Alastair Florence

Search results

• 2010

  A computationally inspired investigation of the solid forms of (R)-1-phenylethylammonium-(S)-2-phenylbutyrate

  Antoniadis, C. D., D'Oria, E., Karamertzanis, P. G., Tocher, D. A., Florence, A. J., Price, S. L. & Jones, A. G., 5 May 2010, In: Chirality. 22, 4, p. 447-455 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Solid 100%
  • Solvent 50%
  • Crystallization 50%
  • Solution and Solubility 50%
  • Energy Landscape 25%
  7 Citations (Scopus)

• A predicted dimer-based polymorph of 10,11-dihydrocarbamazepine (Form IV)

  Arlin, J-B., Johnston, A., Miller, G. J., Kennedy, A., Price, S. L. & Florence, A., 2010, In: CrystEngComm. 12, 1, p. 64-66 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dimer 100%
  • Hydrogen 50%
  • Vapor 50%
  • Contrast 50%
  21 Citations (Scopus)

  246 Downloads (Pure)

• Characterisation of amorphous and nanocrystalline molecular materials by total scattering

  Billinge, S. J. L., Dykhne, T., Juhas, P., Bozin, E., Taylor, R., Florence, A. & Shankland, K., 2010, In: CrystEngComm. 12, 5, p. 1366-1368 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Carbamazepine 100%
  • High-Energy X-Rays 100%
  75 Citations (Scopus)

  164 Downloads (Pure)
• 2009

  3-aminocarbonylpyridinium difluoroacetate at 123 k

  Bardin, J., Florence, A. J., Arlin, J. B., Kennedy, A. R. & Wong, L. V., Nov 2009, In: Acta Crystallographica Section E: Structure Reports. 65, p. O2896-U2160

  Research output: Contribution to journal › Article › peer-review

  • Difluoroacetate 100%
  • Pyridine Ring 33%

• A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers

  McConville, J. T., Hodges, L. A., Jones, T., Band, J. P., O'Mahony, B., Lindsay, B., Ross, A. C., Florence, A. J., Stanley, A. J., Humphrey, M. J., Wilson, C. & Stevens, H., Nov 2009, In: Journal of Pharmaceutical Sciences. 98, 11, p. 4251-4263 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Technetium 100%
  • Riboflavin 100%
  • Indium 111 100%
  8 Citations (Scopus)

• A chemical preformulation study of a host-guest complex of cucurbit[7]uril and a multinuclear platinum agent for enhanced anticancer drug delivery

  Kennedy, A. R., Florence, A. J., McInnes, F. J. & Wheate, N. J., Jul 2009, In: Dalton Transactions. 2009, 37, p. 7695-7700 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Platinum 100%
  • Antineoplastic Agent 100%
  • Cucurbit[7]uril 100%
  • Host-Guest Complex 100%
  • Single Crystalline Solid 33%
  56 Citations (Scopus)

• Approaches to high-throughput physical form screening and discovery

  Florence, A. J. & Brittain, H. G. (ed.), Jul 2009, Polymorphism in Pharmaceutical Solids, Second Edition. Informa Healthcare, 664 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Crystallization 100%
  • Solvent 25%
  • Recrystallization 25%
  • Drug Development 25%
  • Drug Discovery 25%

• Structure determination from powder data: Mogul and CASTEP

  Florence, A. J., Bardin, J., Johnston, B., Shankland, N., Griffin, T. A. N. & Shankland, K., 31 May 2009, Eleventh European Powder Diffraction Conference. Göbel, H. (ed.). Berlin, Germany, Vol. 30. p. 215-220 5 p. (Zeitschrift fur Kristallografie).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

  Open Access

  File

  • Structure Determination 100%
  • Powder 100%
  • Molecular Structure 66%
  • Molecular Conformation 66%
  • Molecule 66%
  34 Citations (Scopus)

  249 Downloads (Pure)

• The solid state

  Florence, A. J., Florence, A. (ed.) & Siepmann, J. (ed.), May 2009, Modern pharmaceutics, Fifth Edition. New York, USA: Informa Healthcare, Vol. 1. 500 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Drug Development 100%
  • Ensure 100%
  • Drug 100%
  • Inorganic Salt 100%

• Nicotinamide-2,2,2-trifluoroethanol (2/1)

  Bardin, J., Kennedy, A. R., Wong, L. V., Johnston, B. F. & Florence, A. J., Apr 2009, In: Acta Crystallographica Section E: Structure Reports. 65, 4, p. o727-o728

  Research output: Contribution to journal › Article › peer-review

  • Nicotinamide 100%
  • 2,2,2-trifluoroethanol 100%
  2 Citations (Scopus)

• Hydrogen atom behaviour imaged in a short intramolecular hydrogen bond using the combined approach of X-ray and neutron diffraction

  Thomas, L. H., Florence, A. & Wilson, C. C., 2009, In: New Journal of Chemistry. 33, 12, p. 2486-2490 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Atoms 100%
  • Neutron Diffraction 100%
  • Hydrogen 100%
  • X Ray Diffraction 100%
  • Temperature 60%
  41 Citations (Scopus)

• Large-scale distributed computing for accelerated structure solution

  Shankland, K., Griffin, T. A. N., van de Streek, J., Cole, J. H., Shankland, N., Florence, A. J. & David, W. I. F., 2009, In: Zeitschrift fur Kristallografie. 30, p. 227-232 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Type Systems 100%
  • Compute Resource 50%
  1 Citation (Scopus)

• The role of lyophilisation in the enhancement of glibenclamide release from hard gelatin capsules

  Mansour, H., McInnes, F. J., Florence, A. J. & Mullen, A., 2009, In: Journal of Pharmacy and Pharmacology. 61, S1, p. A38-A39

  Research output: Contribution to journal › Conference Contribution › peer-review

  • Gelatin 100%
  • Sodium 50%
  • Antidiabetic Agent 50%
• 2008

  Cytenamide-formic acid (1/1)

  Johnston, A., Florence, A. J., Miller, G. J., Kennedy, A. R. & Bedford, C. T., Aug 2008, In: Acta Crystallographica Section E: Structure Reports. 64, p. 1379-1380 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Formic Acid 100%
  • Solvent 100%
  • Hydrogen 100%
  • Cycloheptatriene 100%
  • Crystal Structure 100%
  2 Citations (Scopus)

• Cytenamide-butyric acid (1/1)

  Johnston, A., Florence, A. J., Fabbiani, F. J. A., Shankland, K. & Bedford, C. T., Jul 2008, In: Acta Crystallographica Section E: Structure Reports. 64, 7, p. O1295-U2200 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heterodimer 100%
  2 Citations (Scopus)

  53 Downloads (Pure)

• Cytenamide trifluoroacetic acid solvate

  Johnston, A., Florence, A. J., Fabianni, F. J. A., Shankland, K., Bedford, C. T. & Bardin, J., Jul 2008, In: Acta Crystallographica Section E: Structure Reports. 64, 7, p. 1215-1216 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trifluoromethyl Group 100%
  3 Citations (Scopus)

  55 Downloads (Pure)

• Chlorothiazide-pyridine (1/3)

  Johnston, A., Florence, A. J. & Kennedy, A. R., Jun 2008, In: Acta Crystallographica Section E: Structure Reports. 64, 6, p. 1105-1106 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Chlorothiazide 100%
  • Benzothiadiazine 33%
  6 Citations (Scopus)

• Cytenamide acetic acid solvate

  Johnston, A., Florence, A. J., Fabianni, F. J. A., Shankland, K. & Bedford, C. T., Jun 2008, In: Acta Crystallographica Section E: Structure Reports. 64, 6, p. 1175-1176 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Solvent 100%
  • Acetic Acid 100%
  • Hydrogen 100%
  • Cycloheptatriene 100%
  • Crystal Structure 100%
  1 Citation (Scopus)

• Urea-N,N-dimethylacetamide (1/1)

  Fernandes, P., Florence, A. J., Fabbiani, F., David, W. I. F. & Shankland, K., Feb 2008, In: Acta Crystallographica Section E: Structure Reports. 64, 2, p. o355-o355

  Research output: Contribution to journal › Article › peer-review

  • N,n Dimethylacetamide 100%
  • Urea 100%
  • N,N-Dimethylacetamide 100%
  2 Citations (Scopus)

• A catemer-to-dimer structural transformation in cyheptamide

  Florence, A. J., Shankland, K., Gelbrich, T., Hursthouse, M. B., Shankland, N., Johnston, A., Fernandes, P. & Leech, C. K., 2008, In: CrystEngComm. 10, p. 26-28 2 p.

  Research output: Contribution to journal › Article › peer-review

  • X Ray Powder Diffraction 100%
  • Solid State 100%
  • Heating 100%
  • Crystal Structure 100%
  28 Citations (Scopus)

• A differential thermal expansion approach to crystal structure determination from powder diffraction data

  Fernandes, P., Shankland, K., David, W. I. F., Markvardsen, A. J., Florence, A. J., Shankland, N. & Leech, C. K., 2008, In: Journal of Applied Crystallography. 41, 6, p. 1089-1094 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Chlorothiazide 100%
  5 Citations (Scopus)

• A systematic experimental and theoretical study of the crystalline state of six chloronitrobenzenes

  Barnett, S. A., Johnston, A., Florence, A. J., Price, S. L. & Tocherr, D. A., 2008, In: Crystal Growth and Design. 8, 1, p. 24-36 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Crystal Structure Determination 100%
  23 Citations (Scopus)

• Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

  Fabbiani, F. P. A., Dittrich, B., Florence, A. J., Gelbrich, T., Hursthouse, M. B., Kuhs, W. F., Shankland, N. & Sowa, H., 2008, In: CrystEngComm. 11, p. 1396-1406 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ciprofloxacin 100%
  • Crystallization 100%
  • Hyperbarism 100%
  • Sodium 100%
  • Monovalent Cation 16%
  84 Citations (Scopus)

• Cytenamide-1,4-dioxane (2/1)

  Johnston, A., Florence, A. J., Fabbiani, F. J. A., Shankland, K. & Bedford, C. T., 2008, In: Acta Crystallographica Section E: Structure Reports. 64, 7, p. 1345-1346 1 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cycloheptatriene 100%
  3 Citations (Scopus)

  64 Downloads (Pure)

• Targeted crystallisation of novel carbamazepine solvates based on a retrospective random forest classification

  Johnston, A., Johnston, B. F., Kennedy, A. R. & Florence, A. J., 2008, In: CrystEngComm. 10, 1, p. 23-25 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbamazepine 100%
  • Crystallization 100%
  • Solvent 66%
  • Anticonvulsant 33%
  52 Citations (Scopus)

• Two-dimensional similarity between forms I and II of cytenamide, a carbamazepine analogue

  Florence, A. J., Bedford, C. T., Fabbiani, F. P. A., Shankland, K., Gelbrich, T., Hursthouse, M. B., Shankland, N. & Johnston, A., 2008, In: CrystEngComm. 10, p. 811-813 2 p.

  Research output: Contribution to journal › Article › peer-review

  • R 100%
  • Carbamazepine 100%
  • Chemical Transformation 50%
  • Solid 50%
  • Heating 50%
  20 Citations (Scopus)
• 2007

  Chlorothiazide formic acid solvate (1/2)

  Johnston, A., Florence, A. J. & Kennedy, A. R., Oct 2007, In: Acta Crystallographica Section E: Structure Reports. 63, 10 p., o4021.

  Research output: Contribution to journal › Article › peer-review

  • Formic Acid 100%
  • Chlorothiazide 100%
  • Formate 100%
  • Molecule 50%
  • Solvent 25%
  5 Citations (Scopus)

• 10,11-dihydrocarbamazepine-form-amide solvate (1/1)

  Johnston, A., Florence, A. J., Fernandes, P., Shankland, N. & Kennedy, A. R., Sept 2007, In: Acta Crystallographica Section E: Structure Reports. 63, p. O3888-U3750 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Amide 100%
  • Formamide 100%
  • Dimer 50%
  • Azepine 50%
  • Hydrogen 50%

• Chlorothiazide dimethyl sulfoxide solvate

  Johnston, A., Florence, A. J., Fernandes, P. & Kennedy, A. R., May 2007, In: Acta Crystallographica Section E: Structure Reports. 63, p. O2423-U781 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Benzothiadiazine 100%
  8 Citations (Scopus)

• Chlorothiazide N,N-dimethylacetamidedisolvate

  Johnston, A., Florence, A. J., Fernandes, P. & Kennedy, A. R., May 2007, In: Acta Crystallographica Section E: Structure Reports. 63, p. O2422-U770 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Chlorothiazide 100%
  • N,n Dimethylacetamide 66%
  • N,N-Dimethylacetamide 66%
  • Solvent 33%
  • Hypochlorite Sodium 33%
  9 Citations (Scopus)

• Crystallization and crystal energy landscape of hydrochlorothiazide

  Johnston, A., Florence, A. J., Shankland, N., Kennedy, A. R., Shankland, K. & Price, S. L., Apr 2007, In: Crystal Growth and Design. 7, 4, p. 705-712 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 2 Pyrrolidinone 100%
  • N,n Dimethylacetamide 100%
  • Diuretic Agent 100%
  • Diuretic 100%
  • Methyl Acetate 100%
  40 Citations (Scopus)

• Search for a predicted hydrogen bonding motif: a multidisciplinary investigation into the polymorphism of 3-Azabicyclo[3.3.1]nonane-2,4-dione

  Hulme, A. T., Johnston, A., Florence, A. J., Fernandes, P., Shankland, K., Bedford, C. T., Welch, G. W. A., Sadiq, G., Haynes, D. A., Motherwell, W. D. S., Tocher, D. A. & Price, S. L., 1 Mar 2007, In: Journal of American Chemical Society. 129, 12, p. 3649-3657 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Structure Prediction 100%
  • Solvate 100%
  • I23 100%
  54 Citations (Scopus)

  482 Downloads (Pure)

• 10,11-dihydrocarbamazepine formic acid solvate

  Johnston, A., Florence, A. J., Fernandes, P., Shankland, N. & Kennedy, A. R., Mar 2007, In: Acta Crystallographica Section E: Structure Reports. 63, 3, p. o1469-o1470 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Formate 100%
  • Carbamazepine 50%
  • Hydrogen 50%
  • Acid 50%
  • Nomenclature 50%
  4 Citations (Scopus)
• 2006

  10,11-Dihydrocarbamazepine-acetic acid (1/1)

  Johnston, A., Florence, A. J., Fernandes, P., Shankland, N. & Kennedy, A. R., Dec 2006, In: Acta Crystallographica Section E: Structure Reports. 62, p. O5361-O5362 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Acetic Acid 100%
  • Nomenclature 33%
  • Taxonomy 33%
  • Molecule 33%
  • Azepine 33%
  4 Citations (Scopus)

• Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate

  Johnston, A., Florence, A. J. & Kennedy, A. R., Nov 2006, In: Acta Crystallographica Section E: Structure Reports. 62, p. O5169-O5171 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Methyl 100%
  • Hydrochlorothiazide 100%
  • Solvent 25%
  • Benzothiadiazine 25%
  • N,N-Dimethylacetamide 25%
  6 Citations (Scopus)

• An automated parallel crystallisation search for predicted crystal structures and packing motifs of carbamazepine

  Florence, A. J., Johnston, A., Price, S. L., Nowell, H., Kennedy, A. R. & Shankland, N., Sept 2006, In: Journal of Pharmaceutical Sciences. 95, 9, p. 1918-1930 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Crystal Structure 100%
  • Carbamazepine 100%
  • Crystallization 100%
  • Solvent 60%
  • Nucleation 40%
  125 Citations (Scopus)

• Hydrochlorothiazide N,N-dimethylacetamide disolvate

  Johnston, A., Florence, A. J. & Kennedy, A. R., Jul 2006, In: Acta Crystallographica Section E: Structure Reports. 62, p. O2926-O2928 3 p.

  Research output: Contribution to journal › Article › peer-review

  • N,N-Dimethylacetamide 100%
  • Hydrochlorothiazide 100%
  • Solvent 50%
  • Benzothiadiazine 50%
  • Hydrogen Bonding 50%
  7 Citations (Scopus)

• Hydrochlorothiazide dimethyl sulfoxide solvate

  Johnston, A., Florence, A. J. & Kennedy, A. R., Jun 2006, In: Acta Crystallographica Section E: Structure Reports. 62, p. O2288-O2290 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydrochlorothiazide 100%
  • Dimethyl Sulfoxide 100%
  7 Citations (Scopus)

• Hydrochlorothiazide N,N-dimethylformamide solvate

  Johnston, A., Florence, A. J. & Kennedy, A. R., May 2006, In: Acta Crystallographica Section E: Structure Reports. 62, p. O1730-O1732 3 p.

  Research output: Contribution to journal › Article › peer-review

  • N,N-Dimethylformamide 100%
  • Hydrochlorothiazide 100%
  • Molecule 66%
  • Solvent 33%
  • Hydrogen Bonding 33%
  7 Citations (Scopus)

• Control and prediction of packing motifs: a rare occurrence of carbamazepine in a catemeric configuration

  Florence, A. J., Leech, C. K., Shankland, N., Shankland, K. & Johnston, A., 2006, In: CrystEngComm. 8, p. 746-747 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Orthorhombic Space Group 100%
  58 Citations (Scopus)

• Reversible extrusion and uptake of HCl molecules by crystalline solids involving coordination bond cleavage and formation

  Espallargas, G. M., Brammer, L., van de Streek, J., Shankland, K., Florence, A. J. & Adams, H., 2006, In: Journal of American Chemical Society. 128, 30, p. 9584-85 9499 p.

  Research output: Contribution to journal › Article › peer-review

  • Coordination 100%
  • Molecule 100%
  • Solid 100%
  • Crystal 100%
  • Aqueous Solution 50%
  108 Citations (Scopus)
• 2005

  3,4-Dichloro-1-nitro­benzene-1,4-dioxane (4/1)

  Barnett, S. A., Johnston, A., Florence, A. J. & Kennedy, A. R., Nov 2005, In: Acta Crystallographica Section E: Structure Reports. 61, 11, p. o3666-o3667

  Research output: Contribution to journal › Article › peer-review

  • 1,4-dioxane 100%
  3 Citations (Scopus)

• Hydrochlorothiazide-1,4-dioxane(1/1)

  Johnston, A., Florence, A. J. & Kennedy, A. R., Aug 2005, In: Acta Crystallographica Section E: Structure Reports. 61, p. O2573-O2575 3 p.

  Research output: Contribution to journal › Article › peer-review

  • 1,4-dioxane 100%
  • Hydrochlorothiazide 100%
  • Dioxane 100%
  • Molecule 66%
  • Hydrogen 66%
  4 Citations (Scopus)

• Hydrochlorothiazide-aniline (1/1)

  Johnston, A., Florence, A. J. & Kennedy, A. R., Aug 2005, In: Acta Crystallographica Section E: Structure Reports. 61, p. O2520-O2522 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydrochlorothiazide 100%
  • Aniline 100%
  • Hydrogen Bonding 50%
  • Crystal Structure 50%
  7 Citations (Scopus)

• 3,4-Dichloro-1-nitrobenzene-aniline (2/1)

  Barnett, S. A., Johnston, A., Florence, A. & Kennedy, A. R., 30 Jun 2005, In: Acta Crystallographica Section E: Structure Reports. 61, 7, p. o2318-o2319

  Research output: Contribution to journal › Article › peer-review

  • Nitrobenzene 100%
  • Aniline 100%
  • Hydrogen Bond 33%
  5 Citations (Scopus)

• Carbamazepine furfural hemisolvate

  Johnston, A., Florence, A. J. & Kennedy, A. R., Jun 2005, In: Acta Crystallographica Section E: Structure Reports. 61, p. O1777-O1779 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Furfural 100%
  17 Citations (Scopus)

• Carbamazepine N,N-dimethylformamide solvate

  Johnston, A., Florence, A. & Kennedy, A. R., 30 Apr 2005, In: Acta Crystallographica Section E: Structure Reports. 61, 5, p. o1509-o1511

  Research output: Contribution to journal › Article › peer-review

  • N,N-Dimethylformamide 100%
  • Carbamazepine 100%
  • Dimethylformamide 100%
  • Carboxamide 25%
  13 Citations (Scopus)

• Solving molecular crystal structures from laboratory X-ray powder diffraction data with DASH: the state of the art and challenges

  Florence, A. J., Shankland, N., Shankland, K., David, W. I. F., Pidcock, E., Xu, X., Johnston, A., Kennedy, A. R., Cox, P. J., Evans, J. S. O., Steele, G., Cosgrove, S. D. & Frampton, C. S., Apr 2005, In: Journal of Applied Crystallography. 38, 2, p. 249-259 10 p.

  Research output: Contribution to journal › Article › peer-review

  • X Ray Powder Diffraction 100%
  • Solution Structure 100%
  • Structural Database 50%
  83 Citations (Scopus)

• Hydrophobic vs hydrophilic: Ionic competition in remacemide salt structures

  Lewis, G. R., Steele, G., McBride, L., Florence, A. J., Kennedy, A. R., Shankland, N., David, W. I. F. & Teat, S. J., 26 Jan 2005, In: Crystal Growth and Design. 5, 2, p. 427-438 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Remacemide 100%
  • Epilepsy 16%
  • Hydrogen Anion 16%
  • Naphthalene 16%
  • 2 Naphthol 16%
  10 Citations (Scopus)
• 2004

  4-Chlorobenzoic acid N, N-dimethylformamide solvate

  Xu, X., Kennedy, A. R., Florence, A. J. & Shankland, N., 9 Oct 2004, In: Acta Crystallographica Section E: Structure Reports. 60, 11, p. 1950-1951 1 p.

  Research output: Contribution to journal › Article › peer-review

  • 4 Chlorobenzoic Acid 100%
  • N,n Dimethylformamide 100%
  1 Citation (Scopus)