Colin Suckling, OBE BSc PhD DSc CChem FRSC FRCS(Glasg) Hon FRCS (Edin) FRSA FRSE

Prof

  • United Kingdom

1991 …2020

Research output per year

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Research Output

2019

Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model

Giordani, F., Khalaf, A. I., Gillingwater, K., Munday, J. C., De Koning, H. P., Suckling, C. J., Barrett, M. P. & Scott, F. J., 28 Mar 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 3021-3035 15 p.

Research output: Contribution to journalArticle

Open Access
File
3 Downloads (Pure)

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Nichol, R., Khalaf, A., Sooda, K., Hussain, O., Griffiths, H., Phillips, R., Javid, F., Suckling, C. J., Allison, S. & Scott, F., 1 Sep 2019, In : Medicinal Chemistry Communications. 10, 9, p. 1620-1634 15 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
1 Downloads (Pure)

Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model

Lumb, F. E., Crowe, J., Doonan, J., Suckling, C. J., Selman, C., Harnett, M. M. & Harnett, W., 31 Dec 2019, In : Molecular and Biochemical Parasitology. 234, 13 p., 111232.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)
2018

Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease

Doonan, J., Thomas, D., Wong, M. H., Ramage, H. J., Al-Riyami, L., Lumb, F. E., Bell, K. S., Fairlie-Clarke, K. J., Suckling, C. J., Michelsen, K. S., Jiang, H-R., Cooke, A., Harnett, M. M. & Harnett, W., 17 Oct 2018, In : Molecules. 23, 10, 14 p., 2669.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
9 Downloads (Pure)

Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis

Doonan, J., Lumb, F. E., Pineda, M. A., Tarafdar, A., Crowe, J., Khan, A. M., Suckling, C. J., Harnett, M. M. & Harnett, W., 14 May 2018, In : Frontiers in Immunology. 9, 13 p., 1016.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
39 Downloads (Pure)

Small molecule analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Suckling, C. J., Alam, S., Olson, M. A., Saikh, K. U., Harnett, M. M. & Harnett, W., 1 Feb 2018, In : Scientific Reports. 8, 11 p., 2123.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
19 Downloads (Pure)

Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis

Suckling, C. J., Mukherjee, S., Khalaf, A. I., Narayan, A., Scott, F. J., Khare, S., Dhakshinamoorthy, S., Harnett, M. M. & Harnett, W., 30 Sep 2018, In : Acta Tropica. 185, p. 212-218 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
6 Downloads (Pure)
2017

An evaluation of minor groove binders as anti-fungal and anti-mycobacterial therapeutics

Scott, F., Nichol, R. J. O., Khalaf, A. I., Giordani, F., Gillingwater, K., Ramu, S., Elliott, A., Zuegg, J., Duffy, P., Rosslee, M-J., Hlaka, L., Kumar, S., Ozturk, M., Brombacher, F., Barrett, M., Guler, R. & Suckling, C. J., 18 Aug 2017, In : European Journal of Medicinal Chemistry. 136, p. 561-572 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
21 Downloads (Pure)

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

Lumb, F. E., Doonan, J., Bell, K. S., Pineda, M. A., Corbet, M., Suckling, C. J., Harnett, M. M. & Harnett, W., 10 May 2017, In : Scientific Reports. 13 p., 1704.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
198 Downloads (Pure)

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., Khalaf, A., Carter, K., Scott, F., Suckling, C. & Guler, R., 1 Dec 2017, In : Journal of Antimicrobial Chemotherapy. 72, 12, p. 3334–3341 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
14 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
53 Downloads (Pure)

Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers

Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N., Scott, R. & 4 others, Suckling, C. J., Sutcliffe, O. B., Young, L. C. & MacKay, S. P., 24 Jul 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7043-7066 24 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
143 Downloads (Pure)

Minor groove binders for DNA as antitypanosomal agents: the veterinary context

Suckling, C. J., Scott, F., Khalaf, A., Gillingwater, K., Morrison, L., de Koning, H., Barrett, M. & Giordani, F., 1 Nov 2017. 19 p.

Research output: Contribution to conferencePaper

Open Access
File

Selectivity in anti-infective minor groove binders

Suckling, C. J. & Scott, F. J., 1 Nov 2017. 18 p.

Research output: Contribution to conferencePaper

Open Access
File
2 Downloads (Pure)

Why antibacterial minor groove binders are a good thing

Suckling, C. J., Khalaf, A., Scott, F. J., Tucker, N., Niemenen, L., Lemonidis, K. & Hunter, I. S., 1 Nov 2017. 21 p.

Research output: Contribution to conferencePaper

Open Access
File
2 Downloads (Pure)
2016

An evaluation of minor groove binders as anti-lung cancer therapeutics

Scott, F., Khalaf, A., Suckling, C., Carter, K., Grant, M., Henderson, C., Westrop, G. & Watson, D., 15 Jun 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
36 Downloads (Pure)

An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics

Scott, F. J., Khalaf, A. I., Giordani, F., Wong, P. E., Duffy, S., Barrett, M., Avery, V. M. & Suckling, C. J., 30 Jun 2016, In : European Journal of Medicinal Chemistry. 116, p. 116-125 10 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
114 Downloads (Pure)

Cell penetrant inhibitors of the KDM4 and KDM5 families of histone lysine demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one derivatives

Westaway, S. M., Preston, A. G. S., Barker, M. D., Brown, F., Brown, J. A., Campbell, M., Chung, C-W., Drewes, G., Eagle, R., Garton, N., Gordon, L., Haslam, C., Hayhow, T. G., Humphreys, P. G., Joberty, G., Katso, R., Kruidenier, L., Leveridge, M., Pemberton, M., Rioja, I. & 9 others, Seal, G. A., Shipley, T., Singh, O., Suckling, C. J., Taylor, J., Thomas, P., Wilson, D. M., Lee, K. & Prinjha, R. K., 25 Feb 2016, In : Journal of Medicinal Chemistry. 59, 4, p. 1370-1387 18 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Selective anti-malarial minor groove binders

Scott, F. J., Khalaf, A. I., Duffy, S., Avery, V. M. & Suckling, C. J., 15 Jul 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, p. 3326-3329 4 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
24 Downloads (Pure)

Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening

Borthwick, J. A., Ancellin, N., Bertrand, S. M., Bingham, R. P., Carter, P. S., Chung, C., Churcher, I., Dodic, N., Fournier, C., Francis, P. L., Hobbs, A., Jamieson, C., Pickett, S. D., Smith, S. E., Somers, D. ON., Spitzfaden, C., Suckling, C. J. & Young, R. J., 24 Mar 2016, In : Journal of Medicinal Chemistry. 59, 6, p. 2452-2467 16 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
49 Downloads (Pure)

Testing small molecule analogues of acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergens

Janicova, L., Rzepecka, J., Rodgers, D. T., Doonan, J., Bell, K., Lumb, F. E., Suckling, C. J., Harnett, M. M. & Harnett, W., 30 Jun 2016, In : Parasite Immunology. 38, 6, p. 340-351 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
44 Downloads (Pure)

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

Coltherd, J. C., Rodgers, D. T., Lawrie, R. E., Al-Riyami, L., Suckling, C. J., Harnett, W. & Harnett, M. M., 14 Jan 2016, In : Scientific Reports. 6, 14 p., 19224.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
105 Downloads (Pure)
2015

Crystal structure of N,N-dimethyl-2-[(4-methylbenzyl) sulfonyl]ethanamine

Kennedy, A. R., Khalaf, A. I., Scott, F. J. & Suckling, C. J., Jul 2015, In : Acta Crystallographica Section E: Structure Reports. 71, 7, p. 757-759 3 p.

Research output: Contribution to journalArticle

Open Access
File
61 Downloads (Pure)

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

Rodgers, D. T., Pineda, M. A., Suckling, C. J., Harnett, W. & Harnett, M. M., 1 Nov 2015, In : Lupus. 24, 13, p. 1437-1442 6 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
59 Downloads (Pure)

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Rzepecka, J., Pineda, M. A., Al-Riyami, L., Rodgers, D. T., Huggan, J. K., Lumb, F. E., Khalaf, A. I., Meakin, P. J., Corbet, M., Ashford, M. L., Suckling, C. J., Harnett, M. M. & Harnett, W., Jun 2015, In : Journal of Autoimmunity. 60, p. 59-73 15 p.

Research output: Contribution to journalArticle

Open Access
File
46 Citations (Scopus)
2274 Downloads (Pure)

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation

Al-Riyami, L., Rodgers, D. T., Rzepecka, J., Pineda, M. A., Suckling, C. J., Harnett, M. M. & Harnett, W., 25 Mar 2015, (Accepted/In press) In : Experimental Parasitology . 5 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
53 Downloads (Pure)

The antibacterial drug MGB-BP3: from discovery to clinical trial

Suckling, C. J., 30 Jun 2015, In : Chemistry and Biology Interface. 5, 3, p. 166-174 8 p.

Research output: Contribution to journalArticle

Open Access
File
77 Downloads (Pure)

The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits

Bertrand, S. M., Ancellin, N., Beaufils, B., Bingham, R. P., Borthwick, J. A., Boullay, A. B., Boursier, E., Carter, P. S., Chung, C. W., Churcher, I., Dodic, N., Fouchet, M. H., Fournier, C., Francis, P. L., Gummer, L. A., Herry, K., Hobbs, A., Hobbs, C. I., Homes, P., Jamieson, C. & 12 others, Nicodeme, E., Pickett, S. D., Reid, I. H., Simpson, G. L., Sloan, L. A., Smith, S. E., Somers, D. O. N., Spitzfaden, C., Suckling, C. J., Valko, K., Washio, Y. & Young, R. J., 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7140-7163 24 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2014

Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase

Chreifi, G., Li, H., McInnes, C., Gibson, C., Suckling, C. & Poulos, T. L., 2014, In : Biochemistry.

Research output: Contribution to journalArticle

File
11 Citations (Scopus)
208 Downloads (Pure)

Novel TPP-riboswitch activators bypass metabolic enzyme dependency

Mayer, G., Lünse, C., Suckling, C. & Scott, F., 1 Jul 2014, (Accepted/In press) In : Frontiers in Chemistry. 2, 53.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
83 Downloads (Pure)

Oligoamides of 2-amino-5-alkylthiazole 4-carboxylic acids: anti-trypanosomal compounds

Lang, S., Khalaf, A. I., Breen, D., Huggan, J., Clements, C., MacKay, S. & Suckling, C., 2014, In : Medicinal Chemistry Research. 23, 3, p. 1170-1179 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Recognition of the DNA minor groove by thiazotropsin analogues

Alniss, H. Y., Salvia, M. V., Sadikov, M., Golovchenko, I., Anthony, N. G., Khalaf, A. I., MacKay, S. P., Suckling, C. J. & Parkinson, J. A., 5 Sep 2014, In : Chembiochem. 15, 13, p. 1978–1990 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Rzepecka, J., Coates, M., Saggar, M., Al-Riyami, L., Coltherd, J., Tay, H. K., Huggan, J., Janicova, L., Khalaf, A., Siebeke, I., Suckling, C., Harnett, M. & Harnett, W., Aug 2014, In : International Journal for Parasitology. 44, 9, p. 669-674 6 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
84 Downloads (Pure)

Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

Khalaf, A. I., Huggan, J., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P., Wong, P. E., Barrack, K. L. & Hunter, W. N., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6479-6494 6 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
291 Downloads (Pure)

The differing biological fates of DNA minor groove-binding (MGB) antibiotics in Gram-negative and Gram-positive bacteria

Nieminen, L. K. L., Hunter, I., Suckling, C. & Tucker, N., 1 Aug 2014, (Unpublished).

Research output: Contribution to conferencePoster

2013
57 Citations (Scopus)
Open Access
File
7 Citations (Scopus)
91 Downloads (Pure)

Mechanistic exploration of the palladium-catalysed process for the synthesis of benzoxazoles and benzothiazoles

Bochatay, V., Boissarie, P., Murphy, J. A., Suckling, C. & Lang, S., 15 Feb 2013, In : Journal of Organic Chemistry. 78, 4, p. 1471-1477 7 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Minor groove binders as anti-infective agents

Barrett, M. P., Gemmell, C. G. & Suckling, C., Jul 2013, In : Pharmacology and Therapeutics. 139, 1, p. 12-23 12 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The diversity-oriented synthesis of pteridines—achievements and potential for development

Suckling, C., Apr 2013, In : IUBMB Life. 65, 4, p. 283-299 17 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove

Salvia, M-V., Addison, F., Alniss, H. Y. H., Buurma, N. J., Khalaf, A., MacKay, S., Anthony, N. G., Suckling, C., Evstigneev, M. P., Santiago, A. H., Waigh, R. & Parkinson, J., Sep 2013, In : Biophysical Chemistry. 179, p. 1-11 11 p.

Research output: Contribution to journalArticle

File
14 Citations (Scopus)
271 Downloads (Pure)
2012

Asymmetric rhodium-catalysed addition of arylboronic acids to acyclic unsaturated esters containing a basic γ-amino group

Anderson, N. A., Fallon, B. J., Valverde, E., MacDonald, S. J. F., Pritchard, J. M., Suckling, C. & Watson, A., Dec 2012, In : Synlett. 23, 19, p. 2817-2821 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups

Khalaf, A., Bourdin, C., Breen, D., Donoghue, G., Scott, F., Suckling, C., MacMillan, D., Clements, C., Fox, K. & Sekibo, D., 2012, In : European Journal of Medicinal Chemistry. 56, p. 39-47 9 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
86 Downloads (Pure)
17 Citations (Scopus)

Pd-catalyzed three-component synthesis of oxazolines and benzoxazoles

Boissarie, P., Hamilton, Z., Lang, S., Murphy, J. A. & Suckling, C., 1 Feb 2012, In : SYNFACTS. 8, 2, p. 138-138 1 p.

Research output: Contribution to journalComment/debate

Rationalising sequence selection by ligand assemblies in the DNA minor groove: the case for thiazotropsin A

Alniss, H. Y., Anthony, N. G. H., Khalaf, A., Mackay, S., Suckling, C., Waigh, R., Wheate, N. & Parkinson, J., 2012, In : Chemical Science. 3, 3, p. 711-722 12 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
86 Downloads (Pure)

Tetrahydrobiopterin and electron transfer in NO synthase

Daff, S., Gazur, B., Papale, D., McInnes, C., Morthala, R. R., Gibson, C. L. & Suckling, C. J., 15 Jul 2012, In : Nitric Oxide: Biology and Chemistry . 27, supplement, p. S5-S5 1 p.

Research output: Contribution to journalMeeting abstract

2011

Amide isosteres in structure-activity studies of antibacterial minor groove binders

Khalaf, A. I., Anthony, N., Breen, D., Donoghue, G., Mackay, S. P., Scott, F. J. & Suckling, C. J., Nov 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5343-5355 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

A powerful palladium-catalyzed multicomponent process for the preparation of oxazolines and benzoxazoles

Boissarie, P., Hamilton, Z., Lang, S., Murphy, J. & Suckling, C., 2 Dec 2011, In : Organic Letters. 13, 23, p. 6256-6259 4 p.

Research output: Contribution to journalLetter

85 Citations (Scopus)
File
11 Citations (Scopus)
377 Downloads (Pure)