Taxonomic identifiation, anti-trypanosomal activity, metabolomics analyses and GenBank accession data of Mediterranean marine sponge associated actinomycetes

  • Cheng Cheng (Julius-Maximilians-Universitat Wurzburg) (Creator)
  • Lynsey Macintyre (Contributor)
  • Usama Ramadan Abdelmohsen (Contributor)
  • Hannes Horn (Contributor)
  • Paraskevi N. Polymenakou (Contributor)
  • Ruangelie Edrada-Ebel (Contributor)
  • Ute Hentschel (Contributor)

Dataset

Description

Marine sponge-associated actinomycetes are considered as promising sources for the discovery of novel biologically active compounds. In the present study, a total of 64 actinomycetes were isolated from 12 different marine sponge species that had been collected offshore the islands of Milos and Crete, Greece, eastern Mediterranean. The isolates were affiliated to 23 genera representing 8 different suborders based on nearly full length 16S rRNA gene sequencing. Four putatively novel species belonging to genera Geodermatophilus, Microlunatus, Rhodococcus and Actinomycetospora were identified based on a 16S rRNA gene sequence similarity of < 98.5% to currently described strains. Eight actinomycete isolates showed bioactivities against Trypanosma brucei brucei TC221 with half maximal inhibitory concentration (IC50) values.

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Date made available11 May 2023
PublisherPANGAEA

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