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Research Output 1999 2019

2019
Open Access
File
Acetaminophen
Crystallization
Particle Size
Reflectometers
Interfacial energy
2018

Crystallisation of oxcarbazepine form III: emergence of crystals with variable twisted habit

Polyzois, H., Guo, R., Warzecha, M., Price, S. & Florence, A., 27 Mar 2018. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Crystallization
Habits
X-Ray Diffraction
Anticonvulsants
Powders
7 Citations
Open Access
File
Workflow
Crystallization
Drug products
Cooling
Pharmaceutical Preparations
Open Access
File
Workflow
Crystallization
Cooling
Pharmaceutical Preparations
Process design
2 Citations
Open Access
File
Secondary Ion Mass Spectrometry
Surface Properties
Acetaminophen
Secondary ion mass spectrometry
secondary ion mass spectrometry

Injection moulding- A novel method of solid oral dosage form manufacturing

Wood, S., Halbert, G. & Florence, A., 18 Jan 2018. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Dosage Forms
Injections
Polymers
Pharmaceutical Preparations
Pressure
Open Access
File
Printing
Dosage Forms
Polymers
Pharmaceutical Preparations
Powders
Open Access
File
Application programming interfaces (API)
Particle size analysis
Aspect ratio
Imaging techniques
Crystals
1 Citations
Open Access
File
Slurries
Particle size
Crystallization
Particle size analysis
Crystals
X Ray Tomography
Drug Compounding
Acoustics
Drug products
Tomography
2 Citations

Rapid continuous antisolvent crystallization of multi-component systems

Raza, S. A., Schacht, U., Svoboda, V., Edwards, D. P., Florence, A. J., Pulham, C. R., Sefcik, J. & Oswald, I. D. H., 3 Jan 2018, In : Crystal Growth and Design. 18, 1, p. 210-218 9 p.

Research output: Contribution to journalArticle

Open Access
File
leucine
Isoleucine
Valine
Crystallization
Leucine
1 Citations

Successful computationally directed templating of metastable pharmaceutical polymorphs

Case, D. H., Srirambhatla, V. K., Guo, R., Watson, R. E., Price, L. S., Polyzois, H., Cockcroft, J. K., Florence, A. J., Tocher, D. A. & Price, S. L., 5 Sep 2018, In : Crystal Growth and Design. 18, 9, p. 5322-5331 10 p.

Research output: Contribution to journalArticle

Open Access
File
Polymorphism
Drug products
Mefenamic Acid
acids
Acids
Open Access
File
Drug Industry
Drug products
Image analysis
Technology
Pharmaceutical Preparations
2017
9 Citations
Open Access
Suspensions
geometry
oscillating flow
liquid
Geometry
5 Citations

Aqueous solubility of organic salts. Investigating trends in a systematic series of 51 crystalline salt forms of methylephedrine

S. de Moraes, L., Edwards, D., Florence, A. J., Johnston, A., Johnston, B. F., Morrison, C. A. & Kennedy, A. R., 7 Jun 2017, In : Crystal Growth and Design. 17, 6, p. 3277-3286 10 p.

Research output: Contribution to journalArticle

Open Access
File
melting points
solubility
Solubility
Melting point
Salts
8 Citations

Direct observation of templated two-step nucleation mechanism during olanzapine hydrate formation

Warzecha, M., Guo, R., Bhardwaj, R. M., Reutzel-Edens, S. M., Price, S. L., Lamprou, D. A. & Florence, A. J., 23 Oct 2017, In : Crystal Growth and Design. p. 1-41 41 p.

Research output: Contribution to journalArticle

Open Access
File
olanzapine
Hydrates
hydrates
Nucleation
nucleation
Open Access
File
Printing
Dosage Forms
Solubility
Pharmaceutical Preparations
Drug and Narcotic Control
1 Citations

Mesoscopic solute-rich clusters in olanzapine solutions

Warzecha, M., Safari, M. S., Florence, A. J. & Vekilov, P. G., 26 Oct 2017, In : Crystal Growth and Design. 9 p.

Research output: Contribution to journalArticle

Open Access
File
olanzapine
Dimers
solutes
Crystals
Hydrates

Solid oral dosage form manufacturing using injection moulding

Wood, S., Halbert, G. & Florence, A., 16 Oct 2017. 1 p.

Research output: Contribution to conferencePoster

Open Access
File

Solid oral dosage form manufacturing using injection moulding

Wood, S., Halbert, G. & Florence, A., 23 Mar 2017.

Research output: Contribution to conferencePoster

Open Access
File
Dosage Forms
Polymers
Injections
Pharmaceutical Preparations
Solubility
3 Citations

Spray drying as a reliable route to produce metastable carbamazepine form IV

Halliwell, R. A., Bhardwaj, R. M., Brown, C., Briggs, N. E. B., Dunn, J., Robertson, J., Nordon, A. & Florence, A. J., 19 Apr 2017, In : Journal of Pharmaceutical Sciences. 106, 7, p. 1874-1880 7 p.

Research output: Contribution to journalArticle

Open Access
File
Carbamazepine
Crystallization
Raman Spectrum Analysis
Epilepsy
Polymers

The solute-rich mesoscopic precursors of crystal nuclei of olanzapine solid forms

Warzecha, M., Vekilov, P. G. & Florence, A., 27 Jun 2017. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
olanzapine
Crystallization
Solubility
Atomic Force Microscopy
Behavior Control
2016

Achieving immediate release dosage forms using DoE and injection moulding

Wood, S., Halbert, G. W. & Florence, A., 30 Nov 2016. 1 p.

Research output: Contribution to conferencePoster

File
Polyvinyl Alcohol
Dosage Forms
Injections
2 Citations

Crystal structure of the co-crystal butylparaben– isonicotinamide (1/1)

Bhardwaj, R. M., Yang, H. & Florence, A. J., 1 Jan 2016, In : Acta Crystallographica Section E: Structure Reports. E72, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

Open Access
File
Butylparaben
Parabens
Crystal structure
dimers
Dimers
6 Citations

Effect of oscillatory flow on nucleation kinetics of butyl paraben

Yang, H., Yu, X., Raval, V., Makkawi, Y. & Florence, A., 3 Feb 2016, In : Crystal Growth and Design . 16, 2, p. 875-886 12 p.

Research output: Contribution to journalArticle

Open Access
File
Parabens
Shear deformation
Nucleation
nucleation
shear
Open Access
File
Acetaminophen
Polymers
Particle Size
Open Access
File
Dosage Forms
Acetaminophen
Injections
Drug Interactions
Powders

Inkjet printing oral dosage forms

Turner, A. J., Halbert, G. W. & Florence, A. J., 5 Sep 2016. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Printing
Dosage Forms
Solubility
Polymers
Pharmaceutical Preparations
Open Access
File
Extruders
Extrusion
Printing
Polymers
Processing
18 Citations
Open Access
File
Crystallization
Polymorphism
Crystal growth
Single crystals
Crystals
Secondary Ion Mass Spectrometry
Surface Properties
Acetaminophen
Secondary ion mass spectrometry
Crystallization
2015
6 Citations

A random forest model for predicting the crystallisability of organic molecules

Bhardwaj, R. M., Johnston, A., Johnston, B. F. & Florence, A. J., 21 Jun 2015, In : CrystEngComm. 17, 23, p. 4272-4275 4 p.

Research output: Contribution to journalArticle

Open Access
File
Crystals
Molecules
Crystallization
crystals
molecules

Atomic force microscopy studies on two-step nucleation and epitaxial growth

Warzecha, M., Bhardwaj, R. M., Reutzel-Edens, S., Lamprou, D. & Florence, A., 21 Jun 2015. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Atomic Force Microscopy
Crystallization
olanzapine
Growth
Humidity

Crystal structure of a mixed solvated form of amoxapine acetate

Bhardwaj, R. M., Raval, V., Oswald, I. D. H., Florence, A. J. & Stoeckli-Evans, H. (ed.), 1 Feb 2015, In : Acta Crystallographica Section E: Structure Reports. 71, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

Open Access
File
Amoxapine
Cyclohexane
Acetic acid
acetates
Hydrogen bonds
3 Citations
Research Design
Crystallization
Research
Research Personnel
Technology
19 Citations
Open Access
File
lactose
Crystallizers
Lactose
Crystallization
Hydrodynamics
8 Citations

Image-based monitoring of encrustation in the crystallisation process

Tachtatzis, C., Sheridan, R., Michie, C., Atkinson, R. C., Cleary, A., Dziewierz, J., Andonovic, I., Briggs, N. E. B., Florence, A. J. & Sefcik, J., 8 Sep 2015, In : Chemical Engineering Science . 133, p. 82-90 9 p.

Research output: Contribution to journalArticle

Open Access
File
Crystallization
Fouling
Monitoring
Crystals
Data acquisition
59 Citations

Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization

McGlone, T., Briggs, N. E. B., Clark, C. A., Brown, C. J., Sefcik, J. & Florence, A. J., 18 Sep 2015, In : Organic Process Research and Development. 19, 9, p. 1186–1202 17 p.

Research output: Contribution to journalArticle

Open Access
File
Crystallization
manufacturing
reactor technology
reactors
crystallization
25 Citations

Seeded crystallization of β-L-glutamic acid in a continuous oscillatory baffled crystallizer

Briggs, N. E. B., Schacht, U., Raval, V., McGlone, T., Sefcik, J. & Florence, A. J., 18 Dec 2015, In : Organic Process Research and Development. 19, 12, p. 1903−1911 9 p.

Research output: Contribution to journalArticle

Open Access
File
Crystallizers
glutamic acid
Supersaturation
Crystallization
supersaturation
2014
20 Citations

Drug solid solutions - a method for tuning phase transformations

Delori, A., Maclure, P., Bhardwaj, R. M., Johnston, A., Florence, A. J., Sutcliffe, O. B. & Oswald, I. D. H., 14 Jul 2014, In : CrystEngComm. 16, 26, p. 5827-5831 5 p.

Research output: Contribution to journalArticle

halides
phase transformations
Solid solutions
drugs
solid solutions
15 Citations

Formulation of liquid propofol as a cocrystalline solid

McKellar, S. C., Kennedy, A. R., McCloy, N. C., McBride, E. & Florence, A. J., 27 Feb 2014, In : Crystal Growth and Design. 14, 5, p. 2422-2430 9 p.

Research output: Contribution to journalArticle

Propofol
drugs
formulations
Liquids
liquids
36 Citations

From discovery to scale-up: alpha-lipoic acid: nicotinamide co-crystals in a continuous oscillatory baffled crystalliser

Zhao, L., Raval, V., Briggs, N. E. B., Bhardwaj, R. M., McGlone, T., Oswald, I. D. H. & Florence, A. J., 14 Jul 2014, In : CrystEngComm. 16, 26, p. 5769-5780 12 p.

Research output: Contribution to journalArticle

Open Access
File
lipoic acid
Thioctic Acid
nicotinamide
Niacinamide
Crystals
2013

4th European conference for crystal growth-crystallisation in focus: from fundamentals to application

Florence, A. J., 28 Mar 2013, In : CrystEngComm. 15, 12, p. 2174-2174 1 p.

Research output: Contribution to journalArticle

23 Citations

Absorbing a little water: the structural, thermodynamic, and kinetic relationship between pyrogallol and its tetarto-hydrate

Braun, D. E., Bhardwaj, R. M., Arlin, J-B., Florence, A. J., Kahlenberg, V., Griesser, U. J., Tocher, D. A. & Price, S. L., 4 Sep 2013, In : Crystal Growth and Design. 13, 9, p. 4071-4083 13 p.

Research output: Contribution to journalArticle

Pyrogallol
Hydrates
hydrates
Thermodynamics
thermodynamics
3 Citations
Loxapine
Succinic Acid
Powder Diffraction
X-Ray Diffraction
Names
22 Citations

Chemical transformations of a crystalline coordination polymer: a multi-stage solid–vapour reaction manifold

Vitorica-Yrezabal, I., Mínguez Espallargas, G., Soleimannejad, J., Florence, A., Fletcher, A. & Brammer, L., 1 Feb 2013, In : Chemical Science. 4, 2, p. 696-708 13 p.

Research output: Contribution to journalArticle

Thymidine Monophosphate
Polymers
Vapors
Alcohols
Crystalline materials
52 Citations

Complex polymorphic system of gallic acid-five monohydrates, three anhydrates, and over 20 solvates

Braun, D. E., Bhardwaj, R. M., Florence, A. J., Tocher, D. A. & Price, S. L., 2 Jan 2013, In : Crystal Growth and Design. 13, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

Gallic Acid
Polymorphism
complex systems
Large scale systems
acids
63 Citations

Exploring the experimental and computed crystal energy landscape of olanzapine

Bhardwaj, R. M., Price, L. S., Price, S. L., Reutzel-Edens, S. M., Miller, G. J., Oswald, I. D. H., Johnston, B. F. & Florence, A. J., Apr 2013, In : Crystal Growth and Design. 13, 4, p. 1602-1617 16 p.

Research output: Contribution to journalArticle

olanzapine
Dimers
dimers
Crystals
crystals
17 Citations

Zipping and unzipping of a paddlewheel metal-organic framework to enable two-step synthetic and structural transformation

Smart, P., Mason, C. A., Loader, J. R., Meijer, A. J. H. M., Florence, A., Shankland, K., Fletcher, A., Thompson, S. P., Brunelli, M., Hill, A. H. & Brammer, L., 11 Mar 2013, In : Chemistry - A European Journal . 19, 11, p. 3552-3557 6 p.

Research output: Contribution to journalArticle

Metals
Ligands
Fasteners
Pyridine
Hot Temperature
2012
1 Citations

6-Methyl-1,3,5-triazine-2,4-diamine butane-1,4-diol monosolvate

Florence, A., Oswald, I. & Miglani Bhardwaj, R., Dec 2012, In : Acta Crystallographica Section E: Structure Reports. E68, 12, p. o3377 1 p.

Research output: Contribution to journalArticle

Triazines
Diamines
Butane
diamines
butanes