Colin Suckling, OBE BSc PhD DSc CChem FRSC FRCS(Glasg) Hon FRCS (Edin) FRSA FRSE

Prof

  • United Kingdom

1991 …2022

Research output per year

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Research Output

2,2,2-Trifluoro-N-(isoquinolin-5-ylmethyl)acetamide

Kennedy, A., Khalaf, A. I. & Suckling, C. J., 2010, In : Acta Crystallographica Section E: Structure Reports. 66, Pt 1, p. o135 11 p.

Research output: Contribution to journalArticle

2-(1-Piperidinyl)-1,3-benzothiazole

Alvarez, R. G., Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., 5 Feb 2005, In : Acta Crystallographica Section E: Structure Reports. 61, p. 569-570 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

3-Acetoxycyclohex-4-ene-1,2-di-carboxylic anhydride

Kennedy, A. R., Khalaf, A. I. & Suckling, C. J., Jun 2000, In : Acta Crystallographica Section C: Crystal Structure Communications. 56, 6, p. e265-e266

Research output: Contribution to journalArticle

1 Citation (Scopus)

3-Nitro-1-(triisopropylsilyl)-1H-pyrrole

Kennedy, A., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., Aug 2006, In : Acta Crystallographica Section E: Structure Reports. 62, 8, p. o3282-o3284 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases

Suckling, C. J., Gibson, C. L., Huggan, J. K., Morthala, R. R., Clarke, B., Kununthur, S., Wadsworth, R. M., Daff, S. & Papale, D., 1 Mar 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 5, p. 1563-1566 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A detailed binding free energy study of 2 : 1 ligand–DNA complex formation by experiment and simulation

Treesuwan, W., Wittayanarakul, K., Anthony, N. G., Huchet, G., Alniss, H., Hannongbua, S., Khalaf, A. I., Suckling, C. J., Parkinson, J. A. & Mackay, S. P., Aug 2009, In : Physical Chemistry Chemical Physics. 11, 45, p. 10682-10693 12 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
220 Downloads (Pure)
6 Citations (Scopus)

A f-19 and deuterium nmr-study of two novel fluorosterols and their properties in model membranes and high-density-lipoprotein

Reid, D. G., MacLachlan, L. K., Suckling, K. E., Gee, A., Cresswell, S. & Suckling, C. J., May 1991, In : Chemistry and Physics of Lipids. 58, 1-2, p. 175-181 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Amide isosteres in structure-activity studies of antibacterial minor groove binders

Khalaf, A. I., Anthony, N., Breen, D., Donoghue, G., Mackay, S. P., Scott, F. J. & Suckling, C. J., Nov 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5343-5355 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2 Citations (Scopus)

An evaluation of minor groove binders as anti-fungal and anti-mycobacterial therapeutics

Scott, F., Nichol, R. J. O., Khalaf, A. I., Giordani, F., Gillingwater, K., Ramu, S., Elliott, A., Zuegg, J., Duffy, P., Rosslee, M-J., Hlaka, L., Kumar, S., Ozturk, M., Brombacher, F., Barrett, M., Guler, R. & Suckling, C. J., 18 Aug 2017, In : European Journal of Medicinal Chemistry. 136, p. 561-572 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
19 Downloads (Pure)

An evaluation of minor groove binders as anti-lung cancer therapeutics

Scott, F., Khalaf, A., Suckling, C., Carter, K., Grant, M., Henderson, C., Westrop, G. & Watson, D., 15 Jun 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 11 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
33 Downloads (Pure)

An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics

Scott, F. J., Khalaf, A. I., Giordani, F., Wong, P. E., Duffy, S., Barrett, M., Avery, V. M. & Suckling, C. J., 30 Jun 2016, In : European Journal of Medicinal Chemistry. 116, p. 116-125 10 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
114 Downloads (Pure)
18 Citations (Scopus)

An in silico footprinting technique to study ligand interactions in the minor groove of DNA

Anthony, N. G., Johnston, B. F., Mackay, S. P., Suckling, C. J. & Waigh, R. D., Aug 2004, In : Drugs of the Future. 29, Suppl. A, p. 150

Research output: Contribution to journalArticle

A novel biotransformation of benzofurans and related compounds catalysed by a chloroperoxidase

Alvarez, R. G., Hunter, I. S., Suckling, C. J., Thomas, M. & Vitinius, U., Oct 2001, In : Tetrahedron. 57, 40, p. 8581-8587 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups

Anthony, N. G. H., Breen, D., Clarke, J., Donoghue, G., Drummond, A. J., Ellis, E., Gemmell, C. G., Helesbeux, J-J., Hunter, I. S., Khalaf, A., MacKay, S., Parkinson, J. A., Suckling, C. J. & Waigh, R. D., Oct 2007, In : Journal of Medicinal Chemistry. 50, 24, p. 6116-6125 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

A powerful palladium-catalyzed multicomponent process for the preparation of oxazolines and benzoxazoles

Boissarie, P., Hamilton, Z., Lang, S., Murphy, J. & Suckling, C., 2 Dec 2011, In : Organic Letters. 13, 23, p. 6256-6259 4 p.

Research output: Contribution to journalLetter

82 Citations (Scopus)

A prototype solid phase synthesis of pteridines and related heterocyclic compounds

Gibson, C. L., La Rosa, S. & Suckling, C. J., 30 Apr 2003, In : Organic and Biomolecular Chemistry. 1, 11, p. 1909-1918 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Asymmetric rhodium-catalysed addition of arylboronic acids to acyclic unsaturated esters containing a basic γ-amino group

Anderson, N. A., Fallon, B. J., Valverde, E., MacDonald, S. J. F., Pritchard, J. M., Suckling, C. & Watson, A., Dec 2012, In : Synlett. 23, 19, p. 2817-2821 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A traceless solid-phase synthesis of pteridines

Gibson, C. L., La Rosa, S. & Suckling, C. J., 3 Feb 2003, In : Tetrahedron Letters. 44, 6, p. 1267-1270 3 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Blocked dihydropteridines as nitric oxide synthase activators

McInnes, C. R., Suckling, C. J., Gibson, C. L., Morthala, R. R., Daff, S. & Gazur, B., 2010, In : Pteridines. 20, p. 27-35 8 p.

Research output: Contribution to journalArticle

File
2 Citations (Scopus)
813 Downloads (Pure)

Catalytic antibodies: a new window on protein chemistry

Suckling, C. J., Tedford, C. M., Proctor, G. R., Khalaf, A. I., Bence, L. M. & Stimson, W. H., 1991, In : Ciba Foundation Symposium. 159, Catal. Antibodies, p. 201-210 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cell penetrant inhibitors of the KDM4 and KDM5 families of histone lysine demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one derivatives

Westaway, S. M., Preston, A. G. S., Barker, M. D., Brown, F., Brown, J. A., Campbell, M., Chung, C-W., Drewes, G., Eagle, R., Garton, N., Gordon, L., Haslam, C., Hayhow, T. G., Humphreys, P. G., Joberty, G., Katso, R., Kruidenier, L., Leveridge, M., Pemberton, M., Rioja, I. & 9 others, Seal, G. A., Shipley, T., Singh, O., Suckling, C. J., Taylor, J., Thomas, P., Wilson, D. M., Lee, K. & Prinjha, R. K., 25 Feb 2016, In : Journal of Medicinal Chemistry. 59, 4, p. 1370-1387 18 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Cholest-5-ene-3 beta,4 beta-diyl diacetate

Kennedy, A. R., Pitt, A. R., Suckling, C. J., Suckling, K. E. & Thomas, M., Sep 1999, In : Acta Crystallographica Section C: Crystal Structure Communications. 55, 9, p. 1570-1572 2 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase

Chreifi, G., Li, H., McInnes, C., Gibson, C., Suckling, C. & Poulos, T. L., 2014, In : Biochemistry.

Research output: Contribution to journalArticle

File
10 Citations (Scopus)
208 Downloads (Pure)

Comparison of DNA complex formation behaviour for two closely related lexitropsin analogues

Parkinson, J. A., Khalaf, A. I., Anthony, N. G., Mackay, S. P., Suckling, C. J. & Waigh, R. D., 2009, In : Helvetica Chimica Acta. 92, 5, p. 795-822 27 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Crystal structure of N,N-dimethyl-2-[(4-methylbenzyl) sulfonyl]ethanamine

Kennedy, A. R., Khalaf, A. I., Scott, F. J. & Suckling, C. J., Jul 2015, In : Acta Crystallographica Section E: Structure Reports. 71, 7, p. 757-759 3 p.

Research output: Contribution to journalArticle

Open Access
File
61 Downloads (Pure)

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

Lumb, F. E., Doonan, J., Bell, K. S., Pineda, M. A., Corbet, M., Suckling, C. J., Harnett, M. M. & Harnett, W., 10 May 2017, In : Scientific Reports. 13 p., 1704.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
195 Downloads (Pure)

Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups

Khalaf, A., Bourdin, C., Breen, D., Donoghue, G., Scott, F., Suckling, C., MacMillan, D., Clements, C., Fox, K. & Sekibo, D., 2012, In : European Journal of Medicinal Chemistry. 56, p. 39-47 9 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
86 Downloads (Pure)
52 Citations (Scopus)

Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity

Khalaf, A. I., Waigh, R. D., Drummond, A. J., Pringle, B., McGroarty, I., Skellern, G. G. & Suckling, C. J., 5 Mar 2004, In : Journal of Medicinal Chemistry. 47, 8, p. 2133-2156 23 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

Gibson, C. L., Huggan, J. K., Kennedy, A., Kiefer, L., Lee, J. H., Suckling, C. J., Clements, C. J., Harvey, A. L., Hunter, W. N. & Tulloch, L. B., 7 May 2009, In : Organic and Biomolecular Chemistry. 7, 9, p. 1829-1842 14 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
305 Downloads (Pure)
File
11 Citations (Scopus)
264 Downloads (Pure)

DNA Binding, Solubility, and Partitioning Characteristics of Extended Lexitropsins

Khalaf, A. I., Pitt, A. R., Scobie, M., Suckling, C. J., Urwin, J., Waigh, R. D., Young, S. C., Fishleigh, R. V. & Fox, K. R., 24 Aug 2000, In : Journal of Medicinal Chemistry. 43, 17, p. 3257-3266 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

DNA binding of a short lexitropsin

Anthony, N. G., Fox, K. R., Johnston, B. F., Khalaf, A. I., Mackay, S. P., McGroarty, I. S., Parkinson, J. A., Skellern, G. G., Suckling, C. J. & Waigh, R. D., 8 Mar 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 5, p. 1353-1356 3 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

DNA Minor Groove Binders

Waigh, R., Suckling, C. & Khalaf, A., 24 Jul 2003, Priority date 24 Dec 2001, Priority No. 0130868.3

Research output: Patent

DNA sequence recognition by an imidazole-containing isopropyl thiazole polyamide (thiazotropsin b)

Suckling, C. J., Hampshire, A. J., Khairallah, H., Khalaf, A. I., Ebrahimabadi, A. H., Waigh, R. D., Brown, T. & Fox, K. R., 1 Jul 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 13, p. 3469-3474 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

DNA sequence recognition by an isopropyl substituted thiazole polyamide

James, P. L., Merkina, E. E., Khalaf, A. I., Suckling, C. J., Waigh, R. D., Brown, T. & Fox, K. R., 5 Jun 2004, In : Nucleic Acids Research. 32, 11, p. 3410-3417 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

Rodgers, D. T., Pineda, M. A., Suckling, C. J., Harnett, W. & Harnett, M. M., 1 Nov 2015, In : Lupus. 24, 13, p. 1437-1442 6 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
58 Downloads (Pure)

Electrochemical properties of blocked dihydropterins

Suckling, C. J., Huggan, J., Berlouis, L. & Gibson, C. L., 2005, In : Pteridines. 16, 112

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ethyl 2-amino-4-isopropyl-1,3-thiazole-5-carboxylate

Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., 17 Jul 2004, In : Acta Crystallographica Section E: Structure Reports. 60, 8, p. 1188-1190 2 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ethyl 2-aminooxazole-5-carboxylate

Kennedy, A., Khalaf, A., Suckling, C. & Waigh, R., 2001, In : Acta Crystallographica Section E: Structure Reports. 57, p. o832-o833 2 p.

Research output: Contribution to journalArticle

Ethyl 5-oxo-2,5-dihydro-4-isoxazolecarboxylate hydroxylamine salt

Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., Sep 2003, In : Acta Crystallographica Section E: Structure Reports. 59, 9, p. 1410-1412 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Evaluating nitric oxide synthase as a potential therapeutic target in schizophrenia

Lee, G., Thomson, D. M., Suckling, C., Morris, B. J. & Pratt, J. A., Aug 2011, In : Journal of Psychopharmacology. 25, 8 Supplement S, p. A67-A67 1 p.

Research output: Contribution to journalMeeting abstract

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., Khalaf, A., Carter, K., Scott, F., Suckling, C. & Guler, R., 1 Dec 2017, In : Journal of Antimicrobial Chemotherapy. 72, 12, p. 3334–3341 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
13 Downloads (Pure)
Open Access
File
7 Citations (Scopus)
91 Downloads (Pure)

Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease

Doonan, J., Thomas, D., Wong, M. H., Ramage, H. J., Al-Riyami, L., Lumb, F. E., Bell, K. S., Fairlie-Clarke, K. J., Suckling, C. J., Michelsen, K. S., Jiang, H-R., Cooke, A., Harnett, M. M. & Harnett, W., 17 Oct 2018, In : Molecules. 23, 10, 14 p., 2669.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
8 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
50 Downloads (Pure)