Projects per year
Over the last ten years, S-acylation has emerged as a prominent protein post-translational modification that impacts all physiological systems and is associated with many different disease states, including cancer, neurological disorders and diabetes. Quantitative proteomics approaches have indicated that up to 10% of the proteome is modified by S-acylation, and this can affect protein localisation, stability, interactions and function. A family of twenty-three DHHC acyltransferase enzymes whose mechanism of action and regulation are poorly understood mediates S-acylation. Since joining Prof Chamberlain’s group at the University of Strathclyde in 2012, I have been involved in various projects exploring the regulation of DHHC cellular localization in neurons (in collaboration with Dr Trevor Bushell), and in the mechanisms underlying DHHC enzyme-substrate recognition and specificity. S-acylation has received growing interest from Pharma as a potential novel therapeutic target for a range of diseases. However, we lack selective inhibitors of the DHHC enzyme family. I was involved in a collaborative project (with Prof Nicholas Tomkinson) and the Japanese company Ono Pharma Ltd that led to the discovery of novel inhibitors of DHHC enzymes.
I am currently developing projects exploring the contribution of S-acylation to viral biology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, Institut Pasteur
1 Sep 1997 → 21 Nov 2001
Award Date: 21 Nov 2001
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Role of S-acylation in viral biology
1/07/20 → …
Honours student project: How does S-acylation stabilise SARS-CoV-2 proteins?
24/10/22 → 9/12/22
Project: Research - no external funding
- 8 Article
S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interactionButler, L., Locatelli, C., Allagioti, D., Lousa, I., Lemonidis, K., Tomkinson, N. C. O., Salaun, C. & Chamberlain, L. H., 31 Jan 2023, In: Journal of Biological Chemistry. 299, 1, 13 p., 102754.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Downloads (Pure)
Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylationSalaun, C., Takizawa, H., Galindo, A., Munro, K. R., McLellan, J., Sugimoto, I., Okino, T., Tomkinson, N. C. O. & Chamberlain, L. H., 31 Oct 2022, In: Journal of Biological Chemistry. 298, 10, 22 p., 102469.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Biochemical Society (The) (External organisation)
Christine Salaun (Member)2023
Activity: Membership types › Membership of network
Christine Salaun (Host) & Luke Chamberlain (Host)21 Sep 2022
Activity: Hosting a visitor types › Hosting an academic visitor