Research output per year
Research output per year
- 1 - 50 out of 159 results
Search results
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2021
Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging
Sheridan, R., Cardona, J., Tachtatzis, C., Chen, Y-C., Cleary, A., Briggs, N. E. B., Florence, A., Atkinson, R., Michie, C., Andonovic, I. & Sefcik, J., 11 Oct 2021, (E-pub ahead of print) In: Chemical Engineering Science . 117188.Research output: Contribution to journal › Article › peer-review
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Heat transfer and residence time distribution in plug flow continuous oscillatory baffled crystallisers
Briggs, N. E. B., McGinty, J., McCabe, C., Raval, V., Sefcik, J. & Florence, A. J., 20 Jul 2021, In: ACS Omega. 6, 28, p. 18352-18363 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Investigation of wet milling and indirect ultrasound as means for controlling nucleation in the continuous crystallization of an active pharmaceutical ingredient
Yang, Y., Ahmed, B., Mitchell, C., Quon, J. L., Siddique, H., Houson, I., Florence, A. J. & Papageorgiou, C. D., 17 Sep 2021, In: Organic Process Research and Development. 25, 9, p. 2119-2132 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Mechanistic insights of evaporation-induced actuation in supramolecular crystals
Piotrowska, R., Hesketh, T., Wang, H., Martin, A. R. G., Bowering, D., Zhang, C., Hu, C. T., McPhee, S. A., Wang, T., Park, Y., Singla, P., McGlone, T., Florence, A., Tuttle, T., Ulijn, R. V. & Chen, X., 1 Mar 2021, In: Nature Materials . 20, p. 403–409 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)31 Downloads (Pure) -
The ambiguous functions of the precursors that enable nonclassical modes of olanzapine nucleation and growth
Warzecha, M., Florence, A. J. & Vekilov, P. G., 26 Jun 2021, In: Crystals. 11, 7, 16 p., 738.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
2020
A micro-XRT image analysis and machine learning methodology for the characterisation of multi- particulate capsule formulations
Doerr, F. J. S. & Florence, A. J., 1 Dec 2020, In: International Journal of Pharmaceutics: X. 2, 11 p., 100041.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)22 Downloads (Pure) -
A micro-XRT image analysis and machine learning methodology for the characterisation of multi- particulate capsule formulations [Video Abstract]
Doerr, F. J. S. & Florence, A. J., 1 Dec 2020Research output: Non-textual form › Digital or Visual Products
Open AccessFile7 Downloads (Pure) -
Data mining crystallization kinetics
Brown, C., Maldonado, D., Vassileiou, A., Johnston, B. & Florence, A., 11 Aug 2020, (E-pub ahead of print) 40 p.Research output: Working paper
File15 Downloads (Pure) -
Data mining crystallization kinetics
Brown, C., Maldonado, D. A., Vassileiou, A., Johnston, B. & Florence, A., 19 Aug 2020, (Unpublished).Research output: Contribution to conference › Speech
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Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC)
Raval, V., Siddique, H., Brown, C. J. & Florence, A. J., 7 Apr 2020, In: CrystEngComm. 22, 13, p. 2288-2296 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
Humidity responsive tripeptide crystals
Piotrowska, R., Hesketh, T., Wang, H., Martin, A. R. G., Bowering, D., Zhang, C., Hu, C. T., McPhee, S., Wang, T., Park, Y., Singla, P., McGlone, T., Florence, A., Tuttle, T., Ulijn, R. V. & Chen, X., 17 May 2020. 1 p.Research output: Contribution to conference › Poster
Open AccessFile10 Downloads (Pure) -
Manual versus microfluidic-assisted nanoparticle manufacture: impact of silk fibroin stock on nanoparticle characteristics
Solomun, J. I., Totten, J. D., Wongpinyochit, T., Florence, A. J. & Seib, F. P., 11 May 2020, In: ACS Biomaterials Science & Engineering. 6, 5, p. 2796-2804 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)44 Downloads (Pure) -
Multistage, multi-zones antisolvent-cooling crystallisation of a proprietary API: experimental comparison of effect of geometry and hydrodynamics in four batch crystallisers
Ojo, E., Osman, M., Mnemo, M., Anwar, A., Houson, I., O'Meahdra, R., Berthold, S. & Florence, A., 21 Oct 2020. 1 p.Research output: Contribution to conference › Poster
Open AccessFile4 Downloads (Pure) -
Olanzapine crystal symmetry originates in preformed centrosymmetric solute dimers
Warzecha, M., Verma, L., Johnston, B. F., Palmer, J. C., Florence, A. J. & Vekilov, P. G., 23 Sep 2020, In: Nature Chemistry. 12, 10, p. 914-920 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)16 Downloads (Pure) -
Peptide isolation via spray drying: particle formation, process design and implementation for the production of spray dried glucagon
Doerr, F. J. S., Burns, L. J., Lee, B., Hinds, J., Davis-Harrison, R. L., Frank, S. A. & Florence, A. J., 14 Dec 2020, In: Pharmaceutical Research. 37, 12, 19 p., 255.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Reversible two-step single-crystal to single-crystal phase transitions between desloratadine forms I, II and III
Srirambhatla, V. K., Guo, R., Dawson, D. M., Price, S. L. & Florence, A. J., 4 Mar 2020, In: Crystal Growth and Design. 20, 3, p. 1800-1810 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)4 Downloads (Pure) -
2019
Developing mechanistic understanding of unconventional growth in pharmaceutical crystals using scanning electron microscopy, atomic force microscopy and time-of-flight secondary ion mass spectrometry
Polyzois, H., Warzecha, M., Paladino, E., Bowering, D., Guo, R., Price, S. L., Halbert, G. & Florence, A., 16 Oct 2019. 1 p.Research output: Contribution to conference › Poster
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Developing process understanding for continuous manufacturing of Lamivudine (Epivir®) Stable Form I
Ojo, E., Hosni, Z., Onyemelukwe, I., Ramakers, L., Houson, I. & Florence, A., 9 Jul 2019. 1 p.Research output: Contribution to conference › Poster
Open AccessFile20 Downloads (Pure) -
Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisol™ 15LV filaments for Fused Filament Fabrication (FFF) 3D printing
Prasad, E., Islam, M. T., Goodwin, D. J., Megarry, A. J., Halbert, G. W., Florence, A. J. & Robertson, J., 1 Oct 2019, In: Additive Manufacturing. 29, 16 p., 100776.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)4 Downloads (Pure) -
Digital design and operation of continuous crystallization processes via mechanistic modelling
Mitchell, N., Mack, J., Tahir, F., Brown, C., Islam, M., Robertson, J., Lopez-Montero, E. & Florence, A., 12 Nov 2019.Research output: Contribution to conference › Speech
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Enabling model-predictive design: rapid development of a PBM for an anti-solvent and cooling crystallisation in two different reactor geometries
Ojo, E., Siddique, H., Houson, I., Brown, C., O'Meahdra, R., Berthold, S. & Florence, A., 3 Nov 2019. 1 p.Research output: Contribution to conference › Poster › peer-review
Open AccessFile2 Downloads (Pure) -
Engineering of acetaminophen particle attributes using a wet milling crystallisation platform
Ahmed, B., Brown, C. J., McGlone, T., Bowering, D. L., Sefcik, J. & Florence, A. J., 10 Jan 2019, In: International Journal of Pharmaceutics. 554, p. 201-211 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)16 Downloads (Pure) -
Improving the prediction of multi-component tablet properties from pure component parameters
Jolliffe, H. G., Papathanasiou, F., Prasad, E., Halbert, G., Robertson, J., Brown, C. J. & Florence, A. J., 25 Jul 2019, 29th European Symposium on Computer Aided Chemical Engineering. Vol. 46. p. 883-888 6 p. (Computer Aided Chemical Engineering).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book
Open AccessFile7 Downloads (Pure) -
Nanofocused X-ray tomography and image processing for quantitative analysis of pharmaceutical particulate solid products
Doerr, F. & Florence, A., 11 Apr 2019.Research output: Contribution to conference › Speech
Open AccessFile8 Downloads (Pure) -
Olanzapine Crystal Symmetry Originates in Preformed Centrosymmetric Solute Dimers
Warzecha, M., Verma, L., Palmer, J., Florence, A. & Vekilov, P. G., 23 Jun 2019.Research output: Contribution to conference › Poster › peer-review
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Oxcarbazepine form III: observation of twisted habit in crystals of an elusive pharmaceutical polymorph
Polyzois, H., Guo, R., Warzecha, M., Price, S. L. . & Florence, A. J., 9 Jul 2019, p. 69. 1 p.Research output: Contribution to conference › Poster
Open AccessFile12 Downloads (Pure) -
Polymorph screening studies of oxcarbazepine: twisted habit in crystals of the elusive form III
Polyzois, H., Guo, R., Warzecha, M., Price, S. L. & Florence, A., 23 Jun 2019. 1 p.Research output: Contribution to conference › Poster
Open AccessFile9 Downloads (Pure) -
Quality by design approach for early understanding of active pharmaceutical ingredient recovery process through dead-end filtration
Ojo, E., Rayat, ACME., Brown, C., Price, C., Hoare, M., Florence, A. & Johnston, A., 9 Nov 2019. 1 p.Research output: Contribution to conference › Poster › peer-review
File1 Downloads (Pure) -
Unconventional ultra scale-down techniques for active pharmaceutical ingredient filtration and size reduction
Ojo, E. O., Rayat, A., Price, C. J., Brown, C. J., Hoare, M., Johnston, A. & Florence, A. J., 11 Jul 2019, p. 88. 1 p.Research output: Contribution to conference › Poster
Open AccessFile15 Citations (Scopus)8 Downloads (Pure) -
Use of terahertz-Raman spectroscopy to determine solubility of the crystalline active pharmaceutical ingredient in polymeric matrices during hot melt extrusion
Bordos, E., Islam, M. T., Florence, A. J., Halbert, G. W. & Robertson, J., 7 Oct 2019, In: Molecular Pharmaceutics. 16, 10, p. 4361-4371 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)18 Downloads (Pure) -
Why we need continuous pharmaceutical manufacturing and how to make it happen: a summary of thoughts from the international symposium on continuous manufacturing
Badman, C., Cooney, C. L., Haslam, R. T., Florence, A., Konstantinov, K., Krumme, M., Mascia, S., Nasr, M., Trout, B. L. & Baddour, R. F., 30 Nov 2019, In: Journal of Pharmaceutical Sciences. 108, 11, p. 3521-3523 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)5 Downloads (Pure) -
2018
A random forest model for predicting crystal packing of olanzapine solvates
Bhardwaj, R. M., Reutzel-Edens, S. M., Johnston, B. F. & Florence, A. J., 24 Apr 2018, In: CrystEngComm. 20, 28, p. 3947-3950 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)20 Downloads (Pure) -
A rational single particle design approach using an acoustic levitation system and X-ray tomography
Doerr, F., Florence, A. & Oswald, I., 24 Apr 2018.Research output: Contribution to conference › Speech
Open AccessFile7 Downloads (Pure) -
Crystallisation of oxcarbazepine form III: emergence of crystals with variable twisted habit
Polyzois, H., Guo, R., Warzecha, M., Price, S. & Florence, A., 27 Mar 2018. 1 p.Research output: Contribution to conference › Poster
Open AccessFile18 Downloads (Pure) -
Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations
Brown, C. J., McGlone, T., Yerdelen, S., Srirambhatla, V., Mabbott, F., Gurung, R., Briuglia, M. L., Ahmed, B., Polyzois, H., McGinty, J., Perciballi, F., Fysikopoulos, D., Macfhionnghaile, P., Siddique, H., Raval, V., Harrington, T. S., Vassileiou, A. D., Robertson, M., Prasad, E., Johnston, A. & 9 others, , 1 Jun 2018, In: Molecular Systems Design & Engineering. 2018, 3, p. 518-549 32 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)85 Downloads (Pure) -
Impact of paracetamol impurities on face properties: investigating the surface of single crystals using TOF-SIMS
Ottoboni, S., Chrubasik, M., Mir Bruce, L., Nguyen, T. T. H., Robertson, M., Johnston, B., Oswald, I. D. H., Florence, A. & Price, C., 2 May 2018, In: Crystal Growth and Design. 18, 5, p. 2750–2758 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)60 Downloads (Pure) -
Injection moulding- A novel method of solid oral dosage form manufacturing
Wood, S., Halbert, G. & Florence, A., 18 Jan 2018. 1 p.Research output: Contribution to conference › Poster
Open AccessFile42 Downloads (Pure) -
Inkjet printing of oral dosage forms to solubilize BCS Class II drugs
Turner, A. J., Halbert, G. W. & Florence, A. J., 18 Jan 2018.Research output: Contribution to conference › Poster
Open AccessFile30 Downloads (Pure) -
Microfactory – Blend – Compression - Performance test
Prasad, E., Robertson, J., Brown, C., Jolliffe, H., Florence, A. & Halbert, G., 25 Oct 2018.Research output: Contribution to conference › Poster
Open AccessFile5 Downloads (Pure) -
Monitoring API crystal breakage in wet milling using inline imaging and chord length distribution measurements
Ahmed, B., Svoboda, V., Agimelen, O., Cardona, J., Dziewierz, J., Brown, C., McGlone, T., Cleary, A., Tachtatzis, C., Michie, C., Florence, A. J., Andonovic, I., Mulholland, A. & Sefcik, J., 24 Apr 2018. 2 p.Research output: Contribution to conference › Abstract › peer-review
Open AccessFile28 Downloads (Pure) -
Multi-sensor inline measurements of crystal size and shape distributions during high shear wet milling of crystal slurries
Agimelen, O. S., Svoboda, V., Ahmed, B., Cardona, J., Dziewierz, J., Brown, C. J., McGlone, T., Cleary, A., Tachtatzis, C., Michie, C., Florence, A. J., Andonovic, I., Mulholland, A. J. & Sefcik, J., 31 Dec 2018, In: Advanced Powder Technology. 29, 12, p. 2987-2995 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)27 Downloads (Pure) -
Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography
Doerr, F. J. S., Oswald, I. D. H. & Florence, A. J., 1 Dec 2018, In: Advanced Powder Technology. 29, 12, p. 2996-3006 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)11 Downloads (Pure) -
Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography [Video Abstract]
Doerr, F. J. S., Oswald, I. D. H. & Florence, A. J., 1 Dec 2018Research output: Non-textual form › Digital or Visual Products
Open AccessFile6 Downloads (Pure) -
Rapid continuous antisolvent crystallization of multi-component systems
Raza, S. A., Schacht, U., Svoboda, V., Edwards, D. P., Florence, A. J., Pulham, C. R., Sefcik, J. & Oswald, I. D. H., 3 Jan 2018, In: Crystal Growth and Design. 18, 1, p. 210-218 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)87 Downloads (Pure) -
Successful computationally directed templating of metastable pharmaceutical polymorphs
Case, D. H., Srirambhatla, V. K., Guo, R., Watson, R. E., Price, L. S., Polyzois, H., Cockcroft, J. K., Florence, A. J., Tocher, D. A. & Price, S. L., 5 Sep 2018, In: Crystal Growth and Design. 18, 9, p. 5322-5331 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)16 Downloads (Pure) -
The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry
Cardona, J., Ferreira, C., Svoboda, V., Ahmed, B., McGinty, J., Agimelen, O. S., Hamilton, A., Cleary, A., Atkinson, R., Michie, C., Marshall, S., Florence, A. J., Chen, Y-C., Sefcik, J., Andonovic, I. & Tachtatzis, C., 11 Sep 2018, Advances in Manufacturing Technology XXXII: proceedings of the 16th International Conference on Manufacturing Research. Thorvald, P. & Case, K. (eds.). Netherlands: IOS Press, p. 27-32 6 p. (Advances in Transdisciplinary Engineering; vol. 8).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book
Open AccessFile46 Downloads (Pure) -
XRT: Extraction of quantitative structural descriptors from solid pharmaceutical products
Doerr, F. J. S. & Florence, A. J., 17 Apr 2018.Research output: Contribution to conference › Speech
Open AccessFile10 Downloads (Pure) -
2017
A factorial approach to understanding the effect of inner geometry of baffled meso-scale tubes on solids suspension and axial dispersion in continuous, oscillatory liquid-solid plug flows
Ejim, L. N., Yerdelen, S., McGlone, T., Onyemelukwe, I., Johnston, B., Florence, A. J. & Reis, N. M., 15 Jan 2017, In: Chemical Engineering Journal. 308, p. 669–682 14 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Aqueous solubility of organic salts. Investigating trends in a systematic series of 51 crystalline salt forms of methylephedrine
S. de Moraes, L., Edwards, D., Florence, A. J., Johnston, A., Johnston, B. F., Morrison, C. A. & Kennedy, A. R., 7 Jun 2017, In: Crystal Growth and Design. 17, 6, p. 3277-3286 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)51 Downloads (Pure) -
Continuous crystallisation
Brown, C., McGlone, T. & Florence, A., 31 Jul 2017, Continuous Manufacturing of Pharmaceuticals. Kleinebudde, P., Khinast, J. & Rantanen, J. (eds.). Hoboken: John Wiley & Sons Inc., p. 169-226 58 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open AccessFile24 Downloads (Pure)