Research Output per year
Research Output 1999 2019
- 1 - 50 out of 121 results
- Publication Year, Title (descending)
2019
Engineering of acetaminophen particle attributes using a wet milling crystallisation platform
Ahmed, B., Brown, C. J., McGlone, T., Bowering, D. L., Sefcik, J. & Florence, A. J., 10 Jan 2019, In : International Journal of Pharmaceutics. 554, p. 201-211 11 p.Research output: Contribution to journal › Article
Open Access
File
Acetaminophen
Crystallization
Particle Size
Reflectometers
Interfacial energy
2018
Crystallisation of oxcarbazepine form III: emergence of crystals with variable twisted habit
Polyzois, H., Guo, R., Warzecha, M., Price, S. & Florence, A., 27 Mar 2018. 1 p.Research output: Contribution to conference › Poster
Open Access
File
Crystallization
Habits
X-Ray Diffraction
Anticonvulsants
Powders
Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations
Brown, C. J., McGlone, T., Yerdelen, S., Srirambhatla, V., Mabbott, F., Gurung, R., Briuglia, M. L., Ahmed, B., Polyzois, H., Mcginty, J., Perciballi, F., Fysikopoulos, D., Macfhionnghaile, P., Siddique, H., Raval, V., Harrington, T. S., Vassileiou, A. D., Robertson, M., Prasad, E., Johnston, A. & 9 others, 1 Jun 2018, In : Molecular Systems Design and Engineering. 3, 3, p. 518-549 32 p.Research output: Contribution to journal › Article
Open Access
File
Workflow
Crystallization
Drug products
Cooling
Pharmaceutical Preparations
Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisation
Brown, C. J., McGlone, T., Yerdelen, S., Srirambhatla, V., Mabbott, F., Gurung, R., Briuglia, M. L., Ahmed, B., Polyzois, H., McGinty, J., Perciballi, F., Fysikopoulos, D., Macfhionnghaile, P., Siddique, H., Raval, V., Harrington, T. S., Vassileiou, A., Robertson, M., Prasad, E., Johnston, A. & 9 others, 1 Jun 2018, In : Molecular Systems Design & Engineering. 2018, 3, p. 518-549 32 p.Research output: Contribution to journal › Article
Open Access
File
Workflow
Crystallization
Cooling
Pharmaceutical Preparations
Process design
Impact of paracetamol impurities on face properties: investigating the surface of single crystals using TOF-SIMS
Ottoboni, S., Chrubasik, M., Mir Bruce, L., Nguyen, T. T. H., Robertson, M., Johnston, B., Oswald, I. D. H., Florence, A. & Price, C., 2 May 2018, In : Crystal Growth and Design. 18, 5, p. 2750–2758 9 p.Research output: Contribution to journal › Article
Open Access
File
Secondary Ion Mass Spectrometry
Surface Properties
Acetaminophen
Secondary ion mass spectrometry
secondary ion mass spectrometry
Injection moulding- A novel method of solid oral dosage form manufacturing
Wood, S., Halbert, G. & Florence, A., 18 Jan 2018. 1 p.Research output: Contribution to conference › Poster
Open Access
File
Dosage Forms
Injections
Polymers
Pharmaceutical Preparations
Pressure
Inkjet printing of oral dosage forms to solubilize BCS Class II drugs
Turner, A. J., Halbert, G. W. & Florence, A. J., 18 Jan 2018.Research output: Contribution to conference › Poster
Open Access
File
Printing
Dosage Forms
Polymers
Pharmaceutical Preparations
Powders
Monitoring API crystal breakage in wet milling using inline imaging and chord length distribution measurements
Ahmed, B., Svoboda, V., Agimelen, O., Cardona, J., Dziewierz, J., Brown, C., McGlone, T., Cleary, A., Tachtatzis, C., Michie, C., Florence, A. J., Andonovic, I., Mulholland, A. & Sefcik, J., 24 Apr 2018. 2 p.Research output: Contribution to conference › Abstract
Open Access
File
Application programming interfaces (API)
Particle size analysis
Aspect ratio
Imaging techniques
Crystals
Multi-sensor inline measurements of crystal size and shape distributions during high shear wet milling of crystal slurries
Agimelen, O. S., Svoboda, V., Ahmed, B., Cardona, J., Dziewierz, J., Brown, C. J., McGlone, T., Cleary, A., Tachtatzis, C., Michie, C., Florence, A. J., Andonovic, I., Mulholland, A. J. & Sefcik, J., 31 Dec 2018, In : Advanced Powder Technology. 29, 12, p. 2987-2995 9 p.Research output: Contribution to journal › Article
Open Access
File
Slurries
Particle size
Crystallization
Particle size analysis
Crystals
Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography
Doerr, F. J. S., Oswald, I. D. H. & Florence, A. J., 12 Oct 2018, In : Advanced Powder Technology. 11 p.Research output: Contribution to journal › Article
X Ray Tomography
Drug Compounding
Acoustics
Drug products
Tomography
Rapid continuous antisolvent crystallization of multi-component systems
Raza, S. A., Schacht, U., Svoboda, V., Edwards, D. P., Florence, A. J., Pulham, C. R., Sefcik, J. & Oswald, I. D. H., 3 Jan 2018, In : Crystal Growth and Design. 18, 1, p. 210-218 9 p.Research output: Contribution to journal › Article
Open Access
File
leucine
Isoleucine
Valine
Crystallization
Leucine
Successful computationally directed templating of metastable pharmaceutical polymorphs
Case, D. H., Srirambhatla, V. K., Guo, R., Watson, R. E., Price, L. S., Polyzois, H., Cockcroft, J. K., Florence, A. J., Tocher, D. A. & Price, S. L., 5 Sep 2018, In : Crystal Growth and Design. 18, 9, p. 5322-5331 10 p.Research output: Contribution to journal › Article
Open Access
File
Polymorphism
Drug products
Mefenamic Acid
acids
Acids
The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry
Cardona, J., Ferreira, C., Svoboda, V., Ahmed, B., McGinty, J., Agimelen, O. S., Hamilton, A., Cleary, A., Atkinson, R., Michie, C., Marshall, S., Florence, A. J., Chen, Y-C., Sefcik, J., Andonovic, I. & Tachtatzis, C., 11 Sep 2018. 6 p.Research output: Contribution to conference › Paper
Open Access
File
Drug Industry
Drug products
Image analysis
Technology
Pharmaceutical Preparations
2017
A factorial approach to understanding the effect of inner geometry of baffled meso-scale tubes on solids suspension and axial dispersion in continuous, oscillatory liquid-solid plug flows
Ejim, L. N., Yerdelen, S., McGlone, T., Onyemelukwe, I., Johnston, B., Florence, A. J. & Reis, N. M., 15 Jan 2017, In : Chemical Engineering Journal. 308, p. 669–682 14 p.Research output: Contribution to journal › Article
Open Access
Suspensions
geometry
oscillating flow
liquid
Geometry
Aqueous solubility of organic salts. Investigating trends in a systematic series of 51 crystalline salt forms of methylephedrine
S. de Moraes, L., Edwards, D., Florence, A. J., Johnston, A., Johnston, B. F., Morrison, C. A. & Kennedy, A. R., 7 Jun 2017, In : Crystal Growth and Design. 17, 6, p. 3277-3286 10 p.Research output: Contribution to journal › Article
Open Access
File
melting points
solubility
Solubility
Melting point
Salts
Direct observation of templated two-step nucleation mechanism during olanzapine hydrate formation
Warzecha, M., Guo, R., Bhardwaj, R. M., Reutzel-Edens, S. M., Price, S. L., Lamprou, D. A. & Florence, A. J., 23 Oct 2017, In : Crystal Growth and Design. p. 1-41 41 p.Research output: Contribution to journal › Article
Open Access
File
olanzapine
Hydrates
hydrates
Nucleation
nucleation
Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs
Turner, A., Halbert, G. & Florence, A., 15 Nov 2017.Research output: Contribution to conference › Poster
Open Access
File
Printing
Dosage Forms
Solubility
Pharmaceutical Preparations
Drug and Narcotic Control
Mesoscopic solute-rich clusters in olanzapine solutions
Warzecha, M., Safari, M. S., Florence, A. J. & Vekilov, P. G., 26 Oct 2017, In : Crystal Growth and Design. 9 p.Research output: Contribution to journal › Article
Open Access
File
olanzapine
Dimers
solutes
Crystals
Hydrates
Solid oral dosage form manufacturing using injection moulding
Wood, S., Halbert, G. & Florence, A., 16 Oct 2017. 1 p.Research output: Contribution to conference › Poster
Open Access
File
Solid oral dosage form manufacturing using injection moulding
Wood, S., Halbert, G. & Florence, A., 23 Mar 2017.Research output: Contribution to conference › Poster
Open Access
File
Dosage Forms
Polymers
Injections
Pharmaceutical Preparations
Solubility
Spray drying as a reliable route to produce metastable carbamazepine form IV
Halliwell, R. A., Bhardwaj, R. M., Brown, C., Briggs, N. E. B., Dunn, J., Robertson, J., Nordon, A. & Florence, A. J., 19 Apr 2017, In : Journal of Pharmaceutical Sciences. 106, 7, p. 1874-1880 7 p.Research output: Contribution to journal › Article
Open Access
File
Carbamazepine
Crystallization
Raman Spectrum Analysis
Epilepsy
Polymers
The solute-rich mesoscopic precursors of crystal nuclei of olanzapine solid forms
Warzecha, M., Vekilov, P. G. & Florence, A., 27 Jun 2017. 1 p.Research output: Contribution to conference › Poster
Open Access
File
olanzapine
Crystallization
Solubility
Atomic Force Microscopy
Behavior Control
2016
Achieving immediate release dosage forms using DoE and injection moulding
Wood, S., Halbert, G. W. & Florence, A., 30 Nov 2016. 1 p.Research output: Contribution to conference › Poster
File
Polyvinyl Alcohol
Dosage Forms
Injections
Crystal structure of the co-crystal butylparaben– isonicotinamide (1/1)
Bhardwaj, R. M., Yang, H. & Florence, A. J., 1 Jan 2016, In : Acta Crystallographica Section E: Structure Reports. E72, 1, p. 53-55 3 p.Research output: Contribution to journal › Article
Open Access
File
Butylparaben
Parabens
Crystal structure
dimers
Dimers
Effect of oscillatory flow on nucleation kinetics of butyl paraben
Yang, H., Yu, X., Raval, V., Makkawi, Y. & Florence, A., 3 Feb 2016, In : Crystal Growth and Design . 16, 2, p. 875-886 12 p.Research output: Contribution to journal › Article
Open Access
File
Parabens
Shear deformation
Nucleation
nucleation
shear
Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion: HPMC-Affinisol paracetamol system
Islam, M. T., Robertson, J. & Florence, A. J., 20 Jul 2016, (Accepted/In press). 1 p.Research output: Contribution to conference › Abstract
Open Access
File
Acetaminophen
Polymers
Particle Size
Injection moulding: a novel approach to the manufacture of homogenous immediate release solid oral dosage forms
Wood, S., Halbert, G. & Florence, A., 5 Sep 2016.Research output: Contribution to conference › Poster
Open Access
File
Dosage Forms
Acetaminophen
Injections
Drug Interactions
Powders
Inkjet printing oral dosage forms
Turner, A. J., Halbert, G. W. & Florence, A. J., 5 Sep 2016. 1 p.Research output: Contribution to conference › Poster
Open Access
File
Printing
Dosage Forms
Solubility
Polymers
Pharmaceutical Preparations
Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)
Islam, M. T., Robertson, J., Tahir, F. & Florence, A., 7 Sep 2016.Research output: Contribution to conference › Poster
Open Access
File
Extruders
Extrusion
Printing
Polymers
Processing
Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs
Srirambhatla, V., Guo, R., Price, S. L. & Florence, A. J., 11 Jun 2016, In : Chemical Communications. 52, 46, p. 7384-7386 4 p.Research output: Contribution to journal › Article
Open Access
File
Crystallization
Polymorphism
Crystal growth
Single crystals
Crystals
The impact of paracetamol impurities on face-specific properties: investigating the surface of single crystals using TOF-SIMS
Ottoboni, S., Chrubasik, M., Mir Bruce, L., Nguyen, T. T. H., Johnston, B., Florence, A. & Price, C. J., 28 Jun 2016.Research output: Contribution to conference › Abstract
Secondary Ion Mass Spectrometry
Surface Properties
Acetaminophen
Secondary ion mass spectrometry
Crystallization
2015
A random forest model for predicting the crystallisability of organic molecules
Bhardwaj, R. M., Johnston, A., Johnston, B. F. & Florence, A. J., 21 Jun 2015, In : CrystEngComm. 17, 23, p. 4272-4275 4 p.Research output: Contribution to journal › Article
Open Access
File
Crystals
Molecules
Crystallization
crystals
molecules
Atomic force microscopy studies on two-step nucleation and epitaxial growth
Warzecha, M., Bhardwaj, R. M., Reutzel-Edens, S., Lamprou, D. & Florence, A., 21 Jun 2015. 1 p.Research output: Contribution to conference › Poster
Open Access
File
Atomic Force Microscopy
Crystallization
olanzapine
Growth
Humidity
Crystal structure of a mixed solvated form of amoxapine acetate
Bhardwaj, R. M., Raval, V., Oswald, I. D. H., Florence, A. J. & Stoeckli-Evans, H. (ed.), 1 Feb 2015, In : Acta Crystallographica Section E: Structure Reports. 71, 2, p. 139-141 3 p.Research output: Contribution to journal › Article
Open Access
File
Amoxapine
Cyclohexane
Acetic acid
acetates
Hydrogen bonds
3
Citations
Developing a data acquisition, analysis and reporting system for an academic research centre
Robertson, M., McGlone, T., Johnston, A., Florence, A., Johnston, B., Dziewierz, J., Tachtatzis, C., Cleary, A., Gachagan, A., Andonovic, I. & Sefcik, J., 26 Jun 2015. 6 p.Research output: Contribution to conference › Paper
Research Design
Crystallization
Research
Research Personnel
Technology
Establishment of a continuous sonocrystallization process for lactose in an oscillatory baffled crystallizer
Siddique, H., Brown, C. J., Houson, I. & Florence, A. J., 18 Dec 2015, In : Organic Process Research and Development. 19, 12, p. 1871-1881 11 p.Research output: Contribution to journal › Article
Open Access
File
lactose
Crystallizers
Lactose
Crystallization
Hydrodynamics
Image-based monitoring of encrustation in the crystallisation process
Tachtatzis, C., Sheridan, R., Michie, C., Atkinson, R. C., Cleary, A., Dziewierz, J., Andonovic, I., Briggs, N. E. B., Florence, A. J. & Sefcik, J., 8 Sep 2015, In : Chemical Engineering Science . 133, p. 82-90 9 p.Research output: Contribution to journal › Article
Open Access
File
Crystallization
Fouling
Monitoring
Crystals
Data acquisition
Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization
McGlone, T., Briggs, N. E. B., Clark, C. A., Brown, C. J., Sefcik, J. & Florence, A. J., 18 Sep 2015, In : Organic Process Research and Development. 19, 9, p. 1186–1202 17 p.Research output: Contribution to journal › Article
Open Access
File
Crystallization
manufacturing
reactor technology
reactors
crystallization
Seeded crystallization of β-L-glutamic acid in a continuous oscillatory baffled crystallizer
Briggs, N. E. B., Schacht, U., Raval, V., McGlone, T., Sefcik, J. & Florence, A. J., 18 Dec 2015, In : Organic Process Research and Development. 19, 12, p. 1903−1911 9 p.Research output: Contribution to journal › Article
Open Access
File
Crystallizers
glutamic acid
Supersaturation
Crystallization
supersaturation
2014
Drug solid solutions - a method for tuning phase transformations
Delori, A., Maclure, P., Bhardwaj, R. M., Johnston, A., Florence, A. J., Sutcliffe, O. B. & Oswald, I. D. H., 14 Jul 2014, In : CrystEngComm. 16, 26, p. 5827-5831 5 p.Research output: Contribution to journal › Article
halides
phase transformations
Solid solutions
drugs
solid solutions
Formulation of liquid propofol as a cocrystalline solid
McKellar, S. C., Kennedy, A. R., McCloy, N. C., McBride, E. & Florence, A. J., 27 Feb 2014, In : Crystal Growth and Design. 14, 5, p. 2422-2430 9 p.Research output: Contribution to journal › Article
Propofol
drugs
formulations
Liquids
liquids
From discovery to scale-up: alpha-lipoic acid: nicotinamide co-crystals in a continuous oscillatory baffled crystalliser
Zhao, L., Raval, V., Briggs, N. E. B., Bhardwaj, R. M., McGlone, T., Oswald, I. D. H. & Florence, A. J., 14 Jul 2014, In : CrystEngComm. 16, 26, p. 5769-5780 12 p.Research output: Contribution to journal › Article
Open Access
File
lipoic acid
Thioctic Acid
nicotinamide
Niacinamide
Crystals
2013
4th European conference for crystal growth-crystallisation in focus: from fundamentals to application
Florence, A. J., 28 Mar 2013, In : CrystEngComm. 15, 12, p. 2174-2174 1 p.Research output: Contribution to journal › Article
Absorbing a little water: the structural, thermodynamic, and kinetic relationship between pyrogallol and its tetarto-hydrate
Braun, D. E., Bhardwaj, R. M., Arlin, J-B., Florence, A. J., Kahlenberg, V., Griesser, U. J., Tocher, D. A. & Price, S. L., 4 Sep 2013, In : Crystal Growth and Design. 13, 9, p. 4071-4083 13 p.Research output: Contribution to journal › Article
Pyrogallol
Hydrates
hydrates
Thermodynamics
thermodynamics
A complementary experimental and computational study of loxapine succinate and its monohydrate
Bhardwaj, R. M., Johnston, B. F., Oswald, I. D. H. & Florence, A. J., 1 Nov 2013, In : Acta Crystallographica Section C: Crystal Structure Communications. 69, 11, p. 1273-1378 6 p.Research output: Contribution to journal › Article
Loxapine
Succinic Acid
Powder Diffraction
X-Ray Diffraction
Names
Chemical transformations of a crystalline coordination polymer: a multi-stage solid–vapour reaction manifold
Vitorica-Yrezabal, I., Mínguez Espallargas, G., Soleimannejad, J., Florence, A., Fletcher, A. & Brammer, L., 1 Feb 2013, In : Chemical Science. 4, 2, p. 696-708 13 p.Research output: Contribution to journal › Article
Thymidine Monophosphate
Polymers
Vapors
Alcohols
Crystalline materials
Complex polymorphic system of gallic acid-five monohydrates, three anhydrates, and over 20 solvates
Braun, D. E., Bhardwaj, R. M., Florence, A. J., Tocher, D. A. & Price, S. L., 2 Jan 2013, In : Crystal Growth and Design. 13, 1, p. 19-23 5 p.Research output: Contribution to journal › Article
Gallic Acid
Polymorphism
complex systems
Large scale systems
acids
Exploring the experimental and computed crystal energy landscape of olanzapine
Bhardwaj, R. M., Price, L. S., Price, S. L., Reutzel-Edens, S. M., Miller, G. J., Oswald, I. D. H., Johnston, B. F. & Florence, A. J., Apr 2013, In : Crystal Growth and Design. 13, 4, p. 1602-1617 16 p.Research output: Contribution to journal › Article
olanzapine
Dimers
dimers
Crystals
crystals
Zipping and unzipping of a paddlewheel metal-organic framework to enable two-step synthetic and structural transformation
Smart, P., Mason, C. A., Loader, J. R., Meijer, A. J. H. M., Florence, A., Shankland, K., Fletcher, A., Thompson, S. P., Brunelli, M., Hill, A. H. & Brammer, L., 11 Mar 2013, In : Chemistry - A European Journal . 19, 11, p. 3552-3557 6 p.Research output: Contribution to journal › Article
Metals
Ligands
Fasteners
Pyridine
Hot Temperature
2012
6-Methyl-1,3,5-triazine-2,4-diamine butane-1,4-diol monosolvate
Florence, A., Oswald, I. & Miglani Bhardwaj, R., Dec 2012, In : Acta Crystallographica Section E: Structure Reports. E68, 12, p. o3377 1 p.Research output: Contribution to journal › Article
Triazines
Diamines
Butane
diamines
butanes