Research output per year
Research output per year
- 1 - 50 out of 206 results
Search results
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2024
Flow‐Xl: a new facility for the analysis of crystallization in flow systems
Turner, T. D., O'Shaughnessy, C., He, X., Levenstein, M. A., Hunter, L., Wojciechowski, J., Bristowe, H., Stone, R., Wilson, C. C., Florence, A., Robertson, K., Kapur, N. & Meldrum, F. C., Oct 2024, In: Journal of Applied Crystallography. 57, 5Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
A hybrid system of mixture models for the prediction of particle size and shape, density, and flowability of pharmaceutical powder blends
Salehian, M., Moores, J., Goldie, J., Ibrahim, I., Mendez Torrecillas, C., Abbas, F., Maclean, N., Robertson, J., Florence, A. & Markl, D., 23 Aug 2024, (Accepted/In press) In: International Journal of Pharmaceutics: X.Research output: Contribution to journal › Article › peer-review
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Integration of a model-driven workflow into an industrial pharmaceutical facility: supporting process development of API crystallisation
Pickles, T., Svoboda, V., Marziano, I., Brown, C. J. & Florence, A. J., 29 Jul 2024, In: CrystEngComm. 26, 34, p. 4678-4689 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Emerging applications and regulatory strategies for advanced medicines manufacturing - towards the development of a platform approach
Srai, J. S., Bauer, P., Badman, C., Bresciani, M., Cooney, C. L., Florence, A., Hausner, D., Konstantinov, K., Lee, S. L., Mascia, S., Nasr, M. & Trout, B. L., 1 Jul 2024, In: Journal of Pharmaceutical Sciences. 113, 7, p. 1701-1710 10 p.Research output: Contribution to journal › Article › peer-review
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Integrated continuous process design for crystallisation, spherical agglomeration, and filtration of lovastatin
Brown, C. J., McGinty, J., Islam, M. T., Rajoub, N., Arjmandi-Tash, O., Ottoboni, S., Shahid, M., Urwin, S. J., Lee, Y. S., Chong, M. W. S., Papathanasiou, F., Prakash, A. S., Prasad, E., Spence, B., Sefcik, J., Robertson, J., Smith, R., Litster, J. D., Price, C. J., Nordon, A., & 2 others, 1 Mar 2024, In: Journal of Pharmaceutical Innovation. 19, 2, 19 p., 9.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Downloads (Pure) -
Comparative study on adaptive Bayesian optimization for batch cooling crystallization for slow and fast kinetic regimes
Pickles, T., Mustoe, C., Brown, C. J. & Florence, A. J., 7 Feb 2024, In: Crystal Growth and Design. 24, 3, p. 1245-1253 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)24 Downloads (Pure) -
Developing a model-driven workflow for the digital design of small-scale batch cooling crystallisation with the antiviral lamivudine
Pickles, T., Mustoe, C., Boyle, C., Cardona, J., Brown, C. J. & Florence, A. J., 8 Jan 2024, In: CrystEngComm. 26, 6, p. 822-834 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)21 Downloads (Pure) -
2023
Tautomerism unveils a self-inhibition mechanism of crystallization
Tang, W., Yang, T., Morales-Rivera, C. A., Geng, X., Srirambhatla, V. K., Kang, X., Chauhan, V. P., Hong, S., Tu, Q., Florence, A. J., Mo, H., Calderon, H. A., Kisielowski, C., Hernandez, F. C. R., Zou, X., Mpourmpakis, G. & Rimer, J. D., Dec 2023, In: Nature Communications. 14, 1, 13 p., 561.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)66 Downloads (Pure) -
Expanding the pharmaceutical formulation space in material extrusion 3D printing applications
Prasad, E., Robertson, J., Florence, A. J. & Halbert, G. W., 14 Oct 2023, In: Additive Manufacturing. 77, 11 p., 103803.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)55 Downloads (Pure) -
Digital process design to define and deliver pharmaceutical particle attributes
Urwin, S. J., Chong, M. W. S., Li, W., McGinty, J., Mehta, B., Ottoboni, S., Pathan, M., Prasad, E., Robertson, M., McGowan, M., al-Attili, M., Gramadnikova, E., Siddique, M., Houson, I., Feilden, H., Benyahia, B., Brown, C. J., Halbert, G. W., Johnston, B., Nordon, A., & 4 others, 31 Aug 2023, In: Chemical Engineering Research and Design. 196, p. 726-749 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)67 Downloads (Pure) -
Experimental methodology for measuring performance of 3D printed Coiled Flow Reactors
Josifovic, A., Barrera, M. C., Leech, D., Wildman, R., Alfrod, G., Florence, A. & Brown, C., 7 Aug 2023, IEEE EUROCON 2023 - 20th International Conference on Smart Technologies. Piscataway, NJ: IEEE, 6 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book
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The application of SIFT-MS for examining the degradation of polymers
Smith, A., Bordos, E., Robertson, J. & Florence, A., 14 Jun 2023.Research output: Contribution to conference › Poster
Open AccessFile51 Downloads (Pure) -
Machine learning approaches to the prediction of powder flow behaviour of pharmaceutical materials from physical properties
Pereira Diaz, L., Brown, C. J., Ojo, E., Mustoe, C. & Florence, A. J., 1 Jun 2023, In: Digital Discovery. 2, 3, p. 692-701 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)97 Downloads (Pure) -
A unified ML framework for solubility prediction across organic solvents
Vassileiou, A. D., Robertson, M. N., Wareham, B. G., Soundaranathan, M., Ottoboni, S., Florence, A. J., Hartwig, T. & Johnston, B. F., 1 Apr 2023, In: Digital Discovery. 2, 2, p. 356-367 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)46 Downloads (Pure) -
Predicting pharmaceutical powder flow from microscopy images using deep learning
Wilkinson, M. R., Pereira Diaz, L., Vassileiou, A. D., Armstrong, J. A., Brown, C. J., Castro-Dominguez, B. & Florence, A. J., 1 Apr 2023, In: Digital Discovery. 2, 2, p. 459-470 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)60 Downloads (Pure) -
Machine learning derived correlations for scale-up and technology transfer of primary nucleation kinetics
Yerdelen, S., Yang, Y., Quon, J. L., Papageorgiou, C. D., Mitchell, C., Houson, I., Sefcik, J., ter Horst, J. H., Florence, A. J. & Brown, C. J., 1 Feb 2023, In: Crystal Growth and Design. 23, 2, p. 681-693 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)45 Downloads (Pure) -
2022
Prediction of mefenamic acid crystal shape by random forest classification
Nakapraves, S., Warzecha, M., Mustoe, C. L., Srirambhatla, V. & Florence, A. J. (ed.), 19 Dec 2022, (E-pub ahead of print) In: Pharmaceutical Research. 39, 12, p. 3099-3111 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)36 Downloads (Pure) -
Comparative studies of powder flow predictions using milligrams of powder for identifying powder flow issues
Deng, T., Garg, V., Pereira Diaz, L., Markl, D., Brown, C., Florence, A. & Bradley, M. S. A., 25 Nov 2022, In: International Journal of Pharmaceutics. 628, 11 p., 122309.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)80 Downloads (Pure) -
High spatial resolution ToF-SIMS imaging and image analysis strategies to monitor and quantify early phase separation in amorphous solid dispersions
Paladino, E., Doerr, F. J. S., Bordos, E., Onyemelukwe, I. I., Lamprou, D. A., Florence, A. J., Gilmore, I. S. & Halbert, G. W., 25 Nov 2022, In: International Journal of Pharmaceutics. 628, 12 p., 122191.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)55 Downloads (Pure) -
Temperature correction of spectra to improve solute concentration monitoring by in situ ultraviolet and mid-infrared spectrometries towards isothermal local model performance
Chong, M. W. S., McGlone, T., Chai, C. Y., Briggs, N. E. B., Brown, C. J., Perciballi, F., Dunn, J., Parrott, A. J., Dallin, P., Andrews, J., Nordon, A. & Florence, A. J., 18 Nov 2022, In: Organic Process Research and Development. 26, 11, p. 3096-3105 10 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)43 Downloads (Pure) -
Autonomous DataFactory: high-throughput screening for large-scale data collection to inform medicine manufacture
Pickles, T., Mustoe, C., Brown, C. & Florence, A., 1 Nov 2022, (E-pub ahead of print) In: British Journal of Pharmacy. 7, 2, 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Downloads (Pure) -
Data mining crystallization kinetics
Maldonado, D. A., Vassileiou, A., Johnston, B., Florence, A. J. & Brown, C. J., 1 Aug 2022, (E-pub ahead of print) In: Digital Discovery. 1, 5, p. 621-635 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)51 Downloads (Pure) -
Crystal structure and twisted aggregates of oxcarbazepine form III
Polyzois, H., Guo, R., Srirambhatla, V. K., Warzecha, M., Prasad, E., Turner, A., Halbert, G. W., Keating, P., Price, S. L. & Florence, A. J., 6 Jul 2022, In: Crystal Growth and Design. 22, 7, p. 4146-4156 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)23 Downloads (Pure) -
A crystallisation development workflow for the manufacturability improvement of active pharmaceutical ingredients
Siddique, H., Hamilton, N., Robertson, M., Warzecha, M., Smith, K., Brown, C., Johnston, B., Florence, A. J., Douieb, S., Hadjittofis, E., Assaf, G., Carly, N., Pasha, M., Cocchini, U. & Mantanus, J., 16 May 2022, p. 49-49. 1 p.Research output: Contribution to conference › Poster
Open AccessFile34 Downloads (Pure) -
A unified AI framework for solubility prediction across organic solvents
Vassileiou, A. D., Robertson, M. N., Wareham, B. G., Soundaranathan, M., Ottoboni, S., Florence, A. J., Hartwig, T. & Johnston, B. F., 16 May 2022, p. 24-24. 1 p.Research output: Contribution to conference › Poster
Open AccessFile71 Downloads (Pure) -
Crystallisation MicroFactory test bed
Pathan, M., McGinty, J., Chong, M. W. S., Robertson, M., Ottoboni, S., Li, W., McGowan, M., Ojo, E., Anwar, A., Brown, C. J., Sefcik, J., Nordon, A., Johnston, B., Price, C. J., Rielly, C. D., Benyahia, B., Houson, I. & Florence, A. J., 16 May 2022, p. 63-63. 1 p.Research output: Contribution to conference › Poster
Open AccessFile28 Downloads (Pure) -
Developing an autonomous DataFactory workflow for smallscale batch cooling crystallisation with the antiviral lamivudine
Pickles, T., Mustoe, C., Brown, C. & Florence, A., 16 May 2022, p. 67-67. 1 p.Research output: Contribution to conference › Poster
Open AccessFile31 Downloads (Pure) -
Discovery and applications of a novel solid-state arrangement: water bridge salt form
Tanveer, S., Oswald, I. D. H. & Florence, A. J., 16 May 2022, p. 34-34. 1 p.Research output: Contribution to conference › Poster
Open AccessFile22 Downloads (Pure) -
In-line process reactor test bed & sensor development
Josifovic, A., Barrera, M., Brown, C., Johnston, B., Robertson, J. & Florence, A., 16 May 2022, p. 12-12. 1 p.Research output: Contribution to conference › Poster
Open AccessFile18 Downloads (Pure) -
Machine learning workflows to predict crystallisability, glass forming ability, mechanical properties of small organic compounds
Srirambhatla, V. K., Johnston, B. & Florence, A., 16 May 2022, p. 23-23. 1 p.Research output: Contribution to conference › Poster
Open AccessFile15 Downloads (Pure) -
Mechanistic model development of α-lactose monohydrate crystallisation
Johnston, J., Brown, C. & Florence, A., 16 May 2022, p. 56-56. 1 p.Research output: Contribution to conference › Poster
Open AccessFile27 Downloads (Pure) -
Particle engineering-size controlled spherical agglomeration of benzoic acid
Raval, V., McGowan, M., Smith, K. & Florence, A., 16 May 2022, p. 48-48. 1 p.Research output: Contribution to conference › Poster
Open AccessFile45 Downloads (Pure) -
Prediction of mefenamic acid crystal shape by random forest classification
Nakapraves, S., Warzecha, M., Mustoe, C. & Florence, A. J., 16 May 2022, p. 31-31. 1 p.Research output: Contribution to conference › Poster
Open AccessFile22 Downloads (Pure) -
Prediction of powder flow of pharmaceutical materials using machine learning
Pereira-Diaz, L., Brown, C. J. & Florence, A. J., 16 May 2022, p. 78-78. 1 p.Research output: Contribution to conference › Poster
Open AccessFile35 Downloads (Pure) -
The CMAC MicroFactory: mefenamic acid
Chong, M., Brown, C., Mustoe, C., McGinty, J., Li, W., Pathan, M., Ottoboni, S., Prasad, E., Robertson, M., Mehta, B., McGowan, M., Siddique, H., Raval, V., Pereira Diaz, L., Siddique, M., Eales, W., Turner, A., Johnston, B., Robertson, J., Halbert, G., & 10 others, 16 May 2022, p. 62-62. 1 p.Research output: Contribution to conference › Poster
Open AccessFile66 Downloads (Pure) -
The CMAC quality by digital design workflow
Mustoe, C., Brown, C., Markl, D., Houson, I., Feilden, H., Robertson, M. & Florence, A., 16 May 2022, p. 65-65. 1 p.Research output: Contribution to conference › Poster
Open AccessFile37 Downloads (Pure) -
Towards an autonomous DataFactory for the small-batch cooling crystallisation of active pharmaceutical ingredients
Mustoe, C., Pickles, T., Brown, C. & Florence, A., 16 May 2022, p. 66-66. 1 p.Research output: Contribution to conference › Poster
Open AccessFile34 Downloads (Pure) -
Understanding the effect of spherical agglomeration on tablet manufacturability and performance
Creswick, J., Raval, V., Florence, A. & Markl, D., 16 May 2022, p. 71-71. 1 p.Research output: Contribution to conference › Poster
Open AccessFile27 Downloads (Pure) -
Using machine learning to predict residence time distributions in Coiled Flow Inverter (CFI) reactors
Barrera, M. C., Josifovic, A., Robertson, J., Johnston, B., Brown, C. & Florence, A., 16 May 2022, p. 11-11. 1 p.Research output: Contribution to conference › Poster
Open AccessFile21 Downloads (Pure) -
Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging
Sheridan, R., Cardona, J., Tachtatzis, C., Chen, Y-C., Cleary, A., Briggs, N. E. B., Florence, A., Atkinson, R., Michie, C., Andonovic, I. & Sefcik, J., 28 Apr 2022, In: Chemical Engineering Science . 252, 117188.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)43 Downloads (Pure) -
Direct image feature extraction and multivariate analysis for crystallisation process characterisation
Doerr, F. J. S., Brown, C. J. & Florence, A. J., 6 Apr 2022, In: Crystal Growth and Design. 22, 4, p. 2105-2116 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)40 Downloads (Pure) -
Precrystallization solute assemblies and crystal symmetry
Warzecha, M., Verma, L., Chakrabarti, R., Hadjiev, V. G., Florence, A. J., Palmer, J. C. & Vekilov, P. G., Jan 2022, In: Faraday Discussions. 235, p. 307-321 15 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
2021
Investigation of wet milling and indirect ultrasound as means for controlling nucleation in the continuous crystallization of an active pharmaceutical ingredient
Yang, Y., Ahmed, B., Mitchell, C., Quon, J. L., Siddique, H., Houson, I., Florence, A. J. & Papageorgiou, C. D., 17 Sept 2021, In: Organic Process Research and Development. 25, 9, p. 2119-2132 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)114 Downloads (Pure) -
Heat transfer and residence time distribution in plug flow continuous oscillatory baffled crystallisers
Briggs, N. E. B., McGinty, J., McCabe, C., Raval, V., Sefcik, J. & Florence, A. J., 20 Jul 2021, In: ACS Omega. 6, 28, p. 18352-18363 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)268 Downloads (Pure) -
The ambiguous functions of the precursors that enable nonclassical modes of olanzapine nucleation and growth
Warzecha, M., Florence, A. J. & Vekilov, P. G., 26 Jun 2021, In: Crystals. 11, 7, 16 p., 738.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)53 Downloads (Pure) -
Mechanistic insights of evaporation-induced actuation in supramolecular crystals
Piotrowska, R., Hesketh, T., Wang, H., Martin, A. R. G., Bowering, D., Zhang, C., Hu, C. T., McPhee, S. A., Wang, T., Park, Y., Singla, P., McGlone, T., Florence, A., Tuttle, T., Ulijn, R. V. & Chen, X., 1 Mar 2021, In: Nature Materials . 20, p. 403–409 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)94 Downloads (Pure) -
2020
Peptide isolation via spray drying: particle formation, process design and implementation for the production of spray dried glucagon
Doerr, F. J. S., Burns, L. J., Lee, B., Hinds, J., Davis-Harrison, R. L., Frank, S. A. & Florence, A. J., 14 Dec 2020, In: Pharmaceutical Research. 37, 12, 19 p., 255.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)47 Downloads (Pure) -
A micro-XRT image analysis and machine learning methodology for the characterisation of multi- particulate capsule formulations
Doerr, F. J. S. & Florence, A. J., 1 Dec 2020, In: International Journal of Pharmaceutics: X. 2, 11 p., 100041.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)56 Downloads (Pure) -
A micro-XRT image analysis and machine learning methodology for the characterisation of multi- particulate capsule formulations [Video Abstract]
Doerr, F. J. S. & Florence, A. J., 1 Dec 2020Research output: Non-textual form › Digital or Visual Products
Open AccessFile10 Downloads (Pure) -
Multistage, multi-zones antisolvent-cooling crystallisation of a proprietary API: experimental comparison of effect of geometry and hydrodynamics in four batch crystallisers
Ojo, E., Osman, M., Mnemo, M., Anwar, A., Houson, I., O'Meahdra, R., Berthold, S. & Florence, A., 21 Oct 2020. 1 p.Research output: Contribution to conference › Poster
Open AccessFile45 Downloads (Pure)