Colin Suckling, OBE BSc PhD DSc CChem FRSC FRCS(Glasg) Hon FRCS (Edin) FRSA FRSE

Prof

  • United Kingdom

1991 …2022

Research output per year

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Research Output

1991

A f-19 and deuterium nmr-study of two novel fluorosterols and their properties in model membranes and high-density-lipoprotein

Reid, D. G., MacLachlan, L. K., Suckling, K. E., Gee, A., Cresswell, S. & Suckling, C. J., May 1991, In : Chemistry and Physics of Lipids. 58, 1-2, p. 175-181 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Catalytic antibodies: a new window on protein chemistry

Suckling, C. J., Tedford, C. M., Proctor, G. R., Khalaf, A. I., Bence, L. M. & Stimson, W. H., 1991, In : Ciba Foundation Symposium. 159, Catal. Antibodies, p. 201-210 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1992

Remarkably efficient hydrolysis of a 4-nitrophenyl ester by a catalytic antibody raised to an ammonium hapten

Khalaf, A. I., Proctor, G. R., Suckling, C. J., Bence, L. H., Irvine, J. I. & Stimson, W. H., 1992, In : Journal of the Chemical Society, Perkin Transactions 1. 12, p. 1475-1481 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1999

Cholest-5-ene-3 beta,4 beta-diyl diacetate

Kennedy, A. R., Pitt, A. R., Suckling, C. J., Suckling, K. E. & Thomas, M., Sep 1999, In : Acta Crystallographica Section C: Crystal Structure Communications. 55, 9, p. 1570-1572 2 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Methyl 2-amino-4-(methoxymethyl)thiazole-5-carboxylate

Kennedy, A., Khalaf, A. I., Pitt, A. P., Scobie, M., Suckling, C. J., Urwin, J., Waigh, R. D. & Young, S. C., 1999, In : Acta Crystallographica Section C: Crystal Structure Communications. C55, 7, ii, IUC9900072.

Research output: Contribution to journalArticle

2000

3-Acetoxycyclohex-4-ene-1,2-di-carboxylic anhydride

Kennedy, A. R., Khalaf, A. I. & Suckling, C. J., Jun 2000, In : Acta Crystallographica Section C: Crystal Structure Communications. 56, 6, p. e265-e266

Research output: Contribution to journalArticle

1 Citation (Scopus)

DNA Binding, Solubility, and Partitioning Characteristics of Extended Lexitropsins

Khalaf, A. I., Pitt, A. R., Scobie, M., Suckling, C. J., Urwin, J., Waigh, R. D., Young, S. C., Fishleigh, R. V. & Fox, K. R., 24 Aug 2000, In : Journal of Medicinal Chemistry. 43, 17, p. 3257-3266 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

On the specificity of reactions catalysed by the antibody H11

Khalaf, A. I., Linaza, S., Pitt, A. R., Stimson, W. H. & Suckling, C. J., 14 Jan 2000, In : Tetrahedron. 56, 3, p. 489-495 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of novel DNA binding agents: indole-containing analogs of bis-netropsin

Khalaf, A. I., Pitt, A. R., Scobie, M., Suckling, C. J., Urwin, J., Waigh, R. D., Fishleigh, R. V. & Young, S. C., 2000, In : International Journal of Chemical Research. 6, p. 264-265 2 p.

Research output: Contribution to journalArticle

Synthesis of Pyrimidine Libraries: Development of Solid Phase Methodology

Suckling, C. J., Gibson, C. L. & McCluskey, A., 23 Jun 2000, (Unpublished) Solid Phase Synthesis and Combinatorial Chemical Libraries. p. 359-360 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The Synthesis of Some Head to Head Linked DNA Minor Groove Binders

Khalaf, A. I., Pitt, A. R., Scobie, M., Suckling, C. J., Urwin, J., Waigh, R. D., Young, S. C., Fishleigh, R. V. & Wylie, W. A., 14 Jul 2000, In : International Journal of Chemical Research. 56, 29, p. 5225-5239 14 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The synthesis of some indole-containing amino acids as linkers for the construction of DNA minor groove binders

Khalaf, A. I., Pitt, A. R., Scobie, M., Suckling, C. J., Urwin, J., Waigh, R. D., Young, S. C. & Fishleigh, R. V., 1 Jun 2000, In : International Journal of Chemical Research. 2000, 6, p. 264-265 1 p.

Research output: Contribution to journalArticle

Unexpected Dealkylation During Nucleophilic Substitution: Synthesis of 2-N,N-Dialkylamino Benzoxazoles and Benzothiazoles

Khalaf, A. I., Alvarez, R. G., Suckling, C. J. & Waigh, R. D., 20 Oct 2000, In : Tetrahedron. 56, 43, p. 8567-8571 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2001

A novel biotransformation of benzofurans and related compounds catalysed by a chloroperoxidase

Alvarez, R. G., Hunter, I. S., Suckling, C. J., Thomas, M. & Vitinius, U., Oct 2001, In : Tetrahedron. 57, 40, p. 8581-8587 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Ethyl 2-aminooxazole-5-carboxylate

Kennedy, A., Khalaf, A., Suckling, C. & Waigh, R., 2001, In : Acta Crystallographica Section E: Structure Reports. 57, p. o832-o833 2 p.

Research output: Contribution to journalArticle

2002

Solution and solid phase synthesis of pteridines, purides and related compounds

La Rosa, S., Boyle, P. H., Suckling, C. J., Gibson, C. L. & Guiney, D., 31 May 2002, The Chemistry and Biology of Pteridines and Folates. UK, p. 25-29 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Strategies for the synthesis of pteridines and related compounds with high diversity

Gibson, C. L., Boyle, P. H., Guiney, D., La Rosa, S. & Suckling, C. J., 31 May 2002, The Chemistry and Biology of Pteridines and Folates. p. 421-425 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synthesis of Pteridines with C-2 and C-6 functional group diversity

Guiney, D., Boyle, P. H., Gibson, C. L., La Rosa, S. & Suckling, C. J., 31 May 2002, The Chemistry and Biology of Pteridines and Folates. p. 31-35 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The amazingly patient tutor: students' interactions with an online carbohydrate chemistry course

Littlejohn, A., Suckling, C. J., Campbell, L. & McNicol, D., Jun 2002, In : British Journal of Educational Technology. 33, 3, p. 313-321 8 p.

Research output: Contribution to journalArticle

2003

A prototype solid phase synthesis of pteridines and related heterocyclic compounds

Gibson, C. L., La Rosa, S. & Suckling, C. J., 30 Apr 2003, In : Organic and Biomolecular Chemistry. 1, 11, p. 1909-1918 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

A traceless solid-phase synthesis of pteridines

Gibson, C. L., La Rosa, S. & Suckling, C. J., 3 Feb 2003, In : Tetrahedron Letters. 44, 6, p. 1267-1270 3 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

DNA Minor Groove Binders

Waigh, R., Suckling, C. & Khalaf, A., 24 Jul 2003, Priority date 24 Dec 2001, Priority No. 0130868.3

Research output: Patent

Ethyl 5-oxo-2,5-dihydro-4-isoxazolecarboxylate hydroxylamine salt

Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., Sep 2003, In : Acta Crystallographica Section E: Structure Reports. 59, 9, p. 1410-1412 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Minor groove binders substituted by lipophilic groups

Suckling, C. J., Waigh, R. D., Khalaf, A. L., Parkinson, J., Hunter, I. S. & Williams, R. M. (ed.), 16 Jul 2003, 19th International Congress on Heterocyclic Chemistry. p. 98-98

Research output: Chapter in Book/Report/Conference proceedingChapter

Solid phase synthesis of pteridines and related compounds

Suckling, C. J., Gibson, C. L., La Rosa, S., Huggan, J., Oppilliart, S. & Williams, R. M. (ed.), 16 Jul 2003, 19th International Congress on Heterocyclic Chemistry. p. 322-322

Research output: Chapter in Book/Report/Conference proceedingChapter

Syntheses of highly functionalised 6-substituted pteridines

Guiney, D., Gibson, C. L. & Suckling, C. J., 3 Jan 2003, In : Organic and Biomolecular Chemistry. 1, 4, p. 664-675 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2004

An in silico footprinting technique to study ligand interactions in the minor groove of DNA

Anthony, N. G., Johnston, B. F., Mackay, S. P., Suckling, C. J. & Waigh, R. D., Aug 2004, In : Drugs of the Future. 29, Suppl. A, p. 150

Research output: Contribution to journalArticle

Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity

Khalaf, A. I., Waigh, R. D., Drummond, A. J., Pringle, B., McGroarty, I., Skellern, G. G. & Suckling, C. J., 5 Mar 2004, In : Journal of Medicinal Chemistry. 47, 8, p. 2133-2156 23 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

DNA binding of a short lexitropsin

Anthony, N. G., Fox, K. R., Johnston, B. F., Khalaf, A. I., Mackay, S. P., McGroarty, I. S., Parkinson, J. A., Skellern, G. G., Suckling, C. J. & Waigh, R. D., 8 Mar 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 5, p. 1353-1356 3 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

DNA sequence recognition by an isopropyl substituted thiazole polyamide

James, P. L., Merkina, E. E., Khalaf, A. I., Suckling, C. J., Waigh, R. D., Brown, T. & Fox, K. R., 5 Jun 2004, In : Nucleic Acids Research. 32, 11, p. 3410-3417 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Ethyl 2-amino-4-isopropyl-1,3-thiazole-5-carboxylate

Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., 17 Jul 2004, In : Acta Crystallographica Section E: Structure Reports. 60, 8, p. 1188-1190 2 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Methyl 2-amino-5-iso­propyl-1,3-thia­zole-4-carboxyl­ate

Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., Sep 2004, In : Acta Crystallographica Section E: Structure Reports. 60, 9, p. 1510-1512 2 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
41 Downloads (Pure)

Minor groove binders 1998-2004

Suckling, C. J., 1 Dec 2004, In : Expert Opinion on Therapeutic Patents. 14, 12, p. 1693-1724 31 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Short Lexitropsin that Recognizes the DNA Minor Groove at 5'-ACTAGT-3': Understanding the Role of Isopropyl-thiazole

Anthony, N. G., Johnston, B. F., Khalaf, A. I., Mackay, S. P., Parkinson, J. A., Suckling, C. J. & Waigh, R. D., 19 Aug 2004, In : Journal of the American Chemical Society. 126, 36, p. 11338-11349 11 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Solid phase synthesis of pteridines and related compounds

Suckling, C. J., Gibson, C. L., Huggan, J., Oppilliart, S., La Rosa, S. & Epton, R. (ed.), 2004, 8th Millennium Symposium, Solid Phase Synthesis and Combinational Libraries. p. 39-42 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synthesis and antimicrobial activity of some netropsin analogues

Khalaf, A. I., Ebrahimabadi, A. H., Drummond, A. J., Anthony, N. G., Mackay, S. P., Suckling, C. J. & Waigh, R. D., 10 Sep 2004, In : Organic and Biomolecular Chemistry. 2, 21, p. 3119-3127 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase 1

Gibson, C. L., La Rosa, S., Ohta, K., Boyle, P. H., Leurquin, F., Lemaçon, A. & Suckling, C. J., 19 Jan 2004, In : Tetrahedron. 60, 4, p. 943-959 16 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2005

2-(1-Piperidinyl)-1,3-benzothiazole

Alvarez, R. G., Kennedy, A. R., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., 5 Feb 2005, In : Acta Crystallographica Section E: Structure Reports. 61, p. 569-570 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Electrochemical properties of blocked dihydropterins

Suckling, C. J., Huggan, J., Berlouis, L. & Gibson, C. L., 2005, In : Pteridines. 16, 112

Research output: Contribution to journalArticle

Highly flexible solid phase syntheses of pteridines and related compounds

Suckling, C. J., Huggan, J., Rao, R. M., Kiefer, L. & Gibson, C. L., 2005, In : Pteridines. 16, 88

Research output: Contribution to journalArticle

Highly flexible syntheses of pteridines and related compounds

Suckling, C. J., Huggan, J., Rao, R. M., Kiefer, L. & Gibson, C. L., 2005, In : Pteridines. 16, 53

Research output: Contribution to journalArticle

In Silico Footprinting of Ligands Binding to the Minor Groove of DNA

Anthony, N. G., Huchet, G., Johnston, B. F., Parkinson, B. F., Suckling, C. J., Waigh, R. D. & Mackay, S. P., 5 Oct 2005, In : Journal of Chemical Information and Modeling. 45, 6, p. 1896-1907 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Modulation of pulmonary vascular tone by novel analogues of tetrahydrobiopterin

Suckling, C. J., Kununthur, S. R., Gibson, C. L. & Wadsworth, R. M., 2005, In : Pteridines. 16, 112

Research output: Contribution to journalArticle

Pteridine derivatives as nitric oxide synthase activators

Wadsworth, R., Suckling, C. J. & Gibson, C. L., 2005, IPC No. A61K 31/525, Patent No. US 2006/0194800 A1

Research output: Patent

2006

3-Nitro-1-(triisopropylsilyl)-1H-pyrrole

Kennedy, A., Khalaf, A. I., Suckling, C. J. & Waigh, R. D., Aug 2006, In : Acta Crystallographica Section E: Structure Reports. 62, 8, p. o3282-o3284 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2 Citations (Scopus)

DNA sequence recognition by an imidazole-containing isopropyl thiazole polyamide (thiazotropsin b)

Suckling, C. J., Hampshire, A. J., Khairallah, H., Khalaf, A. I., Ebrahimabadi, A. H., Waigh, R. D., Brown, T. & Fox, K. R., 1 Jul 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 13, p. 3469-3474 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
3 Citations (Scopus)
2007

Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups

Anthony, N. G. H., Breen, D., Clarke, J., Donoghue, G., Drummond, A. J., Ellis, E., Gemmell, C. G., Helesbeux, J-J., Hunter, I. S., Khalaf, A., MacKay, S., Parkinson, J. A., Suckling, C. J. & Waigh, R. D., Oct 2007, In : Journal of Medicinal Chemistry. 50, 24, p. 6116-6125 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds

Suckling, C. J., Murphy, J. A., Khalaf, A. I., Zhou, S., Lizos, D. E., Nguyen Van Nhien, A., Yasumatsu, H., McVie, A., Young, L. C., McCraw, C., Waterman, P. G., Morris, B. J., Pratt, J. A. & Harvey, A., 1 May 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 9, p. 2649-2655 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)