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Research Output 1987 2019

2019

Developing process understanding for continuous manufacturing of Lamivudine (Epivir®) Stable Form I

Ojo, E., Hosni, Z., Onyemelukwe, I., Ramakers, L., Houson, I. & Florence, A., 9 Jul 2019. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Lamivudine
Virus Diseases
Crystallization
Hepatitis B
Research
1 Citation (Scopus)
Extrusion
Printing
Fabrication
Chemical analysis
Pharmaceutical Preparations
3 Citations (Scopus)
Open Access
File
Acetaminophen
Crystallization
Particle Size
Reflectometers
Interfacial energy

Nucleation and Growth of Pharmaceutical Crystals

Warzecha, M., 1 Apr 2019, Glasgow: University of Strathclyde. 197 p.

Research output: ThesisDoctoral Thesis

olanzapine
Crystallization
Pharmaceutical Preparations
Growth

Olanzapine Crystal Symmetry Originates in Preformed Centrosymmetric Solute Dimers

Warzecha, M., Verma, L., Palmer, J., Florence, A. & Vekilov, P. G., 23 Jun 2019.

Research output: Contribution to conferencePoster

solutes
dimers
symmetry
crystals
minorities

Oxcarbazepine form III: observation of twisted habit in crystals of an elusive pharmaceutical polymorph

Polyzois, H., Guo, R., Warzecha, M., Price, S. L. . & Florence, A. J., 9 Jul 2019, p. 69. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Polymorphism
Drug products
Crystals
Pharmaceutical Preparations
Crystal structure

Polymorph screening studies of oxcarbazepine: twisted habit in crystals of the elusive form III

Polyzois, H., Guo, R., Warzecha, M., Price, S. L. & Florence, A., 23 Jun 2019. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Polymorphism
Screening
Crystals
Crystal structure
Drug products

Unconventional ultra scale-down techniques for active pharmaceutical ingredient filtration and size reduction

Ojo, E. O., Rayat, A., Price, C. J., Brown, C. J., Hoare, M., Johnston, A. & Florence, A. J., 11 Jul 2019, p. 88. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Drug products
Crystals
Pharmaceutical Preparations
Pore size
Particle size analysis
Open Access
File
Terahertz Spectroscopy
Raman Spectrum Analysis
Solubility
Polymers
Pharmaceutical Preparations
2018
2 Citations (Scopus)

A random forest model for predicting crystal packing of olanzapine solvates

Bhardwaj, R. M., Reutzel-Edens, S. M., Johnston, B. F. & Florence, A. J., 24 Apr 2018, In : CrystEngComm. 20, 28, p. 3947-3950 4 p.

Research output: Contribution to journalArticle

Open Access
File
olanzapine
Crystals
crystals
Covalent bonds
covalent bonds

Crystallisation of oxcarbazepine form III: emergence of crystals with variable twisted habit

Polyzois, H., Guo, R., Warzecha, M., Price, S. & Florence, A., 27 Mar 2018. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Crystallization
Habits
X-Ray Diffraction
Anticonvulsants
Powders

Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisation

Brown, C. J., McGlone, T., Yerdelen, S., Srirambhatla, V., Mabbott, F., Gurung, R., Briuglia, M. L., Ahmed, B., Polyzois, H., McGinty, J., Perciballi, F., Fysikopoulos, D., Macfhionnghaile, P., Siddique, H., Raval, V., Harrington, T. S., Vassileiou, A., Robertson, M., Prasad, E., Johnston, A. & 9 othersJohnston, B., Nordon, A., Srai, J., Halbert, G., Ter Horst, J. H., Price, C. J., Rielly, C. D., Sefcik, J. & Florence, A. J., 1 Jun 2018, In : Molecular Systems Design & Engineering. 2018, 3, p. 518-549 32 p.

Research output: Contribution to journalArticle

Open Access
File
Workflow
Crystallization
Cooling
Pharmaceutical Preparations
Process design
12 Citations (Scopus)

Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations

Brown, C. J., McGlone, T., Yerdelen, S., Srirambhatla, V., Mabbott, F., Gurung, R., Briuglia, M. L., Ahmed, B., Polyzois, H., Mcginty, J., Perciballi, F., Fysikopoulos, D., Macfhionnghaile, P., Siddique, H., Raval, V., Harrington, T. S., Vassileiou, A. D., Robertson, M., Prasad, E., Johnston, A. & 9 othersJohnston, B., Nordon, A., Srai, J. S., Halbert, G., ter Horst, J. H., Price, C. J., Rielly, C. D., Sefcik, J. & Florence, A. J., 1 Jun 2018, In : Molecular Systems Design and Engineering. 3, 3, p. 518-549 32 p.

Research output: Contribution to journalArticle

Open Access
File
Workflow
Crystallization
Drug products
Cooling
Pharmaceutical Preparations
4 Citations (Scopus)
Open Access
File
Secondary Ion Mass Spectrometry
Surface Properties
Acetaminophen
Secondary ion mass spectrometry
secondary ion mass spectrometry

Injection moulding- A novel method of solid oral dosage form manufacturing

Wood, S., Halbert, G. & Florence, A., 18 Jan 2018. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Dosage Forms
Injections
Polymers
Pharmaceutical Preparations
Pressure
Open Access
File
Printing
Dosage Forms
Polymers
Pharmaceutical Preparations
Powders
Open Access
File
Application programming interfaces (API)
Particle size analysis
Aspect ratio
Imaging techniques
Crystals
3 Citations (Scopus)
Open Access
File
Slurries
Particle size
Crystallization
Particle size analysis
Crystals
Open Access
File
X Ray Tomography
Drug Compounding
Acoustics
Drug products
Tomography
2 Citations (Scopus)

Rapid continuous antisolvent crystallization of multi-component systems

Raza, S. A., Schacht, U., Svoboda, V., Edwards, D. P., Florence, A. J., Pulham, C. R., Sefcik, J. & Oswald, I. D. H., 3 Jan 2018, In : Crystal Growth and Design. 18, 1, p. 210-218 9 p.

Research output: Contribution to journalArticle

Open Access
File
leucine
Isoleucine
Valine
Crystallization
Leucine
4 Citations (Scopus)

Successful computationally directed templating of metastable pharmaceutical polymorphs

Case, D. H., Srirambhatla, V. K., Guo, R., Watson, R. E., Price, L. S., Polyzois, H., Cockcroft, J. K., Florence, A. J., Tocher, D. A. & Price, S. L., 5 Sep 2018, In : Crystal Growth and Design. 18, 9, p. 5322-5331 10 p.

Research output: Contribution to journalArticle

Open Access
File
Polymorphism
Drug products
Mefenamic Acid
acids
Acids

The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry

Cardona, J., Ferreira, C., Svoboda, V., Ahmed, B., McGinty, J., Agimelen, O. S., Hamilton, A., Cleary, A., Atkinson, R., Michie, C., Marshall, S., Florence, A. J., Chen, Y-C., Sefcik, J., Andonovic, I. & Tachtatzis, C., 11 Sep 2018, Advances in manufacturing technology XXXII: proceedings of the 16th International Conference on Manufacturing Research. Thorvald, P. & Case, K. (eds.). Netherlands, p. 27-32 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Open Access
File
Drug Industry
Drug products
Image analysis
Technology
Pharmaceutical Preparations
2017
13 Citations (Scopus)
Open Access
Suspensions
geometry
oscillating flow
liquid
Geometry
7 Citations (Scopus)

Aqueous solubility of organic salts. Investigating trends in a systematic series of 51 crystalline salt forms of methylephedrine

S. de Moraes, L., Edwards, D., Florence, A. J., Johnston, A., Johnston, B. F., Morrison, C. A. & Kennedy, A. R., 7 Jun 2017, In : Crystal Growth and Design. 17, 6, p. 3277-3286 10 p.

Research output: Contribution to journalArticle

Open Access
File
melting points
solubility
Solubility
Melting point
Salts
11 Citations (Scopus)

Direct observation of templated two-step nucleation mechanism during olanzapine hydrate formation

Warzecha, M., Guo, R., Bhardwaj, R. M., Reutzel-Edens, S. M., Price, S. L., Lamprou, D. A. & Florence, A. J., 23 Oct 2017, In : Crystal Growth and Design. 17, 12, p. 6382-6393 12 p.

Research output: Contribution to journalArticle

Open Access
File
olanzapine
Hydrates
hydrates
Nucleation
nucleation
Open Access
File
Printing
Dosage Forms
Solubility
Pharmaceutical Preparations
Drug and Narcotic Control
4 Citations (Scopus)

Mesoscopic solute-rich clusters in olanzapine solutions

Warzecha, M., Safari, M. S., Florence, A. J. & Vekilov, P. G., 26 Oct 2017, In : Crystal Growth and Design. p. 6668-6676 9 p.

Research output: Contribution to journalArticle

Open Access
File
olanzapine
Dimers
solutes
Crystals
Hydrates

Solid oral dosage form manufacturing using injection moulding

Wood, S., Halbert, G. & Florence, A., 23 Mar 2017.

Research output: Contribution to conferencePoster

Open Access
File
Dosage Forms
Polymers
Injections
Pharmaceutical Preparations
Solubility

Solid oral dosage form manufacturing using injection moulding

Wood, S., Halbert, G. & Florence, A., 16 Oct 2017. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
6 Citations (Scopus)

Spray drying as a reliable route to produce metastable carbamazepine form IV

Halliwell, R. A., Bhardwaj, R. M., Brown, C., Briggs, N. E. B., Dunn, J., Robertson, J., Nordon, A. & Florence, A. J., 19 Apr 2017, In : Journal of Pharmaceutical Sciences. 106, 7, p. 1874-1880 7 p.

Research output: Contribution to journalArticle

Open Access
File
Carbamazepine
Crystallization
Raman Spectrum Analysis
Epilepsy
Polymers

The solute-rich mesoscopic precursors of crystal nuclei of olanzapine solid forms

Warzecha, M., Vekilov, P. G. & Florence, A., 27 Jun 2017. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
olanzapine
Crystallization
Solubility
Atomic Force Microscopy
Behavior Control
2016

Achieving immediate release dosage forms using DoE and injection moulding

Wood, S., Halbert, G. W. & Florence, A., 30 Nov 2016. 1 p.

Research output: Contribution to conferencePoster

File
Polyvinyl Alcohol
Dosage Forms
Injections
2 Citations (Scopus)

Crystal structure of the co-crystal butylparaben– isonicotinamide (1/1)

Bhardwaj, R. M., Yang, H. & Florence, A. J., 1 Jan 2016, In : Acta Crystallographica Section E: Structure Reports. E72, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

Open Access
File
Butylparaben
Parabens
Crystal structure
dimers
Dimers
7 Citations (Scopus)

Effect of oscillatory flow on nucleation kinetics of butyl paraben

Yang, H., Yu, X., Raval, V., Makkawi, Y. & Florence, A., 3 Feb 2016, In : Crystal Growth and Design . 16, 2, p. 875-886 12 p.

Research output: Contribution to journalArticle

Open Access
File
Parabens
Shear deformation
Nucleation
nucleation
shear
Open Access
File
Acetaminophen
Polymers
Particle Size
Open Access
File
Dosage Forms
Acetaminophen
Injections
Drug Interactions
Powders

Inkjet printing oral dosage forms

Turner, A. J., Halbert, G. W. & Florence, A. J., 5 Sep 2016. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Printing
Dosage Forms
Solubility
Polymers
Pharmaceutical Preparations
Open Access
File
Extruders
Extrusion
Printing
Polymers
Processing
21 Citations (Scopus)
Open Access
File
Crystallization
Polymorphism
Crystal growth
Single crystals
Crystals
Secondary Ion Mass Spectrometry
Surface Properties
Acetaminophen
Secondary ion mass spectrometry
Crystallization
2015
6 Citations (Scopus)

A random forest model for predicting the crystallisability of organic molecules

Bhardwaj, R. M., Johnston, A., Johnston, B. F. & Florence, A. J., 21 Jun 2015, In : CrystEngComm. 17, 23, p. 4272-4275 4 p.

Research output: Contribution to journalArticle

Open Access
File
Crystals
Molecules
Crystallization
crystals
molecules

Atomic force microscopy studies on two-step nucleation and epitaxial growth

Warzecha, M., Bhardwaj, R. M., Reutzel-Edens, S., Lamprou, D. & Florence, A., 21 Jun 2015. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Atomic Force Microscopy
Crystallization
olanzapine
Growth
Humidity

Crystal structure of a mixed solvated form of amoxapine acetate

Bhardwaj, R. M., Raval, V., Oswald, I. D. H., Florence, A. J. & Stoeckli-Evans, H. (ed.), 1 Feb 2015, In : Acta Crystallographica Section E: Structure Reports. 71, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

Open Access
File
Amoxapine
Cyclohexane
Acetic acid
acetates
Hydrogen bonds
Research Design
Crystallization
Research
Research Personnel
Technology
27 Citations (Scopus)
Open Access
File
lactose
Crystallizers
Lactose
Crystallization
Hydrodynamics
11 Citations (Scopus)

Image-based monitoring for early detection of fouling in crystallisation processes

Tachtatzis, C., Sheridan, R., Michie, C., Atkinson, R. C., Cleary, A., Dziewierz, J., Andonovic, I., Briggs, N. E. B., Florence, A. J. & Sefcik, J., 8 Sep 2015, In : Chemical Engineering Science . 133, p. 82-90 9 p.

Research output: Contribution to journalArticle

Open Access
File
Crystallization
Fouling
Monitoring
Crystals
Data acquisition
73 Citations (Scopus)

Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization

McGlone, T., Briggs, N. E. B., Clark, C. A., Brown, C. J., Sefcik, J. & Florence, A. J., 18 Sep 2015, In : Organic Process Research and Development. 19, 9, p. 1186–1202 17 p.

Research output: Contribution to journalArticle

Open Access
File
Crystallization
manufacturing
reactor technology
reactors
crystallization
34 Citations (Scopus)

Seeded crystallization of β-L-glutamic acid in a continuous oscillatory baffled crystallizer

Briggs, N. E. B., Schacht, U., Raval, V., McGlone, T., Sefcik, J. & Florence, A. J., 18 Dec 2015, In : Organic Process Research and Development. 19, 12, p. 1903−1911 9 p.

Research output: Contribution to journalArticle

Open Access
File
Crystallizers
glutamic acid
Supersaturation
Crystallization
supersaturation
2014
20 Citations (Scopus)

Drug solid solutions - a method for tuning phase transformations

Delori, A., Maclure, P., Bhardwaj, R. M., Johnston, A., Florence, A. J., Sutcliffe, O. B. & Oswald, I. D. H., 14 Jul 2014, In : CrystEngComm. 16, 26, p. 5827-5831 5 p.

Research output: Contribution to journalArticle

halides
phase transformations
Solid solutions
drugs
solid solutions
15 Citations (Scopus)

Formulation of liquid propofol as a cocrystalline solid

McKellar, S. C., Kennedy, A. R., McCloy, N. C., McBride, E. & Florence, A. J., 27 Feb 2014, In : Crystal Growth and Design. 14, 5, p. 2422-2430 9 p.

Research output: Contribution to journalArticle

Propofol
drugs
formulations
Liquids
liquids