Data for: "Mixing and flow-induced nanoprecipitation for morphology control of silk fibroin self-assembly"

Semi-batch and micro-mixers are promising platforms for nanoprecipitation of aqueous silk fibroin with aqueous-miscible solvents under conditions of polymer flow. Although the shear rates experienced by regenerated silk feeds and the aqueous–organic mixing time are critical for process scalability, their influence on the properties of the resulting assemblies remains poorly understood. Here, we implement low and high shear semi-batch systems and low and high shear micro-mixer systems to investigate the roles of shear and mixing in nanoprecipitation of the silk biopolymer. This work facilitates the modulation of silk nanoparticle shape and aids the transition of sustainable silk nanomedicines from lab to pilot-scale technology.

All equipment, software and measurements are detailed in the Readme file. Raw and processed data pertaining to each figure and table are documented in the respective zipped folders.

This dataset has been corrected as follows:

1. Copy errors in the zeta potential data for the semi-batch system in Figure 4, Figure S3 (Folder: Figure4_FigureS3_Conc_Shear.zip) at 0 rpm and 400 rpm have been corrected in the files contained within the sub-folders named Raw Data, Statistics, and Images. Copy error in the PDI data for the semi-batch system in Figure 4, Figure S3 (Folder: Figure4_FigureS3_Conc_Shear.zip) at 0 rpm has been corrected in the file contained within the sub-folder named Raw Data.

2. Copy errors in the SEM images for the semi-batch system in Figure 5 (Folder: Figure5_SEM.zip) have been corrected in the files contained within the sub-folder Images. (Sept 2022)