Projects per year
My research focuses on the interaction between gastrointestinal (GI) parasitic helminths (worms) and their hosts. Infection with GI helminths parasites has an impact on a number of immunological issues including oral vaccination and dysregulation of immune respones that predispose for intestinal inflammation. This has direct implications for the design and application of anti-parasite therapies and treatments but also has wider importance for immunoregulation in mucosal tissues in general. My work concentrates on two related themes:
Immunopathology - the key mechanisms whereby expulsion of GI nematodes is achieved are still in doubt. It had always been assumed that intestinal pathology was obligatory for expulsion of GIP parasites. However, I have shown that sever pathology is not required for the expulsion of nematode parasites. Recently we showed that mast cell derived cytokines are essential in the promotion of and amplification of the protective and pathological immunes responses associated with infection with GI helminths. This has important implications as it now places mast cells as key cells in the induction, amplification and perpetuation of the Th2 response induced following infection with GI helminths rather than as acting as endpoint effector cells.
Role of mast cells in inflammatory disease - this work is now being further extended to analyse the role of mast cells in inflammatory disorders such as rheumatoid arthritis (in collaboration with Professor I McInnes, University of Glasgow), cardiovascular disease ( Dr P Maffia and S Kennedy, University of Glasgow), and stroke (with Dr H Carswell).
More recently I have been developing research in evaluating novel anthelminthics in collaboration with Dr Chris Carter.
Doctor of Philosophy, University of Nottingham
Award Date: 1 Jan 1990
Bachelor of Science, Imperial College of Science, Technology and Medicine
Award Date: 1 Jan 1986
External Examiner, Kingston University1 Oct 2016 → 30 Sep 2020
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedingsMcFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., Brezzo, G., Carare, R. O., Carswell, H. V., Clarkson, A. N., Currie, G., Farr, T. D., Fowler, J. H., Good, M., Hainsworth, A. H., Hall, C., Horsburgh, K., Kalaria, R., Kehoe, P., Lawrence, C. & 18 others, , 1 Jul 2020, In : Journal of Cerebral Blood Flow and Metabolism. 40, 7, p. 1402-1414 13 p.
Research output: Contribution to journal › ArticleOpen AccessFile1 Downloads (Pure)
Isolation of a novel flavanonol and an alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolisSiheri, W., Ebiloma, G. U., Igoli, J. O., Gray, A. I., Biddau, M., Akrachalanont, P., Samya Sh M D Alenezi, S., Alwashih, M. A., Edrada Ebel, R., Müller, S., Lawrence, C. E., Fearnley, J., Watson, D. G. & De Koning, H. P., 15 Mar 2019, In : Molecules. 24, 6, 12 p., 1041.
Research output: Contribution to journal › ArticleOpen AccessFile2 Citations (Scopus)12 Downloads (Pure)
Impact: Impact - for External Portal › Culture and creativity, Public understanding, information and debate, EducationFile