalaf, A., 3 Apr 2008, Priority date 30 Sep 2006, Priority No. 0619325.4

Research output: Patent

Tetramic acid and imidazolidinone syntheses via unexpected base induced cyclisations of alanine derived Weinreb amides

Gibson, C., Kennedy, A. R., Morthala, R. R., Parkinson, J. A. & Suckling, C. J., 4 Aug 2008, In : Tetrahedron. 64, 32, p. 7619-7625 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2007

Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups

Anthony, N. G. H., Breen, D., Clarke, J., Donoghue, G., Drummond, A. J., Ellis, E., Gemmell, C. G., Helesbeux, J-J., Hunter, I. S., Khalaf, A., MacKay, S., Parkinson, J. A., Suckling, C. J. & Waigh, R. D., Oct 2007, In : Journal of Medicinal Chemistry. 50, 24, p. 6116-6125 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds

Suckling, C. J., Murphy, J. A., Khalaf, A. I., Zhou, S., Lizos, D. E., Nguyen Van Nhien, A., Yasumatsu, H., McVie, A., Young, L. C., McCraw, C., Waterman, P. G., Morris, B. J., Pratt, J. A. & Harvey, A., 1 May 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 9, p. 2649-2655 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2006

3-Nitro-1-(triisopropylsilyl)-1H-pyrrole

Kennedy, A., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., Aug 2006, In : Acta Crystallographica Section E: Structure Reports. 62, 8, p. o3282-o3284 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2 Citations (Scopus)

DNA sequence recognition by an imidazole-containing isopropyl thiazole polyamide (thiazotropsin b)

Suckling, C. J., Hampshire, A. J., Khairallah, H., Khalaf, A. I., Ebrahimabadi, A. H., Waigh, R. D., Brown, T. & Fox, K. R., 1 Jul 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 13, p. 3469-3474 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
3 Citations (Scopus)
2005

2-(1-Piperidinyl)-1,3-benzothiazole

Alvarez, R. G., Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., 5 Feb 2005, In : Acta Crystallographica Section E: Structure Reports. 61, p. 569-570 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Electrochemical properties of blocked dihydropterins

Suckling, C. J., Huggan, J., Berlouis, L. & Gibson, C. L., 2005, In : Pteridines. 16, 112

Research output: Contribution to journalArticle

Highly flexible solid phase syntheses of pteridines and related compounds

Suckling, C. J., Huggan, J., Rao, R. M., Kiefer, L. & Gibson, C. L., 2005, In : Pteridines. 16, 88

Research output: Contribution to journalArticle

Highly flexible syntheses of pteridines and related compounds

Suckling, C. J., Huggan, J., Rao, R. M., Kiefer, L. & Gibson, C. L., 2005, In : Pteridines. 16, 53

Research output: Contribution to journalArticle

In Silico Footprinting of Ligands Binding to the Minor Groove of DNA

Anthony, N. G., Huchet, G., Johnston, B. F., Parkinson, B. F., Suckling, C. J., Waigh, R. D. & Mackay, S. P., 5 Oct 2005, In : Journal of Chemical Information and Modeling. 45, 6, p. 1896-1907 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Modulation of pulmonary vascular tone by novel analogues of tetrahydrobiopterin

Suckling, C. J., Kununthur, S. R., Gibson, C. L. & Wadsworth, R. M., 2005, In : Pteridines. 16, 112

Research output: Contribution to journalArticle

Pteridine derivatives as nitric oxide synthase activators

Wadsworth, R., Suckling, C. J. & Gibson, C. L., 2005, IPC No. A61K 31/525, Patent No. US 2006/0194800 A1

Research output: Patent

2004

An in silico footprinting technique to study ligand interactions in the minor groove of DNA

Anthony, N. G., Johnston, B. F., Mackay, S. P., Suckling, C. J. & Waigh, R. D., Aug 2004, In : Drugs of the Future. 29, Suppl. A, p. 150

Research output: Contribution to journalArticle

Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity

Khalaf, A. I., Waigh, R. D., Drummond, A. J., Pringle, B., McGroarty, I., Skellern, G. G. & Suckling, C. J., 5 Mar 2004, In : Journal of Medicinal Chemistry. 47, 8, p. 2133-2156 23 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

DNA binding of a short lexitropsin

Anthony, N. G., Fox, K. R., Johnston, B. F., Khalaf, A. I., Mackay, S. P., McGroarty, I. S., Parkinson, J. A., Skellern, G. G., Suckling, C. J. & Waigh, R. D., 8 Mar 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 5, p. 1353-1356 3 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

DNA sequence recognition by an isopropyl substituted thiazole polyamide

James, P. L., Merkina, E. E., Khalaf, A. I., Suckling, C. J., Waigh, R. D., Brown, T. & Fox, K. R., 5 Jun 2004, In : Nucleic Acids Research. 32, 11, p. 3410-3417 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Ethyl 2-amino-4-isopropyl-1,3-thiazole-5-carboxylate

Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., 17 Jul 2004, In : Acta Crystallographica Section E: Structure Reports. 60, 8, p. 1188-1190 2 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Methyl 2-amino-5-iso­propyl-1,3-thia­zole-4-carboxyl­ate

Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., Sep 2004, In : Acta Crystallographica Section E: Structure Reports. 60, 9, p. 1510-1512 2 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
41 Downloads (Pure)

Minor groove binders 1998-2004

Suckling, C. J., 1 Dec 2004, In : Expert Opinion on Therapeutic Patents. 14, 12, p. 1693-1724 31 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Short Lexitropsin that Recognizes the DNA Minor Groove at 5'-ACTAGT-3': Understanding the Role of Isopropyl-thiazole

Anthony, N. G., Johnston, B. F., Khalaf, A. I., Mackay, S. P., Parkinson, J. A., Suckling, C. J. & Waigh, R. D., 19 Aug 2004, In : Journal of the American Chemical Society. 126, 36, p. 11338-11349 11 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Solid phase synthesis of pteridines and related compounds

Suckling, C. J., Gibson, C. L., Huggan, J., Oppilliart, S., La Rosa, S. & Epton, R. (ed.), 2004, 8th Millennium Symposium, Solid Phase Synthesis and Combinational Libraries. p. 39-42 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synthesis and antimicrobial activity of some netropsin analogues

Khalaf, A. I., Ebrahimabadi, A. H., Drummond, A. J., Anthony, N. G., Mackay, S. P., Suckling, C. J. & Waigh, R. D., 10 Sep 2004, In : Organic and Biomolecular Chemistry. 2, 21, p. 3119-3127 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase 1

Gibson, C. L., La Rosa, S., Ohta, K., Boyle, P. H., Leurquin, F., Lemaçon, A. & Suckling, C. J., 19 Jan 2004, In : Tetrahedron. 60, 4, p. 943-959 16 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2003

A prototype solid phase synthesis of pteridines and related heterocyclic compounds

Gibson, C. L., La Rosa, S. & Suckling, C. J., 30 Apr 2003, In : Organic and Biomolecular Chemistry. 1, 11, p. 1909-1918 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

A traceless solid-phase synthesis of pteridines

Gibson, C. L., La Rosa, S. & Suckling, C. J., 3 Feb 2003, In : Tetrahedron Letters. 44, 6, p. 1267-1270 3 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

DNA Minor Groove Binders

Waigh, R., Suckling, C. & Khalaf, A., 24 Jul 2003, Priority date 24 Dec 2001, Priority No. 0130868.3

Research output: Patent

Ethyl 5-oxo-2,5-dihydro-4-isoxazolecarboxylate hydroxylamine salt

Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., Sep 2003, In : Acta Crystallographica Section E: Structure Reports. 59, 9, p. 1410-1412 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Minor groove binders substituted by lipophilic groups

Suckling, C. J., Waigh, R. D., Khalaf, A. L., Parkinson, J., Hunter, I. S. & Williams, R. M. (ed.), 16 Jul 2003, 19th International Congress on Heterocyclic Chemistry. p. 98-98

Research output: Chapter in Book/Report/Conference proceedingChapter

Solid phase synthesis of pteridines and related compounds

Suckling, C. J., Gibson, C. L., La Rosa, S., Huggan, J., Oppilliart, S. & Williams, R. M. (ed.), 16 Jul 2003, 19th International Congress on Heterocyclic Chemistry. p. 322-322

Research output: Chapter in Book/Report/Conference proceedingChapter

Syntheses of highly functionalised 6-substituted pteridines

Guiney, D., Gibson, C. L. & Suckling, C. J., 3 Jan 2003, In : Organic and Biomolecular Chemistry. 1, 4, p. 664-675 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2002

Solution and solid phase synthesis of pteridines, purides and related compounds

La Rosa, S., Boyle, P. H., Suckling, C. J., Gibson, C. L. & Guiney, D., 31 May 2002, The Chemistry and Biology of Pteridines and Folates. UK, p. 25-29 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter