Projects per year
Personal profile
Personal Statement
Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.
Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.
Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Advisory board member , Functional Materials Manufacturing Programme, Imperial College
2015 → …
Advisory board member, Leeds University
2015 → …
Chairman, British Association of Crystal Growth
2014 → …
Innovation Strategy Board member, KTN
2014 → …
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Collaborations and top research areas from the last five years
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Correlating Digital and Experimental Chemical Space to Pharmaceutical Manufacturing Processes
El-Habbak, O., Brown, C. & Florence, A.
1/12/23 → 1/12/27
Project: Research Studentship - Internally Allocated
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DTP 2224 University of Strathclyde | El-Habbak, Omar
Brown, C., Florence, A. & El-Habbak, O.
EPSRC (Engineering and Physical Sciences Research Council)
1/12/23 → 1/06/27
Project: Research Studentship - Internally Allocated
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Flow‐Xl: a new facility for the analysis of crystallization in flow systems
Turner, T. D., O'Shaughnessy, C., He, X., Levenstein, M. A., Hunter, L., Wojciechowski, J., Bristowe, H., Stone, R., Wilson, C. C., Florence, A., Robertson, K., Kapur, N. & Meldrum, F. C., Oct 2024, In: Journal of Applied Crystallography. 57, 5Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Integration of a model-driven workflow into an industrial pharmaceutical facility: supporting process development of API crystallisation
Pickles, T., Svoboda, V., Marziano, I., Brown, C. J. & Florence, A. J., 29 Jul 2024, In: CrystEngComm. 26, 34, p. 4678-4689 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure)
Datasets
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Data for: "Fusion of laser diffraction and chord length distribution data for estimation of particle size distribution using multi-objective optimisation"
Agimelen, O. S. (Creator), Ferreira, C. S. (Data Collector), Ahmed, B. (Data Collector), Cardona Amengual, J. (Data Collector), Chen, Y. (Contributor), Tachtatzis, C. (Contributor), Florence, A. (Contributor), Andonovic, I. (Contributor), Sefcik, J. (Contributor) & Mulholland, A. (Contributor), University of Strathclyde, 13 Sept 2018
DOI: 10.15129/d75a345c-e9f6-4bdd-8494-c20e6eae3231
Dataset
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Data for: "The impact of paracetamol impurities on face properties: investigating the surface of single crystals using TOF-SIMS"
Robertson, M. (Creator), Ottoboni, S. (Contributor), Chrubasik, M. (Contributor), Parsons, L. (Contributor), Johnston, B. (Contributor), Price, C. J. (Contributor), Florence, A. (Contributor), Oswald, I. (Contributor) & Nguyen, T. T. H. (Contributor), University of Strathclyde, 21 Mar 2018
DOI: 10.15129/7e48f205-e591-465c-89e2-2fc44055a1a7
Dataset
Prizes
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Best Poster Award @ CMAC Annual Open Day 2018
Hosni, Zied (Recipient), Ojo, Ebenezer (Recipient), Onyemelukwe, Iyke I. (Recipient), Ramakers, Lennart (Recipient), Houson, Ian (Recipient) & Florence, Alastair (Recipient), 25 Oct 2018
Prize: Prize (including medals and awards)
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Royal Pharmaceutical Society of Great Britain Conference Science Medal
Florence, Alastair (Recipient), Sept 2004
Prize: Prize (including medals and awards)
Activities
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Application of calibration free approaches for rapid polymorph discrimination by low frequency Raman spectroscopy
Magdalene Chong (Speaker), Chantal Mustoe (Contributor), Martin Ward (Contributor), Catriona McFarlan (Contributor), Andrew Parrott (Contributor), Iain Oswald (Contributor), Alastair Florence (Contributor) & Alison Nordon (Contributor)
25 Apr 2024Activity: Talk or presentation types › Oral presentation
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Organic Process Research and Development (Journal)
Alastair Florence (Peer reviewer)
1 Dec 2023Activity: Publication peer-review and editorial work types › Journal peer review
Equipment
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3PI capsule filler
Strathclyde Institute Of Pharmacy And Biomedical SciencesFacility/equipment: Equipment
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Alexanderwerk roller compactor
Strathclyde Institute Of Pharmacy And Biomedical SciencesFacility/equipment: Equipment