Description
Drug-eluting stents are the preferred treatment for symptomatic coronary artery disease.However, despite rapid evolution of the stent design there remain limitations in their use and efficacy. The precise contribution of the drug dose and release kinetics from stents to device efficacy is unclear and existing models are limited in their capacity to fully evaluate this. This work developed a predictive computational model of drug release and tissue distribution from the stent into the artery wall tissue, using in vitro data and validating with in vivo data. The data used to inform and validate this model are contained within his repository,
| Date made available | 12 Mar 2019 |
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| Publisher | University of Strathclyde |
| Date of data production | 1 Jan 2015 - 31 Dec 2018 |
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Combining mathematical modelling with in vitro experiments to predict in vivo drug-eluting stent performance
McKittrick, C. M., McKee, S., Kennedy, S., Oldroyd, K., Wheel, M., Pontrelli, G., Dixon, S., McGinty, S. & McCormick, C., 10 Jun 2019, In: Journal of Controlled Release. 303, p. 151-161 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Link opens in a new tab Citations (Scopus)76 Downloads (Pure) -
Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics
McGinty, S., McCormick, C., McKittrick, C. M., Kennedy, S., Oldroyd, K. G., Wheel, M., Scullion, B., Pontrelli, G., McKee, S., Nithiarasu, P. (Editor) & Robertson, A. M. (Editor), 10 Apr 2017, 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Swansea UK, p. 1011-1014 4 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book
Open AccessFile
Projects
- 2 Finished
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Fast-tracking Health Innovation for NHS Scotland. MRC Confidence in Concept / R180246-105
McCormick, C. (Principal Investigator) & McKittrick, C. (Researcher)
MRC (Medical Research Council)
1/03/18 → 28/02/20
Project: Research - Internally Allocated
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Optimal designs of drug eluting stents
McKee, S. (Principal Investigator), Ainsworth, M. (Co-investigator), Wadsworth, R. (Co-investigator) & McCormick, C. (Research Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/04/12 → 30/09/15
Project: Research
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