• United Kingdom

Accepting PhD Students

20002019
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Research Output 2000 2019

2019

Anti-tumor activity of intravenously administered plumbagin entrapped in targeted nanoparticles

Sakpakdeejaroen, I., Somani, S., Laskar, P., Irving, C., Mullin, M. & Dufes, C., 1 Aug 2019, (Accepted/In press) In : Journal of Biomedical Nanotechnology.

Research output: Contribution to journalArticle

Nanoparticles
Tumors
Bearings (structural)
Transferrin
Intravenous Administration

Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells

Laskar, P., Somani, S., Campbell, S. J., Mullin, M., Keating, P., Tate, R. J., Irving, C., Leung, H. Y. & Dufès, C., 14 Nov 2019, In : Nanoscale. 11, 42, p. 20058-20071 14 p.

Research output: Contribution to journalArticle

Dendrimers
Camptothecin
Drug delivery
Oxidation-Reduction
Genes

Development of transferrin-bearing vesicles encapsulating aspirin for cancer therapy

Sakpakdeejaroen, I., Somani, S., Mullin, M. & Dufès, C., 22 Apr 2019, (Accepted/In press) In : Journal of Liposome Research. 30 p.

Research output: Contribution to journalArticle

Transferrin
Aspirin
Neoplasms
Pharmaceutical Preparations
Therapeutics
6 Citations (Scopus)

On the issue of transparency and reproducibility in nanomedicine

Leong, H. S., Butler, K. S., Brinker, C. J., Azzawi, M., Conlan, S., Dufes, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M. A., Kozlov, S. V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R. M., McNeil, S. E., Fadeel, B. & 58 others, Tran, L., Foss Hansen, S., Hartmann, N. B., Clausen, L. P. W., Skjolding, L. M., Baun, A., Ågerstrand, M., Gu, Z., Lamprou, D. A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K. D., Jiang, W., Kim, B. Y. S., Wheeler, K. E., Chetwynd, A. J., Lynch, I., Moghimi, S. M., Nel, A., Xia, T., Weiss, P. S., Sarmento, B., das Neves, J., Santos, H. A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M. M., Alonso, M. J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R. G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L. R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R. H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D. M., Zheng, G. & Pastore, C., 3 Jul 2019, In : Nature Nanotechnology. 14, 7, p. 629-635 7 p.

Research output: Contribution to journalComment/debate

Medical nanotechnology
Transparency
1 Downloads (Pure)

Transferrin-targeted liposomes entrapping plumbagin for cancer therapy

Sakpakdeejaroen, I., Somani, S., Laskar, P., Mullin, M. & Dufès, C., 26 Jun 2019, In : Journal of Interdisciplinary Nanomedicine . 4, 2, p. 54-71 18 p.

Research output: Contribution to journalArticle

Open Access
File
Transferrin
Liposomes
Neoplasms
Therapeutics
Intravenous Administration
2018
6 Citations (Scopus)
9 Downloads (Pure)

Challenges and opportunities of nanotechnology as delivery platform for tocotrienols in cancer therapy

Maniam, G., Mai, C-W., Jusoh, M. Z. M., Dufès, C., Tan, D. M-Y. & Fu, J-Y., 26 Nov 2018, In : Frontiers in Pharmacology . 9, 9 p., 1358.

Research output: Contribution to journalArticle

Open Access
File
Tocotrienols
Nanotechnology
Liposomes
Neoplasms
Transferrin
8 Citations (Scopus)
20 Downloads (Pure)

PEGylation of polypropylenimine dendrimers: effects on cytotoxicity, DNA condensation, gene delivery and expression in cancer cells

Somani, S., Laskar, P., Altwaijry, N., Kewcharoenvong, P., Irving, C., Robb, G., Pickard, B. S. & Dufès, C., 20 Jun 2018, In : Scientific Reports. 8, 13 p., 9410.

Research output: Contribution to journalArticle

Open Access
File
Dendrimers
Gene Expression
DNA
Neoplasms
Gene Transfer Techniques
8 Downloads (Pure)
Open Access
File
Surface-Active Agents
Small Interfering RNA
Luciferases
Proteins
Liposomes
7 Citations (Scopus)

Redox-sensitive, cholesterol-bearing PEGylated poly(propyleneimine)-based dendrimersomes for drug and gene delivery to cancer cells

Laskar, P., Somani, S., Altwaijry, N. A. S., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y. & Dufès, C., 28 Dec 2018, In : Nanoscale. 10, 48, p. 22830-22847 18 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Cholesterol
Genes
Cells
Dendrimers
8 Citations (Scopus)
44 Downloads (Pure)

Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL and interleukin-12

Altwaijry, N., Somani, S., Parkinson, J. A., Tate, R. J., Keating, P., Warzecha, M., MacKenzie, G. R., Leung, H. Y. & Dufès, C., 1 Mar 2018, In : Drug Delivery. 25, 1, p. 679-689 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lactoferrin
Interleukin-12
Intravenous Administration
Prostate
Prostatic Neoplasms
6 Citations (Scopus)
13 Downloads (Pure)

Targeted nonviral gene therapy in prostate cancer

Altwaijry, N., Somani, S. & Dufès, C., 25 Sep 2018, In : International Journal of Nanomedicine. 13, p. 5753—5767 15 p.

Research output: Contribution to journalArticle

Open Access
File
Gene therapy
Genetic Therapy
Prostatic Neoplasms
DNA
Radiotherapy
2017
10 Citations (Scopus)
26 Downloads (Pure)

Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol

Karim, R., Somani, S., Al Robaian, M., Mullin, M., Amor, R., McConnell, G. & Dufès, C., 28 Jan 2017, In : Journal of Controlled Release. 246, p. 79-87 9 p.

Research output: Contribution to journalArticle

Open Access
File
Tocotrienols
Vitamin E
Intravenous Administration
Neoplasms
Transferrin
2015
114 Downloads (Pure)

Anti-cancer efficacy of intravenously administered tumor-targeted vesicles entrapping tocotrienol

Fu, J. Y. & Dufès, C., 15 May 2015, In : Pharmaceutical Nanotechnology. 2, 4, p. 172-181 10 p.

Research output: Contribution to journalArticle

Open Access
File
Tocotrienols
Neoplasms
Transferrin
Experimental Melanomas
Transferrin Receptors
14 Citations (Scopus)
41 Downloads (Pure)
Open Access
File
Lactoferrin
Intravenous Administration
Gene Expression
Dendrimers
Brain
5 Citations (Scopus)
48 Downloads (Pure)

Transferrin-bearing dendrimers for cancer therapy: an update

Somani, S. & Dufes, C., Jul 2015, In : Nanomedicine. 10, 14, p. 2125-2127 3 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Dendrimers
Transferrin
Cells
Nucleic acids
21 Citations (Scopus)
261 Downloads (Pure)

Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes

Lim, L. Y., Koh, P. Y., Somani, S., Al Robaian, M., Karim, R., Yean, Y. L., Mitchell, J., Tate, R. J., Edrada-Ebel, R., Blatchford, D. R., Mullin, M. & Dufès, C., Aug 2015, In : Nanomedicine: Nanotechnology, Biology and Medicine. 11, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Lactoferrin
Intravenous Administration
Tumors
Dendrimers
2014
35 Citations (Scopus)
327 Downloads (Pure)

Applications of dendrimers for brain delivery and cancer therapy

Somani, S. & Dufès, C., Oct 2014, In : Nanomedicine. 9, 15, p. 2403-2414 12 p.

Research output: Contribution to journalArticle

Open Access
File
Dendrimers
Gene Transfer Techniques
Drug Delivery Systems
Brain Neoplasms
brain
17 Citations (Scopus)
70 Downloads (Pure)

E2F1 drives chemotherapeutic drug resistance via ABCG2

Rosenfeldt, M., Bell, L., Long, J., O'Prey, J., Nixon, C., Roberts, F., Dufès, C. & Ryan, K., 2014, In : Oncogene. 33, p. 4164-4172 9 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Resistance
Multiple Drug Resistance
Neoplasms
Drug Therapy
ATP-Binding Cassette Transporters
Prostatic Neoplasms
Neoplasms
Therapeutics
Lactoferrin
Genetic Therapy
67 Downloads (Pure)

Size-tuneable nanometric MRI contrast agents for the imaging of molecular weight dependent transport processes

El-Hammadi, M. M., MacLellan, S., Dufès, C., Holmes, W. M., Condon, B., Uchegbu, I. F. & Schatzlein, A. G., 2014, In : Pharmaceutical Nanotechnology. 2, 3, p. 129-137 9 p.

Research output: Contribution to journalArticle

Open Access
File
Pentetic Acid
Contrast Media
Molecular Weight
Heterografts
Blood Vessels
9 Citations (Scopus)

The application of nanotechnology in medicine: treatment and diagnostics

Owain, A., Dufès, C., Moscatelli, D., Mayes, E., Lovell, J., Katti, K., Sokolov, K., Mazza, M., Fontaine, O., Rannard, S. & Stone, V., 31 Jul 2014, In : Nanomedicine. 9, 9, p. 1291-1294 4 p.

Research output: Contribution to journalArticle

Nanomedicine
Medical nanotechnology
Nanotechnology
Medicine
Charities
20 Citations (Scopus)
122 Downloads (Pure)

Therapeutic efficacy of intravenously administered transferrin-conjugated dendriplexes on prostate carcinomas

Al Robaian, M. M. M., Chiam, K. Y., Blatchford, D. & Dufès, C., 2014, In : Nanomedicine. 9, 4, p. 421-434 4 p.

Research output: Contribution to journalArticle

Open Access
File
Transferrin
tumor
Tumors
Prostate
cancer
48 Citations (Scopus)
100 Downloads (Pure)

Transferrin-bearing polypropylenimine dendrimer for targeted gene delivery to the brain

Somani, S., Blatchford, D. R., Millington, O., Stevenson, M. L. & Dufès, C., 28 Aug 2014, In : Journal of Controlled Release. 188, p. 78-86 9 p.

Research output: Contribution to journalArticle

Open Access
File
Dendrimers
Transferrin
Brain
Genes
Transferrin Receptors
2013
14 Citations (Scopus)
142 Downloads (Pure)

Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration

Lemarié, F., Chang, C. W., Blatchford, D., Amor, R., Norris, G., Tetley, L., McConnell, G. & Dufès, C., 2013, In : Nanomedicine. 8, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
tea
Polyphenols
Tea
vesicle

Dendrimer-Based Drug Delivery Systems: From Theory to Practice Edited by Yiyun Cheng

Dufès, C., Feb 2013, In : ChemMedChem. 8, 2, p. 336 1 p.

Research output: Contribution to journalBook/Film/Article review

Dendrimers
Drug Delivery Systems
53 Citations (Scopus)
11 Downloads (Pure)

Transferrin and the transferrin receptor for the targeted delivery of therapeutic agents to the brain and cancer cells

Dufès, C., Al Robaian, M. & Somani, S., 7 May 2013, In : Therapeutic Delivery. 4, 5, p. 629-640 12 p.

Research output: Contribution to journalArticle

Open Access
File
Transferrin Receptors
Transferrin
Brain Neoplasms
Gene Transfer Techniques
Drug Delivery Systems
2012
24 Citations (Scopus)

Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system

Lemarié, F., Croft, D., Tate, R., Ryan, K. M. & Dufès, C., 2012, In : Biomaterials. 33, p. 2701-2709 9 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Intravenous Administration
Tumors
Genes
Dendrimers
2011
2 Citations (Scopus)

Brain delivery of peptides and proteins

Dufès, C., 2011, Peptide and protein delivery. van der Walle, C. (ed.). 1st ed. Vol. 1. p. 105-122 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Blood-Brain Barrier
Peptides
Brain
Proteins
Brain Diseases
2 Citations (Scopus)
200 Downloads (Pure)

Delivery of the vitamin E compound tocotrienol to cancer cells

Dufès, C., 2011, In : Therapeutic Delivery. 2, 11, p. 1385-1389 5 p.

Research output: Contribution to journalArticle

Open Access
File
Tocotrienols
Vitamin E
Neoplasms
Transferrin Receptors
Transferrin

Drug and gene delivery systems

Dufès, C. & Watson, D. G. (ed.), Jan 2011, Pharmaceutical Chemistry. First ed. p. 581-590 632 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene Transfer Techniques
Drug Delivery Systems
Pharmaceutical Preparations
Genes
15 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., 2011, In : Nanomedicine: Nanotechnology, Biology and Medicine. 7, 5, p. 815-823 9 p.

Research output: Contribution to journalArticle

Bearings (structural)
Polyethyleneimine
Arginine
Gene expression
Leucine
38 Citations (Scopus)
6 Downloads (Pure)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex

Aldawsari, H. M., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., Sep 2011, In : Biomaterials. 32, 25, p. 5889-5899 11 p.

Research output: Contribution to journalArticle

Bearings (structural)
Arginine
Gene expression
Leucine
Intravenous Administration
19 Citations (Scopus)
11 Downloads (Pure)

Novel tocotrienol-entrapping vesicles can eradicate solid tumors after intravenous administration

Fu, J. Y., Zhang, W., Blatchford, D., Tetley, L., Mcconnell, G. & Dufès, C., 25 Aug 2011, In : Journal of Controlled Release. 154, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

Tocotrienols
Intravenous Administration
Neoplasms
Transferrin
Transferrin Receptors

Novel tocotrienol-entrapping vesicles can eradicate solid tumors after intravenous administration

Fu, J. Y., Zhang, W., Blatchford, D., Tetley, L., Mcconnell, G. & Dufès, C., Aug 2011, (Unpublished).

Research output: Contribution to conferenceOther

Tocotrienols
Manuscripts
Intravenous Administration
Neoplasms
Education

Targeted dendrimers

Dufès, C., 5 May 2011, IPC No. A61K 47/48, Patent No. WO 2011/051667 A1

Research output: Patent

Dendrimers
Lactoferrin
Transferrin
Neoplasms
poly(propyleneimine)

Targeted dendrimers for brain delivery

Dufes, C. & Somani, S., 5 May 2011, Priority date 27 Oct 2009, Priority No. 0918822.8

Research output: Patent

21 Citations (Scopus)
157 Downloads (Pure)

The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy

Wilkinson, S., Croft, D., O'Prey, J., Meedendorp, A., O’Prey, M., Dufès, C. & Ryan, K., Nov 2011, In : Autophagy. 7, 11, p. 1295-1301 7 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclin-Dependent Kinases
Autophagy
Drosophila
Lysosomes
Organelles
2010

Enhanced transfection efficacy of polyethylenimine by surface modification with arginine, lysine, and leucine

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R. & Dufès, C., 2010, In : Controlled Release Society Newsletter. 27, 6, p. 12-14 3 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Leucine
Lysine
Transfection
Arginine
74 Citations (Scopus)
3 Downloads (Pure)

Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA

Koppu, S., Oh, Y. J., Edrada-Ebel, R., Blatchford, D. R., Tetley, L., Tate, R. & Dufès, C., 19 Apr 2010, In : Journal of Controlled Release. 143, 2, p. 215-221 7 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Plasmids
DNA
Intravenous Administration
Transferrin
2009
29 Citations (Scopus)
2 Downloads (Pure)

Tumor regression after systemic administration of tocotrienol entrapped in tumor-targeted vesicles

Fu, J. Y., Blatchford, D. R., Tetley, L. & Dufès, C., 3 Dec 2009, In : Journal of Controlled Release. 140, 2, p. 95-99 5 p.

Research output: Contribution to journalArticle

Tocotrienols
Transferrin
Intravenous Administration
Neoplasms
Transferrin Receptors
2008
4 Citations (Scopus)
170 Downloads (Pure)

High-resolution 3D isotropic MR imaging of mouse flank tumours obtained in vivo with solenoid RF micro-coil

Holmes, W. M., Maclellan, S., Condon, B., Dufès, C., Evans, T. R. J., Uchegbu, I. F. & Schätzlein, A. G., 2008, In : Physics in Medicine and Biology. 53, p. 505-513 8 p.

Research output: Contribution to journalArticle

Open Access
File
Neoplasms
Signal-To-Noise Ratio
Contrast Media
Angiography
Magnetic Resonance Imaging

Polymers and dendrimers for gene delivery in gene therapy

Uchegbu, I. F., Dufès, C. M., Kan, P. L., Schätzlein, A. G. & Templeton, N. S. (ed.), 6 Oct 2008, Gene and cell therapy: therapeutic mechanisms and strategies 3rd ed. p. 321-339 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dendrimers
Genetic Therapy
Polymers
Gene Expression Regulation
Genes
2007
73 Citations (Scopus)
57 Downloads (Pure)

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo

Bell, H. S., Dufès, C., O'Prey, J., Crighton, D., Bergamaschi, D., Lu, X., Schätzlein, A. G., Vousden, K. H. & Ryan, K., 2 Apr 2007, In : Journal of Clinical Investigation . 117, 4, p. 1008-1018 11 p.

Research output: Contribution to journalArticle

Open Access
File
Peptides
Neoplasms
Null Lymphocytes
Helper-Inducer T-Lymphocytes
Transgenes
2006

Bioactive polymers

Uchegbu, I. F., Dufès, C., Schätzlein, A. G. & I.F. Uchegbu (Patent applicant), 2006, Patent No. WO/2006/040579

Research output: Patent

Polymers
Neoplasms
Polyamines
Psoriasis
Genetic Therapy
81 Citations (Scopus)

Carbohydrate-based micelle clusters which enhance hydrophobic drug bioavailability by up to 1 order of magnitude

Qu, X., Khutoryanskiy, V. V., Stewart, A., Rahman, S., Papahadjopoulos-Sternberg, B., Dufès, C., McCarthy, D., Wilson, C. G., Lyons, R., Carter, K. C., Schätzlein, A. & Uchegbu, I. F., 2006, In : Biomacromolecules. 7, 12, p. 3452-3459 7 p.

Research output: Contribution to journalArticle

Micelles
Carbohydrates
Prednisolone
Pharmacodynamics
Pharmaceutical Preparations
2005
767 Citations (Scopus)
501 Downloads (Pure)

Dendrimers in gene delivery

Dufès, C., Uchegbu, I. F. & Schätzlein, A. G., 2005, In : Advanced Drug Delivery Reviews. 57, 15, p. 2177-2202 25 p.

Research output: Contribution to journalArticle

Open Access
File
Dendrimers
Nucleic Acids
Genes
Nanomedicine
Transfection
108 Citations (Scopus)

Preferential liver gene expression with polypropylenimine dendrimers

Schätzlein, A. G., Zinselmeyer, B. H., Elouzi, A., Dufès, C., Chim, Y. T. A., Roberts, C. J., Davies, M. C., Munro, A., Gray, A. I. & Uchegbu, I. F., 2005, In : Journal of Controlled Release. 101, 1-3, p. 247-258 12 p.

Research output: Contribution to journalArticle

Dendrimers
Gene Expression
Liver
DNA
Gene Transfer Techniques
111 Citations (Scopus)

Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors

Dufès, C., Keith, W. N., Bilsland, A., Proutski, I., Uchegbu, I. F. & Schätzlein, A. G., 2005, In : Cancer Research. 65, 18, p. 8079-84 7995 p.

Research output: Contribution to journalArticle

Synthetic Genes
Dendrimers
Medicine
Genetic Therapy
Tumor Necrosis Factor-alpha
2004
90 Citations (Scopus)
151 Downloads (Pure)

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles

Dufès, C., Muller, J-M., Couet, W., Olivier, J-C., Uchegbu, I. F. & Schätzlein, A. G., 2004, In : Pharmaceutical Research. 21, 1, p. 101-7 94 p.

Research output: Contribution to journalArticle

Open Access
File
Chitosan
Transferrin
Drug delivery
Doxorubicin
Pharmaceutical Preparations
56 Citations (Scopus)
82 Downloads (Pure)

Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain

Dufès, C., Gaillard, F., Uchegbu, I. F., Schätzlein, A. G., Olivier, J-C. & Muller, J-M., 2004, In : International Journal of Pharmaceutics. 285, 1-2, p. 77-85 9 p.

Research output: Contribution to journalArticle

Open Access
File
Vasoactive Intestinal Peptide
Liposomes
Glucose
Brain
Radioactivity