Research Output per year
Research Output 1993 2019
Meeting abstract
Pro-inflammatory signalling in vascular endothelium: a novel role for CaMKIIdelta in ageing
McCluskey, C., Paul, A. & Currie, S., 30 Jun 2015, In : Heart . 101, S4, A100-A101.Research output: Contribution to journal › Meeting abstract
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Vascular Endothelium
Interleukin-1beta
Human Umbilical Vein Endothelial Cells
Tumor Necrosis Factor-alpha
Conference Contribution
Does receptor activation initiate the NF kappa B pathway in hippocampal neurones?
Pytka, K., Librowski, T., Filipek, B., Paul, A. & Bushell, T., 2010, In : Pharmacological Reports. 62, supplement, p. 59-59 1 p.Research output: Contribution to journal › Conference Contribution
NF-kappa B
Neurons
Article
Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts
Martin, T. P., Lawan, A., Robinson, E., Grieve, D. J., Plevin, R., Paul, A. & Currie, S., 28 Feb 2014, In : Pflugers Archiv - European Journal of Physiology. 466, 2, p. 319–330 12 p.Research output: Contribution to journal › Article
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Fibroblasts
Fibrosis
Cardiomegaly
103
Citations
(Scopus)
Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock
McDonald, M. C., Mota-Filipe, H., Paul, A., Cuzzocrea, S., Abdelrahman, M., Harwood, S., Plevin, R. J., Chatterjee, P. K., Yaqoob, M. M. & Thiemermann, C., 2001, In : FASEB Journal. 15, 1, p. 171-186 15 p.Research output: Contribution to journal › Article
Calpain
Hemorrhagic Shock
NF-kappa B
Chemical activation
Liver
CaMKIIδ interacts directly with IKKβ and modulates NF-kB signalling in adult cardiac fibroblasts
Martin, T. P., McCluskey, C., Cunningham, M. R., Beattie, J., Paul, A. & Currie, S., 27 Jul 2018, In : Cellular Signalling.Research output: Contribution to journal › Article
Open Access
File
Calcium-Calmodulin-Dependent Protein Kinases
NF-kappa B
Fibroblasts
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Surface Plasmon Resonance
Characterisation of P2X receptors expressed in rat pulmonary arteries
Syed, N-I-H., Tengah, A., Paul, A. & Kennedy, C., 15 Dec 2010, In : European Journal of Pharmacology. 649, 1-3, p. 342-348 7 p.Research output: Contribution to journal › Article
Pulmonary Artery
Purinergic P2X1 Receptors
Suramin
Messenger RNA
Purinergic P2X3 Receptors
Compromised cardiovascular function in aged rats corresponds with increased expression and activity of calcium/calmodulin dependent protein kinase IIδ in aortic endothelium
McCluskey, C., Mooney, L., Paul, A. & Currie, S., 31 Jul 2019, In : Vascular pharmacology. 118-119, 11 p., 106560.Research output: Contribution to journal › Article
Calcium-Calmodulin-Dependent Protein Kinases
Endothelium
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Aorta
Endothelial Cells
Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis
Petch, D., Anderson, R. J., Cunningham, A., George, S. E., Hibbs, D. E., Liu, R., Mackay, S. P., Paul, A., Small, D. A. P. & Groundwater, P. W., 1 Oct 2012, In : Bioorganic and Medicinal Chemistry. 20, 19, p. 5901-5914 14 p.Research output: Contribution to journal › Article
Dimerization
Keratinocytes
Psoriasis
Assays
Charge coupled devices
Differential modulation of TLR-3 and TLR-4 mediated dendritic cell maturation and function by progesterone
Jones, L. A., Kreem, S., Shweash, M., Paul, A., Alexander, J. & Roberts, C. W., 15 Oct 2010, In : Journal of Immunology. 185, 8, p. 4525-4534 10 p.Research output: Contribution to journal › Article
Dendritic Cells
Progesterone
Glucocorticoid Receptors
Progesterone Receptors
Norgestrel
Essential role for verotoxin in sustained stress-activated protein kinase and nuclear factor kappa b signaling, stimulated by escherichia coli o157:H7 in vero cells
Cameron, P., Bingham, D., Paul, A., Pavelka, M., Cameron, S., Rotondo, D. & Plevin, R. J., 2002, In : Infection and Immunity. 70, 10, p. 5370-5380 11 p.Research output: Contribution to journal › Article
Shiga Toxins
Vero Cells
Escherichia coli O157
Heat-Shock Proteins
Protein Kinases
High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer
Bennett, L., Quinn, J., McCall, P., Mallon, E. A., Horgan, P. G., McMillan, D. C., Paul, A. & Edwards, J., 22 Dec 2016, In : International Journal of Cancer. 12 p.Research output: Contribution to journal › Article
Open Access
File
Estrogen Receptors
Breast Neoplasms
Recurrence
Neoplasms
Tamoxifen
Hydrogen peroxide-mediated inhibition of lipopolysaccharide-stimulated inhibitory kappa b kinase activity in rat aortic smooth muscle cells
Torrie, L. J., MacKenzie, C., Paul, A. & Plevin, R. J., 2001, In : British Journal of Pharmacology. 134, 2, p. 393-401 9 p.Research output: Contribution to journal › Article
Hydrogen Peroxide
Smooth Muscle Myocytes
Lipopolysaccharides
Phosphotransferases
Phosphoric Monoester Hydrolases
IKKalpha and IKKbeta function in TNFalpha-stimulated adhesion molecule expression in human aortic smooth muscle cells
MacKenzie, C., Ritchie, E., Paul, A. & Plevin, R. J., 2007, In : Cellular Signalling. 19, p. 75-80 6 p.Research output: Contribution to journal › Article
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
Smooth Muscle Myocytes
Tumor Necrosis Factor-alpha
DNA
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
Ng, P. Y., McIntosh, K. A., Hargrave, G., Ho, K. H., Paul, A. & Plevin, R., 30 Nov 2018, In : Cellular Signalling. 51, p. 59-71 13 p.Research output: Contribution to journal › Article
Open Access
File
Purinergic Receptors
JNK Mitogen-Activated Protein Kinases
Endothelial Cells
Cytokines
Adenine Nucleotides
122
Citations
(Scopus)
Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway
Cameron, P., McGachy, H. A., Anderson, M., Paul, A., Coombs, G. H., Mottram, J. C., Alexander, J. & Plevin, R. J., Sep 2004, In : Journal of Immunology. 173, 5, p. 3297-3304 7 p.Research output: Contribution to journal › Article
Leishmania mexicana
tripeptide aminopeptidase
NF-kappa B
Interleukin-12
Cysteine
Inhibitory kappa B kinases as targets for pharmacological regulation
Gamble, C., McIntosh, K., Scott, R., Ho, K. H., Plevin, R. & Paul, A., 2011, In : British Journal of Pharmacology. 165, 4, p. 802–819 18 p.Research output: Contribution to journal › Article
Phosphotransferases
Pharmacology
Adenosine Triphosphate
Intestinal Neoplasms
Proteins
Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers
Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N., Scott, R. & 4 others, 24 Jul 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7043-7066 24 p.Research output: Contribution to journal › Article
Open Access
File
Protein Isoforms
Phosphotransferases
Biomarkers
NF-kappa B
Phosphorylation
Interaction of calcium/calmodulin-dependent protein kinase IIδC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes
Currie, S., Anthony, D. F., Beattie, J. & Paul, A., 2007, In : Journal of Molecular and Cellular Cardiology. 43, 4, p. 492-503 11 p.Research output: Contribution to journal › Article
Calcium-Calmodulin-Dependent Protein Kinases
Ryanodine Receptor Calcium Release Channel
Cardiac Myocytes
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Surface Plasmon Resonance
Nuclear factor κB predicts poor outcome in patients with hormone-naive prostate cancer with high nuclear androgen receptor
MacKenzie, L., McCall, P., Hatziieremia, S., Catlow, J., Adams, C., McArdle, P., Seywright, M., Tanahill, C., Paul, A., Underwood, M., Mackay, S., Plevin, R. & Edwards, J., Sep 2012, In : Human pathology. 43, 9, p. 1491-500 10 p.Research output: Contribution to journal › Article
Androgen Receptors
Cytoplasmic and Nuclear Receptors
Prostatic Neoplasms
Hormones
Mortality
12
Citations
(Scopus)
Phosphatidylcholine hydrolysis: a multiple messenger generating system
Wakelam, M. J., Pettitt, T. R., Kaur, P., Briscoe, C. P., Stewart, A., Paul, A., Paterson, A., Cross, M. J., Gardner, S. D. & Currie, S., 1993, In : Advances in Second Messenger and Phosphoprotein Research. 28, p. 73-80 8 p.Research output: Contribution to journal › Article
Phosphatidylcholines
Hydrolysis
Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa b kinases in NCTC 2544 keratinocytes
Kanke, T., MacFarlane, S. R., Seatter, M. J., Davenport, E. L., Paul, A., McKenzie, R. C. & Plevin, R. J., 2001, In : Journal of Biological Chemistry. 276, 34, p. 31657-31666 10 p.Research output: Contribution to journal › Article
PAR-2 Receptor
Heat-Shock Proteins
Keratinocytes
Trypsin
Protein Kinases
Surgical optimization and characterization of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice
Martin, T. P., Robinson, E., Harvey, A. P., Macdonald, M., Grieve, D. J., Paul, A. & Currie, S., 1 Jul 2012, In : Experimental Physiology. 97, 7, p. 822-832 11 p.Research output: Contribution to journal › Article
Cardiomegaly
Blood Pressure
Body Weight
Weights and Measures
Minimally Invasive Surgical Procedures
Switching leukemia cell phenotype between life and death
Tucker, S. J., Rae, C., Littlejohn, A. F., Paul, A. & MacEwan, D. J., 2004, In : Proceedings of the National Academy of Sciences . 101, 35, p. 12940-12945 6 p.Research output: Contribution to journal › Article
Leukemia
Phenotype
JNK Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
Tumor Necrosis Factor-alpha
The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and nFkappaB signalling pathways in monocytes/macrophages
Hatziieremia, S., Gray, A., Ferro, V. A., Paul, A. & Plevin, R. J., 2006, In : British Journal of Pharmacology. 149, p. 188-198 10 p.Research output: Contribution to journal › Article
Mitogen-Activated Protein Kinases
Lipopolysaccharides
Monocytes
Macrophages
Phosphorylation
The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
Bennett, L., Mallon, E. A., Horgan, P. G., Paul, A., McMillan, D. C. & Edwards, J., 9 Mar 2017, In : Oncotarget. 8, 20, p. 33002-33013 12 p.Research output: Contribution to journal › Article
Open Access
File
Tumor Microenvironment
Breast Neoplasms
Survival
Neoplasms
Cell Survival