20002019
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Personal profile

Personal Statement

Dr Christine Dufès is a Senior Lecturer (Associate Professor) at the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). She teaches on the Master of Pharmacy and on various MSc / MRes postgraduate degrees.

Christine obtained a Doctorate in Pharmacy (with Distinction and congratulations of the Jury, 1997) and a PhD (with a European Label, Distinction and congratulations of the Jury, 2002) from the University of Poitiers (France). After four years as a post-doctoral researcher at the Cancer Research UK Beatson Laboratories in Glasgow, she was appointed as a Lecturer at SIPBS in 2006, obtained fellowship of the Higher Education Academy in 2007 and became a Senior Lecturer in 2012.

Christine has been awarded the Biochemical Journal Young Investigator Award (2009) and the Tom Gibson Memorial Award (2012) for her research, in addition to the Best Overall Strathclyde Teaching Excellence Award (2013) for her teaching. She sits on the editorial boards for 18 journals.

Her research interests are:

  • Design and development of novel tumour-targeted anti-cancer nanomedicines.
  • Design and development of novel nanomedicines able to reach the brain after intravenous administration, with the ultimate aim to facilitate drug and gene delivery to brain tumours and neurodegenerative disorders.

Her research highlights include:

  • Tumour regression after intravenous administration of a tumour-targeted dendriplex  encoding TNFα (complete disappearance of 90% of the tumours)
  • Tumour regression after intravenous administration of tumour-targeted vesicles entrapping tocotrienol (complete disappearance of 40% of the tumours) (doctoral work of Dr Ju Yen Fu)
  • Tumour regression after intravenous administration of a tumour-targeted dendriplex encoding p73 (complete disappearance of 10% of the tumours)
  • Tumour regression after intravenous administration of the green tea extract epigallocatechin gallate encapsulated in tumour-targeted vesicles (complete disappearance of 40% of the tumours)
  • Regression of prostate tumours after intravenous administration of tumour-targeted dendriplexes encoding TNFα, TRAIL and IL-12 (complete disappearance of up to 60% of PC-3 tumours and up to 50% of DU145 tumours) (doctoral work of Dr Majed Al Robaian).
  • Increase of gene expression in tumours by surface modification of polyethylenimine and polypropylenimine dendrimer with the amino acids arginine, lysine and leucine (doctoral work of Dr Hibah Aldawsari)
  • Increase of gene expression in the brain following intravenous injection of transferrin-bearing dendriplex (at least twice higher than that of the unmodified dendriplex), while decreasing the non-specific gene expression in the lung. Gene expression was at least 3-fold higher in the brain than in any tested peripheral organs (doctoral work of Dr Sukrut Somani).

Podcast about recent research results: http://www.youtube.com/embed/JhbIoXsAM7M 

Website: http://www.dufeslab.com/

 

Research Interests

  • Design and development of novel tumour-targeted anti-cancer nanomedicines.
  • Design and development of novel nanomedicines able to reach the brain after intravenous administration, with the ultimate aim to facilitate drug and gene delivery to brain tumours and neurodegenerative disorders.

Teaching Interests

Christine Dufès teaches on the Master of Pharmacy and on various MSc / MRes postgraduate degrees. 

  • TEACHING COORDINATION:

- Year Coordinator for Year 2 MPharm

- Class coordinator for Medicines manufacture and Quality Control 2 (MP415)

- Class coordinator for Advanced Drug Discovery class (MP506)

- Class coordinator for the MRes Advanced topics in pharmaceutical materials and formulation (MP958)

- Class coordinator for the MRes Advanced topics in drug discovery (MP978)

 

  • UNDERGRADUATE TEACHING (MPharm)

- Being a Pharmacist (MP220)

- Normal function of the gastrointestinal system (MP221)

- Normal function of the nervous and endocrine systems (MP223)

- Management of Infection and Infectious Diseases (MP321)

- Medicines Manufacture and Quality Control 2  (MP415, MC413)

- Advanced drug discovery (MP506)

- Clinical pharmacology and prescribing (MP509)

  

  • POSTGRADUATE TEACHING

- Bioanalysis, biotechnology and quality management (MP919)

- Advanced techniques in pharmaceutical materials and formulation (MP948)

- Advanced topics in pharmaceutical materials and formulation (MP958) 

 

Keywords

  • Targeted nanomedicines
  • Cancer therapy
  • Brain delivery
  • Gene therapy
  • Nutraceuticals
  • Dendrimers

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 6 Similar Profiles
Dendrimers Medicine & Life Sciences
Intravenous Administration Medicine & Life Sciences
Bearings (structural) Chemical Compounds
Neoplasms Medicine & Life Sciences
Transferrin Medicine & Life Sciences
Tocotrienols Medicine & Life Sciences
Gene Transfer Techniques Medicine & Life Sciences
Tumors Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2008 2019

Research Output 2000 2018

Challenges and opportunities of nanotechnology as delivery platform for tocotrienols in cancer therapy

Maniam, G., Mai, C-W., Jusoh, M. Z. M., Dufès, C., Tan, D. M-Y. & Fu, J-Y., 26 Nov 2018, In : Frontiers in Pharmacology . 9, 9 p., 1358

Research output: Contribution to journalArticle

Open Access
File
Tocotrienols
Nanotechnology
Liposomes
Neoplasms
Transferrin
Open Access
File
Dendrimers
Gene Expression
DNA
Neoplasms
Gene Transfer Techniques

Thesis

Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA

Author: Zainulabedeen R M H Mirza, Z., 1 Jan 2015

Supervisor: Yu, J. (Supervisor) & Dufes, C. (Supervisor)

Student thesis: Doctoral Thesis

Novel gene delivery systems for brain targeting

Author: Somani, S., 1 May 2015

Supervisor: Dufes, C. (Supervisor) & McConnell, G. (Supervisor)

Student thesis: Doctoral Thesis

Prizes

Award of the "Best Overall" Strathclyde Teaching Excellence award 2013

Christine Dufes (Recipient), May 2013

Prize: Prize (including medals and awards)

Biochemical Journal Young Investigator Award

Christine Dufes (Recipient), Apr 2009

Prize: Prize (including medals and awards)

Activities 2005 2018

Invited talk at the 5th International Conference on Nanotechnology in Medicine (Nanomed) (Manchester)

Dufes, C. (Invited speaker)
26 Jun 201828 Jun 2018

Activity: Talk or presentationInvited talk