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Personal profile

Personal Statement

Ion Transport in Bacteria

Research in my laboratory is focused on membrane proteins involved in transport of ions across cellular membranes and in signalling processes relating to ion availability. Studies of membrane transporters/channels have had a great impact on our understanding human disease and drug design; indeed ion channels are, at present, the third biggest target classe in drug discovery and about 30% of current clinically marked drugs are targeted against these proteins.
The philosophy of my research, is to use simple and well studied bacterial model organisms, and a multidisciplinary approach to shed more light on two ubiquitous families of ion transporters both of which are conserved from bacteria to man: the ammonium transporter from the Amt/Rh family (TC 1.A.11) and the sulphate permease from the SulP/SLC26A family (TC 2.A.53).

I am a Fellow of the Higher Education Academy.

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Projects

Research Output

A two-lane mechanism for selective biological ammonium transport

Williamson, G., Tamburrino, G., Bizior, A., Boeckstaens, M., Dias Mirandela, G., Bage, M., Pisliakov, A., Ives, C. M., Terras, E., Hoskisson, P. A., Marini, A. M., Zachariae, U. & Javelle, A., 14 Jul 2020, In : eLife. 9, e57183.

Research output: Contribution to journalArticle

Open Access
File
  • 3 Downloads (Pure)

    The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB

    Dias Mirandela, G., Tamburrino, G., Hoskisson, P. A., Zachariae, U. & Javelle, A., 1 Feb 2019, In : FASEB Journal. 33, 2, p. 1989-1999 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 6 Citations (Scopus)
    12 Downloads (Pure)

    Thesis

    Structural, functional and mechanistic analysis of the Escherichia coli ammonium transporter AmtB

    Author: Dias Mirandela, G., 28 Jan 2019

    Supervisor: Javelle, A. (Supervisor) & Hoskisson, P. (Supervisor)

    Student thesis: Doctoral Thesis

    Structural, functional and mechanistic analysis of the Escherichia coli ammonium transporter AmtB

    Author: Dias Mirandela, G., 28 Jan 2019

    Supervisor: Javelle, A. (Supervisor) & Hoskisson, P. (Supervisor)

    Student thesis: Doctoral Thesis

    Activities

    • 10 Invited talk
    • 3 Examination
    • 2 Membership of committee

    “The ammonium transporter from the Amt/Mep/Rh family Mystery solved?”

    Arnaud Javelle (Speaker)
    30 Apr 20192 May 2019

    Activity: Talk or presentation typesInvited talk

    The ammonium transporter from the Amt/Mep/Rh family: Mystery solved?

    Arnaud Javelle (Speaker)
    5 Dec 2018

    Activity: Talk or presentation typesInvited talk