Projects per year
Personal profile
Personal Statement
Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.
Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.
Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Advisory board member , Functional Materials Manufacturing Programme, Imperial College
2015 → …
Advisory board member, Leeds University
2015 → …
Chairman, British Association of Crystal Growth
2014 → …
Innovation Strategy Board member, KTN
2014 → …
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Network
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Recounting an Ancient Story of Crystallisation: Saffron Rock Candy
Salehian, M., Al Qaraghuli, M., Hone, S., Clark, C., Markl, D. & Florence, A.
9/01/23 → 9/07/23
Project: External Facilities/Resources
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Industrial CASE Account - University of Strathclyde 2022 | Osman, Amal
Johnston, B., Florence, A. & Osman, A.
EPSRC (Engineering and Physical Sciences Research Council)
1/12/22 → 1/12/25
Project: Research Studentship Case - Internally allocated
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Tautomerism unveils a self-inhibition mechanism of crystallization
Tang, W., Yang, T., Morales-Rivera, C. A., Geng, X., Srirambhatla, V. K., Kang, X., Chauhan, V. P., Hong, S., Tu, Q., Florence, A. J., Mo, H., Calderon, H. A., Kisielowski, C., Hernandez, F. C. R., Zou, X., Mpourmpakis, G. & Rimer, J. D., 2 Feb 2023, (E-pub ahead of print) In: Nature Communications. 14, 1, 13 p., 561.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Machine learning derived correlations for scale-up and technology transfer of primary nucleation kinetics
Yerdelen, S., Yang, Y., Quon, J. L., Papageorgiou, C. D., Mitchell, C., Houson, I., Sefcik, J., ter Horst, J. H., Florence, A. J. & Brown, C. J., 18 Jan 2023, (E-pub ahead of print) In: Crystal Growth and Design. 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure)
Datasets
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Data for: “Machine Learning Approach to the Prediction of Powder Flow Behaviour of Pharmaceutical Materials from Physical Properties”
Pereira-Diaz, L. (Creator), Florence, A. (Supervisor) & Brown, C. (Supervisor), University of Strathclyde, 27 Sep 2022
DOI: 10.15129/3005493b-a125-4a5d-8599-525ce952facf
Dataset
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Data for: "Direct image feature extraction and multivariate analysis for crystallisation process characterisation"
Doerr, F. (Creator), Brown, C. (Supervisor) & Florence, A. (Supervisor), University of Strathclyde, 15 Mar 2022
DOI: 10.15129/75002e1c-80dc-42ab-984a-3444fbef9c03, https://github.com/FrederikDoerr/Crystalline_ImgAnlys
Dataset
Prizes
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Best Poster Award @ CMAC Annual Open Day 2018
Hosni, Zied (Recipient), Ojo, Ebenezer (Recipient), Onyemelukwe, Iyke I. (Recipient), Ramakers, Lennart (Recipient), Houson, Ian (Recipient) & Florence, Alastair (Recipient), 25 Oct 2018
Prize: Prize (including medals and awards)
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Royal Pharmaceutical Society of Great Britain Conference Science Medal
Florence, Alastair (Recipient), Sep 2004
Prize: Prize (including medals and awards)
Activities
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PMTC Expert Panel
Alastair Florence (Participant)
26 Jan 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Sensor Enabled Automation
Gareth Pierce (Keynote speaker), Charles Norman MacLeod (Contributor), Gordon Dobie (Contributor), Randika Kosala Wathavana Vithanage (Contributor), Yashar Javadi (Contributor), Ehsan Mohseni (Contributor), Charalampos LOUKAS (Contributor), Momchil Vasilev (Contributor), Rastislav Zimermann (Contributor), Alastair Poole (Contributor), Shaun McKnight (Contributor), David Lines (Contributor), Nina Sweeney (Contributor), Muhammad Khalid Rizwan (Contributor), Euan Foster (Contributor), Ewan Nicolson (Contributor), William Jackson (Contributor), Robert Watson (Contributor), Chantal Mustoe (Contributor), Daniel Markl (Contributor), Thomas Pickles (Contributor), Faisal Abbas (Contributor), Alastair Florence (Contributor), Stewart Williams (Contributor), Jialuo Ding (Contributor), Alan Oakley (Contributor), Janet O'Brien-O'Reilly (Contributor), Scott Paton (Contributor), Gavin Munro (Contributor), Tom O'Hare (Contributor), Michael Grosser (Contributor), Jim Sibson (Contributor), Tony Burnett (Contributor), Bert Holt (Contributor) & Mark Symington (Contributor)
14 Sep 2022 → 16 Sep 2022Activity: Talk or presentation types › Invited talk
Equipment
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3PI capsule filler
Strathclyde Institute Of Pharmacy And Biomedical SciencesFacility/equipment: Equipment
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Alexanderwerk roller compactor
Strathclyde Institute Of Pharmacy And Biomedical SciencesFacility/equipment: Equipment