Organization profile

Organisation profile

A Collaborative MPhil and PhD Programme and now Doctoral Training Centre has been established between the University of Strathclyde and the pharmaceutical company GlaxoSmithKline. This unique and expansive partnership has led to a framework which enables GSK employees and other hosted researchers to work towards a higher research degree.

Researchers are registered as Strathclyde students and are based either within GlaxoSmithKline laboratories or within the Faculty of Science at the University of Strathclyde. Supervision is completely collaborative between the University and GSK.

http://www.strath.ac.uk/research/gskandstrathclyde/

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Iridium Chemical Compounds
Nucleophiles Chemical Compounds
Hydrogen Chemical Compounds
phosphine Chemical Compounds
Substrates Chemical Compounds
Methylation Chemical Compounds
Boronic Acids Chemical Compounds
Scaffolds Chemical Compounds

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Projects 2015 2019

Research Output 2013 2019

Concerted nucleophilic aromatic substitution reactions

Rohrbach, S., Smith, A. J., Pang, J. H., Poole, D. L., Tuttle, T., Chiba, S. & Murphy, J. A., 16 Apr 2019, In : Angewandte Chemie International Edition. 22 p.

Research output: Contribution to journalArticle

Open Access
File
Substitution reactions
Computational chemistry
Nucleophiles
Transition metals
Chemical activation

Mechanism of Cu-catalyzed aryl boronic acid halodeboronation using electrophilic halogen: development of a base-catalyzed iododeboronation for radiolabeling applications

Molloy, J. J., O'rourke, K. M., Frias, C. P., Sloan, N. L., West, M. J., Pimlott, S. L., Sutherland, A. & Watson, A. J. B., 5 Apr 2019, In : Organic Letters. 21, 7, p. 2488-2492 5 p.

Research output: Contribution to journalArticle

Open Access
File
Lewis Bases
Boronic Acids
Lewis base
Halogens
Single-Photon Emission-Computed Tomography

Profile of a highly selective quaternized pyrrolidine betaine αvβ6 integrin inhibitor - (3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2- (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate synthesized by stereoselective methylation

Barrett, T. N., Taylor, J. A., Barker, D., Procopiou, P. A., Thompson, J. D. F., Barrett, J., Le, J., Lynn, S. M., Pogany, P., Pratley, C., Pritchard, J. M., Roper, J. A., Rowedder, J. E., Slack, R. J., Vitulli, G., Macdonald, S. J. F. & Kerr, W. J., 22 Aug 2019, In : Journal of Medicinal Chemistry. 62, 16, p. 7543-7556 14 p.

Research output: Contribution to journalArticle

Integrin alpha6
Integrin alpha Chains
Betaine
Methylation
Pharmacokinetics