Projects per year
Ion Transport in Bacteria
Research in my laboratory is focused on membrane proteins involved in transport of ions across cellular membranes and in signalling processes relating to ion availability. Studies of membrane transporters/channels have had a great impact on our understanding human disease and drug design; indeed ion channels are, at present, the third biggest target classe in drug discovery and about 30% of current clinically marked drugs are targeted against these proteins.
The philosophy of my research, is to use simple and well studied bacterial model organisms, and a multidisciplinary approach to shed more light on two ubiquitous families of ion transporters both of which are conserved from bacteria to man: the ammonium transporter from the Amt/Rh family (TC 1.A.11) and the sulphate permease from the SulP/SLC26A family (TC 2.A.53).
I am a Fellow of the Higher Education Academy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
- 1 Similar Profiles
Dive into details
Select a country/territory to view shared publications and projects
Visit to Devro (Gordon Paul, Darren Quinn, Katrina Davidson for PhD studentships via IBioIC/Strathclyde CD
11/06/18 → …
Project: Knowledge Exchange
Visit to CPI (Valentina Mangiafridda) for PhD studentships via IBioIC/Strathclyde CDT
19/08/16 → …
Project: Knowledge Exchange
- 23 Article
Coexistence of ammonium transporter and channel mechanisms in Amt-Mep-Rh Twin-His variants impairs the filamentation signalling capacity of fungal Mep2 transceptorsWilliamson, G., Brito, A. S., Bizior, A., Tamburrino, G., Dias Mirandela, G., Harris, T., Hoskisson, P. A., Zachariae, U., Marini, A. M., Boeckstaens, M. & Javelle, A., 26 Apr 2022, In: mBio. 13, 2, 17 p., e02913-21.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Correction: a two-lane mechanism for selective biological ammonium transportWilliamson, G., Tamburrino, G., Bizior, A., Boeckstaens, M., Dias Mirandela, G., Bage, M. G., Pisliakov, A., Ives, C. M., Terras, E., Hoskisson, P. A., Marini, A-M., Zachariae, U. & Javelle, A., 27 Jan 2022, (E-pub ahead of print) In: eLife. 11, e77377.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile5 Downloads (Pure)
Chancellor’s Fellowship, Function/physiological role and potential druggability of bacterial transporter and channel
Javelle, Arnaud (Recipient), 1 Oct 2014
Prize: Fellowship awarded competitively
“The ammonium transporter from the Amt/Mep/Rh family Mystery solved?”
Arnaud Javelle (Speaker)30 Apr 2019 → 2 May 2019
Activity: Talk or presentation types › Invited talk
Investigating the metamorphic properties of annexin A5 during membrane integration
Arnaud Javelle (External Examiner)4 Dec 2018
Activity: Examination types › Examination