Research output per year
Research output per year
- 50 - 100 out of 206 results
Search results
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2020
Olanzapine crystal symmetry originates in preformed centrosymmetric solute dimers
Warzecha, M., Verma, L., Johnston, B. F., Palmer, J. C., Florence, A. J. & Vekilov, P. G., 23 Sept 2020, In: Nature Chemistry. 12, 10, p. 914-920 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)48 Downloads (Pure) -
Data mining crystallization kinetics
Brown, C., Maldonado, D. A., Vassileiou, A., Johnston, B. & Florence, A., 19 Aug 2020, (Unpublished).Research output: Contribution to conference › Presentation/Speech
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Data mining crystallization kinetics
Brown, C., Maldonado, D., Vassileiou, A., Johnston, B. & Florence, A., 11 Aug 2020, (E-pub ahead of print) 40 p.Research output: Working paper
File50 Downloads (Pure) -
Recent advances in co-processed APIs and proposals for enabling commercialization of these transformative technologies
Schenck, L., Erdemir, D., Saunders Gorka, L., Merritt, J. M., Marziano, I., Ho, R., Lee, M., Bullard, J., Boukerche, M., Ferguson, S., Florence, A. J., Khan, S. A. & Sun, C. C., 6 Jul 2020, In: Molecular Pharmaceutics. 17, 7, p. 2232-2244 13 p.Research output: Contribution to journal › Review article › peer-review
44 Citations (Scopus) -
Humidity responsive tripeptide crystals
Piotrowska, R., Hesketh, T., Wang, H., Martin, A. R. G., Bowering, D., Zhang, C., Hu, C. T., McPhee, S., Wang, T., Park, Y., Singla, P., McGlone, T., Florence, A., Tuttle, T., Ulijn, R. V. & Chen, X., 17 May 2020. 1 p.Research output: Contribution to conference › Poster
Open AccessFile42 Downloads (Pure) -
Manual versus microfluidic-assisted nanoparticle manufacture: impact of silk fibroin stock on nanoparticle characteristics
Solomun, J. I., Totten, J. D., Wongpinyochit, T., Florence, A. J. & Seib, F. P., 11 May 2020, In: ACS Biomaterials Science & Engineering. 6, 5, p. 2796-2804 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)84 Downloads (Pure) -
Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC)
Raval, V., Siddique, H., Brown, C. J. & Florence, A. J., 7 Apr 2020, In: CrystEngComm. 22, 13, p. 2288-2296 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)28 Downloads (Pure) -
Reversible two-step single-crystal to single-crystal phase transitions between desloratadine forms I, II and III
Srirambhatla, V. K., Guo, R., Dawson, D. M., Price, S. L. & Florence, A. J., 4 Mar 2020, In: Crystal Growth and Design. 20, 3, p. 1800-1810 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)23 Downloads (Pure) -
2019
Why we need continuous pharmaceutical manufacturing and how to make it happen: a summary of thoughts from the international symposium on continuous manufacturing
Badman, C., Cooney, C. L., Haslam, R. T., Florence, A., Konstantinov, K., Krumme, M., Mascia, S., Nasr, M., Trout, B. L. & Baddour, R. F., 30 Nov 2019, In: Journal of Pharmaceutical Sciences. 108, 11, p. 3521-3523 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile94 Citations (Scopus)34 Downloads (Pure) -
Digital design and operation of continuous crystallization processes via mechanistic modelling
Mitchell, N., Mack, J., Tahir, F., Brown, C., Islam, M., Robertson, J., Lopez-Montero, E. & Florence, A., 12 Nov 2019.Research output: Contribution to conference › Presentation/Speech
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Digital design and operation of continuous crystallization processes via mechanistic modelling
Mitchell, N., Mack, J., Tahir, F., Brown, C., Islam, T., Robertson, J., Lopez-Montero, E. & Florence, A., 12 Nov 2019, 2019 AIChE Annual Meeting. New YorkResearch output: Chapter in Book/Report/Conference proceeding › Conference contribution book
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Quality by design approach for early understanding of active pharmaceutical ingredient recovery process through dead-end filtration
Ojo, E., Rayat, ACME., Brown, C., Price, C., Hoare, M., Florence, A. & Johnston, A., 9 Nov 2019. 1 p.Research output: Contribution to conference › Poster › peer-review
File24 Downloads (Pure) -
Enabling model-predictive design: rapid development of a PBM for an anti-solvent and cooling crystallisation in two different reactor geometries
Ojo, E., Siddique, H., Houson, I., Brown, C., O'Meahdra, R., Berthold, S. & Florence, A., 3 Nov 2019. 1 p.Research output: Contribution to conference › Poster › peer-review
Open AccessFile32 Downloads (Pure) -
Developing mechanistic understanding of unconventional growth in pharmaceutical crystals using scanning electron microscopy, atomic force microscopy and time-of-flight secondary ion mass spectrometry
Polyzois, H., Warzecha, M., Paladino, E., Bowering, D., Guo, R., Price, S. L., Halbert, G. & Florence, A., 16 Oct 2019. 1 p.Research output: Contribution to conference › Poster
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Use of terahertz-Raman spectroscopy to determine solubility of the crystalline active pharmaceutical ingredient in polymeric matrices during hot melt extrusion
Bordos, E., Islam, M. T., Florence, A. J., Halbert, G. W. & Robertson, J., 7 Oct 2019, In: Molecular Pharmaceutics. 16, 10, p. 4361-4371 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)40 Downloads (Pure) -
Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisol™ 15LV filaments for Fused Filament Fabrication (FFF) 3D printing
Prasad, E., Islam, M. T., Goodwin, D. J., Megarry, A. J., Halbert, G. W., Florence, A. J. & Robertson, J., 1 Oct 2019, In: Additive Manufacturing. 29, 16 p., 100776.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Citations (Scopus)45 Downloads (Pure) -
Improving the prediction of multi-component tablet properties from pure component parameters
Jolliffe, H. G., Papathanasiou, F., Prasad, E., Halbert, G., Robertson, J., Brown, C. J. & Florence, A. J., 25 Jul 2019, 29th European Symposium on Computer Aided Chemical Engineering. Vol. 46. p. 883-888 6 p. (Computer Aided Chemical Engineering).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book
Open AccessFile7 Citations (Scopus)47 Downloads (Pure) -
Unconventional ultra scale-down techniques for active pharmaceutical ingredient filtration and size reduction
Ojo, E. O., Rayat, A., Price, C. J., Brown, C. J., Hoare, M., Johnston, A. & Florence, A. J., 11 Jul 2019, p. 88. 1 p.Research output: Contribution to conference › Poster
Open AccessFile41 Citations (Scopus)27 Downloads (Pure) -
Developing process understanding for continuous manufacturing of Lamivudine (Epivir®) Stable Form I
Ojo, E., Hosni, Z., Onyemelukwe, I., Ramakers, L., Houson, I. & Florence, A., 9 Jul 2019. 1 p.Research output: Contribution to conference › Poster
Open AccessFile41 Downloads (Pure) -
Oxcarbazepine form III: observation of twisted habit in crystals of an elusive pharmaceutical polymorph
Polyzois, H., Guo, R., Warzecha, M., Price, S. L. . & Florence, A. J., 9 Jul 2019, p. 69. 1 p.Research output: Contribution to conference › Poster
Open AccessFile35 Downloads (Pure) -
Olanzapine Crystal Symmetry Originates in Preformed Centrosymmetric Solute Dimers
Warzecha, M., Verma, L., Palmer, J., Florence, A. & Vekilov, P. G., 23 Jun 2019.Research output: Contribution to conference › Poster › peer-review
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Polymorph screening studies of oxcarbazepine: twisted habit in crystals of the elusive form III
Polyzois, H., Guo, R., Warzecha, M., Price, S. L. & Florence, A., 23 Jun 2019. 1 p.Research output: Contribution to conference › Poster
Open AccessFile23 Downloads (Pure) -
Nanofocused X-ray tomography and image processing for quantitative analysis of pharmaceutical particulate solid products
Doerr, F. & Florence, A., 11 Apr 2019.Research output: Contribution to conference › Presentation/Speech
Open AccessFile40 Downloads (Pure) -
Engineering of acetaminophen particle attributes using a wet milling crystallisation platform
Ahmed, B., Brown, C. J., McGlone, T., Bowering, D. L., Sefcik, J. & Florence, A. J., 10 Jan 2019, In: International Journal of Pharmaceutics. 554, p. 201-211 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)36 Downloads (Pure) -
2018
Multi-sensor inline measurements of crystal size and shape distributions during high shear wet milling of crystal slurries
Agimelen, O. S., Svoboda, V., Ahmed, B., Cardona, J., Dziewierz, J., Brown, C. J., McGlone, T., Cleary, A., Tachtatzis, C., Michie, C., Florence, A. J., Andonovic, I., Mulholland, A. J. & Sefcik, J., 31 Dec 2018, In: Advanced Powder Technology. 29, 12, p. 2987-2995 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)49 Downloads (Pure) -
Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography
Doerr, F. J. S., Oswald, I. D. H. & Florence, A. J., 1 Dec 2018, In: Advanced Powder Technology. 29, 12, p. 2996-3006 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)37 Downloads (Pure) -
Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography [Video Abstract]
Doerr, F. J. S., Oswald, I. D. H. & Florence, A. J., 1 Dec 2018Research output: Non-textual form › Digital or Visual Products
Open AccessFile28 Downloads (Pure) -
Microfactory – Blend – Compression - Performance test
Prasad, E., Robertson, J., Brown, C., Jolliffe, H., Florence, A. & Halbert, G., 25 Oct 2018.Research output: Contribution to conference › Poster
Open AccessFile15 Downloads (Pure) -
The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry
Cardona, J., Ferreira, C., Svoboda, V., Ahmed, B., McGinty, J., Agimelen, O. S., Hamilton, A., Cleary, A., Atkinson, R., Michie, C., Marshall, S., Florence, A. J., Chen, Y-C., Sefcik, J., Andonovic, I. & Tachtatzis, C., 11 Sept 2018, Advances in Manufacturing Technology XXXII: proceedings of the 16th International Conference on Manufacturing Research. Thorvald, P. & Case, K. (eds.). Netherlands: IOS Press, p. 27-32 6 p. (Advances in Transdisciplinary Engineering; vol. 8).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book
Open AccessFile1 Citation (Scopus)78 Downloads (Pure) -
Successful computationally directed templating of metastable pharmaceutical polymorphs
Case, D. H., Srirambhatla, V. K., Guo, R., Watson, R. E., Price, L. S., Polyzois, H., Cockcroft, J. K., Florence, A. J., Tocher, D. A. & Price, S. L., 5 Sept 2018, In: Crystal Growth and Design. 18, 9, p. 5322-5331 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Citations (Scopus)44 Downloads (Pure) -
Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations
Brown, C. J., McGlone, T., Yerdelen, S., Srirambhatla, V., Mabbott, F., Gurung, R., Briuglia, M. L., Ahmed, B., Polyzois, H., McGinty, J., Perciballi, F., Fysikopoulos, D., Macfhionnghaile, P., Siddique, H., Raval, V., Harrington, T. S., Vassileiou, A. D., Robertson, M., Prasad, E., Johnston, A., & 9 others, 1 Jun 2018, In: Molecular Systems Design & Engineering. 2018, 3, p. 518-549 32 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Citations (Scopus)139 Downloads (Pure) -
Impact of paracetamol impurities on face properties: investigating the surface of single crystals using TOF-SIMS
Ottoboni, S., Chrubasik, M., Mir Bruce, L., Nguyen, T. T. H., Robertson, M., Johnston, B., Oswald, I. D. H., Florence, A. & Price, C., 2 May 2018, In: Crystal Growth and Design. 18, 5, p. 2750–2758 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)153 Downloads (Pure) -
A random forest model for predicting crystal packing of olanzapine solvates
Bhardwaj, R. M., Reutzel-Edens, S. M., Johnston, B. F. & Florence, A. J., 24 Apr 2018, In: CrystEngComm. 20, 28, p. 3947-3950 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)34 Downloads (Pure) -
A rational single particle design approach using an acoustic levitation system and X-ray tomography
Doerr, F., Florence, A. & Oswald, I., 24 Apr 2018.Research output: Contribution to conference › Presentation/Speech
Open AccessFile30 Downloads (Pure) -
Monitoring API crystal breakage in wet milling using inline imaging and chord length distribution measurements
Ahmed, B., Svoboda, V., Agimelen, O., Cardona, J., Dziewierz, J., Brown, C., McGlone, T., Cleary, A., Tachtatzis, C., Michie, C., Florence, A. J., Andonovic, I., Mulholland, A. & Sefcik, J., 24 Apr 2018. 2 p.Research output: Contribution to conference › Abstract › peer-review
Open AccessFile60 Downloads (Pure) -
XRT: Extraction of quantitative structural descriptors from solid pharmaceutical products
Doerr, F. J. S. & Florence, A. J., 17 Apr 2018.Research output: Contribution to conference › Presentation/Speech
Open AccessFile53 Downloads (Pure) -
Crystallisation of oxcarbazepine form III: emergence of crystals with variable twisted habit
Polyzois, H., Guo, R., Warzecha, M., Price, S. & Florence, A., 27 Mar 2018. 1 p.Research output: Contribution to conference › Poster
Open AccessFile40 Downloads (Pure) -
Injection moulding- A novel method of solid oral dosage form manufacturing
Wood, S., Halbert, G. & Florence, A., 18 Jan 2018. 1 p.Research output: Contribution to conference › Poster
Open AccessFile66 Downloads (Pure) -
Inkjet printing of oral dosage forms to solubilize BCS Class II drugs
Turner, A. J., Halbert, G. W. & Florence, A. J., 18 Jan 2018.Research output: Contribution to conference › Poster
Open AccessFile52 Downloads (Pure) -
Rapid continuous antisolvent crystallization of multi-component systems
Raza, S. A., Schacht, U., Svoboda, V., Edwards, D. P., Florence, A. J., Pulham, C. R., Sefcik, J. & Oswald, I. D. H., 3 Jan 2018, In: Crystal Growth and Design. 18, 1, p. 210-218 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)124 Downloads (Pure) -
2017
Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs
Turner, A., Halbert, G. & Florence, A., 15 Nov 2017.Research output: Contribution to conference › Poster
Open AccessFile65 Downloads (Pure) -
Mesoscopic solute-rich clusters in olanzapine solutions
Warzecha, M., Safari, M. S., Florence, A. J. & Vekilov, P. G., 26 Oct 2017, In: Crystal Growth and Design. p. 6668-6676 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)68 Downloads (Pure) -
Direct observation of templated two-step nucleation mechanism during olanzapine hydrate formation
Warzecha, M., Guo, R., Bhardwaj, R. M., Reutzel-Edens, S. M., Price, S. L., Lamprou, D. A. & Florence, A. J., 23 Oct 2017, In: Crystal Growth and Design. 17, 12, p. 6382-6393 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus)27 Downloads (Pure) -
Solid oral dosage form manufacturing using injection moulding
Wood, S., Halbert, G. & Florence, A., 16 Oct 2017. 1 p.Research output: Contribution to conference › Poster
Open AccessFile170 Downloads (Pure) -
Advanced control of a continuous oscillatory flow crystalliser
Tahir, F., Krzemieniewska-Nandwani, K., Mack, J., Lovett, D., Siddique, H., Mabbott, F., Raval, V., Houson, I. & Florence, A., 1 Oct 2017, In: Control Engineering Practice. 67, p. 64-75 12 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Combined chemoinformatics approach to solvent library design using clusterSim and multidimensional scaling
Johnston, A., Bhardwaj-Miglani, R., Gurung, R., Vassileiou, A. D., Florence, A. J. & Johnston, B. F., 28 Aug 2017, In: Journal of Chemical Information and Modeling. 57, 8, p. 1807-1815 9 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Continuous crystallisation
Brown, C., McGlone, T. & Florence, A., 31 Jul 2017, Continuous Manufacturing of Pharmaceuticals. Kleinebudde, P., Khinast, J. & Rantanen, J. (eds.). Hoboken: John Wiley & Sons Inc., p. 169-226 58 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open AccessFile127 Downloads (Pure) -
Continuous Crystallisation
Brown, C., McGlone, T. & Florence, A., 14 Jul 2017, Continuous Manufacturing of Pharmaceuticals. Khinast, J., Rantanen, J. & Kleinebudde, P. (eds.). p. 169-226 58 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open Access -
Process development for recovery of crystals using DoE
Ojo, E., Rayat, A., Johnston, A., Price, C. J., Price, C., Florence, A. & Hoare, M., 9 Jul 2017. 1 p.Research output: Contribution to conference › Poster
Open AccessFile19 Downloads (Pure) -
The solute-rich mesoscopic precursors of crystal nuclei of olanzapine solid forms
Warzecha, M., Vekilov, P. G. & Florence, A., 27 Jun 2017. 1 p.Research output: Contribution to conference › Poster › peer-review
Open AccessFile94 Downloads (Pure)