Alastair Florence

Personal profile

Personal Statement

Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.

Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.

Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.

External positions

Advisory board member , Functional Materials Manufacturing Programme, Imperial College

2015 → …

Advisory board member, Leeds University

2015 → …

Chairman, British Association of Crystal Growth

2014 → …

Innovation Strategy Board member, KTN

2014 → …

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Projects

11 Active
53 Finished

Digital Design Accelerator Platform to Connect Active Material Design to Product Performance (Manufacturing Made Smarter)

Florence, A. & Johnston, B.

Innovate UK

1/03/20 → 28/02/22

Project: Research

Doctoral Training Partnership 2018-19 University of Strathclyde | Pereira Diaz, Laura

Florence, A., Johnston, B. & Pereira Diaz, L.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/19 → 1/04/23

Project: Research Studentship - Internally Allocated

Research Output

A micro-XRT image analysis and machine learning methodology for the characterisation of multi- particulate capsule formulations

Doerr, F. J. S. & Florence, A. J., 15 Jan 2020, In : International Journal of Pharmaceutics: X. 2, 11 p., 100041.

Research output: Contribution to journal › Article

Open Access

File

11 Downloads (Pure)

A micro-XRT image analysis and machine learning methodology for the characterisation of multi- particulate capsule formulations [Video Abstract]

Doerr, F. J. S. & Florence, A. J., 15 Jan 2020

Research output: Non-textual form › Digital or Visual Products

Open Access

File

3 Downloads (Pure)

Datasets

Data for: "Data mining crystallization kinetics"

Maldonado, D. (Creator), University of Strathclyde, 30 Jan 2020

DOI: 10.15129/8f47a175-3ac7-4791-a310-82e6652bd9f5

Dataset

Data for: "Fusion of laser diffraction and chord length distribution data for estimation of particle size distribution using multi-objective optimisation"

Agimelen, O. S. (Creator), University of Strathclyde, 13 Sep 2018

DOI: 10.15129/d75a345c-e9f6-4bdd-8494-c20e6eae3231

Dataset

Thesis

Antisolvent crystallisation in oscillatory baffled platforms

Author: Davidson, S., 20 Mar 2020

Supervisor: Florence, A. (Supervisor) & Ter Horst, J. (Supervisor)

Student thesis: Doctoral Thesis

Application of machine learning methods for design of crystallisation processes

Author: Gurung, R., 3 Feb 2020

Supervisor: Florence, A. (Supervisor) & Johnston, B. (Supervisor)

Student thesis: Doctoral Thesis

Prizes

Best Poster Award @ CMAC Annual Open Day 2018

Zied Hosni (Recipient), Ebenezer Ojo (Recipient), Iyke I. Onyemelukwe (Recipient), Lennart Ramakers (Recipient), Ian Houson (Recipient) & Alastair Florence (Recipient), 25 Oct 2018

Prize: Prize (including medals and awards)