Projects per year
Personal profile
Personal Statement
Over the last ten years, S-acylation has emerged as a prominent protein post-translational modification that impacts all physiological systems and is associated with many different disease states, including cancer, neurological disorders and diabetes. Quantitative proteomics approaches have indicated that up to 10% of the proteome is modified by S-acylation, and this can affect protein localisation, stability, interactions and function. A family of twenty-three DHHC acyltransferase enzymes whose mechanism of action and regulation are poorly understood mediates S-acylation. Since joining Prof Chamberlain’s group at the University of Strathclyde in 2012, I have been involved in various projects exploring the regulation of DHHC cellular localization in neurons (in collaboration with Dr Trevor Bushell), and in the mechanisms underlying DHHC enzyme-substrate recognition and specificity. S-acylation has received growing interest from Pharma as a potential novel therapeutic target for a range of diseases. However, we lack selective inhibitors of the DHHC enzyme family. I was involved in a collaborative project (with Prof Nicholas Tomkinson) and the Japanese company Ono Pharma Ltd that led to the discovery of novel inhibitors of DHHC enzymes.
I am currently developing projects exploring the contribution of S-acylation to viral biology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Structure of the amphotropic murine leukemia virus receptor / phosphate transporter Pit2: topology, oligomerization and regulation by the extracellular inorganic phosphate., Institut Pasteur
1 Sept 1997 → 21 Nov 2001
Award Date: 21 Nov 2001
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Collaborations and top research areas from the last five years
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Honours student project: How does S-acylation stabilise SARS-CoV-2 proteins?
24/10/22 → 9/12/22
Project: Research - no external funding
Research output
- 10 Article
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Increased TRPV4 channel expression enhances and impairs blood vessel function in hypertension
Zhang, X., Buckley, C., Lee, M. D., Salaun, C., MacDonald, M., Wilson, C. & McCarron, J. G., 23 Oct 2024, (E-pub ahead of print) In: Hypertension. 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
Salaun, C., Tomkinson, N. C. O. & Chamberlain, L. H., 31 Oct 2023, In: Journal of Biological Chemistry . 299, 10, 15 p., 105201.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)31 Downloads (Pure)
Activities
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Biochemical Society (The) (External organisation)
Christine Salaun (Member)
2023Activity: Membership types › Membership of network
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Krzysztof Wypijewski
Christine Salaun (Host) & Luke Chamberlain (Host)
21 Sept 2022Activity: Hosting a visitor types › Hosting an academic visitor