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Personal profile

Personal Statement

Ion Transport in Bacteria

Research in my laboratory is focused on membrane proteins involved in transport of ions across cellular membranes and in signalling processes relating to ion availability. Studies of membrane transporters/channels have had a great impact on our understanding human disease and drug design; indeed ion channels are, at present, the third biggest target classe in drug discovery and about 30% of current clinically marked drugs are targeted against these proteins.
The philosophy of my research, is to use simple and well studied bacterial model organisms, and a multidisciplinary approach to shed more light on two ubiquitous families of ion transporters both of which are conserved from bacteria to man: the ammonium transporter from the Amt/Rh family (TC 1.A.11) and the sulphate permease from the SulP/SLC26A family (TC 2.A.53).

I am a Fellow of the Higher Education Academy.

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Projects 2015 2018

Research Output 2001 2019

2 Citations (Scopus)

The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB

Dias Mirandela, G., Tamburrino, G., Hoskisson, P. A., Zachariae, U. & Javelle, A., 1 Feb 2019, In : FASEB Journal. 33, 2, p. 1989-1999 11 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphatidylglycerols
Ammonium Compounds
Escherichia coli
Lipids
Protein Unfolding
1 Citation (Scopus)

Merging in-solution X-ray and neutron scattering data allows fine structural analysis of membrane-protein detergent complexes

Dias Mirandela, G., Tamburrino, G., Ivanović, M. T., Strnad, F. M., Byron, O., Rasmussen, T., Hoskisson, P. A., Hub, J. S., Zachariae, U., Gabel, F. & Javelle, A., 25 Jun 2018, In : Journal of Physical Chemistry Letters. 9, 14, p. 3910–3914 5 p.

Research output: Contribution to journalArticle

Open Access
File
detergents
Detergents
Neutron scattering
X ray scattering
Merging

Thesis

Structural, functional and mechanistic analysis of the Escherichia coli ammonium transporter AmtB

Author: Dias Mirandela, G., 1 Oct 2018

Supervisor: Javelle, A. (Supervisor) & Hoskisson, P. (Supervisor)

Student thesis: Doctoral Thesis

Structural, functional and mechanistic analysis of the Escherichia coli ammonium transporter AmtB

Author: Dias Mirandela, G., 1 Oct 2018

Supervisor: Javelle, A. (Supervisor) & Hoskisson, P. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2015 2019

  • 10 Invited talk
  • 3 Examination
  • 2 Membership of committee

“The ammonium transporter from the Amt/Mep/Rh family Mystery solved?”

Arnaud Javelle (Speaker)
30 Apr 20192 May 2019

Activity: Talk or presentation typesInvited talk

Investigating the metamorphic properties of annexin A5 during membrane integration

Arnaud Javelle (External Examiner)
4 Dec 2018

Activity: Examination typesExamination