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Research Output 1993 2019

  • 23 Article
  • 1 Meeting abstract
  • 1 Conference Contribution
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Article
2019
Calcium-Calmodulin-Dependent Protein Kinases
Endothelium
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Aorta
Endothelial Cells
2018
1 Citation (Scopus)

CaMKIIδ interacts directly with IKKβ and modulates NF-kB signalling in adult cardiac fibroblasts

Martin, T. P., McCluskey, C., Cunningham, M. R., Beattie, J., Paul, A. & Currie, S., 27 Jul 2018, In : Cellular Signalling.

Research output: Contribution to journalArticle

Open Access
File
Calcium-Calmodulin-Dependent Protein Kinases
NF-kappa B
Fibroblasts
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Surface Plasmon Resonance

Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells

Ng, P. Y., McIntosh, K. A., Hargrave, G., Ho, K. H., Paul, A. & Plevin, R., 30 Nov 2018, In : Cellular Signalling. 51, p. 59-71 13 p.

Research output: Contribution to journalArticle

Open Access
File
Purinergic Receptors
JNK Mitogen-Activated Protein Kinases
Endothelial Cells
Cytokines
Adenine Nucleotides
2017
3 Citations (Scopus)

Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers

Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N., Scott, R. & 4 othersSuckling, C. J., Sutcliffe, O. B., Young, L. C. & MacKay, S. P., 24 Jul 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7043-7066 24 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Isoforms
Phosphotransferases
Biomarkers
NF-kappa B
Phosphorylation
4 Citations (Scopus)

The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer

Bennett, L., Mallon, E. A., Horgan, P. G., Paul, A., McMillan, D. C. & Edwards, J., 9 Mar 2017, In : Oncotarget. 8, 20, p. 33002-33013 12 p.

Research output: Contribution to journalArticle

Open Access
File
Tumor Microenvironment
Breast Neoplasms
Survival
Neoplasms
Cell Survival
2016
6 Citations (Scopus)

High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer

Bennett, L., Quinn, J., McCall, P., Mallon, E. A., Horgan, P. G., McMillan, D. C., Paul, A. & Edwards, J., 22 Dec 2016, In : International Journal of Cancer. 12 p.

Research output: Contribution to journalArticle

Open Access
File
Estrogen Receptors
Breast Neoplasms
Recurrence
Neoplasms
Tamoxifen
2014
9 Citations (Scopus)

Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts

Martin, T. P., Lawan, A., Robinson, E., Grieve, D. J., Plevin, R., Paul, A. & Currie, S., 28 Feb 2014, In : Pflugers Archiv - European Journal of Physiology. 466, 2, p. 319–330 12 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Fibroblasts
Fibrosis
Cardiomegaly
2012
14 Citations (Scopus)

Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis

Petch, D., Anderson, R. J., Cunningham, A., George, S. E., Hibbs, D. E., Liu, R., Mackay, S. P., Paul, A., Small, D. A. P. & Groundwater, P. W., 1 Oct 2012, In : Bioorganic and Medicinal Chemistry. 20, 19, p. 5901-5914 14 p.

Research output: Contribution to journalArticle

Dimerization
Keratinocytes
Psoriasis
Assays
Charge coupled devices
13 Citations (Scopus)

Nuclear factor κB predicts poor outcome in patients with hormone-naive prostate cancer with high nuclear androgen receptor

MacKenzie, L., McCall, P., Hatziieremia, S., Catlow, J., Adams, C., McArdle, P., Seywright, M., Tanahill, C., Paul, A., Underwood, M., Mackay, S., Plevin, R. & Edwards, J., Sep 2012, In : Human pathology. 43, 9, p. 1491-500 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Cytoplasmic and Nuclear Receptors
Prostatic Neoplasms
Hormones
Mortality
14 Citations (Scopus)

Surgical optimization and characterization of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice

Martin, T. P., Robinson, E., Harvey, A. P., Macdonald, M., Grieve, D. J., Paul, A. & Currie, S., 1 Jul 2012, In : Experimental Physiology. 97, 7, p. 822-832 11 p.

Research output: Contribution to journalArticle

Cardiomegaly
Blood Pressure
Body Weight
Weights and Measures
Minimally Invasive Surgical Procedures
2011
52 Citations (Scopus)

Inhibitory kappa B kinases as targets for pharmacological regulation

Gamble, C., McIntosh, K., Scott, R., Ho, K. H., Plevin, R. & Paul, A., 2011, In : British Journal of Pharmacology. 165, 4, p. 802–819 18 p.

Research output: Contribution to journalArticle

Phosphotransferases
Pharmacology
Adenosine Triphosphate
Intestinal Neoplasms
Proteins
2010
14 Citations (Scopus)

Characterisation of P2X receptors expressed in rat pulmonary arteries

Syed, N-I-H., Tengah, A., Paul, A. & Kennedy, C., 15 Dec 2010, In : European Journal of Pharmacology. 649, 1-3, p. 342-348 7 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Purinergic P2X1 Receptors
Suramin
Messenger RNA
Purinergic P2X3 Receptors
38 Citations (Scopus)

Differential modulation of TLR-3 and TLR-4 mediated dendritic cell maturation and function by progesterone

Jones, L. A., Kreem, S., Shweash, M., Paul, A., Alexander, J. & Roberts, C. W., 15 Oct 2010, In : Journal of Immunology. 185, 8, p. 4525-4534 10 p.

Research output: Contribution to journalArticle

Dendritic Cells
Progesterone
Glucocorticoid Receptors
Progesterone Receptors
Norgestrel
2007
12 Citations (Scopus)

IKKalpha and IKKbeta function in TNFalpha-stimulated adhesion molecule expression in human aortic smooth muscle cells

MacKenzie, C., Ritchie, E., Paul, A. & Plevin, R. J., 2007, In : Cellular Signalling. 19, p. 75-80 6 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
Smooth Muscle Myocytes
Tumor Necrosis Factor-alpha
DNA
20 Citations (Scopus)
Calcium-Calmodulin-Dependent Protein Kinases
Ryanodine Receptor Calcium Release Channel
Cardiac Myocytes
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Surface Plasmon Resonance
2006
82 Citations (Scopus)
Mitogen-Activated Protein Kinases
Lipopolysaccharides
Monocytes
Macrophages
Phosphorylation
2004
122 Citations (Scopus)

Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway

Cameron, P., McGachy, H. A., Anderson, M., Paul, A., Coombs, G. H., Mottram, J. C., Alexander, J. & Plevin, R. J., Sep 2004, In : Journal of Immunology. 173, 5, p. 3297-3304 7 p.

Research output: Contribution to journalArticle

Leishmania mexicana
tripeptide aminopeptidase
NF-kappa B
Interleukin-12
Cysteine
28 Citations (Scopus)

Switching leukemia cell phenotype between life and death

Tucker, S. J., Rae, C., Littlejohn, A. F., Paul, A. & MacEwan, D. J., 2004, In : Proceedings of the National Academy of Sciences . 101, 35, p. 12940-12945 6 p.

Research output: Contribution to journalArticle

Leukemia
Phenotype
JNK Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
Tumor Necrosis Factor-alpha
2002
11 Citations (Scopus)

Essential role for verotoxin in sustained stress-activated protein kinase and nuclear factor kappa b signaling, stimulated by escherichia coli o157:H7 in vero cells

Cameron, P., Bingham, D., Paul, A., Pavelka, M., Cameron, S., Rotondo, D. & Plevin, R. J., 2002, In : Infection and Immunity. 70, 10, p. 5370-5380 11 p.

Research output: Contribution to journalArticle

Shiga Toxins
Vero Cells
Escherichia coli O157
Heat-Shock Proteins
Protein Kinases
2001
103 Citations (Scopus)

Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock

McDonald, M. C., Mota-Filipe, H., Paul, A., Cuzzocrea, S., Abdelrahman, M., Harwood, S., Plevin, R. J., Chatterjee, P. K., Yaqoob, M. M. & Thiemermann, C., 2001, In : FASEB Journal. 15, 1, p. 171-186 15 p.

Research output: Contribution to journalArticle

Calpain
Hemorrhagic Shock
NF-kappa B
Chemical activation
Liver
19 Citations (Scopus)
Hydrogen Peroxide
Smooth Muscle Myocytes
Lipopolysaccharides
Phosphotransferases
Phosphoric Monoester Hydrolases
95 Citations (Scopus)

Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa b kinases in NCTC 2544 keratinocytes

Kanke, T., MacFarlane, S. R., Seatter, M. J., Davenport, E. L., Paul, A., McKenzie, R. C. & Plevin, R. J., 2001, In : Journal of Biological Chemistry. 276, 34, p. 31657-31666 10 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Heat-Shock Proteins
Keratinocytes
Trypsin
Protein Kinases
1993
12 Citations (Scopus)

Phosphatidylcholine hydrolysis: a multiple messenger generating system

Wakelam, M. J., Pettitt, T. R., Kaur, P., Briscoe, C. P., Stewart, A., Paul, A., Paterson, A., Cross, M. J., Gardner, S. D. & Currie, S., 1993, In : Advances in Second Messenger and Phosphoprotein Research. 28, p. 73-80 8 p.

Research output: Contribution to journalArticle

Phosphatidylcholines
Hydrolysis