• United Kingdom

Accepting PhD Students

PhD projects

- Development of novel tumour-targeted nanomedicines for cancer therapy

20002019

Research output per year

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Research Output

2019

Anti-tumor activity of intravenously administered plumbagin entrapped in targeted nanoparticles

Sakpakdeejaroen, I., Somani, S., Laskar, P., Irving, C., Mullin, M. & Dufes, C., 1 Aug 2019, (Accepted/In press) In : Journal of Biomedical Nanotechnology.

Research output: Contribution to journalArticle

Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells

Laskar, P., Somani, S., Campbell, S. J., Mullin, M., Keating, P., Tate, R. J., Irving, C., Leung, H. Y. & Dufès, C., 14 Nov 2019, In : Nanoscale. 11, 42, p. 20058-20071 14 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)

Development of transferrin-bearing vesicles encapsulating aspirin for cancer therapy

Sakpakdeejaroen, I., Somani, S., Mullin, M. & Dufès, C., 22 Apr 2019, (Accepted/In press) In : Journal of Liposome Research. 30 p.

Research output: Contribution to journalArticle

Open Access
File
4 Downloads (Pure)

On the issue of transparency and reproducibility in nanomedicine

Leong, H. S., Butler, K. S., Brinker, C. J., Azzawi, M., Conlan, S., Dufes, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M. A., Kozlov, S. V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R. M., McNeil, S. E., Fadeel, B. & 58 others, Tran, L., Foss Hansen, S., Hartmann, N. B., Clausen, L. P. W., Skjolding, L. M., Baun, A., Ågerstrand, M., Gu, Z., Lamprou, D. A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K. D., Jiang, W., Kim, B. Y. S., Wheeler, K. E., Chetwynd, A. J., Lynch, I., Moghimi, S. M., Nel, A., Xia, T., Weiss, P. S., Sarmento, B., das Neves, J., Santos, H. A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M. M., Alonso, M. J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R. G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L. R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R. H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D. M., Zheng, G. & Pastore, C., 3 Jul 2019, In : Nature Nanotechnology. 14, 7, p. 629-635 7 p.

Research output: Contribution to journalComment/debate

41 Citations (Scopus)

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment

Rushworth, L. K., Hewit, K., Munnings-Tomes, S., Somani, S., James, D., Shanks, E., Dufès, C., Straube, A., Patel, R. & Leung, H. Y., 17 Dec 2019, In : British Journal of Cancer. p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
3 Downloads (Pure)

Transferrin-targeted liposomes entrapping plumbagin for cancer therapy

Sakpakdeejaroen, I., Somani, S., Laskar, P., Mullin, M. & Dufès, C., 26 Jun 2019, In : Journal of Interdisciplinary Nanomedicine . 4, 2, p. 54-71 18 p.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)
2018

Challenges and opportunities of nanotechnology as delivery platform for tocotrienols in cancer therapy

Maniam, G., Mai, C-W., Jusoh, M. Z. M., Dufès, C., Tan, D. M-Y. & Fu, J-Y., 26 Nov 2018, In : Frontiers in Pharmacology . 9, 9 p., 1358.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
11 Downloads (Pure)

PEGylation of polypropylenimine dendrimers: effects on cytotoxicity, DNA condensation, gene delivery and expression in cancer cells

Somani, S., Laskar, P., Altwaijry, N., Kewcharoenvong, P., Irving, C., Robb, G., Pickard, B. S. & Dufès, C., 20 Jun 2018, In : Scientific Reports. 8, 13 p., 9410.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
21 Downloads (Pure)
Open Access
File
12 Downloads (Pure)

Redox-sensitive, cholesterol-bearing PEGylated poly(propyleneimine)-based dendrimersomes for drug and gene delivery to cancer cells

Laskar, P., Somani, S., Altwaijry, N. A. S., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y. & Dufès, C., 28 Dec 2018, In : Nanoscale. 10, 48, p. 22830-22847 18 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
5 Downloads (Pure)

Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL and interleukin-12

Altwaijry, N., Somani, S., Parkinson, J. A., Tate, R. J., Keating, P., Warzecha, M., MacKenzie, G. R., Leung, H. Y. & Dufès, C., 1 Mar 2018, In : Drug Delivery. 25, 1, p. 679-689 11 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
49 Downloads (Pure)

Targeted nonviral gene therapy in prostate cancer

Altwaijry, N., Somani, S. & Dufès, C., 25 Sep 2018, In : International Journal of Nanomedicine. 13, p. 5753—5767 15 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
21 Downloads (Pure)
2017

Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol

Karim, R., Somani, S., Al Robaian, M., Mullin, M., Amor, R., McConnell, G. & Dufès, C., 28 Jan 2017, In : Journal of Controlled Release. 246, p. 79-87 9 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
31 Downloads (Pure)
2015

Anti-cancer efficacy of intravenously administered tumor-targeted vesicles entrapping tocotrienol

Fu, J. Y. & Dufès, C., 15 May 2015, In : Pharmaceutical Nanotechnology. 2, 4, p. 172-181 10 p.

Research output: Contribution to journalArticle

Open Access
File
120 Downloads (Pure)
Open Access
File
19 Citations (Scopus)
44 Downloads (Pure)

Transferrin-bearing dendrimers for cancer therapy: an update

Somani, S. & Dufes, C., Jul 2015, In : Nanomedicine. 10, 14, p. 2125-2127 3 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
54 Downloads (Pure)

Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes

Lim, L. Y., Koh, P. Y., Somani, S., Al Robaian, M., Karim, R., Yean, Y. L., Mitchell, J., Tate, R. J., Edrada-Ebel, R., Blatchford, D. R., Mullin, M. & Dufès, C., Aug 2015, In : Nanomedicine: Nanotechnology, Biology and Medicine. 11, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
276 Downloads (Pure)
2014

Applications of dendrimers for brain delivery and cancer therapy

Somani, S. & Dufès, C., Oct 2014, In : Nanomedicine. 9, 15, p. 2403-2414 12 p.

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
381 Downloads (Pure)

E2F1 drives chemotherapeutic drug resistance via ABCG2

Rosenfeldt, MT., Bell, LA., Long, JS., O'Prey, J., Nixon, C., Roberts, F., Dufès, C. & Ryan, KM., 7 Aug 2014, In : Oncogene. 33, p. 4164-4172 9 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
72 Downloads (Pure)

Size-tuneable nanometric MRI contrast agents for the imaging of molecular weight dependent transport processes

El-Hammadi, M. M., MacLellan, S., Dufès, C., Holmes, W. M., Condon, B., Uchegbu, I. F. & Schatzlein, A. G., 2014, In : Pharmaceutical Nanotechnology. 2, 3, p. 129-137 9 p.

Research output: Contribution to journalArticle

Open Access
File
70 Downloads (Pure)

The application of nanotechnology in medicine: treatment and diagnostics

Owain, A., Dufès, C., Moscatelli, D., Mayes, E., Lovell, J., Katti, K., Sokolov, K., Mazza, M., Fontaine, O., Rannard, S. & Stone, V., 31 Jul 2014, In : Nanomedicine. 9, 9, p. 1291-1294 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Therapeutic efficacy of intravenously administered transferrin-conjugated dendriplexes on prostate carcinomas

Al Robaian, M. M. M., Chiam, K. Y., Blatchford, D. & Dufès, C., 2014, In : Nanomedicine. 9, 4, p. 421-434 4 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
127 Downloads (Pure)

Transferrin-bearing polypropylenimine dendrimer for targeted gene delivery to the brain

Somani, S., Blatchford, D. R., Millington, O., Stevenson, M. L. & Dufès, C., 28 Aug 2014, In : Journal of Controlled Release. 188, p. 78-86 9 p.

Research output: Contribution to journalArticle

Open Access
File
53 Citations (Scopus)
105 Downloads (Pure)
2013

Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration

Lemarié, F., Chang, C. W., Blatchford, D., Amor, R., Norris, G., Tetley, L., McConnell, G. & Dufès, C., 2013, In : Nanomedicine. 8, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
145 Downloads (Pure)

Dendrimer-Based Drug Delivery Systems: From Theory to Practice Edited by Yiyun Cheng

Dufès, C., Feb 2013, In : ChemMedChem. 8, 2, p. 336 1 p.

Research output: Contribution to journalBook/Film/Article review

Transferrin and the transferrin receptor for the targeted delivery of therapeutic agents to the brain and cancer cells

Dufès, C., Al Robaian, M. & Somani, S., 7 May 2013, In : Therapeutic Delivery. 4, 5, p. 629-640 12 p.

Research output: Contribution to journalArticle

Open Access
File
58 Citations (Scopus)
24 Downloads (Pure)
2012

Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system

Lemarié, F., Croft, D., Tate, R., Ryan, K. M. & Dufès, C., 2012, In : Biomaterials. 33, p. 2701-2709 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2011

Brain delivery of peptides and proteins

Dufès, C., 2011, Peptide and protein delivery. van der Walle, C. (ed.). 1st ed. Vol. 1. p. 105-122 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Delivery of the vitamin E compound tocotrienol to cancer cells

Dufès, C., 2011, In : Therapeutic Delivery. 2, 11, p. 1385-1389 5 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
243 Downloads (Pure)

Drug and gene delivery systems

Dufès, C. & Watson, D. G. (ed.), Jan 2011, Pharmaceutical Chemistry. First ed. p. 581-590 632 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., 2011, In : Nanomedicine: Nanotechnology, Biology and Medicine. 7, 5, p. 815-823 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex

Aldawsari, H. M., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., Sep 2011, In : Biomaterials. 32, 25, p. 5889-5899 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
6 Downloads (Pure)

Novel tocotrienol-entrapping vesicles can eradicate solid tumors after intravenous administration

Fu, J. Y., Zhang, W., Blatchford, D., Tetley, L., Mcconnell, G. & Dufès, C., Aug 2011, (Unpublished).

Research output: Contribution to conferenceOther

Novel tocotrienol-entrapping vesicles can eradicate solid tumors after intravenous administration

Fu, J. Y., Zhang, W., Blatchford, D., Tetley, L., Mcconnell, G. & Dufès, C., 25 Aug 2011, In : Journal of Controlled Release. 154, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
11 Downloads (Pure)

Targeted dendrimers

Dufès, C., 5 May 2011, IPC No. A61K 47/48, Patent No. WO 2011/051667 A1

Research output: Patent

Targeted dendrimers for brain delivery

Dufes, C. & Somani, S., 5 May 2011, Priority date 27 Oct 2009, Priority No. 0918822.8

Research output: Patent

The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy

Wilkinson, S., Croft, D., O'Prey, J., Meedendorp, A., O’Prey, M., Dufès, C. & Ryan, K., Nov 2011, In : Autophagy. 7, 11, p. 1295-1301 7 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
167 Downloads (Pure)
2010

Enhanced transfection efficacy of polyethylenimine by surface modification with arginine, lysine, and leucine

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R. & Dufès, C., 2010, In : Controlled Release Society Newsletter. 27, 6, p. 12-14 3 p.

Research output: Contribution to journalArticle

Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA

Koppu, S., Oh, Y. J., Edrada-Ebel, R., Blatchford, D. R., Tetley, L., Tate, R. & Dufès, C., 19 Apr 2010, In : Journal of Controlled Release. 143, 2, p. 215-221 7 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
3 Downloads (Pure)
2009

Tumor regression after systemic administration of tocotrienol entrapped in tumor-targeted vesicles

Fu, J. Y., Blatchford, D. R., Tetley, L. & Dufès, C., 3 Dec 2009, In : Journal of Controlled Release. 140, 2, p. 95-99 5 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2 Downloads (Pure)
2008

High-resolution 3D isotropic MR imaging of mouse flank tumours obtained in vivo with solenoid RF micro-coil

Holmes, W. M., Maclellan, S., Condon, B., Dufès, C., Evans, T. R. J., Uchegbu, I. F. & Schätzlein, A. G., 2008, In : Physics in Medicine and Biology. 53, p. 505-513 8 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
172 Downloads (Pure)

Polymers and dendrimers for gene delivery in gene therapy

Uchegbu, I. F., Dufès, C. M., Kan, P. L., Schätzlein, A. G. & Templeton, N. S. (ed.), 6 Oct 2008, Gene and cell therapy: therapeutic mechanisms and strategies 3rd ed. p. 321-339 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2007

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo

Bell, H. S., Dufès, C., O'Prey, J., Crighton, D., Bergamaschi, D., Lu, X., Schätzlein, A. G., Vousden, K. H. & Ryan, K., 2 Apr 2007, In : Journal of Clinical Investigation . 117, 4, p. 1008-1018 11 p.

Research output: Contribution to journalArticle

Open Access
File
73 Citations (Scopus)
59 Downloads (Pure)
2006

Bioactive polymers

Uchegbu, I. F., Dufès, C., Schätzlein, A. G. & I.F. Uchegbu (Patent applicant), 2006, Patent No. WO/2006/040579

Research output: Patent

Carbohydrate-based micelle clusters which enhance hydrophobic drug bioavailability by up to 1 order of magnitude

Qu, X., Khutoryanskiy, V. V., Stewart, A., Rahman, S., Papahadjopoulos-Sternberg, B., Dufès, C., McCarthy, D., Wilson, C. G., Lyons, R., Carter, K. C., Schätzlein, A. & Uchegbu, I. F., 2006, In : Biomacromolecules. 7, 12, p. 3452-3459 7 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)
2005

Dendrimers in gene delivery

Dufès, C., Uchegbu, I. F. & Schätzlein, A. G., 2005, In : Advanced Drug Delivery Reviews. 57, 15, p. 2177-2202 25 p.

Research output: Contribution to journalArticle

Open Access
File
799 Citations (Scopus)
574 Downloads (Pure)

Preferential liver gene expression with polypropylenimine dendrimers

Schätzlein, A. G., Zinselmeyer, B. H., Elouzi, A., Dufès, C., Chim, Y. T. A., Roberts, C. J., Davies, M. C., Munro, A., Gray, A. I. & Uchegbu, I. F., 2005, In : Journal of Controlled Release. 101, 1-3, p. 247-258 12 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors

Dufès, C., Keith, W. N., Bilsland, A., Proutski, I., Uchegbu, I. F. & Schätzlein, A. G., 2005, In : Cancer Research. 65, 18, p. 8079-84 7995 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)
2004

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles

Dufès, C., Muller, J-M., Couet, W., Olivier, J-C., Uchegbu, I. F. & Schätzlein, A. G., 2004, In : Pharmaceutical Research. 21, 1, p. 101-7 94 p.

Research output: Contribution to journalArticle

Open Access
File
91 Citations (Scopus)
153 Downloads (Pure)

Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain

Dufès, C., Gaillard, F., Uchegbu, I. F., Schätzlein, A. G., Olivier, J-C. & Muller, J-M., 2004, In : International Journal of Pharmaceutics. 285, 1-2, p. 77-85 9 p.

Research output: Contribution to journalArticle

Open Access
File
61 Citations (Scopus)
92 Downloads (Pure)