Catherine Lawrence

Dr

  • United Kingdom

Accepting PhD Students

PhD projects

Role of mast cells in Inflammatory arthritis
Mast cells in obesity and diabetes
Development of novel anthelminthics
Protective and pathological responses in parasitic infection

20022020

Research output per year

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Personal profile

Personal Statement

My research focuses on the interaction between gastrointestinal (GI) parasitic helminths (worms) and their hosts. Infection with GI helminths parasites has an impact on a number of immunological issues including oral vaccination and dysregulation of immune respones that predispose for intestinal inflammation. This has direct implications for the design and application of anti-parasite therapies and treatments but also has wider importance for immunoregulation in mucosal tissues in general. My work concentrates on two related themes:

Immunopathology - the key mechanisms whereby expulsion of GI nematodes is achieved are still in doubt. It had always been assumed that intestinal pathology was obligatory for expulsion of GIP parasites. However, I have shown that sever pathology is not required for the expulsion of nematode parasites. Recently we showed that mast cell derived cytokines are essential in the promotion of and amplification of the protective and pathological immunes responses associated with infection with GI helminths. This has important implications as it now places mast cells as key cells in the induction, amplification and perpetuation of the Th2 response induced following infection with GI helminths rather than as acting as endpoint effector cells.

Role of mast cells in inflammatory disease - this work is now being further extended to analyse the role of mast cells in inflammatory disorders such as rheumatoid arthritis (in collaboration with Professor I McInnes, University of Glasgow), cardiovascular disease ( Dr P Maffia and S Kennedy, University of Glasgow), and stroke (with Dr H Carswell).

Antiparasiticals

More recently I have been developing research in evaluating novel anthelminthics in collaboration with Dr Chris Carter.

Education/Academic qualification

Doctor of Philosophy, University of Nottingham

Award Date: 1 Jan 1990

Bachelor of Science, Imperial College of Science, Technology and Medicine

Award Date: 1 Jan 1986

External positions

External Examiner, Kingston University

1 Oct 201630 Sep 2020

Keywords

  • Inflammation
  • parasitology
  • Immunology
  • allergy

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