• 390 Citations
20022020
If you made any changes in Pure these will be visible here soon.

Personal profile

Personal Statement

My research focuses on the interaction between gastrointestinal (GI) parasitic helminths (worms) and their hosts. Infection with GI helminths parasites has an impact on a number of immunological issues including oral vaccination and dysregulation of immune respones that predispose for intestinal inflammation. This has direct implications for the design and application of anti-parasite therapies and treatments but also has wider importance for immunoregulation in mucosal tissues in general. My work concentrates on two related themes:

Immunopathology - the key mechanisms whereby expulsion of GI nematodes is achieved are still in doubt. It had always been assumed that intestinal pathology was obligatory for expulsion of GIP parasites. However, I have shown that sever pathology is not required for the expulsion of nematode parasites. Recently we showed that mast cell derived cytokines are essential in the promotion of and amplification of the protective and pathological immunes responses associated with infection with GI helminths. This has important implications as it now places mast cells as key cells in the induction, amplification and perpetuation of the Th2 response induced following infection with GI helminths rather than as acting as endpoint effector cells.

Role of mast cells in inflammatory disease - this work is now being further extended to analyse the role of mast cells in inflammatory disorders such as rheumatoid arthritis (in collaboration with Professor I McInnes, University of Glasgow), cardiovascular disease ( Dr P Maffia and S Kennedy, University of Glasgow), and stroke (with Dr H Carswell).

Antiparasiticals

More recently I have been developing research in evaluating novel anthelminthics in collaboration with Dr Chris Carter.

Education/Academic qualification

Doctor of Philosophy, University of Nottingham

Bachelor of Science, Imperial College of Science, Technology and Medicine

External positions

External Examiner, Kingston University

1 Oct 201630 Sep 2020

Keywords

  • Inflammation
  • parasitology
  • Immunology
  • allergy

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 13 Similar Profiles
Mast Cells Medicine & Life Sciences
Helminths Medicine & Life Sciences
Trichinella spiralis Medicine & Life Sciences
Infection Medicine & Life Sciences
Parasites Medicine & Life Sciences
Leishmania donovani Medicine & Life Sciences
Posters Medicine & Life Sciences
Ascaris suum Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2003 2020

Research Output 2002 2017

  • 390 Citations
  • 15 Article
  • 3 Meeting abstract

Perivascular mast cells promote neointimal elastin deposit and suppress chronic vein graft restensosis in hyperlipidaemic mice: mast cells and vein graft remodelling

Wu, J., Lawrence, C., Wadsworth, R. M. & Kennedy, S. 23 Jun 2017 (Accepted/In press) In : Vessel Plus. 15 p.

Research output: Contribution to journalArticle

Open Access
File
Elastin
Mast Cells
Veins
Transplants
Apolipoproteins E
8 Citations

Mast cells contribute to porphyromonas gingivalis-induced bone loss

Malcolm, J., Millington, O., Millhouse, E., Campbell, L., Adrados Planell, A., Butcher, J. P., Lawrence, C., Ross, K., Ramage, G., McInnes, I. B. & Culshaw, S. 1 Mar 2016 In : Journal of Dental Research. 7 p.

Research output: Contribution to journalArticle

Open Access
File
Porphyromonas gingivalis
Mast Cells
Tumor Necrosis Factors
Bone and Bones
Periodontitis

Thesis

Evaluation of the role of mast cells in parasitic infection

Author: Alfaiz, F. A. S., 1 Jan 2017

Supervisor: Lawrence, C. (Supervisor) & Carter, K. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2008 2012

  • 5 Organiser of major conference
  • 1 Participation in conference
  • 1 Editorial board member

British Society for Parasitology

Lawrence, C. (Organiser)
2012 → …

Activity: Organiser of major conference

British Society for Parasitology

Lawrence, C. (Organiser)
2012 → …

Activity: Organiser of major conference

Impacts

Images of Research 2015 Public and Urban Health category winner

Kirsty Ross (Main contact), Catherine Lawrence (Participant), Iain McInnes (Participant)

Impact: Impact - for External PortalCulture and creativity, Public understanding, information and debate, Education

File