Molecular Pharmacology of Emerging GPCR Therapeutic Targets

Sophie Bradley (Organiser), Leigh Stoddart (Organiser), Cunningham, M. R. (Organiser)

Activity: Participating in or organising an event typesOrganiser of special symposia

Description

G protein-coupled receptors (GPCRs) regulate a wide variety of physiological processes and are one the most intensively studied drug target. GPCRs are the most successful drug target, with ~34% of currently approved drugs have a GPCR as their target. Despite this, only 27% of GPCRs have been successfully targeted in the clinic leaving a large proportion of physiologically relevant receptors without drugs that can modify their activity. In this session, current trends in GPCR drug discovery will be discussed, opening up a focus on specific GPCRs that have not yet been explored in clinical trials and have untapped therapeutic potential in a range of disease indications including viral GPCRs in glioblastoma, free fatty acid receptors in metabolic disorders and the orphan receptor GPR35 in inflammatory bowel disease.
Period17 Dec 2019
Event typeConference
LocationEdinburgh, United Kingdom
Degree of RecognitionNational